• 한국임상약학회지
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• 제25권2호
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• pp.80-93
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• 2015

Objective: Pegfilgrastim is recently introduced that is long acting G-CSF for prophylaxis of febrile neutropenia. Treatment of non-Hodgikin's lymphoma (NHL) with R-CHOP is classified with relative high risk of febrile neutropenia. The study evaluated the prophylactic effect of pegfilgrastim to reduce the incidence of febrile neutropenia associated with R-CHOP of patient in NHL. And the risk factors associated with the incidence of FN and related events were evaluated. Methods: This retrospective study reviews the Electronic Medical Record of 68 NHL patients who received R-CHOP chemotherapy in single center between September 2013 and August 2014. These patients were classified who receive prophylaxis pegfilgrastim or no prophylaxis. Results: Sixty eight patients received R-CHOP with NHL. In 144 cycles of patients receiving pegfilgrastim, compared with no prophylaxis 178 cycles, had a lower incidence of febrile neutropenia (5.5% vs. 23.6%, p = 0.001), grade 3 or grade 4 neutropenia (14.4% vs. 89.8%, p < 0.001) and neutropenia related events (p < 0.05). The risk of febrile neutropenia after prophylaxis was significantly associated with age ${\geq}65$ (OR: 5.87, 95% CI 1.07-32.27, p = 0.042), $IPI{\geq}3$ (OR: 7.2, 95% CI 1.31-39.6, p = 0.023), S.alb < 3.5 g/dL (OR: 31.01, 95% CI 6.32-152.17, p < 0.0001). In multiple logistic regression analysis, lower baseline serum albumin (OR: 21.1, 95% CI 3.8-116.98, p = 0.001) was significantly associated with occurrence of febrile neutropenia. Conclusion: The study recommends prophylactic pegfilgrastim through risk assessment of febrile neutropenia in patients with non-Hodgikin's lymphoma receiving R-CHOP.

• 한국작물학회:학술대회논문집
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• 한국작물학회 1989년도 춘계 학술대회지
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• pp.80-81
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• 1989

• 한국작물학회:학술대회논문집
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• 한국작물학회 1990년도 춘계 학술대회지
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• pp.118-119
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• 1990

• 정신신체의학
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• 제11권1호
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• pp.25-35
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• 2003

연구목적: 파킨슨병 환자에서 다양한 정신증상이 동반되는 것으로 보고되고 있으며, 특히 우울증상의 동반율이 매우 높다고 보고되고 있다. 특히 파킨슨병은 완치가 어렵고, 치료의 초점이 질병의 진행 억제나 증상의 완화에 있기 때문에 파킨슨병 환자에서의 우울증상에 대한 관심과 치료는 중요하다. 본 연구는 통원치료 중인 파킨슨병 환자들을 대상으로 파킨슨병 관련 임상요인들과 우울증상 사이의 관련성을 조사하는데 목적이 있다. 연구대상 및 방법: 일 대학교병원 신경과 파킨슨병 클리닉에서 특발성 파킨슨병으로 진단 받고 치료중인 환자들 중 본 연구에 참여하기로 동의한 118명의 환자를 대상으로 하였다. 일반적인 인구통계학적 자료, 파킨슨병 관련 자료[발병연령, 치료약물 용량, 임상양상, Hoehn과 Yahr의 단계(Hoehn and Yahr stage, H&Y stage), 일상생활 평가척도(Modified Schwab and England Activities of Daily Living, ADL)], 파킨슨병 환자의 삶의 질 설문지(Parkinson's Disease quality of Life questionnaire, PDQL), 스필버그 상태/특성 불안척도, 간이정신 검사 등을 조사하였고, 우울증상의 평가는 Beck 우울척도(Beck Depression Inventory, BDI)를 이용하였다. 결 과: 대상군의 평균 연령은 $60.4\pm7.1$세(범위:34-73세)였고, 남성이 56명(47.5%), 여성이 62명(52.5%)이었다. 대상군은 BDI 점수에 따라 비우울군 39명(33.1%), 경도 우울군 15명(12.7%), 중등도 우울군 16명(13.6%), 중증 우울군 48명(40.7%)으로 분류되었다. 파킨슨병 환자의 우울증상은 H & Y stage(r=0.34, p<0.001) 및 파킨슨병 증상의 정도(r=0.35, p<0.001), 스필버그 특성 불안 척도(TAI)(r=0.33, p<0.001)와 양의 상관관계가 있었고, 교육정도(r=-0.34, p<0.001), ADL(r=-0.37, p<0.001), PDQL(r=-0.69, p<0.001)과 음의 상관관계를 보였다. 본 연구에서 사용한 검사도구 중 우울증을 예측하는데 가장 의미있는 척도는 PDQL(p<0.005)이었다. 결 론: Beck 우울척도를 이용한 평가에 의하면 본 연구 대상 환자 118명 중 79명(67%)이 주관적인 우울증상을 호소하고 있었다. 본 연구 결과는 파킨슨병 증상이 심할수록, 그리고 H & Y stage가 높을수록 우울증상이 심각함을 보여준다. 또한 BDI 점수가 높을수록 일상생활에서의 활동에 제한이 많으며, 삶의 질이 저하되어 있음을 시사한다. 따라서 본 연구결과는 파킨슨병 환자의 신체증상에 대한 치료 이외 우울증상에 대한 정신의학적 관심과 치료가 중요함을 뒷받침한다.

• 대한수학회보
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• 제51권6호
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• pp.1829-1839
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• 2014

Let (${\Omega}$, $\mathcal{S}$, ${\mu}$) be a probabilistic measure space, ${\varepsilon}{\in}\mathbb{R}$, ${\delta}{\geq}0$, p > 0 be given numbers and let $P{\subset}\mathbb{R}$ be an open interval. We consider a class of functions $f:P{\rightarrow}\mathbb{R}$, satisfying the inequality $$f(EX){\leq}E(f{\circ}X)+{\varepsilon}E({\mid}X-EX{\mid}^p)+{\delta}$$ for each $\mathcal{S}$-measurable simple function $X:{\Omega}{\rightarrow}P$. We show that if additionally the set of values of ${\mu}$ is equal to [0, 1] then $f:P{\rightarrow}\mathbb{R}$ satisfies the above condition if and only if $$f(tx+(1-t)y){\leq}tf(x)+(1-t)f(y)+{\varepsilon}[(1-t)^pt+t^p(1-t)]{\mid}x-y{\mid}^p+{\delta}$$ for $x,y{\in}P$, $t{\in}[0,1]$. We also prove some basic properties of such functions, e.g. the existence of subdifferentials, Hermite-Hadamard inequality.

• Molecules and Cells
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• 제41권6호
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• pp.523-531
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• 2018

Tumour metastasis is one of the most serious challenges of cancer as it is the major cause of mortality in patients with solid tumours, including osteosarcoma (OS). In this regard, anti-metastatic genes have potential for metastasis inhibition strategies. Recent evidence showed the importance of breast cancer metastasis suppressor 1 (BRMS1) in control of OS invasiveness, but the regulation of BRMS1 in OS remains largely unknown. Here, we used bioinformatics analyses to predict BRMS1-targeting microRNAs (miRNAs), and the functional binding of miRNAs to BRMS1 mRNA was evaluated using a dual luciferase reporter assay. Among all BRMS1-targeting miRNAs, only miR-151b, miR-7-5p and miR-3200-5p showed significant expression in OS specimens. Specifically, we found that only miR-3200-5p significantly inhibited protein translation of BRMS1 via pairing to the 3'-UTR of the BRMS1 mRNA. Moreover, we detected significantly lower BRMS1 and significantly higher miR-3200-5p in the OS specimens compared to the paired adjacent non-tumour bone tissues. Furthermore, BRMS1 and miR-3200-5p levels were inversely correlated to each other. Low BRMS1 was correlated with metastasis and poor patient survival. In vitro, overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Thus, our study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.

• 한국산학기술학회논문지
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• 제20권3호
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• pp.429-437
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• 2019

본 연구는 간호대학생의 생명의료 윤리의식, 좋은 죽음 인식, 삶의 의미에 대한 태도가 연명치료 중단에 대한 태도에 영향을 미치는 요인을 확인하기 위한 서술적 조사연구이다. 본 연구의 대상자는 P시에 있는 1개의 간호학과 재학생 293명을 대상으로 2018년 5월 01일부터 5월 11일까지 2주간 자료를 수집하였다. 수집된 자료는 SPSS WIN 22.0의 빈도와 백분율, 평균과 표준편차, Pearson's correlation coefficients, multiple regression을 이용하여 분석하였다. 본 연구의 결과 연명치료 중단에 대한 태도는 생명의료 윤리의식(r=.266, p<.001), 좋은 죽음 인식(r=.373, p<.001), 삶의 의미(r=.122, p=.037)와 양의 상관관계를 나타냈다. 삶의 의미는 생명의료 윤리의식(r=.294, p<.001), 좋은 죽음 인식(r=.230, p<.001)과 양의 상관관계를 나타냈으며, 좋은 죽음 인식은 생명의료 윤리의식(r=.306, p<.001)과 양의 상관관계를 나타냈다. 연명치료 중단에 대한 태도에 영향을 미치는 유의한 요인은 생명의료 윤리의식(${\beta}=.16$, p=.004), 좋은 죽음 인식(${\beta}=.32$, p<.001)으로 나타났으며, 이러한 요인들은 연명치료 중단에 대한 태도를 16.0% 설명하는 것으로 나타났다. 따라서 간호대학생들의 연명치료 중단에 대한 태도의 변화를 위해서는 생명의료 윤리의식과 좋은 죽음 인식에 대한 태도를 긍정적으로 높이기 위한 교육 프로그램을 개발하는 것이 필요하고, 다양한 영향요인을 탐색하기 위한 반복적 연구가 요구된다고 생각된다.

• 대한물리의학회지
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• 제15권1호
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• pp.95-104
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• 2020

PURPOSE: A prospective study was conducted to investigate the correlation between the inspiration ability, bone mineral density, lumbar muscle strength, and muscular endurance for the national softball athletes in the national training center. METHODS: The general characteristics of study subjects, inspiration ability, bone mineral density, muscle strength, and muscular endurance data were analyzed using descriptive statistics. In addition, the Pearson product moment correlation was performed to investigate the correlation between the inspiratory capacity, bone mineral density, muscle strength, and muscular endurance. RESULTS: The inspiration, flow rates, and volume were not correlated with the bone mass and bone mineral density. Inspiration and the flow rates and volume were not correlated with the bone mass and bone mineral density. On the other hand, inspiration was correlated with the Extensor muscles (r=.464, p=.006) at an angular velocity of 60°/s and the flexors (r=.463, p=.006) and extensor muscles (r=.615, p<.001) at an angular velocity of 180°/s. The flow rate was also correlated with the extensor muscles (r=.444, p=.009) at an angular velocity of 60°/s and with flexor muscles (r=.432, p=.011) and extensor muscles (r=.589, p<.001) at an angular velocity of 180°/s. Finally, the volume was correlated at the extensor muscles at an angular velocity of 180°/s (r=.534, p=.001). CONCLUSION: The correlation between the inspiratory capacity, bone mineral density, muscle strength, and muscular endurance of softball athletes did not correlate with the bone mass and bone density. On the other hand, the lumbar muscle strength increased with increasing inspiratory capacity.

• Kyungpook Mathematical Journal
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• 제56권4호
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• pp.1047-1067
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• 2016

In this paper, a new class of diagram algebras which are subalgebras of signed brauer algebras, called the Walled Signed Brauer algebras denoted by ${\overrightarrow{D}}_{r,s}(x)$, where $r,s{\in}{\mathbb{N}}$ and x is an indeterminate are introduced. A presentation of walled signed Brauer algebras in terms of generators and relations is given. The cellularity of a walled signed Brauer algebra is established. Finally, ${\overrightarrow{D}}_{r,s}(x)$, is quasi- hereditary if either the characteristic of a field, say p, p = 0 or p > max(r, s) and either $x {\neq}0$ or x = 0 and $r{\neq}s$.

• Fisheries and Aquatic Sciences
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• 제13권4호
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• pp.272-277
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• 2010

Seagrasses are marine angiosperms of ecological importance in providing shelter and food to aquatic species as well as maintaining the carbon cycle on earth. Phyllospadix iwatensis is a seagrass of the family Zosteraceae and is distributed along the eastern coast of Korea. The nucleotide sequences of P. iwatensis nuclear genes encoding 18S ribosomal RNA (rRNA) and internal transcribed spacer-1 (ITS-1) were determined for molecular phylogenetic analysis. Genomic DNA was isolated from P. iwatensis and used for PCR amplification of 18S rRNA and ITS-1. Examination of the 18S rRNA sequence of P. iwatensis showed a close (99% similarity) relationship to Zostera noltii, another genus of Zosteraceae, but a distant (84% similarity) evolutionary relationship to other macroalgal Laminariales species. Further discrepancies found in ITS-1 nucleotide sequences between closely related species indicate that the sequence information could be used for species identification.