• 대한화학회지
• /
• 제26권3호
• /
• pp.179-187
• /
• 1982

N-acryloylpyrrolidone과 acrylonitrile을 혼성중합시켜 각 단위체의 반응성비를 구한 결과 생성되는 혼성중합체는 pyrrolidone이 음이온 중합에 매우 좋은 개시제임을 알 수 가 있었다. ($r_1$ = 0.43과 $r_2$ = 1.56) 그리고 그 혼성중합체를 개시제로 하여 그라프트된 nylon-4를 합성하여 중합속도 상수를 구했으며, 그에 따르는 여러 인자들의 효과를 관찰하였다. 그 결과 중합속도 상수로 40$^{\circ}$C에서 2.82${\times}10^3$(l/mole, min)와 50$^{\circ}$C에서 2.93${\times}10^3$(l/mole, min)을 얻었다.

• 대한의용생체공학회:의공학회지
• /
• 제23권1호
• /
• pp.1-8
• /
• 2002

심방세동은 가장 많이 나타나는 부정맥으로. 뇌졸중 등 심각한 합병증을 초래하는 질환이다 심방세동이 발작성으로 발생하는 경우 단시간내 불규칙적으로 발생하기 때문에 그 진단이 어렵다 본 연구에서는 발작성 심방세동 환자의 조기진단을 위하여 심실세동 등의 진단에 이용되는 신호평균 심전도를 이용한 분석방법을 사용하였다 심방세동의 징후가 있는 환자는 초기에 심방에서 심근의 전기전도가 지연된다는 이론을 근거로 심전도 P파의 길이를 진단의 기준으로 하였다. p파 길이를 정확히 측정하기 위하여 다양한 종류의 필터와 차단주파수에 대하여 분석하였으며. p파의 시작과 끝점을 판단하는 여러 방법을 시도하였다. 분석 방법의 신뢰성을 높이기 위하여 자동으로 P파 길이를 측정하는 알고리즘을 구현하였다. 구현된 알고리즘의 검증을 위해서 발작성 심방세동 이외의 병력이 없는 환자 38명과 정상인 32명을 대상으로 임상 데이터를 수집하였다. 분석 결과 30 Hz 차주파수를 가지는 LMS 필터를 사용하고. 절대치 8.75 $\mu N$를 기준으로 P파의 시작과 끝점을 측정하여 P파 길이를 계산할 때가 가장 높은 발작성 심방세동의 예측도를 가졌다. 또한 발작성 심방세동의 진단을 위한 가장 적합한 판별 값을 구하기 위하여 수신 동작 특성 곡선을 이용한 결과. 의사결정의 판별 값을 112 ms로 하는 경우 진단의 민감도 88 %. 특이도 64.4 %의 결과를 얻을 수 있었다

• The Korean Journal of Ecology
• /
• 제9권1호
• /
• pp.51-58
• /
• 1986

The decay rates of organic matter were investigated and the leaching rates were determined from the concentration distribution of N,P,K, Ca and Na in the soil profile at Pinus rigida stand on Mt. Gwan-ak and at Pseudosasa japonica stand on Odong-do. In order to determine the leaching rates θo/W wazs substituted with KL in Towner's equation. Decay rates were 0.191 at Pinus stand on Mt. Gwan-ak and 0.234 at Pseudosasa stan don Odong-do. Concentration distributions of N,P, K and Na in soil profiles were corresponed with Towner's model curve. Leaching rates determined from concentration distributions were 0.086, 0.079, 0.041, 0.029, 0.096 on Mt. Gwan-ak and 0.080, 0.056, 0.051, 0.008, 0.028 on Odong-do. The soil of Pseudosasa stand showed on the whole lower leaching rates than that of Pinus stand. The soil of Pseudosasa stand showing higher decay rate and lower leaching rates contained more concentration of each nutrient than that of Pinus stand.

• 한국전기전자재료학회논문지
• /
• 제22권5호
• /
• pp.419-424
• /
• 2009

ZnO films doped with different contents of indium ($0.1{\sim}10$ at.%) were deposited on Si (111) substrate by Pulsed Laser Deposition (PLD). The structural, electrical and optical properties of the films were investigated using XRD, AFM, Hall and PL measurement. Results showed that un-doped ZnO film had (002) plane as the c-axis orientated growth, whereas indium doped ZnO films exhibited the peak of (002) and the weak (101) plane. In addition, in the indium doped ZnO films, the electron concentration is ten times higher than that of un-doped ZnO film, while the resistivity is ten times lower than that of un-doped ZnO film. The indium doped ZnO films have UV emission about 380 nm and show a red shift with increasing contents of indium. The I-V curve of the fabricated diode show the typical diode characteristics and have the turn on voltage of about 2 V.

• 한국자동차공학회논문집
• /
• 제2권6호
• /
• pp.1-8
• /
• 1994

To enhance the strength of gears for transmission, Generally caburizing heat treatment is applied. But there are some problems in this technology the distortion of gears during heat treatment process, and the discontinuity of manufacturing process. For these reasons, the high frequency induction hardening process is widely used. This method is one of the surface hardening process to improve the wear resistance and fatigue life of the machine components. In this study, to compare the bending fatigue strength of caburized gear with that of induction hardened gear, bending fatigue testing of gears with two different cases was performed by using an electrohydraulic servo-controlled fatigue testing machine and double tooth bending fatigue test fixture. Fatigue life distributions at constant stress levels were established directly from fatigue data. For gear design, the fatigue strength distribution at specified life is more important. This distribution is obtained by statical transformation from fatigue life distribution. Reliability of bending fatigue strength was estimated by P-S-N curves and Weibull distribution.

• 항공우주시스템공학회지
• /
• 제14권6호
• /
• pp.58-67
• /
• 2020

In this study, finite element fatigue analysis combined with a fatigue correlation factor is proposed to predict the bending fatigue life of a gear in an electro-mechanical aircraft actuator. First, stress-life curves are obtained for the gear material via a round bar fatigue test. Subsequently, stochastic stress-life (P-S-N) curves are derived for 50% and 1% failure probabilities, separately. The curves are applied to the fatigue analysis model of a single gear tooth, and the effect of the fatigue correction factor is analyzed. The analytical P-S-N curves reflecting the fatigue correction factor matched the experimental data. This shows that the analytical fatigue life is reliable and that the analysis technique is effective.

• 약학회지
• /
• 제46권4호
• /
• pp.265-269
• /
• 2002

The purpose of this study was to report the pharmacokinetic changes of cyclosporine after oral administration of cyclosporine, 10 mg/kg, in rabbits coadministered or pretreated twice per day for 3 days with nimodipine, dose of 5 mg/kg. The area under the plasma concentration-time curve (AUC) of cyclosporine was significantly higher in rabbits pretreated with nimodipine than that in control rabbits (p＜0.01), showing about 149％ increased relative bioavailability. The peak plasma concentration (C$_{max}$), elimination half-life (t$_{1}$2/) and MRT of cyclosporine were increased significantly (p＜0.05) in rabbits pretreated with nimodipine compared with those in control rabbits. This findings could be due to significant reduction of elimination rate constant and total body clearance by pretreated with nimodipine. The effects of nimodipine on the pharmacokinetics of oral cyclosporine were more considerable in rabbits pretreated with nimodipine compared with those in control rabbits. The results suggest that the dosage of cyclosporine should be adjusted when the drug would be coadministered chronically with nimodipine in a clinical situation.n.

• 한국안전학회지
• /
• 제29권4호
• /
• pp.9-14
• /
• 2014

Self-piercing riveting(SPR) is a mechanical fastening technique which is put pressure on the rivet for joining the sheets. Unlike a spot welding, SPR joining does not make the harmful gas and $CO_2$ and needs less energy consumption. In this study, static and fatigue tests were conducted using tensile-shear specimens with Al-5052 plates for evaluation of fatigue strength of the SPR joints. During SPR joining process for the specimen, using the current sheet thickness and a rivet, the optimal applied punching force was found to be 21 kN. And, the maximum static strength of the specimen produced at the optimal punching force was 3430 N. During the fatigue tests for the specimens, interface failure mode occurred on the top substrate close to the rivet head in the most high-loading range region, but on the bottom substrate close to the rivet tail in the low -loading range region. There was a relationship between applied load amplitude $P_{amp}$ and lifetime of cycle N for the tensile-shear, $P_{amp}=3395.5{\times}N^{-0.078}$. Using the stress-strain curve of the Al-5052 from tensile test, the simulations for fatigue specimens have been carried out using the implicit finite element code ABAQUS. The relation between von-Mises equivalent stress amplitude and number of cycles was found to be ${\sigma}_{eq}=514.7{\times}N^{-0.033}$.

• 한국토양비료학회지
• /
• 제20권1호
• /
• pp.55-61
• /
• 1987

담수상태(湛水狀態)의 논토양중(土壤中) 유기물함량(有機物含量), 온도(溫度), pH 질소비종(窒素肥種) 및 시비량등(施肥量等)을 달리했을때 탈질작용(脫窒作用)과 탈질량(脫窒量)을 알고저 질내(窒內)에서 항온시험(恒溫試驗)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 담수상태(湛水狀態)의 논토양(土壤)에서 탈질량(脫窒量)에 관계(關係)가 큰 요인(要因)은 토양유기물함량(土壤有機物含量) > 항온온도(恒溫溫度) > pH가(價) > 질소비종(窒素肥種) > 질소시비량(窒素施肥量)의 순(順)으로 컸다. 2. $N_2O$ gas의 생성량(生成量)은 토양유기물함량(土壤有機物含量) 3.0%인 토양(土壤)에서 항온온도(恒溫溫度) $20^{\circ}C$, pH 6.0일때 $KNO_3$ 20mg/100 토양(土壤) 시용구(施用區)에서 가장 많았다. 3. $N_2O$ gas 1 mole 생성(生成)하는데 소모(消耗)되는 탄소(炭素)는 전체평균(全體平均)이 0.5 mole 이였으며 탄소량(炭素量)이 제일(第一) 많이 요구(要求)되는 경우는 토양유기물함량(土壤有機物含量) 1.0%인 토양(土壤)에서 류안(硫安) 10mg/100g 토양(土壤) 시용시(施用時)(1.06 mole)였으며 제일(第一)적은 탄소요구(炭素要求)의 경우는 유기물함량(有機物含量) 3.0%인 토양(土壤)에서 $KNO_3$ 20mg/100g 토양(土壤) 시용시(施用時)(0.13 mole)였다. 4. Michealis-Menten의 효소반응식(酵素反應式)에서 유도(誘導)된 $N_2O$ gas의 V/2가(價)는 유기물(有機物) 1.0% 토양(土壤)에서 $(NH_2)_2CO$ 시용시(施用時) 550, $KNO_3$ 시용시(施用時)는 $1100N_2O{\mu}g/100g$ 토양(土壤)이였고 3.0%인 토양(土壤)에서 $(NH_4)_2SO_4$ 시용시(施用時)는 $490N_2O{\mu}g/100g$ 토양(土壤)이였으며 $KNO_3$ 시용시(施用時)는 시비량(施肥量)이 증가(增加)할수록 V/2가(價)는 계속 증가(增加)되었다.

• Korean Journal of Radiology
• /
• 제23권1호
• /
• pp.89-100
• /
• 2022

Objective: To improve the N biomarker in the amyloid/tau/neurodegeneration system by radiomics and study its value for predicting cognitive progression in individuals with mild cognitive impairment (MCI). Materials and Methods: A group of 147 healthy controls (HCs) (72 male; mean age ± standard deviation, 73.7 ± 6.3 years), 197 patients with MCI (114 male; 72.2 ± 7.1 years), and 128 patients with Alzheimer's disease (AD) (74 male; 73.7 ± 8.4 years) were included. Optimal A, T, and N biomarkers for discriminating HC and AD were selected using receiver operating characteristic (ROC) curve analysis. A radiomics model containing comprehensive information of the whole cerebral cortex and deep nuclei was established to create a new N biomarker. Cerebrospinal fluid (CSF) biomarkers were evaluated to determine the optimal A or T biomarkers. All MCI patients were followed up until AD conversion or for at least 60 months. The predictive value of A, T, and the radiomics-based N biomarker for cognitive progression of MCI to AD were analyzed using Kaplan-Meier estimates and the log-rank test. Results: The radiomics-based N biomarker showed an ROC curve area of 0.998 for discriminating between AD and HC. CSF Aβ42 and p-tau proteins were identified as the optimal A and T biomarkers, respectively. For MCI patients on the Alzheimer's continuum, isolated A+ was an indicator of cognitive stability, while abnormalities of T and N, separately or simultaneously, indicated a high risk of progression. For MCI patients with suspected non-Alzheimer's disease pathophysiology, isolated T+ indicated cognitive stability, while the appearance of the radiomics-based N+ indicated a high risk of progression to AD. Conclusion: We proposed a new radiomics-based improved N biomarker that could help identify patients with MCI who are at a higher risk for cognitive progression. In addition, we clarified the value of a single A/T/N biomarker for predicting the cognitive progression of MCI.