Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases

  • Zhang, Jian-Hua (Department of Radiology, East Hospital, Tongji University School of Medicine) ;
  • Wang, Ming-Sheng (Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Pan, Hai-Hong (Department of Radiology, East Hospital, Tongji University School of Medicine) ;
  • Li, Shu-Feng (Department of Radiology, East Hospital, Tongji University School of Medicine) ;
  • Wang, Zhong-Qiu (Department of Radiology, East Hospital, Tongji University School of Medicine) ;
  • Chen, Wang-Sheng (Department of Radiology, Hainan Provincial Pepole's Hospital)
  • Published : 2012.04.30
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Abstract

Objectives: To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases. Methods: Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining. Results: Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01). Conclusion: VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.

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