• Journal of Pharmaceutical Investigation
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• v.28 no.4
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• pp.275-282
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• 1998

In order to develop a desirable in vitro release which correlates well with in vivo bioavailability, hollow type suppository containing Propranolol HCl(PPH) powder in the cavity and conventional type suppository with dispersed PPH in the base were prepared. Polyvinyl alcohol (PVA) hydrogel as a base and PPH as a model drug were used for the preparation of suppository. The rates of drug release from the suppositories were studied by Paddle method, Muranish method, Dialysis tubing method and Rotating dialysis cell method. The release profiles from suppositories using the four different release tests were compared. After a rectal administration in rat, the mean $C_{max}$ of hollow type suppository was significantly lower than that of conventional type, but $T_{max}$, $AUC_{0{\to}12}$ and MRT of hollow type were significantly higher 1.6 times, 1.2 times and 1.9 times than those of conventional type, respectively. The computer program was used to simulate plasma concentration from in vitro released amounts of drug and in vivo pharmacokinetic parameters. Based on comparison of the simulated bioavailability from computer program with experimental bioavailability in rat we have found out in vitro release test which correlates well with in vivo bioavailability. Our results have shown the best correlation between in vitro release and in vivo bioavailability in PPH-PVA hydrogel hollow type suppository for the paddle method and conventional type suppository for the rotating dialysis cell method. In this work we propose that PPH-PVA hydrogel suppository shows in vitro-in vivo correlation. This data should help to optimize the formulation of the drug and provide a basis for quality control procedures.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.25 no.1
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• pp.54-61
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• 2016

Washing machine manufacturers typically advise consumers to maintain the relative humidity in the drum less than 80% for three days after the termination of a washing cycle in order to prevent bacteria proliferation. A vent installed in the back of a washing machine is used to release moisture to satisfy this condition. Up to now, the design and installation of the vent have been based on experiments without understanding its roles and physical phenomena. In this study, various CFD results are presented in order to explain the physical mechanism of moisture release in a washing machine. Two methods of moisture release (diffusion and convection) were studied; diffusion was found to be the dominant process in removing moisture. Experiments were also performed to validate this behavior. In addition, this study will aid in the efficient design of vents to keep the relative humidity low inside the drum.

• Fire Science and Engineering
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• v.22 no.1
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• pp.37-44
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• 2008

The reduced scale fire test provides basic data but it is not enough to analysis real fire problem directly because there is no exact analogy theory between a real fire and the reduced scale model. Therefore, we have developed the 10 MW large scale calorimeter in order to real scale fire test. This advanced large scale calorimeter used for physical properties such as a heat release rate, based upon consumption of $O_2$ method. Using the heptane pool fire, we carried out the calibration in order to evaluation for heat release rate. It is approve that this facility has the reliability and it is capable of applying to the advance fire research in the future.

• Smart Structures and Systems
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• v.24 no.1
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• pp.27-35
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• 2019

This paper proposes a quantitative criterion for optimization of actuator placement for the Prestress-Accumulation Release (PAR) strategy of mitigation of vibrations. The PAR strategy is a recently developed semi-active control approach that relies on controlled redistribution of vibration energy into high-order modes, which are high-frequency and thus effectively dissipated by means of the natural mechanisms of material damping. The energy transfer is achieved by a controlled temporary removal of selected structural constraints. This paper considers a short-time decoupling of rotational degrees of freedom in a frame node so that the bending moments temporarily cease to be transferred between the involved beams. We propose and test a quantitative criterion for placement of such actuators. The criterion is based on local modal strain energy that can be released into high-order modes. The numerical time complexity is linear with respect to the number of actuators and potential placements, which facilitates quick analysis in case of large structures.

• 한국연소학회:학술대회논문집
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• 2012.11a
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• pp.309-310
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• 2012

Modeling of biodiesel combustion on compression ignition engine was conducted by using the KIVA3v-Release 2 code coupled with Chemkin chemistry solver2. In order to calculate the chemical kinetics of combustion of biodiesel, a reduced mechanism of methyl decanoate and methyl 9-decanoate was used. It is composed of 123 species and 394 reactions. Also, the experiments were performed on a single-cylinder engine. The simulation results agreed well with experiments results. And soot concentrations of biodiesel were lower than those of diesel.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.39-39
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• 1996

Extracts were prepared from six different poisonous mushrooms in order to identify biologically active natural ligands. The effects of these extracts were examined on the microsomal $^{45}$ Ca$^{2+}$ uptake and $^{45}$ Ca$^{2+}$ release. Five out of six species apparently inhibited the activity of total microsomal ATPases prepared from the epithelial cells of pig airway. (omitted)ted)

• Journal of Korean Society of Environmental Engineers
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• v.29 no.9
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• pp.1003-1012
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• 2007

In this study, we analyzed the release differences for some critical pollution compounds according to the surrounding conditions in order to predict water quality due to the sedimental releases and the release characteristics at different sedimental locations in Lake Leewon, in Tae-An area. COD, nitrogens and phosphates were analyzed using the standard methods for water quality, based on high chloride ion concentration(greater than 2,000 ppm). For COD, the release rate increased in the anoxic basin but almost the same in the oxic basin. For $NH_3$-N, the release rate decreased in the oxic basin as you go A through C point meanwhile, for $NO_3$-N and T-N, the tendency was reversed because of nitrification of them. In the anoxic basin, the release rates of $NH_3$-N and $NO_3$-N went up with A through C path. However, the release rate of T-N was found to decrease. Also, for $PO_4$-P and T-P, the release rates in the oxic basin were lowest at B point mainly because the phosphates were at less released in the highly $O_2$ concentrated environment. In the anoxic reactor, $PO_4$-P was released similarly regardless of the sampling points. In summary, the release rates in the oxic reactor were greater than those in the anoxic reactor for COD and $NO_3$-N. For the other components, the anoxic basin generated the higher release rates.

• Applied Chemistry for Engineering
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• v.34 no.2
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• pp.161-169
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• 2023

In this study, we prepared naproxen (NP) imprinted biodegradable polymer based multi-layer biomaterials using allbanggae starch (ABS), polyvinyl alcohol (PVA), and alginic acid (SA), and investigated their physicochemical properties and the controlled drug release effects. In addition, the prepared multi-layer biomaterials were characterized by FE-SEM and FT-IR. In order to confirm the controlled drug release effect for the transdermal drug delivery system (TDDS), the NP release properties of NP imprinted multi-layer biomaterials were investigated using various pH buffer solutions and artificial skin at 36.5 ℃. The results of NP release in various pH buffer solutions indicated that the NP release at high pH was about 1.3 times faster than that at low pH. In addition, NP release in multi-layer biomaterials was about 4.0 times slower than that in single-layer biomaterials. It was confirmed that the NP release rate in triple-layer biomaterials was 4.0 times slower than that in single-layer biomaterials while using artificial skin. Also, it could be found that NP in double-layer biomaterials and triple-layer biomaterials was released sustainably for 12 h. The NP release mechanism in pH buffer solutions followed the Fickian diffusion mechanism, but followed the non-Fickian diffusion mechanism with artificial skin.

• Journal of Ginseng Research
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• v.14 no.2
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• pp.122-125
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• 1990

Ethylene was released from leaf and fruit but root of Panax ginseng. Root callus showed higher ethylene release (ER) than fruit ER increased with leaf senesence. Fruit during ripening showed decreasing ER in the order of green stage, early stage of reddening and fully ripened stage. between leaves from the plant with fruits in different stages of ripening showed similar trend of fruit in ER but it was about 10 times higher in leaves than in fruits. Leaves of P. quinquefolius showed about 200 times higher ER than that of P ginseng on 22 July Fruits from the plant treated with ethephon showed higher ER after 109 days. Forty-five day-old seedlings grown with various growth regulators showed a significant decrease of stem length and significant increase of ER only in Uniconazole (0.1 ppm) and H-9 (0.0, 5 ppm) solution.

• Journal of Mechanical Science and Technology
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• v.18 no.11
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• pp.1996-2008
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• 2004

A seamless analysis of material behavior incorporating complex geometry and crack- tip modeling is one of greatly interesting topics in engineering and computational fracture mechanics fields. However, there are still large gaps between the industrial applications and fundamental academic studies due to a time consuming detailed modeling. In order to resolve this problem, a numerical method to calculate an energy release rate by virtual crack closure technique was proposed in this paper. Both free mesh method and finite element method have been utilized and, thereafter, robust local and global elements for various geometries and boundary conditions were generated. A validity of the proposed method has been demonstrated through a series of fracture mechanics analyses without tedious crack-tip meshing.