• Title/Summary/Keyword: PS4

Search Result 1,254, Processing Time 0.031 seconds

이온토포레시스에 의한 피리도스티그민과 클로르페니라민의 in vitro 경피흡수

  • 심창구;김종국
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1993.04a
    • /
    • pp.179-179
    • /
    • 1993
  • 1. PS및 CP의 flux는 전류의 새기 및 donor의 약물농도에 비래하였다. 2. pH의 flux는 pH가 증가할수록 증가하였으나, CP(pKa=9.2)의 flux는 pH=2에서 최대치를 보였다. 이는 약물의 해리 정도와 H$^{+}$이온의 mobility, 또 피부의 permselectivity의 balance에 의해 결정된 것으로 생각된다. 3. donor cell에 NaCl을 첨가하면 두 약물 공히, 그러나 특히 PS의 flux가 저하되었다. 이는 두 약물의 이온과 $Na^{+}$의 mobility차이에 기인한다고 생각된다. 4. PS의 경우 taurodeoxycholate(TDC)같은 음이온을 donor cell에 공존시키면 flux가 감소하였다. 이는 PS와 TDC가 전기적으로 중성인 ion-pair complex를 형성함으로써 PS이온의 유효농도가 감소하기 때문으로 생각된다.

  • PDF

Compatibilizing Effect of Polystyrene-Poly(caprolactone) Block Copolymer Synthesized from Macroinitiator in Poly(2, 6-dimethyl-1, 4-phenylene oxide)/Poly(styrene-co-acrylonitrile) Blend (Poly(2, 6-dimethyl-1, 4-phenylene oxide)/Poly(styrene-co-acrylonitrile)블렌드에서 Macroinitiator로 합성한 Polystyrene-Poly(caprolactone) 블록공중합체의 상용제로서의 역할에 관한 연구)

  • Chung, Oong-Kwon;Jeong, Han-Mo;Yang, Sung-Bong;Yoon, Koo-Sik
    • Applied Chemistry for Engineering
    • /
    • v.3 no.2
    • /
    • pp.247-255
    • /
    • 1992
  • Polystyrene-poly(caprolactone) (PS-PCL) block copolymer was synthesized from macroazoinitiator, and its compatibilizing effect in poly(2, 6-dimethyl-1, 4-phenylene oxide) (PPO)/poly(styrene-co-acrylonitrile) (SAN, 25wt% acrylonitrile) blend was studied. PS block and PCL block in the block copolymer had shown miscibility with PPO and SAN respectively. The dissolution of SAN into PPO domain was promoted by the addition of the PS-PCL block copolymer.

  • PDF

Effect of Incorporation Rate of Polyacrylamide Hydrogel on Changes in Physical Properties of Root Media (Polyacrylamide 고흡수성 수지의 혼합 비율이 상토의 물리성에 미치는 영향)

  • Wang, Hyun-Jin;Choi, Jong-Myung;Lee, Jong-Suk
    • Journal of Bio-Environment Control
    • /
    • v.14 no.3
    • /
    • pp.182-189
    • /
    • 2005
  • This research was conducted to determine physical properties of four root media, peatmoss + vermiculite (1:1, v/v; PV), peatmoss + composted rice hall (1:1, PR), peatmoss + composted saw-dust (1:1 : PS) and peatmoss + composted pine bark (1:1 PB), as influenced by incorporation rate of Stock-sorb C (STSB). Each root medium containing STSB was packed in 22 cm diameter plastic pot and the physical properties were determined at 5 weeks after packing. As incorporation rate of STSB were elevated, total porosity increased in PV, PS and PB media with statistical differences at $5{\%}$ level. Those also resulted in increase of container capacity in PS and PB media, but statistical differences were not observed in PV and PR media. Elevated incorporation rate of STSB in PV, PS and PB media resulted in increase of air space with statistical differences. Trends in air space of the three root media showed a linear as well as quadratic responses to STSB contents of media. As incorporation rate of STSB increased, more water was retained in four root media at the soil moisture tension of 4.90 kPa, 9.81 kPa, 29.4 kPa and 1.5 MPa. The amount of water retained in PS medium was the highest at the moisture tension at 29.4 kPa and 1.5 MPa followed by PB, PR and PV medium. These results indicated that elevation of incorporation rate of STSB to various root media increased moisture retention capacity, but did not increase the available water holding capacity.

Effects of Sulfonation Ratio in Petroleum Sulfonate Synthesis on Interfacial Properties and on Fluidity Properties of Cement Mortar (Petroleum Sulfonate의 합성에 있어서 황산화율이 계면활성 특성 및 시멘트 몰타르의 유동성에 미치는 영향)

  • Kim, Young-Ho
    • Korean Chemical Engineering Research
    • /
    • v.48 no.4
    • /
    • pp.444-449
    • /
    • 2010
  • In this study, the petroleum sulfonate(PS) was synthesized from pyolyzed fuel oil by sulfonation reaction with sulfuric acid. The PS synthesized had surfactant behaviors relating to the interfacial properties such as surface tension, surface adsorption, and wetting, etc. These interfacial properties were affected by the sulfonation ratio in the synthesis. As the sulfonation ratio increased, the surface tension of the PS aqueous solution decreased. However, when the ratio was too high, the surface tension was increased due to the extremely higher value of hydrophilicity of PS. At the optimum sulfonation ratio, the PS had a good wettability on the cement particles and a good fluidity of the cement mortar with a high adsorption.

Photoinhibition of Candida Albicans Growth by Psoralen Derivatives

  • Han, Gyu-Seok;Shim, Sang-Chul;Hann, Seung-Kyung;Jang, Nam-Su;Wee, Seong-Ho;Park, Yoon-Kee
    • Journal of Photoscience
    • /
    • v.5 no.4
    • /
    • pp.163-167
    • /
    • 1998
  • Candida albcans growth inhibition experiments were carried out to determine the photoxicity of new monofunctional psoralen derivatives, PzPs and HMPzPs, as well as well known 8-MOP an d5-MOP. Although 8-MOP and 5-MOP showed distince photoxicity, PzPs and HMPzPs did not inhibit the growth of Candida albicans strain indicating that PzPs derivatives were not good candidate for the treatment of psoriasis. However, vitili해 could be treated by PzPs derivatives without severe phototosicity because psoralens are known to treat vitiligo by stimulating melanogenesis on skin.

  • PDF

Skin Transport of Synthetic Oligodeoxynucleotide (합성 올리고데옥시뉴클레오타이드의 피부투과)

  • Lee, Young-Mi;Lee, Sung-Hee;Kim, Jae-Baek;Sohn, Dong-Hwan
    • Journal of Pharmaceutical Investigation
    • /
    • v.25 no.4
    • /
    • pp.347-351
    • /
    • 1995
  • Antisense phosphorothioate oligodeoxynucleotide(PS-ODN) against $TGF-{\beta}$ was developed as scar formation inhibitor. The scar was caused collagen deposition due to overexpression of $TGF-{\beta}$ in wounded skin. The percutaneous absorption of partially modified PS-ODN(25 mer) was investigated for the purpose of its effective delivery. Though PS-ODN has high molecular weight (MW=8,000) and polyanionic charge, it was permeated through skin. The skin permeation of PS-ODN was markedly increased by the removal of stratum corneum and dermis. Moreover, the skin permeation of PS-ODN was decreased in the following order; hairless mouse skin>rat skin>human cadaver skin. Thus, PS-ODN represents a logical candidate for further evalution due to the potential for delivery into the wounded skin.

  • PDF

Effects of antitumor polysaccharides from albizza julibrissin on immune function

  • Moon, Chang-Kiu;Lee, Byeong-Gon;Lee, Soo-Hwan;Kang, Tak-Lim
    • Archives of Pharmacal Research
    • /
    • v.8 no.4
    • /
    • pp.277-282
    • /
    • 1985
  • Polysaccharide fractions were prepared from Albizzia julibrissin by different extraction schedules. The fractions obtained were designated as PS-I and PS-II, respectively. Further purification of PS-I by Sephadex G-200 column chromatography gave two subfractions, Alju A and alju B, Each fraction showed marked antitumor activity against sarcoma 180 solid form but not ascite form. PS-I and PS-II increased delayed hypersensitivity in normal and tumor bearing mice. PS-I treatment led to moderate restoration of the suppressed antibody production in tumor bearing mice.

  • PDF

Extraction of starch from frozen potato whole-tissues using cellulase and its physicochemical properties (셀룰로오스분해효소에 의한 동결감자로부터 전분의 추출 및 물리화학적 특성)

  • Kim, Jaehyun;Kim, Hyun-Seok
    • Korean Journal of Food Science and Technology
    • /
    • v.51 no.4
    • /
    • pp.348-355
    • /
    • 2019
  • This study investigated the impact of cellulase treatment on the extraction yield of potato starch (PS), and compared the physicochemical properties of PS by conventional (CSE) and enzymatic (ESE) starch extraction. In ESE, the PS extraction yield was predominantly influenced by reaction temperature, time and their interaction, compared to the cellulase concentration. When potatoes were treated for 8 h at $40^{\circ}C$ with 1.5% cellulase, the PS extraction yield was about 3.4-fold higher than that by CSE. Compared to CSE-PS, ESE-PS showed lower total starch contents and higher amylose contents, resulting in lower swelling factors and distorted pasting viscosity profiles accompanied by absence of peak and breakdown viscosities. However, ESE did not affect the gelatinization characteristics of PS. Overall results suggested that ESE can provide the highest yield of PS, and ESE-PS can be a potential starch source for extending the utilization of PS in food industries.

Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases

  • Zhang, Jian-Hua;Wang, Ming-Sheng;Pan, Hai-Hong;Li, Shu-Feng;Wang, Zhong-Qiu;Chen, Wang-Sheng
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.13 no.4
    • /
    • pp.1575-1578
    • /
    • 2012
  • Objectives: To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases. Methods: Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining. Results: Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01). Conclusion: VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.

Design and Implementation of Publish/Subscribe Model Based RPC Middleware (Publish/Subscribe 모델 기반 RPC 미들웨어 설계와 구현)

  • Park, Sanghyun;Choi, Junesung;Kook, Kwangho
    • Journal of IKEEE
    • /
    • v.19 no.3
    • /
    • pp.327-334
    • /
    • 2015
  • Various types of middle-ware were created for integration between legacy systems and newly built systems. RPC(Remote Procedure Call), MOM(Message Oriented Middle-ware) and TM(Transaction processing Monitor) are the typical types of middle-ware. One of the most known MOM type middle-ware is PS(Publish/Subscribe). PS enables to create a system which has low coupling and high scalability. But PS based systems also have low cohesiveness. On the contrary, RPC has high cohesiveness but also has high coupling. This paper proposed design and implementation of hybrid model which offset disadvantages of RPC and PS.