• Journal of Microbiology and Biotechnology
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• v.30 no.6
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• pp.811-821
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• 2020

Mycobacterium tuberculosis produces mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled by diguanylate cyclases (DGC) and phosphodiesterases (PDE). The transcriptional regulator dosR, is involved in response to low oxygen, a condition likely happening to a subset of cells within biofilms. Here, we found that in M. bovis BCG, expression of both BCG1416c and BCG1419c genes, which code for a DGC and a PDE, respectively, decreased in both stationary phase and during biofilm production. The kasA, kasB, and fas genes, which are involved in mycolic acid biosynthesis, were induced in biofilm cultures, as was dosR, therefore suggesting an inverse correlation in their expression compared with that of genes involved in c-di-GMP metabolism. The relative abundance within trehalose dimycolate (TDM) of α-mycolates decreased during biofilm maturation, with methoxy mycolates increasing over time, and keto species remaining practically stable. Moreover, addition of synthetic c-di-GMP to mid-log phase BCG cultures reduced methoxy mycolates, increased keto species and practically did not affect α-mycolates, showing a differential effect of c-di-GMP on keto- and methoxy-mycolic acid metabolism.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.20-37
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• 2023

Although traffic signal installations are continuously expanding, the effect of preventing traffic accidents remains unverified. Totally, 7,045 traffic accident data (such as signal violations) registered with TCS were manually searched for a 7-year period from 2013 to 2019 for 1,602 traffic signals in Daejeon Metropolitan City. The top 20 traffic accident intersections were identified, the traffic accident investigation records and field maps were viewed to compare the driving direction and signal phase of the violated vehicle, and the cause of the traffic accident was divided into insufficient signal operation design (operation) and driver negligence (intentional). Results of the analysis revealed that 75% of traffic accidents occurred in thru-left-turn traffic signals and overlap; moreover, extending the yellow time or operating all red signals due to countermeasures against traffic accidents occurring in yellow signals resulted in reduced traffic accidents. Data indicated that Permissive Left Turn requires improvement with the signal operation. In addition, since The Korean National Police Agency is not computerized for traffic accident sites and signal-related data, the lack of manpower necessitates improvement and utilization of TCS when establishing traffic accident prevention measures. It is believed that it will contribute to signal operation by analyzing vast amounts of data collected in the field and presenting improvement measures.

• Radiation Oncology Journal
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• v.27 no.4
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• pp.228-239
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• 2009

Purpose: 4DCT scans performed for radiotherapy were retrospectively analyzed to assess the possible benefits of respiratory gating in non-small cell lung cancer (NSCLC) and established the predictive factors for identifying patients who could benefit from this approach. Materials and Methods: Three treatment planning was performed for 15 patients with stage I~III NSCLC using different planning target volumes (PTVs) as follows: 1) PTVroutine, derived from the addition of conventional uniform margins to gross tumor volume (GTV) of a single bin, 2) PTVall phases (patient-specific PTV), derived from the composite GTV of all 6 bins of the 4DCT, and 3) PTVgating, derived from the composite GTV of 3 consecutive bins at end-exhalation. Results: The reductions in PTV were 43.2% and 9.5%, respectively, for the PTVall phases vs. PTVroutine and PTVgating vs. PTVall phases. Compared to PTVroutine, the use of PTVall phases and PTVgating reduced the mean lung dose (MLD) by 18.1% and 21.6%, and $V_{20}$ by 18.2% and 22.0%, respectively. Significant correlations were seen between certain predictive factors selected from the tumor mobility and volume analysis, such as the 3D mobility vector, the reduction in 3D mobility and PTV with gating, and the ratio of GTV overlap between 2 extreme bins and additional reductions in both MLD and $V_{20}$ with gating. Conclusion: The additional benefits with gating compared to the use of patient-specific PTV were modest; however, there were distinct correlations and differences according to the predictive factors. Therefore, these predictive factors might be useful for identifying patients who could benefit from respiratory-gated radiotherapy.

• Journal of the Korean earth science society
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• v.34 no.1
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• pp.1-12
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• 2013

To effectively remove chaff echoes, which are often misidentified as precipitation echoes on weather radars, this study examines the relationship between the radar reflectivity and each of dual polarimetric parameters. The dual polarimetric parameters are collected only for the echo areas identified as chaff echoes on the NIMR X-band dual polarization radar. Overall, the polarimetric parameters (i.e., reflectivity, differential reflectivity, cross correlation coefficient, standard deviation of differential reflectivity and specific differential phase) for chaff echoes have a wider range of values than those for precipitation echoes and the chaff filaments tend to be horizontally oriented to radar beams. There appears to be a considerable overlap in the cross correlation coefficient range of chaff and precipitation echoes since some precipitation echoes have cross correlation coefficient lower than 0.8. Therefore, although the cross correlation coefficient is known to be a good variable in identifying and separating chaff echoes from precipitation echoes, it is suggested that additional care should be taken when using the cross correlation coefficient solely in removing chaff echoes.

• Journal of the Korean Recycled Construction Resources Institute
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• v.3 no.3
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• pp.212-219
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• 2015

This study focuses evaluating the efficiency and performance evaluation of composite type sheet-membrane waterproofing method that utilizes a separation behavior inducement system designed to resolve the chronic problems of disintegration and damage of overlap areas of waterproofing layers. As the result of the test, the tensile strength value was at 13.8N/mm and elongation rate at 587% for the separation behavior inducement type specimen, and the compared specimens had 14.2N/mm for tensile strength and 335% for elongation rate. For the separation behavior adhesion method specimen, when tensile stress or displacement occurred, the Zero-Span tension occurrence did not follow, which resulted in that the bottom sheet layer and the top membrane layer did not simultaneously becoming damaged. When undergoing the top and bottom layers were separated through separation behavior due to lack of flexibility, the bottom layer began to damage at the primary stage, and with the allowed boundary the upper membrane layer began to display flexibility and showed continuous displaced resulting in secondary phase damaging.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.8 no.5
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• pp.57-70
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• 2009

According to the change of the traffic conditions, the requirement of controlling the separated left(or right) turn, the median bus lane and bicycle signal is increasing. However, the traffic signal controller standard based on the four-set lights restricts to control the three-set lights which control the separated direction and kind of traffics. This study suggests the method to control the three-set lights signal by improving the hardware and software for the traffic signal controller which is operated currently in the traffic scene. The 6 output ports of Load Signal Unit(LSU) which is consisted of Pedestrian Red, Pedestrian Green, Red, Yellow, Arrow and Green signal reconstitute 2 rows of the Red, Yellow, Green for three-set lights while the Signal Map data's code values which control the signal step of an individual Ring and LSU are established to adjust the LSU's output ports(R1 Y1 G1 R2 Y2 G2) of the three-set lights. The effect of using the separated through/left turn and the median lane bus signal of three-set lights is analyzed from a Mangwoo intersection in Seoul. The results of analysis show that the delay time of the east-west direction where the median bus lane is operated is especially improved with over 70 sec/veh.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4D
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• pp.505-512
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• 2008

Over the past years, complex project which has the object to accomplish housing complex, commercial complex etc, recently is changing to multi-complex projects because of development in IT sector. Improvement in the quality of life, life pattern has been and is being changed, these modernized and improved version of life brings the concept of U-city. Department of urban planning and engineering, civil engineering and architecture engineering in every university educate students according to the changing world in order to handle these complex projects in real world. In most cases department of urban planning and engineering teach project planning and department of civil and architecture engineering teach project design and construction. In most of the projects planning followed by design and construction need to be accomplished, but current observation in the present curriculum shows that it is difficult to expect the continuity. The present curriculum of civil engineering has to change as complex projects deal with various different structures during the design and construction phase of these projects. This study examined curriculums from the department of urban and civil engineering related to structural design and construction and survey importance of design works which overlap urban and civil engineering targeted on design engineers. After understanding design works and results obtained from survey we propose for an advanced efficiency method.

• Journal of Intelligence and Information Systems
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• v.16 no.3
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• pp.121-145
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• 2010

University timetabling depending on the educational environments of universities is an NP-hard problem that the amount of computation required to find solutions increases exponentially with the problem size. For many years, there have been lots of studies on university timetabling from the necessity of automatic timetable generation for students' convenience and effective lesson, and for the effective allocation of subjects, lecturers, and classrooms. Timetables are classified into a course timetable and an examination timetable. This study focuses on the former. In general, a course timetable for liberal arts is scheduled by the office of academic affairs and a course timetable for major subjects is scheduled by each department of a university. We found several problems from the analysis of current course timetabling in departments. First, it is time-consuming and inefficient for each department to do the routine and repetitive timetabling work manually. Second, many classes are concentrated into several time slots in a timetable. This tendency decreases the effectiveness of students' classes. Third, several major subjects might overlap some required subjects in liberal arts at the same time slots in the timetable. In this case, it is required that students should choose only one from the overlapped subjects. Fourth, many subjects are lectured by same lecturers every year and most of lecturers prefer the same time slots for the subjects compared with last year. This means that it will be helpful if departments reuse the previous timetables. To solve such problems and support the effective course timetabling in each department, this study proposes a university timetabling support system based on two phases. In the first phase, each department generates a timetable template from the most similar timetable case, which is based on case-based reasoning. In the second phase, the department schedules a timetable with the help of interactive user interface under the timetabling criteria, which is based on rule-based approach. This study provides the illustrations of Hanshin University. We classified timetabling criteria into intrinsic and extrinsic criteria. In intrinsic criteria, there are three criteria related to lecturer, class, and classroom which are all hard constraints. In extrinsic criteria, there are four criteria related to 'the numbers of lesson hours' by the lecturer, 'prohibition of lecture allocation to specific day-hours' for committee members, 'the number of subjects in the same day-hour,' and 'the use of common classrooms.' In 'the numbers of lesson hours' by the lecturer, there are three kinds of criteria : 'minimum number of lesson hours per week,' 'maximum number of lesson hours per week,' 'maximum number of lesson hours per day.' Extrinsic criteria are also all hard constraints except for 'minimum number of lesson hours per week' considered as a soft constraint. In addition, we proposed two indices for measuring similarities between subjects of current semester and subjects of the previous timetables, and for evaluating distribution degrees of a scheduled timetable. Similarity is measured by comparison of two attributes-subject name and its lecturer-between current semester and a previous semester. The index of distribution degree, based on information entropy, indicates a distribution of subjects in the timetable. To show this study's viability, we implemented a prototype system and performed experiments with the real data of Hanshin University. Average similarity from the most similar cases of all departments was estimated as 41.72%. It means that a timetable template generated from the most similar case will be helpful. Through sensitivity analysis, the result shows that distribution degree will increase if we set 'the number of subjects in the same day-hour' to more than 90%.

• Journal of the Korean Vacuum Society
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• v.15 no.5
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• pp.527-533
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• 2006

Spinel $LiNi_xMn_{2-x}O_4$ thin films were synthesized up to x = 0.9 by a sol-gel method employing spin-coating. The Ni-substituted films were found to maintain cubic structure at low x but to exhibit tetragonal structure for $x{\geq}0.6$. Such cubic-tetragonal phase transition indicates that $Ni^{3+}(d7)$ ions with low-spin $(t_{2g}^6,e_g^1)$ state occupy the octahedral sites of the compound, thus being subject to the Jahn-Teller distortion. By x-ray photoelectron spectroscopy both $Ni^{2+}$ and $Ni^{3+}$ ions were detected. Optical properties of the $LiNi_xMn_{2-x}O_4$ films were investigated by spectroscopic ellipsometry (SE) in the visible?ultraviolet range. The measured dielectric function spectra by SE mainly consist of broad absorption structures attributed to charge-transfer (CT) transitions, $O^{2-}(2p){\rightarrow}Mn^{4+}(3d)$ for 1.9 $(t_{2g})$ and $2.8{\sim}3.0$ eV $(e_g)$ structures and $O^{2-}(2p){\rightarrow}Mn^{3+}(3d)$ for 2.3 $(t_{2g})$ and $3.4{\sim}3.6$ eV $(e_g)$ structures. Also, sharp absorption structures were observed at about 1.6, 1.7, and 1.9 eV, interpreted as due to d-d crystal-field transitions within the octahedral $Mn^{3+}$ ion. The strengths of these absorption structures are reduced by the Ni substitution. Rapid reduction of the CT transition strength involving the eg states for x = 0.6 is attributed to the reduced wavefunction overlap between the $e_g$ and the $O^{2-}(2p)$ states due to the tetragonal extension of the lattice constant by the Jahn-Teller effect.