• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.3111-3111
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• 2001

The implementation of NIR and chemometrics in the Pharmaceutical industries is still in strong progress, both regarding qualitative and quantitative applications and beneficial results are seen. Looking at the development so far, NIR will change the pharmaceutical industry even more in the future. This presentation will address the experiences and progress achieved regarding the application and implementation of quantitative methods for determination of content uniformity and assay of tablets with less than 10% w/w of active, using Near Infrared transmittance spectroscopy in combination with PLS. Also qualitative methods for identification of the same tablets by Near Infrared reflectance spectroscopy will be discussed. Four commercial tablet strengths are formulated and produced from two different compositions by direct compression. Three different strengths are dose proportional, i.e. fixed concentration by varying in size. The aim was to replace the conventional primary methods for analysing content uniformity, assay and identification by NIR. Studies were performed on comparing transmittance versus reflectance spectroscopy for both applications on the dose proportional tablets. The model for determination of content uniformity and assay was developed to cover both coated and uncoated tablets, whereas the qualitative model was developed to identify coated tablets only. The impact of the tablet formulation, tablet size and coating, resulted in individual models far each composition The best calibration was achieved using diffuse reflectance for the identification purposes and diffuse transmittance for the quantitative determination of the active content within the tablets. As NIR in combination with other techniques opens up the possibility of total quality management within the production, the transfer of the above-mentioned models from a laboratory based approach to an at-line approach at H.Lundbeck will be addressed too.

• The Journal of the Korea Contents Association
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• v.10 no.9
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• pp.487-495
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• 2010

Online content evaluation standards were suggested in order to improve quality of education for informatics gifted students in this paper. This evaluation standards were developed by thinking and learning style and characteristics of gifted students which were presented in preceding research. The evaluation standards were reviewed through reliability analysis as well as analysis of the characteristics of items and validity analysis by experts of informatics gifted student education sector. In the result of analysis, reliability of items has been very reliable. Level of difficulty and discrimination about the characteristics of items has also shown satisfactory value. Developed the evaluation standards has 5 evaluation categories such as "talent development", "Interaction", and others. It also has 11 evaluation factors and 40 evaluation items. The online content evaluation standards can be helpful and useful in order to develop qualitative online contents and select online contents for informatics gifted student.

• The KIPS Transactions:PartA
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• v.11A no.5
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• pp.407-412
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• 2004

The e-learning system uses multimedia content for efficiency of a education and learner's convenience. With the web based e-learning, various multimedia services are difficult on account of physical factors such as network state and system performance. Also on the off line based e-learning, we have defects an insufficiency of interactions among learners and instructors, and an insufficiency of an adaptation about the latest information. In this study, we designed a multi-tier e-learning system using hybrid multimedia method, The proposed system can provide interaction and adaptability such as web based systems, and it can provide various multimedia content such as off line based systems. In experiments results, we know the proposed system improved users' convenience and an adaptability about the latest information, and interactions among learners and instructors when compare with existing e-learning system.

• Food Science and Biotechnology
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• v.15 no.6
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• pp.889-895
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• 2006

Cytotoxic effects of extracts from Tremella fuciformis strain FB001 were evaluated on the DLD-1 human colon adenocarcinoma cell line and the content of polyphenolic compounds in the extracts were analyzed. Hexane, chloroform, and ethyl acetate subfractions (experimental setting I) exhibited cytotoxic effects on the human colon adenocarcinoma DLD-1 cell line with $IC_{50}$ values of 350, 400, and 450 ppm, respectively. When T. fuciformis was extracted sequentially with ether, ethyl acetate, chloroform, and ethanol (experimental setting II), the ether extract demonstrated potent cytotoxicity with an $IC_{50}$ value of 150 ppm, followed by ethyl acetate and chloroform fractions. If the first extraction solvent was chloroform instead of ether (experimental setting III), exposure of the cell line to chloroform, ethyl acetate, and ether extracts at 1,000 ppm led to cell death. High levels of phenolic compounds were estimated for all hydrophobic extracts, which exhibited cytotoxic effects. We propose that this useful information gives additional support to our understanding of the biology and utility of this particular mushroom.

• Geomechanics and Engineering
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• v.19 no.5
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• pp.447-462
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• 2019

The vacuum preloading method has been used in many countries for ground improvement and land reclamation works. A sand cushion is required as a horizontal drainage channel for conventional vacuum preloading. In terms of the dredged-fill foundation soil, the treatment effect of the conventional vacuum preloading method is poor, particularly in Tianjin, China, where a shortage of sand exists. To solve this problem, straight-line vacuum preloading without sand is widely adopted in engineering practice to improve the foundation soil. Based on the engineering properties of dredged fill in Lingang City, Tianjin, this paper presents field instrumentation in five sections and analyzes the effect of a prefabricated vertical drain (PVD) layout and a vacuum pumping method on the soft soil ground treatment. Through the arrangement of pore water pressure gauges, settlement marks and vane shear tests, the settlement, pore water pressure and subsoil bearing capacity are analyzed to evaluate the effect of the ground treatment. This study demonstrates that straight-line vacuum preloading without sand can be suitable for areas with a high water content. Furthermore, the consolidation settlement and consolidation degree system is developed based on the grey model to predict the consolidation settlement and consolidation degree under vacuum preloading; the validity of the system is also verified.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.30 no.4
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• pp.431-435
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• 1985

Nine hybrid rices crossed between Korean cytoplasmic-genetic male sterile rices having the WA cytoplasm and the Korean restorer lines or varieties, HR1619A/Nampungbyeo, HR1619A/Gayabyeo, HR1619A/Line234, TongilA/Nampungbyeo, TongilA/Cheongcheongbyeo, Suwon 296A/Line 209, Suwon 296A/Line 237, Suwon 296A/Line 252 and Line 201A/Line 234, and their parents were grown at Yeungnam University in 1984. The rough rice yield of the hybrids Line 201A/Line 234, TongilA/Nampungbyeo and HR1619A/Nampungbyeo were 939, 927 and 900 Kg/10a respectively. The heterosis(F$_1$/Midparent) of the above three hybrids was 40%, 20% and 19%, the heterobeltiosis(F$_1$/Better parent) was 36%, 17% and 10%, and the standard heterosis (F$_1$/Standard variety, Cheongcheongbyeo) was 19%, 17% and 14% respectively. The hybrids HR1619A/ Gayabyeo and Suwon 296A/Line 237 showed negative heterosis in grain yield. Significant heterobeltiosis for grain number per panicle was found while less or no heterobeltiosis was observed in panicle number per hill, 1000-grain weight and grain fertility. The bacterial leaf blight disease reaction of the hybrids tested was almost the same as that of one parent at least. The amylose content of the hybrids was medium to low the same as their parents. The protein content and alkali digestion value of the hybrids were almost the same as their parents.

• Communications of Mathematical Education
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• v.38 no.2
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• pp.93-120
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• 2024

On-line education in mathematics education changed in various aspects before and after COVID-19. This study conducted a systematic literature review of 98 academic papers on on-line education published from 2017 to 2023 in the field of mathematics education before and after COVID19. In particular, this study conducted content analysis to organize on the definitions of various similar terms related to online education. In addition, this study explored research trends on year, research subject, research method, on-line education type, and research topic by the pre-COVID-19, COVID-19, and post-COVID-19 era. Also, a comparative analysis was conducted on literatures on the effects of online education. As a result, first, it was confirmed that there is a need to organize the definitions of terms similar to online education. Also, the implications of identifying the differences and hierarchies between each term can be found. Second, it was confirmed that teachers' expertise for on-line mathematics education was emphasized based on the result of the rapid increase in the number of on-line education studies on teachers since COVID-19. Third, it was confirmed that the number of studies on blended and flipped learning was high in pre-COVID-19, but decreased in the COVID-19 era. Instead, in the COVID-19 era, studies on real-time interactive classes were rapidly active, and even in the post-COVID-19 era, studies on real-time interactive classes still occupied a large proportion. Finally, it was confirmed that the effectiveness of on-line education varies depending on the research background and model. Accordingly, the need to be cautious in interpreting the results of each study on the effectiveness of on-line education was confirmed. Based on these findings, this study presented implications for future research on on-line education in mathematics education.

• Journal of The Korean Society of Grassland and Forage Science
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• v.14 no.1
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• pp.57-63
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• 1994

We use a variety of methods to determine the optimum time for havesting corn for silage. In addition, adequate dry matter for silage must be considered along with maturity stage. The objective of this study was to evaluate using the kernel milk line to determine when to harvest com for silage in 1992 on the Livestock Experimental F m , Keiymung Junior College at Keongsan, Keongsangbukdo. Four hybrids were field grown and com plants were harvested at various stages of kernel development so that kemel milk line movement could be analyzed whilc the corn was in the premature stages. As the plants approached maturity, the ears were collected from each of the hybrids and the position of the milk line wa5 noted. Then the whole plants were chopped and the content of DM was determined. The milk line was a readily identifiable feature of maturing com kemels. We focused on the five development \tage\. The fint was "soft dough". The second was "dent". The third wa, "75% milk". and the fourth wa5 "half milk". The half milk occurs when the milk line is positioned falf way down the kemel face. and the final stages win "no milk", milk disappearance as indicators of physiological maturity in maix. Milk free stage of the kemel occurred from I to 3 days prior to black layer having developed. The range for harvesting com for silage occurs a kemels mature from 75% milk to no milk. Position of milk line was easy to see. and can be used as a visible indicator to determine com matunty stage\ and whole plant dry matter. Whole plant dry matter increased with advancing maturity. averaged over hybrids it was 24.1, 25.6. 28.5. 34.6 and 39.0% at soft dough, dent, 75% milk. half milk and no milk. Milk line was more usehl indicator in monitoring corn maturity prior to physiological maturity.ing corn maturity prior to physiological maturity.

• Korean Journal of Agricultural Science
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• v.48 no.4
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• pp.693-702
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• 2021

The aim of this study was to analyze the genetic diversity and distance of the Korean native black goat line. Thus far, this Korean native black goat line has not been studied intensively, especially in genetic diversity and relationship studies in comparison with other breeds. In total, eleven microsatellite (MS) markers were used to evaluate alleles from 391 Korean native black goats and foreign hybrid animals. The genetic diversity index was evaluated based on the allele distributions. Four Korean native black goat lines showed expected ranges of observed heterozygosity, expected heterozygosity, and polymorphism information content (PIC) values for use in genetic diversity research (0.509 - 0.643, 0.434 - 0.623 and 0.356 - 0.567). Lines from the Korean native black goat and foreign hybrid were clearly separated according to principal coordinates analysis (PCoA), phylogenetic tree and tended to be clustered in each Korean native black goat line. Thus, this study can be used for analyzing the genetic relationships between Korean native black goats and foreign breeds for line preservation and for fundamental information to determine breed improvement strategies.

• Computers and Concrete
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• v.31 no.5
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• pp.395-403
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• 2023

The paper investigates the effect of two parameters - sand content (SC) and grain migration during shearing - on the mechanical properties of gravel-sand mixtures. Consolidated undrained (CU) triaxial tests were carried out on eight series of mixtures containing gravel (1<d<16 mm) and sand (0.1<d<1 mm). The prepared mixtures have sand contents of 0, 10, 15, 20, 40, 54, 94 and 100%, and a relative density of 60%. The transition sand content (TSC) is experimentally defined and marks the transition from gravel-driven to sand-driven behavior. For SC<TSC, the dry density of the mixture increases with SC. This induces an increase in undrained peak strength and dilative trend. The slope and position of the critical state line (CSL) are also deeply dependent on SC. At SC=TSC, the mixtures exhibit the largest dry density and yield the highest undrained peak strength and the largest dilative trend. During shearing, large internal migration of grains was observed at the TSC, causing heterogeneity in the sample. Analysis of the CSL deduced from the final points of the triaxial tests shows that, at the TSC, failure appears to correspond to the behavior of the coarsest fraction of the soil. This fraction is located in the upper part of the sample, where the sand particles had been eliminated by suffusion. On the other hand, in the more stable materials, the CSL is consistent with the bulk grain size distribution of the soil.