• The Journal of Internal Korean Medicine
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• v.45 no.2
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• pp.323-333
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• 2024

Objectives: This case report describes the effect of complex Korean medical treatment on the clinical symptoms of a patient with fibromyalgia syndrome (FMS). Methods: A 60-year-old female woman diagnosed with FMS in 2015 was prescribed Youngsunjaetong-em-hap-Sopunghwalhyeol-tang from 2 May 2023 to 20 June 2023 to reduce excessive sweating and widespread pain. With the same objective, acupuncture, moxibustion, and cupping treatment were administered from 23 May 2023 to 11 June 2023. Changes in excessive sweating and widespread pain were recorded 2 months post-treatment. Results: Treatment with Youngsunjaetong-em-hap-Sopunghwalhyeol-tang led to a considerable improvement in clinical symptoms after 2 months, especially excessive sweating and widespread pain compared to the baseline parameters of the first visit. In addition, no adverse effects, such as liver injury or decreased kidney function, were recorded during the herbal medicine treatment. Conclusion: This case report points to the use of complex Korean medical treatment as a therapeutic option for the management of FMS.

• Herbal Formula Science
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• v.18 no.1
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• pp.79-85
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• 2010

Objectives : This study was conducted to evaluate the acute toxicity and safety of Gumiganghwal-tang (Jiuweiqianghou-tang) in Sprague-Dawley rats though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Gumiganghwal-tang (Jiuweiqianghou-tang) was considered to be over 2000 mg/kg body for both sexes.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.3
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• pp.26-36
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• 2005

Objectives: Maier symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. When exposed to certain allergens, the IgE covered mast cells degranulate and release inflammatory mediators and cytokines which result in a local inflammatory reaction. In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of allergic rhinitis. This experimental study was done to reveal the effects of the Bojungikgi-tang on the allergic rhinitis. We have studied effect of mice on OVA-induced production of IL-4, IL-5, $INF-{\gamma}$ by murine splenocytes and effect of OVA-induced Total IgE and OVA-specific IgE Meterial and Metheds: 21 BALB/c rats were divided into three groups: normal group, control group, experimental group. To induce the allergic rhinitis in control group and experimental group, rats were sentitized intraperitioneally with 0.1% ovalbumin solution 3 times at intervals of 2 weeks. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin solution 3 times at intervals of 2 days for a week. After that time, rats in experimental group were oral administration treated by the Bojuogikgi-tang fer 28 days. We observed changes of IL-4, IL-5, $INF-{\gamma}$, Total IgE and OVA-specific IgE. We used independent-test statistically. Results: 1. In IL-4 study, Bojungikgi-tang treated group didn't show significant differences. 2. In IL-5 study, Bojungikgi-tang treated group shows significant differences. 3. In $INF-{\gamma}$ study, Bojungikgi-tang treated group shows significant differences. 4. In Total IgE, Bojungikgi-tang treated group shows significant differences. 5. In OVA-specific IgE, Bojungikgi-tang treated group didn't show significant differences. According to this result, Bojungikgi-tang was concluded to be effective on lowering the total IgE. Through this. Bojungikgi tang seems to reduce the symptoms of allergic rhinitis. More studies are required to know exact mechanism of Bojungikgi tang to show the anti allergenic effect.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.31-36
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• 2006

The aim of this study was to elucidate the mechanism of anemia associated with Dangguibohyel-tang (DBT) in rats. Using cyclophosphamide-induced (30mg/kg BW) anemic rats, changes in weight gain, the levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb), serum vitamin B12, ALT(GPT) levels and erythropoietin (EPO) gene expression were monitored, and compared with DBT (1,000mg/kg BW, 14d)-treated and EPO (1,000IU/kg BW, 14d, s.c.)-treated rats. Food efficiency ratio (FER) were 31.6%, in normal group, 28.1% in cyclophosphamide-induced control group, 31.7% in DBT-treated group and 25.1%, in EPO-treated group after 14 days. The levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb) of DBT-treated group were significantly higher than those of control. And DBT extract administered group showed dominant effects on the recovery of Hgb level. Serum vitamin B12 and ALT(GPT) levels were significantly increased at DBT-treated groups. EPO gene expression was decreased 91,9% in control group, 79.6% in DBT-treated group and 53.9% in EPO-treated group, respectively. These results suggest that administration of DBT could prevent human patient from chemotherapy derived anemia by improving hematological value and EPO status.

• Journal of Oriental Neuropsychiatry
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• v.33 no.4
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• pp.389-400
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• 2022

Objectives: Depression is a highly prevalent disease, and the market for antidepressant drugs continues to grow at a steady rate. Although current antidepressants are reported to be effective, because of their low remission rate and side effects, new antidepressants are needed. The use of Banhahubak-tang (BHT) to treat the symptoms of depression is supported by experimental evidence. The proposed study will evaluate the efficacy and safety of BHT in treating depression. Methods: A randomized, waitlist-controlled, parallel clinical trial will be conducted to assess the efficacy of BHT in depression. A total of 84 participants with depression will be randomized into the intervention group or waitlist-control group at a 1:1 ratio. Patients in the intervention group will be administered BHT three times a day for four weeks and followed up for four more weeks after therapy completion. Patients in the waitlist-control group will undergo the same intervention and follow-up after a four-week waiting period. The primary outcome is change in the Korean version of the Hamilton Depression Rating Scale (K-HDRS) scores for major depressive disorders after four weeks. The secondary outcomes include scores on the K-HDRS, Korean Symptom Check List 95 (KSCL-95), Insomnia Severity Index (ISI), State-Trait Anxiety Inventory-Korean version (STAI-K), State-Trait Anger Expression Inventory-Korean version (STAXI-K), and the Instrument on Pattern Identifications for Depression and EuroQol-5 Dimension (EQ-5D). Conclusions: This trial will provide high-quality clinical evidence of the efficacy and safety of BHT in the management of depression.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.2
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• pp.178-187
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• 2013

Objectives: These cases are that of three girls who are diagnosed as precocious puberty. It seems that the incidence of precocious puberty is rapidly increasing these days. In addition to the psychosocial disturbances associated with precocious puberty, the premature pubertal growth spurt and the accelerated bone maturation result in reduced adult height. The aim of this study was to report the effect of Jowisengchung-tang in 3 cases of precocious puberty. Methods: Retrospective and comparative analysis of 3 children who had been diagnosed with preco cious puberty. Anthropometric measurements including height, weight, body fat, body fat percent, AHP and body mass index were measured. Endocrine investigations including estradiol, luteinizing hormone(LH), FSH were conducted. Pubertal stages were determined with a questionnaire using Tanner stages. Jowisengchung-tang was given to 3 precocious puberty girls. Results: After treatment, the hormone(estradiol index) and accompanying symptoms (breast bud with elevation of breast and papilla; enlargement of areola) were reduced compared with first visit day. Conclusions: We may conclude that Korean traditional treatment of Jowisengchung-tang is effective in patients with precocious puberty and menopausal symptoms.

• Journal of Haehwa Medicine
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• v.21 no.2
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• pp.133-138
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• 2013

Objectives: The purpose of this study is to show a case of patient with epigastralgia which appeared after Stroke improved by Baekho-tang. Methods: We treated the patient with Herbal med, Acupuncture, Moxa. Results: Every Herbal med was no effect on Epigastralgia of patient. But The epigastralgia of patient was disappeared after using Baekho-tang. Conclusion: We can find out the effect of the Baekho-tang for epigastralgia which appeared after Stroke in this study.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.15 no.2
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• pp.93-99
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• 2009

Objective: The aim of this study is to show one case of cerebral infarction patient with chest discomfort, insomnia and constipation improved by Daehwanghwangryeonsasim-tang. Methods: The patient was treated with herbal medicine (Daehwanghwangryeonsasim-tang) and acupuncture. Changes in symptoms for treatment period were observed. Result: Intensity and frequency of chest discomfort was decreased. Sleep time was increased and constipation was improved. Conclusion: Daehwanghwangryeonsasim-tang is effective on symptoms of the pattern of heart heat and fire-heat.

• Journal of Sasang Constitutional Medicine
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• v.18 no.3
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• pp.216-222
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• 2006

1. Objectives Hiccup is one of common symptoms clinically and caused by various etiologies. also Hiccup is common comlication in Stroke patient. We have tried researching effect of herbal medicines(Jowesungcheong-tang). 2. Methods To heal the hiccup concurred in Taeumin with stroke patient, we used Jowesungcheong-tang. 3. Results A Taeumin patient diagnosed to have hiccup was, treated with Taeumin herbal medicines(Jowesungcheong-tang), and change of patient's symptoms and general condition were improved. 4. Conclusions The constitutional treatment with Jowesungcheong-tang may have an effect on management of hiccup. So we report the healing process and results of this patient in this study.

• Advances in Traditional Medicine
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• v.4 no.1
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• pp.1-8
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• 2004

Ginseng root has been used as a tonic remedy in Traditional Chinese Medicine for centuries. Modern studies have demonstrated that ginseng root has complex components and multiple pharmacological properties. The effects of ginseng leaf, however, are not well known. Recent studies show that compared to ginseng root, ginseng leaf and stem exhibit a higher content of active compositions such as ginsenosides, polysaccharides, triterpene flavonoids, volatile oil, polyacetylenic alcohols, peptides, amino acids and fatty acids. Ginseng leaf possesses multiple pharmacological effects in the central nervous, cardiovascular, growth and metabolism systems. Additionally, the leaf has anti-fatigue, anti-hyperglycemic, anti-oxidant, and anti-aged effects. In general, ginseng leaf is quite safe, but adverse effects may occur if it is abused or is of poor quality. Thus, attention must be paid to dosages, quality, and standardization of ginseng leaf products.