Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Comparison of Dangguibohyel-tang and Erythropoietin on Cyclophosphamide-induced Anemia in Rats

당귀보혈탕(當歸補血湯)과 eryhropoietin이 cyclophosphamide로 유도된 흰쥐의 빈혈에 미치는 영향 비교 연구

  • Kang Soon-Ah (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Chang Mun-Seog (Department of Medicine, division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
  • Oh Myung-Sook (College of Oriental Medicine, Kyung Hee University) ;
  • Kim Do-Rim (College of Oriental Medicine, Kyung Hee University) ;
  • Kim Ji-Sook (College of Oriental Medicine, Kyung Hee University) ;
  • Park Seong-Kyu (College of Oriental Medicine, Kyung Hee University)
  • 강순아 (건국대학교 응용생물화학과 생명분자정보학센터) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 오명숙 (경희대학교 한의과대학) ;
  • 김도림 (경희대학교 한의과대학) ;
  • 김지숙 (경희대학교 한의과대학) ;
  • 박성규 (경희대학교 한의과대학)
  • Published : 2006.02.01
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Abstract

The aim of this study was to elucidate the mechanism of anemia associated with Dangguibohyel-tang (DBT) in rats. Using cyclophosphamide-induced (30mg/kg BW) anemic rats, changes in weight gain, the levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb), serum vitamin B12, ALT(GPT) levels and erythropoietin (EPO) gene expression were monitored, and compared with DBT (1,000mg/kg BW, 14d)-treated and EPO (1,000IU/kg BW, 14d, s.c.)-treated rats. Food efficiency ratio (FER) were 31.6%, in normal group, 28.1% in cyclophosphamide-induced control group, 31.7% in DBT-treated group and 25.1%, in EPO-treated group after 14 days. The levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb) of DBT-treated group were significantly higher than those of control. And DBT extract administered group showed dominant effects on the recovery of Hgb level. Serum vitamin B12 and ALT(GPT) levels were significantly increased at DBT-treated groups. EPO gene expression was decreased 91,9% in control group, 79.6% in DBT-treated group and 53.9% in EPO-treated group, respectively. These results suggest that administration of DBT could prevent human patient from chemotherapy derived anemia by improving hematological value and EPO status.

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References

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