• 제목/요약/키워드: P2X4

검색결과 4,046건 처리시간 0.036초

Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Locoregionally Advanced Nasopharyngeal Carcinoma

  • Yu, Hong-Sheng;Wang, Xin;Song, Ai-Qin;Liu, Ning;Zhang, Wei;Yu, Li
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권8호
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    • pp.3961-3965
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    • 2012
  • Objective: To compare the clinical effects of concurrent radiochemotherapy with those of radiotherapy in treating locally advanced nasopharyngeal carcinoma (Stage III~IVa). Methods: A total of 95 patients suffering from nasopharyngeal carcinoma (Stage III~IVa) were divided into two groups: concurrent radiochemotherapy (Group CCRT, n=49) and radiotherapy (Group RT, n=46). The two groups were both delivered conventional fractionated radiotherapy, while Group CCRT also received three cycles of PF (DDP+5-Fu) or PLF (DDP+5-Fu+CF) chemotherapy. Results: The complete remission rate and total remission rate of Group CCRT were higher than those of Group RT ($X^2$=4.72~7.19, P<0.05). The one-year overall survival (OS) rate calculated by the life table method, was also higher than that of Group RT ($X^2$=4.24, P<0.05) as well as the 3-year OS rate, nasopharyngeal control rate and cervical lymph nodes' control rate ($X^2$=4.28~4.40, P<0.05). In addition, the 5-year OS and metastasis-free rates of Group CCRT were higher than those of Group RT and the differences were of statistical importance ($X^2$=3.96~8.26, P<0.05). However, acute toxicity was also obviously higher, the difference in gastrointestinal reactions being statistically significant ($X^2$=11.70, P<0.05). Conclusion: This study demonstrated that concurrent radiochemotherapy could improve the remission rate, overall survival rate and locally control rate. The toxicity of concurrent radiochemotherapy could be tolerated by the patients.

On the Tensor Product of m-Partition Algebras

  • Kennedy, A. Joseph;Jaish, P.
    • Kyungpook Mathematical Journal
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    • 제61권4호
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    • pp.679-710
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    • 2021
  • We study the tensor product algebra Pk(x1) ⊗ Pk(x2) ⊗ ⋯ ⊗ Pk(xm), where Pk(x) is the partition algebra defined by Jones and Martin. We discuss the centralizer of this algebra and corresponding Schur-Weyl dualities and also index the inequivalent irreducible representations of the algebra Pk(x1) ⊗ Pk(x2) ⊗ ⋯ ⊗ Pk(xm) and compute their dimensions in the semisimple case. In addition, we describe the Bratteli diagrams and branching rules. Along with that, we have also constructed the RS correspondence for the tensor product of m-partition algebras which gives the bijection between the set of tensor product of m-partition diagram of Pk(n1) ⊗ Pk(n2) ⊗ ⋯ ⊗ Pk(nm) and the pairs of m-vacillating tableaux of shape [λ] ∈ Γkm, Γkm = {[λ] = (λ1, λ2, …, λm)|λi ∈ Γk, i ∈ {1, 2, …, m}} where Γk = {λi ⊢ t|0 ≤ t ≤ k}. Also, we provide proof of the identity $(n_1n_2{\cdots}n_m)^k={\sum}_{[{\lambda}]{\in}{\Lambda}^k_{{n_1},{n_2},{\ldots},{n_m}}}$ f[λ]mk[λ] where mk[λ] is the multiplicity of the irreducible representation of $S{_{n_1}}{\times}S{_{n_2}}{\times}....{\times}S{_{n_m}}$ module indexed by ${[{\lambda}]{\in}{\Lambda}^k_{{n_1},{n_2},{\ldots},{n_m}}}$, where f[λ] is the degree of the corresponding representation indexed by ${[{\lambda}]{\in}{\Lambda}^k_{{n_1},{n_2},{\ldots},{n_m}}}$ and ${[{\lambda}]{\in}{\Lambda}^k_{{n_1},{n_2},{\ldots},{n_m}}}=\{[{\lambda}]=({\lambda}_1,{\lambda}_2,{\ldots},{\lambda}_m){\mid}{\lambda}_i{\in}{\Lambda}^k_{n_i},i{\in}\{1,2,{\ldots},m\}\}$ where ${\Lambda}^k_{n_i}=\{{\mu}=({\mu}_1,{\mu}_2,{\ldots},{\mu}_t){\vdash}n_i{\mid}n_i-{\mu}_1{\leq}k\}$.

An Analysis of X-Factor, Triple X-Factor, and the Center of Pressure (COP) according to the Feel of the Golf Driver Swing

  • Kim, Yong-Seok;So, Jae-Moo
    • 한국운동역학회지
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    • 제26권3호
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    • pp.265-272
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    • 2016
  • Objective: The aim of this study was to analyze X-factor, triple X-factor, and the center of pressure (COP) according to the feel of golf driver swing. Method: For this research, 9 golfers from the Korea Professional Golfers' Association (age: $30.11{\pm}2.98yrs$, height: $178.00{\pm}8.42cm$, weight: $76.22{\pm}8.42kg$, experience: $10.06{\pm}3.11yrs$) were recruited to participate in the experiment. Twelve Motion Analysis Eagle-4 cameras were installed and an image analysis was conducted by using the NLT (non-linear transformation) method, and 2 units of Kistler type 5233A dynamometer were used to measure ground reaction force. The sampling ratio was set at 1000 Hz. The golfers each took 10 swings by using their own driver, and chose the best and worse feel from among 10 shots. A paired-sample t-test was used to analyze the results. Results: In regard to feel, no change in head speed, X-factor, and the triple X-factor's X-factor stretch, hip rise, and head swivel, was observed (p>.05). Regarding ground reaction force, a difference was observed between the top of the backswing (p<.05) and impact (p<.05) in the vertical force of the left foot. For COP, a difference was also observed between the mid backswing (p<.001), late backswing (p<.001), and top of the backswing (p<.05) for the right foot X-axis and Y-axis mid follow through (p<.01). Conclusion: It can be reasoned that, irrespective of feel, the head speed, X-factor and triple X-factor's X-factor stretch, hip rise and head swivel did not have an effect on drive distance for domestic golfers, and the vertical reaction force of the left foot and left-right movement span's pressure dispersal of the right foot had an increasing effect on drive distance.

난백의 가열처리에 있어서 난황과 자당 첨가가 pH 및 비중의 변화에 미치는 영향 -난황, 난백 191g과 222g 및 자당 150g의 혼합시- (The Effect of Addition of Egg Yolk and Sucrose on the pH and Specific Gravity for Boated Egg Albumen -Results of Mixed Form from Yolk, Albumen 191g and 222g, and Sucrose 150g-)

  • 하정기;황보종;양기원;황경규
    • 한국가금학회지
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    • 제19권4호
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    • pp.197-204
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    • 1992
  • 본 실험은 난백 191g(시험 1)과 난백 222g(실험 2)에 자당(백색) 150g씩을 첨가한 2개의 실험구로 나누고 다시 각 실험구에 난황 0. 8.71, 17.43및 24.14g 첨가구로서 4구분하였으며 $50^{\circ}C$의 shaking water bath 내에서 1분간 92 왕복 속도로서 진탕시킴과 동시에 2, 4, 6, 8, 10및 12시간 후까지 경시적으로 pH와 비중을 측정하였다. 1. 전 시험구간에 있어서 shaking시간에 따라 pH와 비중은 경시적으로 증가되었으나 난황의 첨가량에 따라 pH 비중은 낮아졌다. 2. 실험 1과 2에서 shaking 10 시간 후 의 pH가 최고치를 나타냈으나, 그 이상의 증가는 없었다. 3. 실험 1과 2에서 얻어진 pH와 비중간에는 다음과 같은 높은 정의 상관관계를 나타내었다. (실험 1) Y=0.1081X+0.272(r=0.900$^{**}$ ), (실험 2) Y=0.083X +0.476(r=0.825$^{**}$ ).

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$CF_4$ 플라즈마에서 반응성 이온식각한 알루미늄 박막의 표면분석 (Surface analysis of reactively ion-etched aluminum films in $CF_4$ plasma)

  • 김동원;이원종
    • 한국결정성장학회지
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    • 제5권4호
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    • pp.351-357
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    • 1995
  • $CF_4$ 플라즈마 분위기에서 반응성 이온식각된 알루미늄의 표면을 XPS 분석하였다. 알루미늄의 표면에$AlF_3$가 형성되었으며 표면에서의 깊이가 깊어질수록 Al - F 결합에 의한 $Al_{2p}$ peak 강도가 감소하고 금속 알루미늄 결합에 의한 $Al_{2p}$ peak 강도가 증가하였다. 입자의 충돌에 의해서 표면원자들이 mixing 됨으로써 알루미늄의 표면에 50~100 $\AA$ 정도의 두께를 가진 $AlF_x$ 층이 형성되는 것으로 분석되었다. 같은 조건에서 반응성 이온식각된 알루미늄 산화막의 경우에는 mixing 효과가 알루미늄보다 작으므로 상대적으로 얕은 범위(10~20 $\AA$)에서 F가 O를 치환하여 $AlF_x$층이 형성되었다.

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$BaTiO_3$에서 $Cd_5(PO_4)_3Cl$의 첨가로 인한 Curie 온도변화 (Variation of the Curie Temperature in $BaTiO_3$ Doping $Cd_5(PO_4)_3Cl$)

  • 김광철
    • 반도체디스플레이기술학회지
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    • 제10권1호
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    • pp.95-99
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    • 2011
  • $(1-x)BaTiO_3+(x)Cd_5(PO_4)_3Cl$ ceramics were prepared by the conventional ceramic technique, i.e., solid state reaction at high temperature. The concentration of $Cd_5(PO_4)_3C$ was varied from 0.01 to 0.15 mole fraction. In order to study the phase transitions of our ceramics, the Raman scattering spectra were measured as functions of concentration x and temperature. It was found that the soluble limit of $Cd_5(PO_4)_3Cl$ in $BaTiO_3$ was the x=0.05 composition and $BaTiO_3$ phase disappeared above x=0.10. A new phase identified as $Ba_4Ti_3P_2O_{15}$ was detected in all samples of our compositions. The Curie temperature shifts up to $130^{\circ}C$ as the concentration x increases from zero to 0.05 and shift down to $95^{\circ}C$ as further increases to 0.08. For the increase of the Curie temperature, it is suggested that it can result from the inhibition of displacement of $Ti^{4+}$ in the distorted octahedron due to well dispersed $Ba_4Ti_3P_2O_{15}$ and $Cd_5(PO_4)_3Cl$ phase.

Palladium(II) p-Tolylamide and Reaction with CO2 to Generate a Carbamato Derivative

  • Seul, Jung-Min;Park, Soon-Heum
    • Bulletin of the Korean Chemical Society
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    • 제31권12호
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    • pp.3745-3748
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    • 2010
  • Pd(II) p-tolylamide Pd(2,6-$(Ph_2PCH_2)_2C_6H_3$)(NH($C_6H_4Me$-p)) (1) was metathetically prepared by the reaction of Pd(2,6-$(Ph_2PCH_2)_2C_6H_3$)Cl with NaNH($C_6H_4Me$-p). Treatment of 1 with carbon dioxide affords the palladium(II) carbamate Pd(2,6-$(Ph_2PCH_2)_2C_6H_3$)(OC(O)NH($C_6H_4Me$-p)) (2), quantitatively. Complex 2 reacts with HX (X = Cl, OTf) to give Pd(2,6-$(Ph_2PCH_2)_2C_6H_3$)X, $NH_2$(p-Tol) and $CO_2$. Reaction of the palladium(II) carbamate with MeI produced Pd(2,6-$(Ph_2PCH_2)_2C_6H_3$)I along with generation of methyl N-tolylcarbamate MeOC(O)NH($C_6H_4Me$-p), exclusively.

Variation of Transcribed X-linked Genes in Bovine Embryos Cloned with Fibroblasts at Different Age and Cell Cycle

  • Jeon, Byeong-Gyun;Rho, Gyu-Jin
    • Reproductive and Developmental Biology
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    • 제35권2호
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    • pp.175-183
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    • 2011
  • The present study compared the developmental potential, telomerase activity and transcript levels of X-linked genes (ANT3, HPRT, MeCP2, RPS4X, XIAP, XIST and ZFX) in the bovine somatic cell nuclear transfer (SCNT) embryos derived from different age and cell cycle of female donor nucleus. In experiment 1, the fusion rate, cleavage rate to 2-cell stage, developmental rate to blastocyst stage, and the mean number of total and ICM cells was slightly increased in embryos cloned with fetal fibroblasts compared to those with adult fibroblasts, but there was no significantly (p<0.05) differences. Telomerase activity was also similar in blastocysts cloned with fetal and adult fibroblasts. Up-regulated RPS4X and down-regulated MeCP2, XIAP, and XIST transcript level were observed in blastocysts cloned with adult fibroblasts, compared to those with fetal fibroblasts. In experiment 2, the fusion rate, cleavage rate to 2-cell stage, developmental rate to blastocyst stage, and the mean number of total and ICM cells was significantly (p<0.05) increased in embryos cloned with fetal fibroblasts at early G1 phase of the cell cycle, compared to those of fetal fibroblasts at late G1 phase. DNMT1 transcript was observed to significantly (p<0.05) increased in the fetal fibroblasts at 3 hrs after trypsin treatment of confluent culture. Further, level of telomerase activity and transcribed X-linked genes was also significantly (p<0.05) higher in the early G1 SCNT blastocysts than those of late G1. The results imply that fetal fibroblasts at early G1 phase induces the enhanced developmental potential and up-regulated telomerase activity and X-linked gene, but aberrant transcript pattern of X-linked genes may be displayed in the SCNT embryos.

Purinergic Receptors Play Roles in Secretion of Rat von Ebner Salivary Gland

  • Kim, Sang-Hee;Cho, Young-Kyung;Chung, Ki-Myung;Kim, Kyung-Nyun
    • International Journal of Oral Biology
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    • 제31권4호
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    • pp.141-148
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    • 2006
  • The effects of adenosine triphosphate(ATP) on salivary glands have been recognized since 1982. The presence of purinergic recepetors(P2Rs) that mediate the effects of ATP in various tissues, including parotid and submandibular salivary gland, has been supported by the cloning of receptor cDNAs and the expression of the receptor proteins. P2Rs have many subtypes, and the activation of these receptor subtypes increase intracellular $Ca^{2+}$, a key ion in the regulation of the secretion in the salivary gland. The apical pores of taste buds in circumvallate and foliate papillae are surrounded by the saliva from von Ebner salivary gland(vEG). Thus, it is important how the secretion of vEG is controlled. This study was designed to elucidate the roles of P2Rs on salivary secretion of vEG. Male Sprague-Dawley rats (about 200 g) were used for this experiment. vEG-rich tissues were obtained from dissecting $500-1,000\;{\mu}m$ thick posterior tongue slices under stereomicroscope view. P2Rs mRNA in vEG acinar cells were identified with RT-PCR. To observe the change in intracellular $Ca^{2+}$ activity, we employed $Ca^{2+}-ion$ specific fluorescence analysis with fura-2. Single acinar cells and cell clusters were isolated by a sequential trypsin/collagenase treatment and were loaded with $10\;{\mu}M$ fura -2 AM for 60 minutes at room temperature. Several agonists and antagonists were used to test a receptor specificity. RT-PCR revealed that the mRNAs of $P2X_4$, $P2Y_1$, $P2Y_2$ and $P2Y_3$ are expressed in vEG acinar cells. The intracellular calcium activity was increased in response to $10\;{\mu}M$ ATP, a P2Rs agonist, and 2-MeSATP, a $P2Y_1$ and $P2Y_2R$ agonist. However, $300\;{\mu}M\;{\alpha}{\beta}-MeATP$, a $P2X_1$ and $P2X_3R$ agonist, did not elicit the response. The responses elicited by $10\;{\mu}M$ ATP and UTP, a $P2Y_2R$ agonists, were maintained when extracellular calcium was removed. $10\;{\mu}M$ suramin, a P2XR antagonist, and reactive blue 2, a P2YR antagonist, partially blocked ATP-induced response. However, when extracellular calciums were removed, suramin did not abolish the responses elicited by ATP. These results suggest that P2Rs play an important role in salivary secretion of vEG acinar cells and the effects of ATP on vEG salivary secretion may be mediated by $P2X_4$, $P2Y_1$, $P2Y_2$, and/or $P2Y_3$.

Electrical Resistivity and Charge Density of Bismuth Telluride Doped with Erbium

  • Yeom, Tae-Ho
    • Journal of Magnetics
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    • 제10권4호
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    • pp.149-151
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    • 2005
  • The electric properties of a single crystal bismuth telluride doped with a small concentration of Erbium, $Bi_{z-x}Er_xTe_3$ with x = 0.002, are investigated as a function of temperature. The resistivity was obtained by using the van der Pauw method. The measured electrical resistivity is 78 ${\mu}{\Omega}cm$ at 4.2 K. The charge density of $Bi_{z-x}Er_xTe_3$ is found to be $2{\times}10^{19}/cm^3$ at 4.2 K. It turns out that $Bi_{z-x}Er_xTe_3$ is a p-type semiconductor. It is discussed that the high mobility and less density support that $Bi_{z-x}Er_xTe_3$ is a potential sensor with high energy resolution. Comparison with an established material (i.e. Au:Er alloy) is also discussed.