• 한국가구학회지
• /
• 제20권5호
• /
• pp.467-479
• /
• 2009

The high-tech computer technology developments have greatly affected the area of design education. Starting from the mid 80s, innovations in visual presentation methods have heightened with 2D computer graphic programs, CAD & 3D modeling, and Rapid Prototype that allows dimensional generation. The specialty and quality in design studio education have advanced due to the development in presentation methods such as Power Point and Keynote. But there are many problems with the current method of presenting the visual outcome in a data format using beam projectors, which is a vertical presenting method compared to the old studio study method of conducting discussions and reviews based on the substantial outcome. The essence of studio study that allows for comparisons and analysis by horizontally opening up the various work outcomes is being offset. Also the requirement for manual idea sketching work that plays an important role in the initial design phase continuing to decrease due to the digital working process dependence and cumbersome procedures in the presentation. In order to resolve this problem, the CALM system (Class Applied LCD Modular System) has been developed that replaces the method of attaching the sketches or renderings on the wall with a digital multi-display system. In a nutshell, individuals will upload the outcomes online and display them on the CALM system studio that is composed of 32 LCD (Columns: 4 $\times$ Rows: 8) monitors that are 19 inches in size so that various personnel can openly study the design outcomes. Also the central 42 inch PDP monitor that offers touch pad capability allows each design outcome to be described and examined by expanding. The concept phase of this development process has elevated to the production of an operating prototype that is being reviewed of its practicality. It is considered that the development of this system will decrease the extreme tendency of depending on digital operation but achieve revitalization of a more realistic and opened studio study environment compared to the individual consulting method of the old study approach.

• 한국경영과학회지
• /
• 제20권1호
• /
• pp.11-26
• /
• 1995

We have used various information technologies (IT) in group decision-making for increasing effectiveness and satisfaction of group decision-making process. Recently, a new form of IT so called Group Decision supprot System (GDSS) was introduced into group decision-making process. Previous experimental studies about effectiveness of GDSSS have been inconsistent and the results were mixed. There was no empirical studies about GDSS in Korea. In this study, we divide two groups-GDSS supported group and traditional face-to-face group and investigate impacts of GDSS on group decision-making processes and outcomes. An idea generation task for operational action plan development, implementing GEO's strategic vision, served as the decision-making context. Supported GDSS is GroupSystems V, which had been developed by Univ. of Arizona. It was translated by Korean. According to the results, Number of nonredundant ideas in GDSS group is two or three times more than Non-GDSS grop. GDSS group feel more equal status, have better interpersonal relationship, have more confidence on group decision than Non-GDSS group. But satisfaction of participants on decision-making process and outcome has not showed a significant difference between two groups. Because all of participants in GDSS group were novice to GDSS. With this results we suggest further studies on transforming western type GDSS to Korean decision-making culture. It will be cornerstone for development of GDSS in Korean desision-making culture. It will be cornerstone for devlopment of GDSS in Korean decsion making culture environment.

• 건축역사연구
• /
• 제22권3호
• /
• pp.15-26
• /
• 2013

This research takes as its object a body of historical researches by a new generation of French architects in the 1970s, who tried to confront the deep crisis in architecture since the years 1960. The research begins by noting that the ideology of the architect as an autonomous and transcendental subject, an ideology held by the architects of the previous generation, was a main target that young architects wanted to criticize and overcome. From this observation, the research focuses on a antihumanistic project which gave basis for a significant number of historical researches on modern architecture and was the result of a reappropriation of the French structuralism intensively developed in the human and social sciences of that time in France. After a series of textual analyzes, we argue that a new perspective on the city and the relationship of the latter with the architecture on the one hand, and the proposal for an "modest" architect as an alternative figure after rejection of the autonomous and transcendental one on the other hand, have been derived as the outcome of anti-humanist historiographic works. Finally, we assume that these historical adventure gave conceptual basis for postmodern architecture in France, freed from the modern myth of unity of author and that of work of art, but tinted by a moralism requesting modesty to architects.

• 한국디지털건축인테리어학회논문집
• /
• 제6권2호
• /
• pp.9-16
• /
• 2006

The research want to know about form creation method's special quality that found in digital construction design process that using digital media, and they comparison analysis that who positive using digital media, Frank O. Gehry, Peter Eisenman, Greg Lynn, UN studio's work. First, In digital design process using digital media is make full use to design unfolding step and application way can change by architect's recognition difference of using digital media and each architect's design general idea unfolding process, and it means form creation process can change. Second, In digital design process a building form doesn't design adaptation to construction system, they directly design the third dimension form. So, they deduction a new form that unification and integration. Third, the architect that appear's in digital design process's part is existing, data from position of the master which it selects the coding selects the outcome goods which appears in computer operation with coordinator role of the originality and construction sense which it is visible.

• Clinical and Experimental Pediatrics
• /
• 제54권3호
• /
• pp.106-110
• /
• 2011

In pediatric patients with acute lymphoblastic leukemia (ALL), the Philadelphia chromosome translocation is uncommon, with a frequency of less than 5%. However, it is classified as a high or very high risk, and only 20-30% of Philadelphia chromosome-positive (Ph+) children with ALL are cured with chemotherapy alone. Allogeneic hematopoietic stem cell transplantation from a closely matched donor cures 60% of patients in first complete remission. Recent data suggest that chemotherapy plus tyrosine kinase inhibitors (TKIs) may be the initial treatment of choice for Ph+ ALL in children. However, longer observation is required to determine whether long-term outcome with intensive imatinib and chemotherapy is indeed equivalent to that with allogeneic related or alternative donor hematopoietic stem cell transplantation (HSCT). Reports on the use of second-generation TKIs in children with Ph+ ALL are limited. A few case reports have indicated the feasibility and clinical benefit of using dasatinib as salvage therapy enabling HSCT. However, more extensive data from clinical trials are needed to determine whether the administration of second-generation TKIs in children is comparable to that in adults. Because Ph+ ALL is rare in children, the question of whether HSCT could be a dispensable part of their therapy may not be answered for some time. An international multicenter study is needed to answer the question of whether imatinib plus chemotherapy could replace sibling allogeneic HSCT in children with Ph+ ALL.

• Molecules and Cells
• /
• 제46권11호
• /
• pp.655-663
• /
• 2023

Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections. Additionally, the decline in autophagic activity contributes to tissue and organ dysfunction and aging-related diseases. Several factors, such as down-regulation of autophagy components and activators, oxidative damage, microinflammation, and impaired autophagy flux, are linked to autophagy decline. An autophagy flux impairment (AFI) has been implicated in neurological disorders and in certain other pathological conditions. Here, to enhance our understanding of AFI, we conducted a comprehensive literature review of findings derived from two well-studied cellular stress models: glucose deprivation and replicative senescence. Glucose deprivation is a condition in which cells heavily rely on oxidative phosphorylation for ATP generation. Autophagy is activated, but its flux is hindered at the autolysis step, primarily due to an impairment of lysosomal acidity. Cells undergoing replicative senescence also experience AFI, which is also known to be caused by lysosomal acidity failure. Both glucose deprivation and replicative senescence elevate levels of reactive oxygen species (ROS), affecting lysosomal acidification. Mitochondrial alterations play a crucial role in elevating ROS generation and reducing lysosomal acidity, highlighting their association with autophagy dysfunction and disease conditions. This paper delves into the underlying molecular and cellular pathways of AFI in glucose-deprived cells, providing insights into potential strategies for managing AFI that is driven by lysosomal acidity failure. Furthermore, the investigation on the roles of mitochondrial dysfunction sheds light on the potential effectiveness of modulating mitochondrial function to overcome AFI, offering new possibilities for therapeutic interventions.

• 융합보안논문지
• /
• 제16권6_1호
• /
• pp.3-13
• /
• 2016

우리는 전쟁에서 당연히 강한 자가 약한 자에게 승리한다고 생각한다. 그러나 현대전쟁에서 약한 자가 강한 자를 상대로 승리한 사례들이 많음을 알 수 있다. 이는 제4세대전쟁 이론을 통해 논리적으로 이해할 수 있다. 북한은 열세한 국력임에도 한반도 무력통일 정책을 포기하지 않고 있다. 그들은 국제사회와 남한을 상대로 다양한 정치 사회 군사적 수준의 도발을 계속하고 있다. 최근에 북한은 5차례의 핵실험, 대륙간탄도미사일 시험발사와, DMZ 도발 등을 자행하였으며, 앞으로도 제4세대전쟁 차원의 도발을 계속할 것으로 예상된다. 이에 점증하고 있는 북한의 제4세대전쟁 위협과 도발에 대한 본질을 이해해야 한다. 이를 통해 그들의 제4세대전쟁 위협에 대한 근본적인 대책중 하나인 향토예비군제도에 대한 가치를 재인식하고 관련 제도를 보완해야 한다. 우리는 개선된 향토예비군제도를 통해 한반도에 세력균형 변화와 힘의 전환점으로 이행을 단호 거부할 수 있다. 즉 예상되는 북한의 제4세대전쟁 위협에 대하여, 우리의 향토예비군제도는 우리의 단호한 전쟁 수행을 위한 의지(意志)이자, 정치 사회 경제 군사적인 수단이며, 최적의 대안으로 기능발휘가 가능하다.

• Journal of Advanced Marine Engineering and Technology
• /
• 제35권5호
• /
• pp.661-666
• /
• 2011

최근 해양교통시설물의 전력원으로 태양광발전과 파력발전을 이용한 하이브리드 발전 형태에 대한 연구가 진행 중이다. 그러나 해상에서 장기간 해양교통시설물을 운용할 경우 해양교통시설물 수주의 유입구에 해조류 증착 문제가 발생하였다. 이러한 문제의 해결을 위해 AFS (Anti-Fouling System)의 연구가 진행되고 있다. 단일채널 방식의 AFS를 이용하였으나 구리 전극봉의 이온화가 각기 다르게 되어 구리 전극봉의 교환주기를 앞당기는 문제가 발생하였다. 본 논문에서는 다채널 전류제어 방식을 이용한 해양 교통시설물용 AFS를 제안하고 시뮬레이션을 하였다. 시뮬레이션의 신뢰성을 높이기 위하여 실제 해양교통시설물의 전극봉 용해결과를 시뮬레이션 프로그램에 반영하였다. 시뮬레이션 결과 제안된 다채널 전류 제어 방식의 AFS의 전극봉이 균일하게 이온화 되는것을 확인할 수 있었다.

• Journal of Genetic Medicine
• /
• 제20권1호
• /
• pp.6-14
• /
• 2023

Fabry disease (FD), a rare X-linked lysosomal storage disorder, is caused by mutations in the α-galactosidase A gene gene encoding α-galactosidase A (α-Gal A). The functional deficiency of α-Gal A results in progressive accumulation of neutral glycosphingolipids, causing multi-organ damages including cardiac, renal, cerebrovascular systems. The current treatment is comprised of enzyme replacement therapy (ERT), oral pharmacological chaperone therapy and adjunctive supportive therapy. ERT has been introduced 20 years ago, changing the outcome of FD patients with proven effectiveness. However, FD patients have many unmet needs. ERT needs a life-long intravenous therapy, inefficient bio-distribution, and generation of anti-drug antibodies. Migalastat, a pharmacological chaperone, augmenting α-Gal A enzyme activity only in patients with mutations amenable to the therapy, is now available for clinical practice. Furthermore, these therapies should be initiated before the organ damage becomes irreversible. Development of novel drugs aim at improving the clinical effectiveness and convenience of therapy. Clinical trial of next generation ERT is underway. Polyethylene glycolylated enzyme has a longer half-life and potentially reduced antigenicity, compared with standard preparations with longer dosing interval. Moss-derived enzyme has a higher affinity for mannose receptors, and seems to have more efficient access to podocytes of kidney which is relatively resistant to reach by conventional ERT. Substrate reduction therapy is currently under clinical trial. Gene therapy has now been started in several clinical trials using in vivo and ex vivo technologies. Early results are emerging. Other strategic approaches at preclinical research level are stem cell-based therapy with genome editing and systemic mRNA therapy.

• Journal of Microbiology and Biotechnology
• /
• 제15권2호
• /
• pp.421-424
• /
• 2005

Effect of antibiotics belonging to three different groups, including third generation cephalosporins, aminoglycosides, and quinolones, on the outer membrane protein (OMP) profile of Klebsiella pneumoniae was examined. It was found that a new OMP (porins) of 40 kDa molecular mass was expressed in Klebsiella pneumoniae, when grown in the presence of ceftazidime, whereas new proteins with 30 kDa and 22 kDa masses were detected in the presence of ofloxacin. The immunoblot analysis showed that the new proteins of 40 kDa and 30 kDa molecular masses were expressed on the outer envelope, when being exposed to antibiotics ceftazidime and ofloxacin, respectively. This finding is important, as the outer surface comes in contact with the immune system, and therefore may have a bearing on the outcome of the disease.