• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.47 no.1
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• pp.20-24
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• 2021

Objectives: The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge regarding medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: This was an observational cross-sectional study that evaluated patients treated with antiresorptive medication at a single cancer hospital. Clinical data were collected and oral examination was performed to assess patient oral health. Results: From July 2017 to December 2018, 90 patients were assessed; 64 were female and 26 were male, and the mean age was 61 years. The most common drug was an intravenous bisphosphonate, zoledronic acid. Among the 90 patients, 47 presented with some type of oral disease, isolated or associated. Among these 47 patients, 9 patients (10%) developed osteonecrosis. Oral hygiene was evaluated, and most patients, with or without MRONJ, presented with regular to poor condition. Regarding patient knowledge of the risks of MRONJ and the risks associated with dental surgery, 60% stated that they were not aware of the risks. Conclusion: Identifying the profile of patients and their needs facilitates not only the preventive process, but also the emergence of new therapeutic options. Our study shows that most patients are weakened both by metastatic disease and antineoplastic treatment as well as by issues associated with aging because most were over 60 years of age. Collectively, this information should be considered for management of preventive and therapeutic measures.

• Journal of Chest Surgery
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• v.13 no.3
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• pp.256-261
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• 1980

Left atrial myxoma constitutes the most significant cardiac tumors, which occupies 30 to 50% of the total in most pathological series with the age range from 3 to 83 years, mostly between the age of 30 to 60 years. Over 90% of myxomas occur in the atria, with 3 to 4 times as many occurring in the left as in the right. They may cause severe and progressive disease mimicking mitral valvular disease with non-specific general symptoms. Recent attentions were focussed in the clinical features along with various diagnostic techniques including angiocardiography, echocardiography and cross-sectional sector scanning echocardiography, and definitive treatment with surgical removal under direct vision using cardiopulmonary bypass. There are several reports on the atrial myxomas removed from various cardiac chambers in Korea, and we report another typical case of left atrial myxoma of 6.8 x 3.8 x 1.7 cm3 attached to the upper margin of fossa ovalis with a short pedicle, also with calcification at it`s distal free end. 29 year old young mother complaining of mild fever, vaginal spotting, numbness of left upper and lower extremities, nocturnal attack of dyspnea and palpitation for 2 months was diagnosed as large left atrial myxoma with the aid of angiocardiography and echocardiography. Trans-right-atrial, transseptal surgical removal of the tumor was successfully performed under the cardiopulmonary bypass for 22 minutes on 24th of July 1980. Postoperative hospital course was uneventful and discharged from hospital on the 12th POD with complete recover from the previous symptoms and signs.

• Journal of Chest Surgery
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• v.18 no.2
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• pp.174-181
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• 1985

From Jun. 1980 to Mar. 1984, 33 cases of atrial septal defect, secundum type, operated at the department of Thoracic and Cardiovascular Surgery, School of Medicine, Keimyung University, were analyzed retrospectively. They were 24.3% of all congenital heart diseases operated in the same period. Among the 33 cases, 17 cases were males and 16 cases were females. Their ages were ranged from 4 to 42 years and cases of over 15 years of age were 60.6%. Main symptoms at admission were exertional dyspnea [69.7%], palpitation [63.6%] and frequent upper respiratory infections [51.5%], but 2 cases [6.1%] were asymptomatic. All 33 cases were operated under the direct vision with cardiopulmonary bypass. All cases were secundum type defect of atrial septal defect and single defect were in 29 cases [90.6%], and oval type defect were in 31 cases [96.9%]. In 7 cases [21.9%], other lesions of cardiovascular system were associated, and the most common lesion was pulmonic valvular stenosis [4 cases; 12.5%]. The defects were closed directly in 27 cases and in 6 cases with Dacron patch. Postoperative complications were occurred in 8 cases [24.2%], and they were pleural effusion, congestive heart failure, and alopecia mainly. One case died due to air embolism postoperatively and operative mortality was 3.1%.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.6
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• pp.133-142
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• 2012

The objective of this study was to correct the bias of the Representative Concentration Pathways (RCP)-based future precipitation data using a quantile mapping method. This method was adopted to correct extreme values because it was designed to adjust simulated data using probability distribution function. The Generalized Extreme Value (GEV) distribution was used to fit distribution for precipitation data obtained from the Korea Meteorological Administration (KMA). The resolutions of precipitation data was 12.5 km in space and 3-hour in time. As the results of bias correction over the past 30 years (1976~2005), the annual precipitation was increased 16.3 % overall. And the results for 90 years (divided into 2011~2040, 2041~2070, 2071~2100) were that the future annual precipitation were increased 8.8 %, 9.6 %, 11.3 % respectively. It also had stronger correction effects on high value than low value. It was concluded that a quantile mapping appeared a good method of correcting extreme value.

• The Korean Journal of Community Living Science
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• v.21 no.1
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• pp.53-69
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• 2010

The purpose of this study was to find how financial structures differ from the family life cycle. The data was drawn from the 2002 Korean Labor and Income Panel Study conducted by the Korea Labor Institute, and 1,957 households. The level of total income and subcategories of income were found to be significantly different from the family life cycle and showed tendencies to increase up to the period of child birth and then sharply dropped down during the retirement period. Household consumption expenditures in total and subcategories showed a U shape by family life cycle and were also found to be significantly different from the family life cycle. The consumption expenditure of dining out showed the highest level at the beginning of family establishment, whereas medical cost showed the highest level for later years. The level of total assets increased gradually from the family life cycle and a little decreased for the later years, and the level of real estate assets showed the highest ratio(90% over) out of total asset components of family life cycle.

• Journal of Korean Physical Therapy Science
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• v.19 no.1
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• pp.63-69
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• 2012

Background : The purpose of this study was to investigate the frequency domain characteristics of ground reaction forces during quiet standing on inclined surfaces twenty healthy individuals(10 elderly women $68.78{\pm}3.29$ years and 10 young women $20.90{\pm}0.74$ years) participated. Methods : Subjects stood in quiet stance over a force platform positioned in one of three different fixed positions: flat, down and up. Healthy participants completed with eyes open for 120 s trials. Evaluation of postural control were generally based on the interpretation of center of pressure(COP) time series. The COP have been determined using an experimental setup with 3D kinematic and the ground reaction force system. All the data were expressed means and standard deviation by using SAS package program. Results : SEF 50% were not significant in AP and ML direction according to surface slope of both groups. SEF 95% were showed highest frequency in AP direction on down slope of both groups. MEF were not significant all direction according to surface slopes of elderly women. There was no difference between young and elderly women. Conclusion : Elderly women used to ankle strategy during a quiet stance according to COP perturbation of AP direction showed more expanded than ML direction. SEF 95% were showed highest frequency on down slope in elderly women who showed more used ankle strategy for postural control on down slope.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.3
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• pp.291-295
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• 2013

Purpose: The purpose of this study was to investigate the effect of under and over refractive correction on visual acuity performance and the variation of the visual performance measurement using two different visual acuity charts. Methods: Ten young adults, aged between 19 and 25 years old, were recruited. Inclusion criteria: no history of ocular injury or pathology with a best-corrected visual acuity of 6/6 on dominant eye. The over and under refractive corrections were induced using minus and plus spherical ophthalmic lenses in 0.50 D steps up to 3.00 D; as well as using three axis orientations of cylindrical ophthalmic lenses ($45^{\circ}$, $90^{\circ}$ and $180^{\circ}$) in 0.50 D steps. The variation of visual acuity performance measurements was investigated using Bailey-Lovie LogMAR chart and Landolt C chart. Results: The visual acuity changes with lenses were significantly different between two charts [F = 49.15, p < 0.05 with plus spherical ophthalmic lenses and F = 174.38, p < 0.05 with minus spherical ophthalmic lenses]. The visual acuity changes with three different cylindrical axis showed no significant difference between Bailey-Lovie LogMAR chart [F = 2.35, p > 0.05] and Landolt C chart [F = 3.12, p = 0.05]. Conclusions: The over and under refractive correction affected the visual acuity performance differently. The Landolt C chart and Bailey-Lovie LogMAR chart demonstrated variation in measurements.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.1
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• pp.99-109
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• 2008

The purpose of this study was to survey sizing system and preferable ease and to decide the body measuring items for pattern making in a men's dress shirt for mass customization industry that is rising to the surface as a new production system. For this, it had a survey subjects were 254 males between 25 to 44 years old who wear dress shirt frequently and the relevant on line companies, and analyzed the garment sizing system and preferable ease. Collected data were analysed by frequency analysis, t-test, $X^2-test$, and ANOVA using SPSS 12.0 for window. Garment pattern making should reflect the sizes of the body parts well, and simplification of the ordering process would work as an important variable. In relation to the preferable ease, older people preferred more ease while younger people preferred fit ease. In relation to the sizes, people wearing the size of '110' preferred more ease than the size of '90'. And people weighing over 90kg preferred sufficient ease than less weighing. People height over 170cm people preferred sufficient ease for the length between shoulders than height under 170cm. In case of the companies had no consistent sizing system. Significant difference was found in the sizes, except for the size of '100', among those companies, there was significant difference in the length between shoulders and the length of the shirt among those companies and those sizes. Significant body parts for a garment pattern making was height, the circumference of the neck, the chest circumference, the length between biacromion, the arms length, and the waist circumference.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.182-186
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• 2007

Cefixime is an orally absorbed cephalosporin with a broad spectrum of activity against Gram-negative bacteria and is highly resistant to beta-lactamase degradation. The purpose of the present study was to evaluate the bioequivalence of two cefixime capsules, Suprax capsule (Dong-A Pharmaceutical Co., reference drug) and Alpha-Cefixime capsule (Alpha Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal subjects, $23.5{\pm}3.72$ years in age and $68.3{\pm}8.89$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. There was one week washout period between the doses. After one capsule containing 100 mg of cefixime was orally administered, plasma was taken at predetermined time intervals and the concentrations of cefixime in plasma were determined using HPLC with UV detector. The pharmacokinetic parameters such as $AUC_{t}$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_{t}$, $C_{max}$ and $T_{max}$ between two products were -3.91%, -2.23% and -3.18%, respectively, when calculated against the reference drug. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of $log0.8{\leq}{\delta}{\leq}log1.25$ (e.g., $log0.8786{\leq}{\delta}{\leq}log1.0523$ and $log0.8889{\leq}{\delta}{\leq}log1.0512$ for $AUC_{t}$ and $C_{max}$, respectively). The 90% confidence intervals using untransformed data was within ${\pm}20%$(e.g., $-10.37%{\leq}{\delta}{\leq}6.73%$ for $T_{max}$). All parameters met the criteria of KFDA for bioequivalence, indicating that Alpha-Cefixime capsule (Alpha Pharmaceutical Co.) is bioequivalent to Suprax capsule (Dong-A Pharmaceutical Co.).

• YAKHAK HOEJI
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• v.47 no.4
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• pp.239-243
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• 2003

Metformin is an oral antihyperglycemic agent used in the therapy of noninsulin-dependent diabetes mellitus and does not cause hypoglycemia at the therapeutic dose. The purpose of the present study was to evaluate the bioequivalence of two metformin hydrochloride tablets, Glucophage tablet (DaeWoong Pharmaceutical Co., reference drug) and Dybis tablet (Shinpoong Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration(KFDA). Twenty-four normal volunteers, 26.6$\pm$4.01 years in age and 60.6$\pm$9.80 kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 500 mg of metformin hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of metformin hydrochloride in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AUCt, Cmax and Tmax were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUCt, Cmax and Tmax between two products were -1.05％, -6.76％ and -4.51％, respectively, when calculated against the reference drug. The 90％ confidence intervals using logarithmically transformed data were within the acceptance range of log0.8$\leq$$\delta$$\leq$log1.25 (e.g., log0.9082$\leq$$\delta$$\leq$log1.0906 and log0.8188$\leq$$\delta$$\leq$log1.0392 for $AUC_{t}$ and $C_{max}$, respectively). The 90％ confidence intervals using untransformed data was within $\pm$20％ (e.g., -17.66％$\leq$$\delta$$\leq$8.63％ for $T_{max}$). All parameters met the criteria of KFDA for bioequivalence, indicating that Dybis tablets (Shinpoong Pharmaceutical Co.) is bioequivalent to Glucophage tablets (DaeWoong Pharmaceutical Co.).