• Biomolecules & Therapeutics
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• 제9권1호
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• pp.1-6
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• 2001

Sa-Mul-Tang (Si-Wu-Tang, SMT), a kind of Chinese medicine, has been used for the hemato-deficient disease for hundreds of years. In this work, investigations on the anti-anemic activity of an aqueous extract of SMT were undertaken in order to find the pharmacological basis for the ethnomedical use of the formulation. Three kinds of Angelicase species, such as Angelica sinensis, Angelica acutiloba, and Angelica gigas, were used for preparing the water extracts of SMT. Anemic model rats were induced by the treatment of phenylhydrazine (40 mg/kg/day, i.p.) for 4 days. After the treatment of phenylhydrazine, rats were divided into several groups for their different treatment of three kinds of SMT. Red blood cell (RBC), hemoglobin (Hg), and hematocrit (Hct) were determined on the day 0, 3, 6, 10, 14 after the treatment of SMTs and erythrocytes deformabilities were also determined at the end of experiments. Oral administration of SMT (1g/kg/day) for 14 days did not ameliorate drug-induced anemic states evaluated by RBC counts, Hg contents, and Hct values. However, the erythrocyte deformabilities were improved in phenylhydrazine-treated group by the administragest that SMTs (p<0.05). Especially, these effects were high in the Angelica acutiloba group. These results suggest that SMTs have an ameliorative effect on blood rheology related to the blood stasis syndrome in oriental diagnostics not on the blood deficient states related to the anemic syndrome.

• 대한한방내과학회지
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• 제41권6호
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• pp.1231-1244
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• 2020

Objective: This study was conducted to report the glucose-lowering effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 21 patients with type 2 diabetes mellitus who were administered Daeshiho-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san at Kyung-Hee University Korean Medical Hospital from 2014 to 2019. The hypoglycemic effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS) and 2-hour postprandial glucose (PP2) levels. For safety assessment, the effects of herbal extracts on liver and kidney function were analyzed by liver function tests, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and kidney function tests, including blood urea nitrogen (BUN) and creatinine (Cr). Patients were stratified according to their glycated hemoglobin (<6.5 or >6.5) levels and the kind of herbal extract used for treatment. Results: After administration of herbal extracts, FBS and PP2 significantly decreased to 20.24 mg/dL and 35.0 mg/dL respectively. Subgroup analysis revealed that, regardless of the glycated hemoglobin level, FBS and PP2 were significantly reduced in both groups. The safety profile showed no significant difference before and after taking herbal extracts. Conclusions: Daeshigo-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san may show the further glucose-lowering effects on patients with type 2 diabetes mellitus who have already treated with anti-hyperglycemic agents.

• 동의생리병리학회지
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• 제18권6호
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• pp.1569-1574
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• 2004

A general review is made on Insamyangwi-tang(인삼양위탕). Following conclusions are drawn from the clinical cases of Insamyangwi-tang in Hyungsang medicine. Insamyangwi-tang is composed of four different prescriptions of Huisaeng-san, Sakoonja-tang, Eajin-tang and Pyungwi-san. Huisaeng-tang is usually prescribed for the intestinal convulsion. Sakoonja-tang for the deficiency of Ki. Eajintang for retention of phlegm, Insamyangwi-tang is effective in strengthening the spleen, drying the dampness, warming the middle-warmer to stop vomiting, regulating the flow of Ki, and eliminating phlegm. Insamyangwi-tang is applicable to malaria caused by cold, intestinal convulsion, abdominal mass, edema, tympanites, Yin syndrome of exogenous febrile disease, distension, lack of appetite, stomachache, and diarrhea. Persons with the following characteristic in Hyungsang are more susceptible to Insamyangwi-tang ; Jung type, Hyul type, fish type, Taium meridian type, white fat damp constitution, person with big mouth, and woman rather than man.

• 생약학회지
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• 제17권4호
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• pp.272-279
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• 1986

This study was conducted about the effect of Shihogesikungang-tang on the central nervous system and cardiovascular system for the investigation of its clinical effect based on the Oriental medicinal references. The results of this study were summerized as follows; Analgesic activity as evaluated by the writhing syndrome in mice was significantly noted. A decrease effect of the spontaneous movement as estimated by wheel cage method, muscle relaxant effect as evaluated by the rotor rod method and the prolonged effect of sleeping time induced by thiopental-Na were significantly shown in mice. A antipyretic activity in febrile rats induced by the endotoxin was recognized. Anti-inflammatory effect in carrageen-induced paw edema in rats was significantly noted. Negative inotropic action on the isolated heart of frogs was noted. A vasodilative action in rabbits peripheral blood vessels and hypotension in anesthetized rabbits were remarkably recognized.

• 대한중풍순환신경학회지
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• 제22권1호
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• pp.45-56
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• 2021

■ Background Heart Failure with Preserved Ejection Fraction(HFpEF) is a heart failure that appears to have normal contraction function. In the case of HFpEF, no pharmacological therapy has been found to improve clinical prognosis, so it should be approached as an symptomatic treatment, therefore alternatives are needed due to concerns over adverse effects such as electrolyte imbalance caused by medication. ■ Case report A 81 year old female patient with Heart Failure with Preserved Ejection Fraction(HFpEF) patient complained dyspnea. Herbal prescription Mokbanggi-tang and Oryeongsan was administered on 6th day and 8th day respectively since the symptoms started. The NYHA Classification and Chest X-ray had been evaluated during the treatment period. Until the 7th day, the patient was classified as Class II, and when discharged from the hospital on the 28th day, it gradually improved and was classified as Class II. Chest X-Ray took on 2nd day showed pleural effusion and it was aggravated until 13th day. Follow up Chest X-Ray showed improving state of pleural effusion from 20th day and gradually got better. Mokbanggi-tang treatment continued for 52 days and stopped on 58th day. After Mokbanggi-tang treatment ended, only Oryeongsan treatment was maintained. ■ Conclusion The present case report suggests that Korean-Western medicine approach with Mokbangki-tang and Oryeongsan might be effective to pleural effusion and heart failure symptoms such as poor physical activity shown in a NYHA Classification. This shows that Mokbanggi-tang and Oryeongsan can be a therapeutic option as a treatment for patient with Heart Failure with Preserved Ejection Fraction(HFpEF).

• Journal of Acupuncture Research
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• 제28권5호
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• pp.103-110
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• 2011

Objectives : The purpose of this study is to investigate the effect and adverse events of Gamiwolbigachul-tang on the changes of body composition and musculoskeletal pain in overweight patients. Methods : A total of 28 patients with overweight patients who were complaining musculoskeletal pain were treated with Gamiwolbigachul-tang more than 4 weeks between January 2011 and August 2011 in Kyung Hee University Oriental Medical Hospital were observed. We have evaluated the efficacy of treatments by measuring the changes of body composition (Body weight, Body mass index, Skeletal muscle mass, Body fat mass and Waist hip ratio) and musculoskeletal pain. The 28 patients were analyzed according to the distribution of sex, age, body compostition and musculoskeletal pain. Results : 1. There were statistically significant changes on Body weight and BMI in 28 patients after 4 weeks of treatment. 2. Gamiwolbigachul-tang had effect on reducing Body fat mass rather than Fat free mass. 3. There were statistically significant changes on musculoskeletal pains such as lower back pain, knee pain after treatment. 4. There were few side effects except those common complications such as insomnia(3 patients), palpitation(2 patients) and indigestion(1 patients), which did not have effects on everyday living. Conclusions : These results suggest that Gamiwolbigachul-tang will be beneficial for overweight patients with musculoskeletal pain, having both effectiveness and safety.

• 대한한의학회지
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• 제16권1호통권29호
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• pp.209-226
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• 1995

In order to investigate the protective effects of Jiyusaenggan-Tang by F-I(Jiyusaenggan-Tang aspirated by distilled water), F-II(Non-polysaccharides in Jiyusaenggan-Tang) and F-III(Polysaccharides in Jiyusaenggan-Tang), experimental studies were performed in mice with liver injury induced by $CCI_4$, and d-galactosamine. The results were summarized as follows : 1. The increases of the serum GOT activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FIII. The increases of the serum GPT, LDH, and ALP activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FI and FIII. 2. The increases of the serum total-cholesterol and triglyceride activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FI, FII and FIII. 3. On liver injury induced by the $CCI_4$, the activities of GOT, GPT, ALP, LDH were inhibited by highly concentrated FIII, F-I, F-II, and F-I, F-II, F-III on total cholesterol level and F-III, F-I, F-II on triglyceride level in order of their efficacies. And F-III is considered to be the most effective component. 4. The increases of the serum GOT, GPT activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI and FIII. The increases of the serum LDH, ALP activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI and FIII. 5. The increases of the serum Total-cholesterol, Triglyceride activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI, FII and FIII. 6. The increases of the serum GOT, GPT activities in mice induced by d-galactosamine were inhibited significantly in F-III administrated group and then F-I in order of efficacies. FII does not showed significant effect, on inhibiting the activities of serum GOT and GPT levels. The activity of ALP was inhibited by F-III, F-I, F-II, LDH by F-III, F-I in order of efficacies, and F-II did not showed significant effect on LDH activity. The triglyceride level was decreased significantly by F-III, F-II, F-I and the total cholesterol level by F-II, F-I, F-III in order of their efficacies. Judging from the above results, it is considered that Jiyusaenggan-Tang has protective effect against liver injury, and that Polysaccharides in Jiyusaenggan-Tang is more effective.

• 대한한방부인과학회지
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• 제18권1호
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• pp.111-127
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• 2005

Objective : This study was conducted to investigate the effect of Mokhyangsaenghwa-tang (MS) and Mokhyangsaenghwa-tang plus Cervi Pantotrichum Cornu (MS-C) on postpartum recovery and lactation. Materials and Methods : We used 18-week pregnant Spraque Dawley rats and administered the decoctions of MS and MS-C to rats once a day for 4 days or 8 days. Then we observed changes in the body weight of pup rats and complete blood cell count, liver function test, renal function test, mammary gland tissue, level of serum prolactin, ${\beta}-casein$ and WAP of postpartum rats. Result : A significant increase in body weight was observed in MS-C treated pup rats compared with in MS treated group. The levels of WBC and platelet from MS group and MS-C group were decreased compared with the control group. The levels of RBC, hemoglobin and hematocrit from MS group and MS-C group showed statistically significant increases compared with the control group. The levels of protein, albumin from MS group and MS-C group were increased compared with the control group. The levels of BUN, creatinine from MS group and MS-C group did not show statistically significant changes compared with the control group. The mammary gland tissues from MS group and MS-C group showed increased angiogenesis. The levels of serum prolactin from MS group and MS-C group were increased compared with the control group. The expression of ${\beta}-casein$ and WAP genes from postpartum rats treated with MS and MS-C was increased. Conclusion : This study shows that MS and MS-C improved postpartum recovery and lactation in rats.

• 대한한방부인과학회지
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• 제36권3호
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• pp.211-225
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• 2023

Objectives: The purpose of this study is to report the effects of Korean medical treatment including Sanhuhyulpung-tang on three postpartum patients who suffered from hyperhidrosis. Methods: We treated three patients complained of postpartum symptoms including hyperhidrosis. The patients were treated by Traditional Korean Medicine including herbal medicine, acupuncture, moxibustion, and cupping therapy. Sanhuhyulpung-tang is a herbal medicine prescription which is used in clinical practice for the treatment of postpartum sweating, anxiety, flushing, and joint pain. Three patients were hospitalized for treatment for 6, 8, and 19 days respectively. During hospitalization, patients took Sanhuhyulpung-tang three times a day, and acupuncture, moxibustion, and cupping were performed once a day. To evaluate the degree of improvement, we used VAS score of the patient's chief complaint during hospitalization. Results: After the treatment, symptoms including hyperhidrosis were improved. The degree of excessive sweating decreased to 30% in two patients, and 55% in one patient. Combined symptoms including lower coldness, burning sensation, chilling, and multiple site pain also improved on discharge day. Conclusions: This case report shows that Korean medicine treatment including Sanhuhyulpung-tang can improve postpartum symptoms including hyperhidrosis.

• 대한한방내과학회지
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• 제43권5호
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• pp.980-988
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• 2022

The most common definition of postherpetic neuralgia is the presence of pain more than a month after the onset of the eruption of zoster. This case report suggests the effect of Korean medicine on postherpetic neuralgia. An 85-year-old male patient with postherpetic neuralgia was treated with a combination of Korean medical remedies. Kyung Hee Gongjin-dan and Hyangbujapalmul-tang-gagam were applied for 23 days. The Numerical Rating Scale was used to measure pain intensity. The Barthel Index and Beck Depression Inventory were used for the functional assessment and depression evaluation, respectively. After treatment, the patient's pain intensity decreased. Additionally, the patient's independence increased during activity, and the severity of their depression decreased. Thus, this case suggests that a combination of Korean medicine treatments might be effective for postherpetic neuralgia. In particular, it shows that Kyung Hee Gongjin-dan and Hyangbujapalmul-tang-gagam can be therapeutic options in the treatment of postherpetic neuralgia.