• 동의생리병리학회지
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• 제18권5호
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• pp.1494-1504
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• 2004

The present paper reports the effects of Hwaotang an atherosclerosis using a spontaneous experimental model, We have also investigated the pharmacological effect of Hwaotang on collagen- and ADP-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in in vitro experiments, and various effects on stimuli-induced superoxide generation in human neutrophils. Hwao-tang was shown to have inhibitory effect on collagen- and ADP-induced blood platelet aggregation, on thrombin-induced conversion of fibrinogen to fibrin and on the activity of plasminogen or plasmin. Hwao-tang also significantly inhibited fMLP-induced superoxide generation in a concentration-dependent manner, but not that induced by arachidonic acid. Hwao-tang inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B4 production, without any effect on 5-lipoxygenase activity. In conclusion, the protection of extracts of Hwao-tang on the ischemic infarction induced artificially might be involved to their inhibition of thrombotic action. The results also indicate that Hwao-tang exerts the effects on superoxide generation related to the inhibition of neutrophil functions.

• 대한예방한의학회지
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• 제1권1호
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• pp.105-117
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• 1997

The result of this paper runs as follows: 1. The theory of preclinic phase (=mibyung) was scientifically completed as one basic philosophy in "NAEKYUNG(內經)" and on influenced in the coming generations. Two principles for mibyung is to grow good energy and to avoid etiological cause. 2. So far oriental medicine has responded to already diseases, while to recognize the importance of mibyung is to convert it into preventive medicine which study and improve health. In spite of the opinion that no disease is health and no health is disease, the contrite of medical approch by the relative importance is necessary by understanding the steps of mibyung between health and disease with subdividing the steps of the occurance therefore, the scope of oriental medicine may be recognized from every disease to mibyung, that is, health. 3. Diagnosing and treating in the step of mibyung has more important meaning than suffering step because the checkup of mibyung means early examination and treatment. Mibyung can make an opportunity that improve scientific contradiction and defect of oriental medicine. However, scince the theory and practice lack the arrangement and study, much exertion and discussion is necessary.4. The diagnosis and cure in mibyung doesn't have many methods for treating, its index and standard isn't nified, and related theory is of small quantity. But the most prominent means of solution. with combination with other sciences and through the convertion into modem clinical examination, is to accomplish moderization, objectivity and indexation, etc. 5. The representive mibyungs are a hereditary disease, immune lack, mutation, early tumor, incubation of hepatitis and each infectious diseases, stress, etc. Since every science is the product of the times, it has the historical limits. As the times develop, the desire for good health is growing. Therefore we should consider above request in this times.

• 한국한의학연구원논문집
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• 제17권3호
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• pp.97-104
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• 2011

Objectives : In this paper, we proposed a method for selecting reliable variables from various vocal features such as frequency derivative features, frequency band ratios, intensities of 5 vowels and an intensity of a sentence, since some features are sensitive to the variation of a subject's utterance. Methods : To obtain the reliable voice variables, the coefficient of variation (CV) was used as the index to evaluate the level of reliability. Since the distributions of a few features are not Gaussian, but are instead skewed to the right or left, we transformed the features by taking the log or square root. Moreover, the definition of the variables that are suitable to represent the vocal property was explained and analyzed. Results : At first, we recorded the vowels and the sentence five times both in the morning and afternoon of the same day, totally ten recordings from each of six subjects (three males and three females). We then analyzed the CVs of each subject's voice to obtain the stable features with a sufficient repeatability. The features having less than 20% CVs for all six subjects were selected. As a result, 92 stable variables from the 222 features were extracted, which included all the transformed variables. Conclusions : Voice can be widely used to classify the four constitution types and to recognize one's health condition from extracting meaningful features as physical quantity in traditional Korean medicine or Western medicine. Therefore, stable voice variables can be useful in the u-Healthcare system of personalized medicine and for improving diagnostic accuracy.

• 대한한의학원전학회지
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• 제25권1호
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• pp.51-68
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• 2012

Objective : This paper is aimed at suggesting further tasks by checking and rectifying the errors of the ancieut Chinese-vernacular Korean translations of Park Ji-won(朴趾源)'s "Kumryosocho". Method : In order to correct the wrongly transcribed "Kumryosocho" was contrasted with the original "Xiangzubiji(香祖筆記)", of which the part is "Kumryosocho". And then the errors and mistakes are discovered in published ancient Chinese-to-vernacular Korean translations. Result : In the course of checking the existing translations of "Kumryosocho", this paper identified the following types of errors. 1. Errors attributable to unfamiliar names of medicinal herbs 2. Errors due to the unfamiliarity with the names of diseases or symptoms in Traditional Koreau Medicine(TKM). 3. Errors committed in hand transcription. These types of errors were committed as well in translating jargons routinely used in TKM books. To the surprise, the errors above have been repeated even in the latest version of its translation. This means that the medicine-related materials by Silhak scholars, including "Kumryosocho", were placed at a dead zone of the research between Chinese classic scholars and TKM scholars. Conclusion : To minimize errors and mistakes, it is needed to activate the cooperative work of heterogeneous experts in two academic fields.

• 동의생리병리학회지
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• 제20권2호
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• pp.471-476
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• 2006

Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.

• 동의생리병리학회지
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• 제20권5호
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• pp.1135-1148
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• 2006

The effect of heat on the cancer have been keen since ancient orint medic. Quantitative biologic techniques were applied to the investigation of heat, and the resulting studies have defined a firm rationale for the expectation that hypertherima will be useful in the treatment of cancer. This promise led to activity in developing physical means to produce and measure hyperthermia in patients. Hyperthermic treatments for cancer are grouped into two categories according two the amount of tissue bing heated during the treatments. The categories commonly used are localized, regional, and whole body hyperthermia. Hyperthermia is a situation referring to yang-heat. In orient medic, It refers to vital-qi and the driving force of life activities. Our paper reviewed the present state of the the hyperthemia, outline some major impediments to progress at this time, and suggest researching approches in order to define the role of hyperthermia in the treatment of cancer.

• 대한의용생체공학회:의공학회지
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• 제42권5호
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• pp.201-210
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• 2021

In Korean medicine, tongue diagnosis is one of the important diagnostic methods for diagnosing abnormalities in the body. Representative features that are used in the tongue diagnosis include color, shape, texture, cracks, and tooth marks. When diagnosing a patient through these features, the diagnosis criteria may be different for each oriental medical doctor, and even the same person may have different diagnosis results depending on time and work environment. In order to overcome this problem, recent studies to automate and standardize tongue diagnosis using machine learning are continuing and the basic process of such a machine learning-based tongue diagnosis system is tongue segmentation. In this paper, image data is augmented based on the main tongue features, and backbones of various famous deep learning architecture models are used for automatic tongue segmentation. The experimental results show that the proposed augmentation technique improves the accuracy of tongue segmentation, and that automatic tongue segmentation can be performed with a high accuracy of 99.12%.

• 동의신경정신과학회지
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• 제28권2호
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• pp.137-143
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• 2017

Objectives: Insomnia is a common disease in the general population. The purpose of this paper was to suggest that insomnia subtype of blood stasis can be effectively treated with Danggwisu-san and acupuncture. Methods: This is a clinical case report of a patient with chronic insomnia that was diagnosed with blood stasis subtype. I treated him with Danggwisu-san (Dangguixu-san) two to three times daily and with acupuncture and moxibustion two to three times weekly. Results: After short-term treatment, the patient was gradually recovering from deteriorating chronic insomnia and multiple accompanying symptoms such as severe constipation, spontaneous bleeding and edema, darkened face, depressive moods, etc. Conclusions: Results revealed a possibility that chronic insomnia subtype of blood stasis may be successfully treated with Danggwisu-san and acupuncture and moxibustion.

• 사상체질의학회지
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• 제22권3호
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• pp.18-28
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• 2010

1. Objectives: Purpose of this paper is to study the reinterpretation of Taeyang disease(太陽病) in "Shanghanlun(傷寒論)" based on the pathologic perspective of Sa-sang Constitutional Medicine by comparing factors as pathologic mechanisms, clinical symptoms, and remedies. 2. Methods: The texts referred to pathologic mechanisms, clinical symptoms, and remedies of Taeyang disease(太陽病) described in "Donguisusebowon Gabobon(東醫壽世保元 甲午本)", "Donguisusebowon Sinchookbon(東醫壽世保元 辛丑本)", and Shanghanlun(傷寒論)" in "Donguibogam(東醫寶鑑)" were analysed. 3. Results and Conclusions 1) Early phase of Ulgwang symptomatic pattern(鬱狂證 初證) and of Mangyang symptomatic pattern(亡陽證初證) of Kidney Heat-based Exterior Heat disease(腎受熱表熱病), a category of Soeumin(少陰人) diseases, were described by adopting pathologic models of Taeyang-sangpung symptomatic pattern(太陽傷風證) and Sanghan-hyeol symptomatic pattern(傷寒血證) from "Sanghanlun(傷寒論)". 2) Soyang-sangpung symptomatic pattern(少陽傷風證) of Spleen Cold-based Exterior Cold diseae (脾受寒表寒病) and Hyunggyeok-yeol symptomatic pattern(胸膈熱證) of Stomach Heat-based Interior Heat disease(胃受熱裏熱病), categories of Soyangin(少陽人) diseases, were described by adopting pathologic models of Taeyang-yangsangpunghan symptomatic pattern(太陽兩傷風寒證), Soyang-sangpung symptomatic pattern(少陽傷風證) and Tayangbyong-sahak symptomatic pattern(太陽病似瘧證) from "Sanghanlun(傷寒論)". 3) Baechu-pyo symptomatic pattern(背顀表病輕證) and Hangual symptomatic pattern(寒厥證) of Esophagus Cold-based Exterior Cold disease(胃脘受寒表寒病), a category of Taeeumin(太陰人) diseases, was described by adopting pathologic models of Taeyang-sanghan symptomatic pattern(太陽傷寒證) and Hangual symptomatic pattern(寒厥證) from "Sanghanlun(傷寒論)". 4) Je-Ma Lee reinterpreted various diseases classified as Taeyang disease(太陽病) with the pathologic perspective of Sa-sang Constitutional Medicine. Different from existing medicine, diseases were analysed and treated by the standard, constitution of the patient.

• 사상체질의학회지
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• 제16권1호
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• pp.1-11
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• 2004

Objectives This paper was tried to find out Dongmu Lee Je-ma's concept about the exterior disease and the interior disease. Methods The study was researched as bibliologically with Dongmu Lee Je-ma's writings such as "Dongyi Suse Bowon Sasang Chobongyun", "Dongyi Suse Bowon" written in 1894, "Dongyi Suse Bowon" published in 1901 Results and Conclusion The conclusions were as follows 1. In Dongmu Lee Je-ma's book, There are no clear definition about the concept of the exterior disease and the interior disease. 2. At Dongmu's early works, the exterior disease and the interior disease were classified by the cause and the region of a disease. On the other hand, That wewe reclassified by the characteristic of Constitutional symptoms at "Dongyi Suse Bowon" published in 1901 3. In Dongmu Lee Je-ma's concept, If men is damaged the exterior Qi(表氣), he will be sick 'he exterior disease'. The other hand, If men is damaged the interior Qi(裏氣), he will be sick 'the interior disease'.