• Journal of Digital Convergence
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• v.17 no.2
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• pp.433-445
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• 2019

The purpose of this study was to investigate the relationship between parenting behaviors and parental insights by examining the effects of parental insights in addition to the main variables found to explain parenting behaviors through previous studies. In addition to the parental insight, this study examined the influence of past childhood experiences(perceived parenting behavior, family of origin' health) and parenting experience (marital satisfaction, parental role satisfaction) in current life. As a result of hierarchical regression analysis of 202 mothers of middle school students, all of the input variables were found to explain the parenting behavior significantly. In particular, parental insight was proved to have significant explanatory power on affection, rejection, regulation, and independence-oriented behavior among the sub-factors of parenting behavior except overprotective. Finally, the implications of this study and future research directions were discussed.

• Korean Journal of Exercise Nutrition
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• v.14 no.2
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• pp.81-86
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• 2010

The purpose of this study was to identify the factors associated with child's Body Mass Index (BMI) and physical activity. The participants (n = 133) were Korean juveniles (3^rd and 4^th graders) and their parents. They completed a questionnaire packet including the SPARK (Sports, Play, and Active Recreation for Kids) survey and the parent equivalent survey. Correlation, multiple linear regression and binary logistic regression analyses were applied to identify the association between child's BMI and 10 factors of SPARK as predict or variables. 25.6% of the participants were classified as overweight (21.1%) or obesity (4.5%). 3 parental factors including mother's BMI and frequency of mother's and father's physical activity were identified as significant predictors of children's BMI. The 10 variables accounted for 28% of the variance (p<.01) in the linear regression model. These results provide insight into parental factors which are related to a child's BMI and physical activity. Parental role modeling which refers to parents' efforts to model an active lifestyle for children plays an important role.

• Journal of Digital Convergence
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• v.15 no.5
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• pp.495-503
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• 2017

The purpose of this study was to investigate the effect of psychobiographical intensive interview(PII) on the parent's insight, parent-child relationship characteristics and counseling session. For this, the PII was conducted to 10 mothers with school age children. PII was semi-structured form that included the intensive interview for exploring psychobiographical information and interpretation counseling of it. The results showed that the level of insight into parent's child problem and relation to parent's own problem was significantly increased. On the other hand, parent-child relationship characteristics (parental efficacy, parenting attitude, and parenting stress) were found to be significant only in some of the parenting stresses. We investigated the possibility as a counseling tool for PII through counseling session impact assessments. As a result of that, we confirmed that there were positive results in task impacts, relationship impacts, and helpful impacts.

• Korean Journal of Biological Psychiatry
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• v.24 no.3
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• pp.83-94
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• 2017

Caregiving for the children seems to be one of the most challenging tasks for the parents who should devote themselves totally despite endangering them. From the evolutionary perspective, this human behavior must have been the advantage in the survival of the species and rooted in ethological origin. John Bowlby, a child psychiatrist, psychoanalyst, and great developmental researcher, had formulated the attachment theory linking psychoanalysis and ethology through evolutionary biology. His and later following researchers' outcomes have provided enormous influence on viewing parental caregiving and the insight of human relationships and interventions. This article overviews the attachment theory in terms of the goal oriented cybernetic system to gain the survival advantage of the offspring and investigates the evolutionary origin of the caregiving and attachment from the retiles of the Mesozoic era to the mammalian revolution and finally to the human being. Deeper understanding of the nurturance and adult relationships from the standpoint of evolution can provide clinical utility of awareness of clients' lives.

• Molecules and Cells
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• v.21 no.3
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• pp.360-366
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• 2006

Up to 35% of the rice genome consists of various kinds of transposons, and CACTA and MITE are two of the major class 2 DNA transposons in the genome. We have employed the consensus sequences of Rim2/Hipa CACTA, Stowaway MITE Pangrangja, and Tourist MITE Ditto for transposon display (TD) analysis to locate them on a genetic map, with 58 SSR markers used to anchor them. The TD analysis produced a high profile of the polymorphisms between the parental lines, Oryza sativa var. Gihobyeo/O. sativa var. Milyang, in intraspecific $F_{15}$ RIL lines, locating 368 markers of Rim2/Hipa CACTA, 78 markers of Tourist MITE Ditto, and 22 markers of Stowaway MITE Pangrangja. In the segregation analysis, non-parental segregating bands and segregation distortion bands were observed. The recombinant genetic map spans 3023.9 cM, with 5.7 cM the average distance between markers. The TD markers were distributed unequally on the chromosomes because many TD markers were located in pericentric chromosomal regions except in the cases of chromosomes 2, 3, 6 and 9. Although the number of transposon markers was not sufficient to include all rice class 2 transposons, the current map of CACTA and MITE transposons should provide new insight into the genome organization of rice since no previous DNA transposon map is available.

• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.253-263
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• 2023

The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluids and contain various bioactive materials, including proteins, lipids, nucleic acids, and mitochondrial DNA. Based on their origin and biogenesis, EVs can be classified as apoptotic bodies, microvesicles, and exosomes. Among these, exosomes are the smallest EVs (30-150 nm in diameter), which play a significant role in cell-to-cell communication and epigenetic regulation. Moreover, exosomal content analysis can reveal the functional state of the parental cell. Therefore, exosomes can be applied to various purposes, including disease diagnosis and treatment, drug delivery, cell-free vaccines, and regenerative medicine. However, exosome-related research faces two major limitations: isolation of exosomes with high yield and purity and distinction of exosomes from other EVs (especially microvesicles). No standardized exosome isolation method has been established to date; however, various exosome isolation strategies have been proposed to investigate their biological roles. Exosome-mediated intercellular communications are known to be involved in alcoholic liver disease and nonalcoholic fatty liver disease development. Damaged hepatocytes or nonparenchymal cells release large numbers of exosomes that promote the progression of inflammation and fibrogenesis through interactions with neighboring cells. Exosomes are expected to provide insight on the progression of liver disease. Here, we review the biogenesis of exosomes, exosome isolation techniques, and biological roles of exosomes in alcoholic liver disease and nonalcoholic fatty liver disease.

• Industry Promotion Research
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• v.5 no.3
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• pp.97-104
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• 2020

The study participants selected three participants in their late 40s and conducted a total of six sessions and in-depth interviews for 90 minutes to collect and analyze data using the phenomenological Giorgi research method. The conclusion according to the research results was drawn as follows. First, the shame, fear, reprimand, violence, passive attitude, and childhood that had to be adjusted seemed to maintain a stable life in the late forties, but still appeared in the present life. It was found that they showed a low self-satisfaction rather than positive satisfaction with self-concept and pursued an ideal self-image. Second, lifestyle was a time of severe depression, lethargy, and emptiness as a child, experiencing an unstable childhood due to a violent family, loss of attachment, overprotection, difficult economic conditions, and parental strife. It has been found that in the late forties, families have been established and religious life is being stabilized, and the responsibility for the family is valued. This shows how a lifestyle that gives meaning and recognizes what experience gives meaning to the childhood that one experienced. Insight into change and growth in middle-aged life, searching for and interpreting the initial recollections that they have experienced, accompanied by social and psychological changes in middle-aged men, discovering inappropriate meanings and goals and preparing for a second life in the age of 100 It is meaningful to provide.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3395-3402
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• 2015

Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.