• Journal of Pharmaceutical Investigation
• /
• 제30권4호
• /
• pp.247-252
• /
• 2000

The advantages of transdermal administration are avoiding hepatic first pass effect, minimizing inter- and intra-patient variation, maintaining steady-state plasma level to provide long-term therapy from a single dose, and allowing a rapid termination of drug input. Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease. For the development of transdermal systems containing clenbuterol, two limiting factors - long lag time and low flux - must be overcome. In this study, we attempted to select optimal formulation for preparation of clenbuterol patch using hairless mouse skin and flow-through diffusion cell. The flux of clenbuterol increased as the percent of clenbuterol dose dependently in the concentration range of 5-15%. Based on this result, we fixed the concentration of clenbuterol as 15%. The effect of various penetration enhancers on percutaneous absorption of clenbuterol through hairless mouse skin was investigated. Labrafil was the most effective enhancer, which increased the permeability of clenbuterol approximately 4-fold compared with the control without penetration enhancer. Optimal enhancer concentration was 3%. The effect of various adhesives on penetration of clenbuterol was also investigated. Among the adhesives studied, MA-31 was the most effective adhesive. Furthermore, the clenbuterol patch composed of 15% clenbuterol, 3% Labrafil and 82% MA-31, which gave most excellent penetration of drug in in vitro penetration study, maintained therapeutic plasma levels in in vivo study using S.D. rats. These studies demonstrated a good feasibility of clenbuterol administration through the intact skin using a transdermal patch, and show a possibility of the development of clenbuterol patches.

• 한국환경복원기술학회지
• /
• 제13권5호
• /
• pp.59-80
• /
• 2010

This research This research aims at developing systemic evaluation model in terms of biotope preservation through reports, literatures, and expert survey analysis by implementing biotope structure analysis in area level with selecting Hyunpoong and Yuga-myeon, Dalseong county, Daegu metropolitan city as a site. First of all, as a result of biotope type classification of research site, biotope type groups are classified into total 13, and its biotope types are divided into total 61. Also, as a result of literature analysis, total 18 items are drawn such as diversity of biotope typical species as a index item to assess the preservation value of biotope, and the first evaluation index are divided into 10 and the second ones are divided into 8 according to characteristic of index items. As a result of expert survey analysis, All 10 index items, first evaluation index, show high importance average (above 4.7). As a result of implementation of main cause for categorizing evaluation index by characteristic, there are 3 factors such as 'obstructive factor.' Based on above survey analysis result, as a result of estimating the weight of each item, 'restoration factor' showed the highest, 3.4541, but 'factor of habitat stability' showed 3.1468, which is the lowest The systemic value evaluation was set by comprehensively analyzing these results. As a result of biotope preservation value evaluation through applying research site, total 19 types which are abundant in vegetation are classified into I class, 12 types in II class, 5 types in III class, 10 types in IV class, and 15 types in V class respectively. Lastly, as a result of second evaluation, it is analyzed that there are 17 special meaningful space to preserve species and biotope(1a, 1b) and 61 meaningful space to preserve species (2a, 2b, 2c).

• Safety and Health at Work
• /
• 제13권2호
• /
• pp.148-154
• /
• 2022

Background: Bus driving is a mentally demanding activity that requires prolonged attention to ensure safety. The aim of the study was to assess mental fatigue caused by driving a public bus and to find a profile of workers at higher risk. Methods: We evaluated changes of critical flicker fusion (CFF) (index of central arousal) and heart rate variability (HRV) (index of autonomic balance) in a 6-hour driving shift on a real route, in 31 professional bus drivers, and we tested the influence of personal factors such as sleep quality, BMI, and age. Paired t-test was used to test differences of CFF and HRV between both initial and final phase of driving, while multiple linear regression tested the influence of personal variables on the indexes of mental fatigue. Results: Results showed that CFF significantly decreased after 6 hours of bus driving (41.91 Hz, sd 3.31 vs. 41.15 Hz, sd 3.15; p = 0.041), and heart rate significantly decreased in the final phase of driving, with respect to the initial phase (85 vs. 78 bpm, p = 0.027). Increasing age (beta = -0.729, p = 0.022), risk of obstructive sleep apnea syndrome (beta = -0.530, p = 0.04), and diurnal sleepiness (beta = -0.406, p = 0.017) showed a significant effect on influencing mental fatigue. Conclusion: Elderly drivers at higher risk of sleep disorders are more prone to mental fatigue, when exposed to driving activity. Monitoring indexes of central arousal and autonomic balance, coupled with the use of structured questionnaires can represent a useful strategy to detect profile of workers at higher risk of mental fatigue in such duty.

• Journal of Medicine and Life Science
• /
• 제18권3호
• /
• pp.61-65
• /
• 2021

Although re-expansion pulmonary edema (RPE) is rare (incidence rate <1%), it is associated with a mortality rate of >20%; therefore, early diagnosis and treatment are important. We report a case of RPE following chest tube insertion in a patient with spontaneous pneumothorax. We have specifically focused on the mechanism underlying RPE and the possible etiology. An 82-year-old man with a history of chronic anemia, chronic obstructive pulmonary disease, diabetes mellitus, and hypertension was referred to the emergency department for management of recurrent right-sided pneumothorax. We performed emergency closed thoracostomy for suspected tension pneumothorax, which led to stabilization of the patient's vital signs; however, he coughed up frothy pink sputum accompanied by severe right-sided chest pain 30 min postoperatively. The patient showed new-onset right pulmonary consolidation on chest radiography, as well as desaturation, tachycardia, and tachypnea and was diagnosed with RPE. He was transferred to the intensive care unit for mechanical ventilation and supportive treatment using diuretics, ionotropic agents, and prophylactic antibiotics. RPE gradually resolved, and the patient was extubated 3 days after admission. He has not experienced recurrent pneumothorax or pulmonary disease for 4 months. We emphasize the importance of RPE prevention and that aggressive ventilator care and supportive treatment can effectively treat RPE following an accurate understanding of the underlying pathogenetic mechanisms and risk factors.

• Korean Circulation Journal
• /
• 제52권12호
• /
• pp.890-900
• /
• 2022

Background and Objectives: Some individuals exhibit discrepancies between risk classifications assessed using clinical factors and those obtained by vascular imaging. We aimed to evaluate whether statins provide clinical outcome benefits in patients classified as having low to moderate cardiovascular risk but with carotid plaque. Methods: This was a retrospective propensity score matching study. A total of 12,158 consecutive patients undergoing carotid ultrasound between January 2012 to February 2020 were screened. Individuals with low to moderate cardiovascular risk who were not currently recommended for statin therapy but had carotid plaques were included. Among 1,611 enrolled individuals, 806 (statin group: 403, control group: 403) were analyzed. The primary outcomes were major adverse cardiovascular and cerebrovascular events (MACCEs: cardiovascular death, myocardial infarction, coronary revascularization, and ischemic stroke or transient ischemic attack) and all-cause mortality. Results: During the median follow-up of 6.0 years, the incidence of MACCEs did not differ between the groups (6.1 and 5.7/1,000 person-years in the control and statin groups, respectively; adjusted hazard ratio [HR], 0.95; p=0.90). The incidence of all-cause mortality did not differ (3.9 and 3.9/1,000 person-years, respectively; adjusted HR, 1.02; p=0.97). Kaplan-Meier curves revealed similar rates of MACCEs (log-rank p=0.72) and all-cause mortality (log-rank p=0.99) in the 2 groups. Age and smoking were independent predictors of MACCEs. Subgroups exhibited no differences in clinical outcomes with statin use. Conclusions: Benefit of statin therapy was likely to be limited in low to moderate risk patients with carotid plaques. These results could guide physicians in clinical decision-making regarding cardiovascular prevention.

• 치위생과학회지
• /
• 제14권4호
• /
• pp.433-441
• /
• 2014

치위생과정을 임상에서 활용하고 정착시키기 위한 방안을 모색하고자 SEM을 이용하여 치과위생사 업무 자율성과 치위생과정의 임상적용 기대효과 및 장애요인이 임상적용 의향에 미치는 효과를 분석하고, 치위생과정에 대한 태도가 임상적용 의향에 미치는 매개효과를 검증한 결과는 다음과 같다. 가설적 모형은 ${\chi}^2=421.67$, GFI=0.858, CFI=0.915, TLI=0.896, RMR=0.039, RMSEA=0.099로 적합한 것으로 나타났다. SEM을 검증한 결과, 치과위생사 업무 자율성(${\beta}=0.398$, p<0.05)과 치위생과정 기대효과(${\beta}=0.363$, p<0.01)는 치위생과정 태도에 정(+)의 방향으로, 치위생과정 태도(${\beta}=0.678$, p<0.05)는 임상적용 의향에 정(+)의 방향으로 영향을 미치는 것으로 나타났다. 치과위생사 업무 자율성(${\beta}=0.269$, p<0.05)과 기대효과(${\beta}=0.246$, p<0.01)는 치위생과정 태도를 매개로 임상적용 의향에 간접적인 영향을 미치는 것으로 확인되었다. 위의 결과로 치과위생사의 업무 자율성, 치위생과정에 대한 기대효과와 태도는 임상적용 의향에 영향을 미치는 중요한 요인임을 확인하였다. 따라서 치위생과정을 임상에 정착시키기 위해서는 치과위생사 역량을 제고하여 업무 자율성을 확보해야 하며, 치위생과정에 대한 경영적 효과와 가치에 대한 객관적인 검증이 이루어져야 한다.

• Journal of Chest Surgery
• /
• 제50권2호
• /
• pp.86-93
• /
• 2017

Background: The influence of lifestyle diseases on postoperative complications and long-term survival in patients with non-small cell lung cancer (NSCLC) is unclear. The aim of this study was to determine whether lifestyle diseases were significant risk factors of perioperative and long-term surgical outcomes in elderly patients with stage I NSCLC. Methods: Between December 1995 and November 2013, 110 patients aged 65 years or older who underwent surgical resection of stage I NSCLC at Dong-A University Hospital were retrospectively studied. We assessed the presence of the following lifestyle diseases as risk factors for postoperative complications and long-term mortality: diabetes, hypertension, chronic obstructive pulmonary disease, stroke, and ischemic heart disease. Results: The mean age of the patients was 71 years (range, 65 to 82 years). Forty-six patients (41.8%) had hypertension, making it the most common lifestyle disease, followed by diabetes (n=23, 20.9%). The in-hospital mortality rate was 0.9% (n=1). The 3-year and 5-year survival rates were 78% and 64%, respectively. Postoperative complications developed in 32 patients (29.1%), including 7 (6.4%) with prolonged air leakage, 6 (5.5%) with atrial fibrillation, 5 (4.5%) with delirium and atelectasis, and 3 (2.7%) with acute kidney injury and pneumonia. Univariate and multivariate analyses showed that the presence of a lifestyle disease was the only independent risk factor for postoperative complications. In survival analysis, univariate analysis showed that age, smoking, body mass index, extent of resection, and pathologic stage were associated with impaired survival. Multivariate analysis revealed that resection type (hazard ratio [HR], 2.20; 95% confidence interval [CI], 1.08 to 4.49; p=0.030) and pathologic stage (HR, 1.89; 95% CI, 1.02 to 3.49; p=0.043) had independent adverse impacts on survival. Conclusion: This study demonstrated that the presence of a lifestyle disease was a significant prognostic factor for postoperative complications, but not of survival, in elderly patients with stage I NSCLC. Therefore, postoperative complications may be influenced by the presence of a lifestyle disease.

• 영재교육연구
• /
• 제22권3호
• /
• pp.663-677
• /
• 2012

본 연구는 Mayfield와 Mayfield(2010)의 창의적 환경에 대한 인식척도를 학교환경에 맞게 수정하여 요인분석을 통해 타당성을 검증한 연구이다. 또한 이 연구는 집단별 차이분석을 통해 창의적 학교환경에 대한 학생들의 인식에 영향을 주는 요인들을 살펴본 연구이다. 연구대상은 경기지역 초등학생 5~6학년 203명이었다. 요인분석 결과 척도는 창의성을 지지하는 환경요인, 일 특성 요인, 창의성을 저해하는 방해 요인으로 구성되어 있었다. 또한 기존 척도와의 상관분석을 통해 수렴타당성을 검증하였는데 척도가 타당한 것으로 나타났다. 독립표본 t 검증 결과 인식에 집단차이가 있는 것으로 나타났는데 6학년이 5학년보다 학교환경이 창의성을 더 방해하고 있다고 응답했다. 또한 창의적 아이디어를 잘 만들어 내는 행동특성을 보이는 학생의 경우는 학교환경이 창의성을 지지하는 것으로 인식하고 있었고, 부정적인 아이디어 생성행동을 보이는 학생의 경우는 학교환경이 창의성을 저해하고 있는 것으로 인식하고 있었다. 이처럼 창의적 학교 환경에 대한 학생들의 인식은 학년과 창의적 아이디어 생성행동과 관련이 있는 것으로 나타났다. 그러므로 교사는 학년별 그리고 창의적 아이디어 생성행동별 집단차이를 고려하여 창의적 학교환경에 대한 학생들의 인식을 변화시킬 필요가 있다.

• 한국환경과학회지
• /
• 제28권1호
• /
• pp.85-97
• /
• 2019

Meteorological factors and air pollutants are associated with respiratory diseases, and appropriate use of weather and air quality information is helpful in the management of patients with such diseases. This study was performed to investigate both the utilization of weather and air quality information by, and the needs of, patients with respiratory diseases. Questionnaires were administered to 112 patients with respiratory diseases, 60.7% of whom were female. The rates of bronchial asthma and chronic obstructive pulmonary disease among patients were 67.0% and 10.7%, respectively. The majority of subjects (90%) responded that prevention was important for respiratory disease management and indicated that they used weather and air quality information either every day or occasionally. However, respondents underestimated the importance of weather and air quality information for disease management and were unaware of some types of weather information. The subjects agreed that respiratory diseases were sensitive to weather and air quality. The most important weather-related factors were diurnal temperature range, minimum temperature, relative humidity, and wind, while those for air quality were particulate matter and Asian dust. Information was gleaned mainly from television programs in patients aged 60 years and older and from smartphone applications for those below 60 years of age. The subjects desired additional information on the management and prevention of respiratory diseases. This study identified problems regarding the utility of weather and air quality information currently available for patients with respiratory diseases, who indicated that they desired disease-related information, including information in the form of action plans, rather than simple health- and air quality-related information. This study highlights the necessity for notification services that can be used to easily obtain information, specifically regarding disease management.

• 한국엔터테인먼트산업학회논문지
• /
• 제14권7호
• /
• pp.175-191
• /
• 2020

이 연구의 목적은 지역문화진흥을 위한 정책부문들에 지역문화산업이 연계되어 활성화될 수 있는 정책대안을 모색하고자 한다. 연구방법은 지방문화진흥의 정책들과 지방문화산업에 관한 정책을 연계하여 그 활성화를 위한 대안을 모색한다. 연구의 결과를 요약하면 다음과 같다. 첫째, 지역문화진흥과 연계하여 지역문화산업을 활성화해야 한다. 1) 지역문화산업은 생활문화센터 등 시설이나 주민들의 생활문화 동호회 활동과 연계해야 한다. 2) 문화도시 및 문화지구의 지정 과정에서 지역의 산업적 여건을 고려해야 한다. 3) 지역문화진흥기금을 조성하고자 할 때, 지역문화산업 정책을 연계시켜야 한다. 4) 지역문화진흥을 위한 전문인력의 양성에 있어서 지역문화산업과 관련시켜야 한다. 둘째, 지역문화산업 활성화에 대한 장애요인들을 제거하고 촉진요인들을 활용해야 한다. 1) 문화산업의 범위를 명확하게 규정함으로써 문화산업정책의 목표를 구체화하고 명확히 해야 한다. 2) 문화산업정책에 있어서 여러 기관들에 분산되어 있는 역할을 명확히 규정하고, 상호 협력체계를 구축해야 한다. 3) 문화도시와 문화지구의 지정에서 문화산업의 개념요소들을 반영하고 지역문화산업을 브랜드화 해야 한다. 4) 관광산업과 같은 지역문화산업의 배경산업을 활용하도록 한다. 5) 지역문화산업 발전을 위한 거버넌스 체제를 구축하고 활용해야 한다. 지역문화산업의 활성화의 궁극적인 목적은 지역문화진흥에 기여하고자 하는 것이다. 이 연구의 결과가 지역문화산업을 활성화는 정책대안으로 활용되어서 지역문화 진흥에 기여하기를 기대한다.