• Journal of Korea Water Resources Association
• /
• v.38 no.4 s.153
• /
• pp.271-280
• /
• 2005

The goal of this study is to recommend a new type of stage-discharge rating curve ($Q=p(h-e)^{\beta}-{\gamma}$) useful for satisfying divergence, and one other seemingly irresolvable problem related to exited rating curves, while also extending this rating curve model. The problem of divergence is that during the finding of the CZF (cease-to-zero flow) parameter e and while minimizing the sum of total errors of the estimated curve, the exponential parameter ${\beta}$ become an abnormally large value. The insoluble problem is that when the value e is greater then the recorded minimum at the gauged stage, it is impossible to have a negative logarithm value (h-e). The two problems above can be satisfied by adapting the control value ${\gamma}$, which affects the reduction of ${\gamma}$ and gives us the possibility of controlling (h-e) over zero. The study results show that the effects of parameter ${\gamma}$ are very similar to that of e when conducting physical and sensitivity analyses. This system can be used towards developing a new stage-discharge rating curve for river discharge, for use in evaluating the acceptability of existing stage-discharge rating curves generated by using hydrologic analyses at all stations.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.747-751
• /
• 2015

Background: Stage III colon cancer patients demonstrate diverse clinical outcomes. The aim of this study was to develop a prognostic model in order to better predict their survival. Materials and Methods: From 2004 to 2010, 548 patients were retrospectively analyzed, among whom 328 were defined as the study group and the remaining 220 served as a validation group. Clinico-pathologic features, including age, gender, histological grade, T stage, number of positive lymph nodes, number of harvest lymph nodes, pretreatment carcinoembryonic antigen (CEA) levels and pretreatment neutrophil lymphocyte ratio (NLR), were collected. Kaplan-Meier survival curves were used to detect prognostic factors and multivariate analysis was applied to identify independent examples on which to develop a prognostic model. Finally, the model was further validated with the validation group. Results: Histological grade (p=0.002), T stage (p=0.011), number of positive lymph nodes (p=0.003), number of harvested lymph nodes (p=0.020), CEA (p=0.005), and NLR (p<0.001) were found as prognostic factors while histological grade [RR(relative risk):0.632, 95%CI (Confidence interval) 0.405~0.985, p=0.043], CEA (RR:0.644, 95%CI:0.431~0.964, p=0.033) and NLR (RR:0.384, 95%CI:0.255~0.580, p<0.001) levels were independent. The prognostic model based on these three factors was able to classify patients into high risk, intermediate and low risk groups (p<0.001), both in study and validation groups. Conclusions: Histological grade, pretreatment CEA and NLR levels are independent prognostic factors in stage III colon cancer patients. A prognostic model based on these factors merits attention in future clinical practice.

• Korean Journal of Food Science and Technology
• /
• v.36 no.2
• /
• pp.349-354
• /
• 2004

Predictive growth model of Vibrio parahaemolyticus in modified surimi-based imitation crab broth was investigated. Growth curves of V. parahaemolyticus were obtained by measuring cell concentration in culture broth under different conditions ($Initial\;cell\;level,\;1{\times}10^{2},\;1{\times}10^{3},\;and\;1{\times}10^{4}\;colony\;forming\;unit\;(CFU)/mL$; temperature, 15, 25 37, and $40^{\circ}C$; pH 6, 7, and 8) and applying them to Gompertz model. Microbial growth indicators, maximum specific growth rate (k), lag time (LT), and generation time (GT), were calculated from Gompertz model. Maximum specific growth rate (k) of V. parahaemolyticus increased with increasing temperature, reaching maximum rate at $37^{\circ}C$. LT and GT were also the shortest at $37^{\circ}C$. pH and initial cell number did not influence k, LT, and GT values significantly (p>0.05). Polynomial model, $k=a{\cdot}\exp(-0.5{\cdot}((T-T_{max}/b)^{2}+((pH-pH_{max)/c^{2}))$, and square root model, ${\sqrt{k}\;0.06(T-9.55)[1-\exp(0.07(T-49.98))]$, were developed to express combination effects of temperature and pH under each initial cell number using Gauss-Newton Algorism of Sigma plot 7.0 (SPSS Inc.). Relative coefficients between experimental k and k Predicted by polynomial model were 0.966, 0.979, and 0.965, respectively, at initial cell numbers of $1{\times}10^{2},\;1{\times}10^{3},\;and\;1{\times}10^{4}CFU/mL$, while that between experimental k and k Predicted by square root model was 0.977. Results revealed growth of V. parahaemolyticus was mainly affected by temperature, and square root model showing effect of temperature was more credible than polynomial model for prediction of V. parahaemolyticus growth.

• Geotechnical Engineering
• /
• v.14 no.6
• /
• pp.81-92
• /
• 1998

A beam on elasto-plastic foundation modeling of soldier pile and woodlagging tieback walls or anchored walls was developed and tested. An instrumented full scale tieback wall in sand was constructed at the National Geotechnical Experimentation Bite located on Texas A&M University. The experimental earth pressure deflection relationship (p-y curves) was developed from the measurements. The construction sequence was simulated in the proposed method. The conceptual methodology of an anchored wall design was introduced by using the proposed method. The proposed method was evaluated with the measurements of case histories in sand and clay. A parametric research was performed to study the most influencing factors for the proposed method. It is concluded that the proposed method represents a significant improvement on the prediction of bending moments and deflections of the properly designed walls.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.25 no.4
• /
• pp.236-243
• /
• 2013

Offshore wind turbines has to be proved against accidental events such as ship collision. In this study, ship collision fragility analysis of offshore wind turbine is done. Dynamic collision analysis is accomplished by considering soil foundation interaction and fluid structure interaction. Uncertainties due to ship weight and speed, angle are also considered. By analyzing dynamic response of offshore wind turbine, fragility curves are obtained for different damage levels. They can be used for restricting boat speed around the wind turbine and allowable size of the boat for inspection and for other purposes. Results of the fragility, it was confirmed fragility of collision speed of bulk ship of 30,000DWT and 850ton barge ship.

• Journal of the Korean Geotechnical Society
• /
• v.32 no.11
• /
• pp.5-19
• /
• 2016

This paper presents the results from three-dimensional finite element (FE) analysis undertaken to provide insight into the lateral behaviors of piled gravity base foundation (GBF) for offshore wind turbine. The piled GBF was originally developed to support the gravity based foundation in very soft clay soil. A GBF is supported by five piles in a cross arrangement to achieve additional vertical bearing capacity. This study considered four different cases including a) single pile, b) three-by-three group pile (with nine piles), c) cross-arrangement group pile (with five piles), and d) piled GBF. All the cases were installed in homogenous soft clay soil with undrained shear strength of 20 kPa. From the numerical results, p-y curves and thus P-multiplier was back-calculated. For the group pile cases, the group effect decreased with increasing the number of piles. Interestingly, for the piled GBF, the P-multipliers showed a unique trend, compared to the group pile cases. This study concluded that the global lateral behaviour of the piled GBF was influenced strongly by the interaction between GBF and contacted soil surface.

• Geophysics and Geophysical Exploration
• /
• v.16 no.3
• /
• pp.109-118
• /
• 2013

On and near the 23-m high earthen Cheongcheon dam in Boryeong City, Korea, short seismic refraction and surface-wave profiles were conducted using a 5-kg sledgehammer. From vertical and horizontal components of the seismic waves, near-surface P-wave velocities (${\nu}_p$) and S-wave velocities (${\nu}_s$) were derived by inverting first-arrival refraction times and dispersion curves of Rayleigh waves. Average ${\nu}_p$ and ${\nu}_s$ for the Jurassic sedimentary basement were determined to be 1650 and 950 m/s at a depth of 30 m directly beneath the dam and 1650 m/s and 940 m/s at a depth of 10 m at the toe of the dam, respectively. The dynamic Poisson's ratio for these strata were therefore in the range of 0.24 to 0.25, which is consistent with ratios for consolidated sedimentary strata. Near a 45-m borehole 152 m downstream from the dam crest, an SH tomogram indicates a refraction boundary with an average ${\nu}_s$ of 870 m/s at depths of 10 ~ 12 m. At this site, the overburden comprises the upper layer with relatively constant ${\nu}_p$ and ${\nu}_s$ around 500 and 200 m/s, respectively, and the lower layer in which both ${\nu}_p$ and ${\nu}_s$ increase with depth almost linearly. The dynamic Poisson's ratios for the overburden were in the range of 0.30 to 0.43.

• Applied Chemistry for Engineering
• /
• v.9 no.2
• /
• pp.255-260
• /
• 1998

Metal hydrides, $LaNi_5$ and $LaNi_{4.5}Al_{0.5}$, were prepared using chemical synthetic method, and their physical properties were examined using various analytic techniques such as TGA, XRD, SEM and EDX. The activation of the chemically prepared $LaNi_5$ and $LaNi_{4.5}Al_{0.5}$ was achieved by two hydriding/dehydriding cycles only. The miasurements of P-C-T curves revealed that 6 and 5.5 hydrogen atoms were stored in LaNi5and $LaNi_{4.5}Al_{0.5}$, respectively. The hydriding reaction rated for $LaNi_{4.5}Al_{0.5}$ were measured by the method of initial rates. It was found that the shrinking unreacted core model could be applied for the analysis of hydriding kinetics of $LaNi_5$. The rate controlling step of this reaction was the dissociative chemisorption of hydrogen molecules on the surface of $LaNi_5$. The activation energy was $9.506kcal/mol-H_2$. The rates measured in the temperature range from 273 to 343K and in pressure difference ($P_o-P_{eq}$) range form 0.25 to 0.66atm could be expressed as the following equation ; $\frac{dX}{dt}=4.636(P_o-P_{eq})$ exp($\frac{-9506}{RT}$).

• Journal of Gastric Cancer
• /
• v.18 no.2
• /
• pp.142-151
• /
• 2018

Purpose: The modification of the cancer classification system aimed to improve the classical anatomy-based tumor, node, metastasis (TNM) staging by considering tumor biology, which is associated with patient prognosis, because such information provides additional precision and flexibility. Materials and Methods: We previously developed an mRNA expression-based single patient classifier (SPC) algorithm that could predict the prognosis of patients with stage II/III gastric cancer. We also validated its utilization in clinical settings. The prognostic single patient classifier (pSPC) differentiates based on 3 prognostic groups (low-, intermediate-, and high-risk), and these groups were considered as independent prognostic factors along with TNM stages. We evaluated whether the modified TNM staging system based on the pSPC has a better prognostic performance than the TNM 8th edition staging system. The data of 652 patients who underwent gastrectomy with curative intent for gastric cancer between 2000 and 2004 were evaluated. Furthermore, 2 other cohorts (n=307 and 625) from a previous study were assessed. Thus, 1,584 patients were included in the analysis. To modify the TNM staging system, one-grade down-staging was applied to low-risk patients according to the pSPC in the TNM 8th edition staging system; for intermediate- and high-risk groups, the modified TNM and TNM 8th edition staging systems were identical. Results: Among the 1,584 patients, 187 (11.8%), 664 (41.9%), and 733 (46.3%) were classified into the low-, intermediate-, and high-risk groups, respectively, according to the pSPC. pSPC prognoses and survival curves of the overall population were well stratified, and the TNM stage-adjusted hazard ratios of the intermediate- and high-risk groups were 1.96 (95% confidence interval [CI], 1.41-2.72; P<0.001) and 2.54 (95% CI, 1.84-3.50; P<0.001), respectively. Using Harrell's C-index, the prognostic performance of the modified TNM system was evaluated, and the results showed that its prognostic performance was better than that of the TNM 8th edition staging system in terms of overall survival (0.635 vs. 0.620, P<0.001). Conclusions: The pSPC-modified TNM staging is an alternative staging system for stage II/III gastric cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.7
• /
• pp.3299-3304
• /
• 2014

Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.