• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.314-314
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• 1996

We investigate the scheduling problem for periodic job shops with blocking. We develop Petri net models for periodic job shops with finite buffers. A buffer control method would allow the jobs to enter the input buffer of the next machine in the order for which they are completed. We discuss difficulties in using such a random order buffer control method and random access buffers. We thus propose an alternative buffer control policy that restricts the jobs to enter the input buffer of the next machine in a predetermined order. The buffer control method simplifies job flows and control systems. Further, it requires only a cost-effective simple sequential buffer. We show that the periodic scheduling model with finite buffers using the buffer control policy can be transformed into an equivalent periodic scheduling model with no buffer, which is modeled as a timed marked graph. We characterize the structural properties for deadlock detection. Finally, we develop a mixed integer programming model for the no buffer problem that finds a deadlock-free optimal sequence that minimizes the cycle time.

• Membrane and Water Treatment
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• 제4권1호
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• pp.1-9
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• 2013

The process of electromembrane transformation of L-lysine monohydrochlorides into their zwitterionic form in four- and two-chamber electrodialysis apparatus was investigated. The process of transformation at various concentrations of lysine monohydrochloride (0.1-0.6 mol.L-1) was studied and it was established that at the optimum density of current optimal concentrations of lysine hydrochloride during electrodyalisis was in the range of 0.2-0.4 mol.L-1. It was determined that the process of total transformation was accomplished when pH of the lysine solution achieved 10. Changes of concentrations of $Cl^-$ ions and lysine diffused into the neighboring chamber were determined depending on the time. The method developed by us allows adjusting the removal coefficient of $Cl^-$ ions during transformation to a maximal value, the losses of lysine diffused into the next chamber after its return to the technological cycle being less than 1.0 %. The specific energy consumption during the process of transformation in two- and four-chamber electrodialyzers was 0.19 and 0.205 A.h.kg-1 and the current efficiency was 75.9 and 73.1 %, correspondingly. Study of the process of electromembrane transformation allowed obtaining zwitterionic form of L-lysine from L-lysine monohydrochloride with minimal reagent and energy consumption.

• Advances in Automotive Engineering
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• 제1권1호
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• pp.105-121
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• 2018

The hybrid electric powertrain is a robust solution that allows for major improvements in both fuel economy and emission reduction. In the present study, a through-the-road hybrid vehicle model with an electric motor driving the rear axle and an Internal Combustion Engine (ICE) driving the front axle has been constructed. We then present a systematic method for the determination of a real time applicable optimal Energy Management Strategy (EMS) for a hybrid road vehicle. More precisely, we compare the performance of rule-based EMS strategies to an optimization-based strategy, namely ECMS (Equivalent Consumption Minimization Strategy). The comparison is conducted in parallel with a parameterization of the size of the internal combustion engine and the implementation of a Continuously Variable Transmission (CVT) that allows following the line of best fuel economy. For the FTP-75 driving cycle, the constrained engine On-off control algorithm is shown to offer a 28% improvement potential of fuel consumption compared to the conventional internal combustion engine while the ECMS strategy achieves an improved potential of nearly 33%.

• 상하수도학회지
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• 제27권6호
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• pp.815-826
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• 2013

Using a developed mathematical model and calibrated kinetic constants, numerical experiments for a aerobic digestion of wastewater sludge by SBR aerobic digestion process combined with ultrasonication (USSBR) were performed in this study. It simulated well the phenomena of the decomposition of particulate organics and the release of organic nitrogen and transformation. To achieve 40 % of particulate organics removal, USSBR process requires only 6 days of SRT and 14 W/L of ultrasonic power whereas SBR aerobic digestion process requires 12 days of SRT. Based on the model simulation results, an empirical equation was presented here. This equation will be used to predict digestion efficiency for the given variables of SRT and ultrasonic power dose. USSBR aerobic digestion process can reduce the nitrogen concentration. The optimal operation strategy for the simultaneous removal of solids and soluble nitrogen in this process is estimated to 7 days of SRT with 14 W/L of ultrasonic power dose while anoxic period was 6 hours out of 24 hours of cycle time. In this condition, 40 % of particulate organics as well as 36 % of total nitrogen will be removed and the soluble nitrogen concentration of the centrate will be lower less then 40 mg/L.

• 한국통신학회논문지
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• 제35권9B호
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• pp.1322-1329
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• 2010

As body sensor network (BSN) research becomes mature, the need for managing power consumption of sensor nodes has become evident since most of the applications are designed for continuous monitoring. Real time Electrocardiograph (ECG) analysis on sensor nodes is proposed as an optimal choice for saving power consumption by reducing data transmission overhead. Smart sensor nodes with the ability to categorize lately detected ECG cycles communicate with base station only when ECG cycles are classified as abnormal. In this paper, ECG classification algorithms are described, which categorize detected ECG cycles as normal or abnormal, or even more specific cardiac diseases. Our Euclidean distance (ED) based classification method is validated to be most power efficient and very accurate in determining normal or abnormal ECG cycles. A close comparison of power efficiency and classification accuracy between our ED classification algorithm and generalized linear model (GLM) based classification algorithm is provided. Through experiments we show that, CPU cycle power consumption of ED based classification algorithm can be reduced by 31.21% and overall power consumption can be reduced by 13.63% at most when compared with GLM based method. The accuracy of detecting NSR, APC, PVC, SVT, VT, and VF using GLM based method range from 55% to 99% meanwhile, we show that the accuracy of detecting normal and abnormal ECG cycles using our ED based method is higher than 86%.

• 미생물학회지
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• 제16권3호
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• pp.111-121
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• 1978

About 40 temperature-sensitive mutants have been isolated as a preliminary step to study the spore germination, the cell cycle, and the control of macromolecular synthesis in Aspergillus nidulans. To obtain temperature-sensitive mutants rapidly and effectively, the selective enrichment method using antifungal antibiotic nystatin was developed. Based on the data which had applied to the concentration of auxotrophic mutants by the earlier investigators, the optimal concentration and the time of treatment at the nonpermissive temeprature were determined as 50 to 100 units per ml and 4.5 hr., respectively. Out of 41 ts mutants assigned to the strain symbol PK, thirteen that seemed to be arrested at the earlystage of spore germination were subjected to the further cytological and genetic analysis. Elght of these mutants are able to form germ tube and five not. Staining with acid fuchsin for the 5PK strains shows that one irreversible mutant, PK6 strain able to form germ tube, accumulate mitotic spindle, being arrested in mitosis. Another PK15 and PK23 strain have more than one intact nucleolus without germ tube formation at the restrictive temperature. the temperature-senstive mutation in PK12 strain, the onlystrain which is able occurred in certain gene specific for the germination of spore. All of the ts markers are recessive and complement each other in heterokaryon between two different ts markers at the restrictive temperature.

• 방사성폐기물학회지
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• 제19권2호
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• pp.243-253
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• 2021

In the dismantling process of a reactor coolant system (RCS) piping, a radiation protection plan should be established to minimize the radiation exposure doses of dismantling workers. Hence, it is necessary to estimate the individual effective dose in the RCS piping dismantling process when decommissioning a nuclear power plant. In this study, the radiation exposure doses of the dismantling workers at different positions was estimated using the MicroShield dose assessment program based on the NUREG/CR-1595 report. The individual effective dose, which is the sum of the effective dose to each tissue considering the working time, was used to estimate the radiation exposure dose. The estimations of the simulation results for all RCS piping dismantling tasks satisfied the dose limits prescribed by the ICRP-60 report. In dismantling the RCS piping of the Kori-1 or Wolsong-1 units in South Korea, the estimation and reduction method for the radiation exposure dose, and the simulated results of this study can be used to implement the radiation safety for optimal dismantling by providing information on the radiation exposure doses of the dismantling workers.

• Journal of the Korean Wood Science and Technology
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• 제49권3호
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• pp.254-266
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• 2021

Using forest resources involves solving complex and diverse tasks. At the same time, one of the key goals in the field is improving the quality of forest infrastructure. This direction requires adequate mathematical and economic justification. Moreover, creating an effective infrastructure will not only increase the accessibility and usage volumes of wood and other forest resources, but also contribute to the development of continuous and sustainable forest management. The existing practice of making decisions in terms of the organizational and technological aspects of logging, based on the personal experiences of managers or leading specialists in enterprises, hinders the achievement of constant optimal efficiency. The paper presents results that are a continuation of the research cycle of the authors' team in the fields of optimization and algorithmization of various logging processes. The focus of the study lies in the processing and movement of wood resources, the most valuable products of the investigated groups of enterprises. To this end, the paper presents a developed algorithm for determining an effective technological chain of transportation in logging operations, and for improving loading and unloading processing operations under dynamic natural and production conditions. This algorithm serves as the methodological basis for designing logging infrastructure in a dynamically changing environment.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권12호
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• pp.4081-4098
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• 2022

With the aim of tackling the contradiction between computation intensive industrial applications and resource-weak Edge Devices (EDs) in Industrial Internet of Things (IIoT), a novel computation task offloading scheme in SDIN-enabled MEC based IIoT is proposed in this paper. With the aim of reducing the task accomplished latency and energy consumption of EDs, a joint optimization method is proposed for optimizing the local CPU-cycle frequency, offloading decision, and wireless and computation resources allocation jointly. Based on the optimization, the task offloading problem is formulated into a Mixed Integer Nonlinear Programming (MINLP) problem which is a large-scale NP-hard problem. In order to solve this problem in an accessible time complexity, a sub-optimal algorithm GPCOA, which is based on hybrid evolutionary computation, is proposed. Outcomes of emulation revel that the proposed method outperforms other baseline methods, and the optimization result shows that the latency-related weight is efficient for reducing the task execution delay and improving the energy efficiency.

• International Journal of Stem Cells
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• 제17권1호
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• pp.80-90
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• 2024

Cellular senescence causes cell cycle arrest and promotes permanent cessation of proliferation. Since the senescence of mesenchymal stem cells (MSCs) reduces proliferation and multipotency and increases immunogenicity, aged MSCs are not suitable for cell therapy. Therefore, it is important to inhibit cellular senescence in MSCs. It has recently been reported that metabolites can control aging diseases. Therefore, we aimed to identify novel metabolites that regulate the replicative senescence in MSCs. Using a fecal metabolites library, we identified nervonic acid (NA) as a candidate metabolite for replicative senescence regulation. In replicative senescent MSCs, NA reduced senescence-associated 𝛽-galactosidase positive cells, the expression of senescence-related genes, as well as increased stemness and adipogenesis. Moreover, in non-senescent MSCs, NA treatment delayed senescence caused by sequential subculture and promoted proliferation. We confirmed, for the first time, that NA delayed and inhibited cellular senescence. Considering optimal concentration, duration, and timing of drug treatment, NA is a novel potential metabolite that can be used in the development of technologies that regulate cellular senescence.