• Title/Summary/Keyword: PMC

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Structure Analysis of pmcABCDEFT Gene Cluster for Degradation of Protocatechuate from Comamonas sp. Strain DJ-12 (Comamonas sp. Strain DJ-12로부터 Protocatechuate의 분해에 관여하는 pmcABCDEFT 유전자군의 구조 분석)

  • Kang Cheol-Hee;Lee Sang-Mhan;Lee Kyoung;Lee Dong-Hun;Kim Chi-Kyung
    • Korean Journal of Microbiology
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    • v.41 no.3
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    • pp.195-200
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    • 2005
  • Comamonas sp. strain DJ-12 is a bacterial isolate capable of degrading of 4-chlorobiphenyl (4CB) as a carbon and energy source. The degradation pathway was characterized as being conducted by consecutive reactions of the meta-degradation of 4CB, hydrolytic dechlorination of 4-chlorobenzoate (4CBA), hydroxylation of 4-hydroxybenzoate, and meta-degradation of protocatechuate to product TCA metabolites. The 6.8 kb fragment from the chromosomal DNA of Comamonas sp. strain DJ-12 included the genes encoding for the meta-degradation of PCA; the genes of protocatechuate 4,5-dioxygenase alpha and beta subunits (pmcA and pmcB), 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (pmcC), 2-pyrone-4,6-dicarboxylate hydrolase (pmcD), 4-oxalomesaconate (OMA) hydratase(pmcE), 4-oxalocitramalate (OCM) aldolase (pmcF), and transporter gene (pmcT). They were organized in the order of pmcT-pmcE-pmcF-pmcD-pmcA-pmcB-pmcC. The amino acid sequences deduced from the nucleotide sequences of pmcABCDEFT genes from Comamonas sp. strain DJ-12 exhibited 94 to $98\%$ homologies with those of Comamonas testosteroni BR6020 and Pseudomonas ochraceae NGJ1, but only 52 to $74\%$ with homologies Sphingomonas paucimobilis SYK-6, Sphingomonas sp. LB126, and Arthrobacter keyseri 12B.

A Study on Noisy Speech Recognition Using Discriminative Training for PMC Algorithm (PMC 방식에서의 분별적 학습을 이용한 잡음 음성인식에 관한 연구)

  • 정용주
    • The Journal of the Acoustical Society of Korea
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    • v.19 no.2
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    • pp.83-89
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    • 2000
  • In this paper, we proposed a discriminative adaptation method for PMC algorithm and achieved improved speech recognition rate. For the adaptation, we adopted modified PMC(MPMC) which is a variant of PMC and discriminatively adapted the association factor for each mixture of the HMM in the MPMC. From the recognition experiments, the proposed method showed better recognition rate than the conventional PMC. Also, compared with STAR algorithm which is another model parameter compensation method, the proposed method showed superior performance when the SNR is very low and the adaptation data is not sufficient.

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Analysis of Perception Difference between Domestic and International Engineering Firms -Focusing on the Competitiveness of International PMC Market- (해외 PMC 시장 경쟁력에 대한 국내외의 인식차이 분석 - 한국 엔지니어링 기업을 중심으로 -)

  • Jang, Woosik;Lee, Baul;Kim, Yeonsoo;Han, Seung Heon
    • Korean Journal of Construction Engineering and Management
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    • v.18 no.6
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    • pp.3-12
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    • 2017
  • In recent years, Project Management Consultant(PMC) project has been emerging as a high-value-added engineering project. However, domestic engineering firms have difficulties in entering the overseas PMC market because of poor project performance and lack of PMC capabilities. To overcome these limitations, this study analyzes the key competitiveness factors for successfully performing the global PMC projects. PMC competency factors based on Porter's double diamond theory were extracted, and a questionnaire survey was conducted on domestic and overseas engineering firms. In addition, the important PMC competency factors were derived through paired t-test and IPA matrix analysis. As a result, the PMC competitiveness of domestic engineering firms was analyzed as around 60% compared to that of global engineering firms. Furthermore, 'PMC track records' and 'project management/owner response skills' were identified as top priority competency factors which are the most necessary factors for present domestic engineering firms. This study is expected to support to establish the international PMC market entry strategies by providing priorities of key competitiveness factors.

A Study on the PMC Adaptation for Speech Recognition under Noisy Conditions (잡음 환경에서의 음성인식을 위한 PMC 적응에 관한 연구)

  • 김현기
    • Journal of Korea Society of Industrial Information Systems
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    • v.7 no.3
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    • pp.9-14
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    • 2002
  • In this paper we propose a method for performance enhancement of speech recognizer under noisy conditions. The parallel combination model which is presented at the PMC method using multiple Gaussian-distributed mixtures have been adapted to the variation of each mixture. The CDHMM(continuous observation density HMM) which has multiple Gaussian distributed mixtures are combined by the proposed PMC method. Also, the EM(expectation maximization) algorithm is used for adapting the model mean parameter in order to reduce the variation of the mixture density. The result of simulation, the proposed PMC adaptation method show better performance than the conventional PMC method.

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International PMC Project Competency Enhancement Strategies for Domestic Engineering Companies (국내 엔지니어링 기업의 해외 PMC 사업 역량강화 방안)

  • Lee, Baul;Lee, Changjun;Han, Seung Heon;Lee, Jeonghun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.38 no.1
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    • pp.121-132
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    • 2018
  • Korea's construction engineering companies are facing difficulties in deterioration of international construction profitability because they focus on traditional engineering fields such as design and construction supervision. Therefore, it is necessary to strengthen competency of high-add-value engineering field such as Project-Management-Consultancy (PMC). This paper aims to suggest the strategies to enhance the international PMC competency. This study identified the competency factors for international PMC, using Borich needs assessment and Locus for focus model. As a result, step-by-step strategies were suggested according to the competency level in domestic engineering companies. The results of this study will assist Korean engineering companies to consider the important competencies for international PMC projects. Furthermore, enhancement strategies are going to be proper references for domestic engineering companies which prepare the international PMC project.

Study on the Property of Sintered Silver Clay for Rapid Modeling (신속 조형용 은점토 소결체의 물성 연구)

  • Kim, Jun-Hwan;Kim, Keum-Jong;Kim, Myung-Ro;Song, Oh-Sung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.9 no.6
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    • pp.1548-1554
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    • 2008
  • The market of silver precious metal clay (PMC) is promising as its application for agile metal craft. The property of suitable hardness and shrinkage as well as environment-safe is strictly required as people make the final product with bare hands. We propose a silver PMC with new organic binder made of palm oil, glycolic acid and water. Then we prepared disk specimen of our proposed PMC and well-known commercial PMC. We investigated the hardness, weight change, linear shrinkage, density and micro structure evolution with sintering temperature of $700{\sim}900^{\circ}C$ ($50^{\circ}C$ gap) for 15minutes. We confirm our proposed PMC has suitable property for craft product comparable for commercial PMC, and the optimum sintering condition is $850^{\circ}C$-15minutes for metal craft application.

Solubilization and Fomulation as Soft Gelatine Capsule of Biphenyldimethyldicarboxylate (비페닐디메칠디카르복실레이트의 가용화 및 연질캅셀제로의 설계)

  • Park, Gee-Bae;Chung, Chae-Kyong;Lee, Kwang-Pyo
    • Journal of Pharmaceutical Investigation
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    • v.26 no.1
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    • pp.1-11
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    • 1996
  • Biphenyldimethyldicarboxylate (PMC), which has been used to treat hepatitis, is insoluble in water, therefore it has low bioavailability after oral administration. For the purpose of increasing the dissolution rate of PMC, the physical mixtures and inclusion complexes of PMC and $dimethyl-{\beta}-cyclodextrin\;(DM\;{\beta}CD)\;or\;hydroxypropyl-{\beta}-cyclodextrin\;(HP{\beta}CD)$ in molar ratio of 1 : 1 and 1 : 2 were prepared by solvent evaporation method. Mixed micelles of PMC were prepared by reacting PMC with bile salts [sodium cholate(NaC), sodium glycocholate (NaGC)] and oleic acid (OA) or palmitoylcarnitine chloride(PCC). Chloroform/water partition coefficient (PC) of PMC was 36.14 in artificial gastric juice (AGJ) and 33.47 in artificial intestinal juice (AIJ), respectively, on the other hand octanol/water PC was 63.36. PMC formulation was prepared by reacting PMC with PEG400-glycerin system(95 : 5, 90 : 10, respectively) and PEG400-PEG4000-glycerin system (70 : 25 : 5, 65 : 25 : 10, respectively). Dissolution test was performed in AGJ and AIJ by paddle method at $37{\pm}0.5^{\circ}C$. The dissolution rates of PMC tablets on the market were 5.74% and 8.26% at AGJ and AIJ, respectively and marketed PMC capsules were 22.14% and 28.64% at AGJ and AIJ, respectively. The dissolution rates of inclusion complexes of PMC with $DM{\beta}CD$ and $HP{\beta}CD$ in a molar ratio of 1 : 1 were more fast than those of corresponding physical mixtures. The decreasing order of dissolution rates was as follows; PMC-PEG400-PEG4000-glycerin formulation > PMC-PEG400-glycerin formulation > mixed micelles > CD inclusion complexes. The dissolution rates of PMC-PEG400-glycerin and PMC-PEG400-PEG4000-glycerin formulation were most fast and the percentage of dissolution was almost 100% within 20 minutes. And their dissolution rates after 120 minutes were markedly increased as compared with capsules on the market (4.0-fold and 3.2-fold in PMC-PEG400-glycerin formulation at AGJ and AIJ, respectively, and 4.8-fold and 3.7-fold in PMC-PEG400-PEG4000-glycerin formulation at AGJ and AIJ, respectively).

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A Study of the Effect of PMC and Human Resource Competency on Construction Project Performance Outcomes (PMC (Project Management Consultant)와 인적자원역량이 건설프로젝트성과에 미치는 영향에 관한 연구)

  • Lee, Heonchang;Lee, Jeongryun;Ahn, Byeonghoon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.42 no.5
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    • pp.701-710
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    • 2022
  • This study aims to prove the importance and necessity of a project management consultancy (PMC) that systematically manages construction projects to ensure their successful implementation. In order to analyze the interrelationship between the role of PMC and the outcome of the construction projects, structural equation modelling(SEM) was conducted. Hence, one of the critical aspects when conducting the project, human resource competency, especially referring to the competency of project team members and the project manager's leadership, affects the performance of construction projects. As a result of this study, PMC is found to have significant effects on human resource competency and construction project performance. In addition,human resource competency also had a significant effect on construction project performance. Consequently, the research outcomes suggest that introducing PMC services should be done when implementing large domestic infrastructure projects successfully, as doing so will enhance PM leadership and strengthen the capacity of the project team members.

Effect of Consecutive Application of Organic Matter on Soil Chemical Properties and Enzyme Activity in Potato Cultivation Soil (유기물 연용이 감자재배 비화산회토양의 화학성과 효소활성에 미치는 영향)

  • Joa, Jae-Ho;Moon, Kyung-Hwan;Seo, Hyeong-Ho;Choi, Kyung-San;Kim, Seong-Cheol
    • Korean Journal of Soil Science and Fertilizer
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    • v.44 no.5
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    • pp.801-807
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    • 2011
  • This study was carried out to evaluate effect of consecutive application of organic matter on soil chemical properties and dehydrogenase, acid phosphatase activity in non-volcanic ash soil during three cropping season. Organic matter mixture and organic fertilizer (MOF, $2,000kg\;10a^{-1}$), food waste compost (FWC, $2,000kg\;10a^{-1}$), and pig manure compost (PMC, 2,000, 4,000, and $6,000kg\;10a^{-1}$) were applied for each cropping season. Soil pH values were increased after three cropping season in all treatment. In the soils of the increased application of PMC, soil pH, total-nitrogen, available phosphate, exchangeable cations (K, Ca, and Mg), and heavy metal (Zn and Cu) contents were increased. In addition, Soil dehydrogenase activity was significantly increased in proportions to PMC application rate and cropping season during potato cultivation period. The activity was two times higher in PMC ($4,000kg\;10a^{-1}$) than control after the third cropping season. Soil dehydrogenase activity was in order of PMC>FWC>NPK+PMC>MOF. Acid phosphatase activity was higher in PMC ($6,000kg\;10a^{-1}$) than other treatment. Soil Zn content and dehydrogenase activity showed linearly correlation, which were MOF ($R^2$=0.427), FWC ($R^2$=0.427) and PMC ($R^2$=0.411, p<0.01), respectively. This study demonstrated that soil chemical properties and enzyme activity could be affected greatly by consecutive application of different organic matter in the potato cultivation field.

Analysis of Clostridium Difficile Toxin Value in Diarrhea Patients (설사증 환자에서 Clostridium Difficile Toxin Value 분석)

  • Kwon, Se-Young;Yoon, In-Sook
    • The Journal of the Korea Contents Association
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    • v.10 no.5
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    • pp.259-266
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    • 2010
  • Clostridium difficile-associated disease (CDAD) is an important nosocomial infectious diarrhea and is associated with antibiotic use. Recently, incidence of C. difficile has been increasing in hospitals. A total of 1,329 stool specimens were examined from January, 2005 to December, 2008. This study analyzed the incidence and clinical characteristics of C. difficile infections on them. Out of 1,329 stool specimens, 283 specimens showed toxin A/B positive, using EIA. The positive rate was 21.2%; with the highest incidence among and above the 70years old. On endoscopy, psedo membranous colitis was found in 57.7%, and 19.5% of patients were normal. Pathologic finding showed PMC in 26.8% of patients, AAC in 52.2%. C. difficile was associated with PMC, however, endoscopic and pathologic findings tests showed normal to PMC.