• Journal of Pharmacopuncture
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• v.11 no.3
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• pp.113-122
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• 2008

Objective: The purpose of this study was to invigorate the use of infrared thermal imaging apparatus as a diagnostic tool in Oriental medicine by providing standard temperature on specific acupoints. Methods: Subjects for the study was recruited through an advertisement in the school homepage(www.sangji.ac.kr) explaining the objectives and methods. 100 volunteers agreeing to terms were selected and measured the full body thermal image. Common acupoints used in the clinical surrounding were chosen and final 63 acupoints were selected for the measurement. Male/female and right/left readings were obtained for the analysis. Results: Following results were obtained from analyzing the body temperature of 50 male subjects and 50 female subjects 1. Subjects participating in the study ranged from 19 years of age to 44 years. Median male age at $26.86{\pm}6.02$ and female age at $22.88{\pm}2.74$, respectively. 2. For all acupoints, no significant differences were witnessed between the gender and right, left side of the body. 3. 10 acupoints from the facial region(18 bilateral), 8 acupoints from the chest/abdomen region(10 bilateral), 6 acupoints from the back region(11 bilateral), 17 acupoints from the upper extremity(34 bilateral), and 22 acupoints from the lower extremity(44 bilateral) were chosen. 4. In the facial region, BL2 showed the highest temperature and GV26 showed the lowest. 5. In the chest/abdomen region, CV22 showed the highest temperature and CV6 showed the lowest. 6. In the back region, GV14 showed the highest temperature and BL23 showed the lowest. 7. In the upper extremity region, jianqian(extra point) showed the highest temperature and baxie(extra point) showed the lowest. 8. In the lower extremity region, KI1 and bafeng(extra point) shoed the highest temperature and BL40 showed the lowest. Conclusions: Based on the standard body temperature measured on specific acupoints throughout the body, we hope these findings can trigger further studies on applications of infrared thermal imaging and clinical usage in the field of oriental medicine.

• Journal of Korean Medical classics
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• v.26 no.1
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• pp.27-38
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• 2013

Objective : This article shows that while Seishu Hanaoka(華岡靑洲) is known to have developed an effective anesthetic formula composed of traditional herbs and performed the world first partial mastectomy under a general anesthesia in 1804, anesthetic formulas very similar to those developed by him were widely recorded and deemed used in Japan and Northeast Asia before his invention. The origin of the formulas will be tracked down to compare with the several formulas broadly administered in the region. Methods : Historical literature analysis was adopted to achieve the objective. 1. Mayaku-ku (麻藥考): this book is the main medical classic by Nakagawa Syutei(中川修亭) that introduces Seishu Hanaoka, his anesthetic formulas and mastectomy. 2. Northeast medical classics: Seuideukhyobang (世醫得效方) in 1337, Uibangryuchui (醫方類聚), Uihui(宜彙) and so on. Result : Herbs such as aconitum and datura were applied as a anesthetic agent early on before the Chinese Yuan dynasty. In Korea as well, some old medical books documented such use of those herbs and relevant formulas. Conclusion : Formulas that counted as invented and employed by Seishu Hanaoka as anesthetics, in fact, had been widely known and used in the region before his era. We should pay due attention to his creativity that combined a western surgical intervention and traditional anesthetic agents and successfully performed a newly introduced surgical practice in Japan. The point is that Hanaoka took note of anesthetic herbs or formulas traditionally inherited in North-east Asian medicine and successfully applied them to the surgical procedures for breast cancer, or mastectomy and mammotomy. This history alerts us to neglected or forgotten potentials of traditional medicine in anesthetic treatment and more.

• Journal of Acupuncture Research
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• v.18 no.3
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• pp.171-183
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• 2001

Objective : To study the effects and merits of the Yanzhen Therapy(眼針療法), Method : We researched through studying 28 kinds of literature. Result : 1. The Division of Eye Region(眼區分劃), the Position of Yanxue(眼穴定位) and the mutual connection with Internal Organ(臟腑) during the Yanzhen Therapy(眼鍼療法) were made according to Huata's Thesis, and were made by combining Neijing(內經) Theory about eyes, Yinyang and Five Elements(陰陽五行) Theory, Meridian & Zang-Xiang Theory(經絡臟象學說), the Five Circles & Eight Regions(五輪八廓學說) Theory, and the Zhouyi Eight Diagrams(周易八卦) Theory. 2. The assignment between the Internal Organ and Eye-Division(眼區分劃) was formed on the basis of the Five-Circles and Eight-Regions Theory in Ophthalmology(眼科五輪八廓學說) of Zhengzhizhunsheng(證治準繩). 3. The Assignment(排列) & Position(方位) of the Congenital Eight Diagram(先天八卦) and the Acquired Eight Diagram(後天八卦) have influenced the Division of Eight Eye Region(眼鍼八區) and the Position of Yanxue(眼穴定位) significantly. 4. It showed no difference with the Map of Eye Position of Eight-Division(八廓眼位圖) like as Shenshiyaohan(審視瑤函), Yinhaizhinan(銀海指南) and Sanzijing of Ophthalmology(眼科三字經). Conclusion : While combining organically with other methods of acupuncture, the Yanzhen Therapy(眼鍼療法) may have better clinical effectiveness, and is also expect to expand the clinical indication.

• Journal of Mechanical Science and Technology
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• v.15 no.7
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• pp.876-888
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• 2001

For a large scaled optimization based on response surface methods, an efficient quadratic approximation method is presented in the context of the trust region model management strategy. If the number of design variables is η, the proposed method requires only 2η+1 design points for one approximation, which are a center point and tow additional axial points within a systematically adjusted trust region. These design points are used to uniquely determine the main effect terms such as the linear and quadratic regression coefficients. A quasi-Newton formula then uses these linear and quadratic coefficients to progressively update the two-factor interaction effect terms as the sequential approximate optimization progresses. In order to show the numerical performance of the proposed method, a typical unconstrained optimization problem and two dynamic response optimization problems with multiple objective are solved. Finally, their optimization results compared with those of the central composite designs (CCD) or the over-determined D-optimality criterion show that the proposed method gives more efficient results than others.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.38 no.2
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• pp.6-12
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• 2001

When CBR source traffics are loaded to ATM switch and broadband network termination, CTD values of ATM switch and broadband network termination are measured and then the values of CTD in the domestic region arc estimated. The estimation values of CTD satisfy the objective of CTD in the domestic region allocated by allocation rules of 1.356. The peak-to-peak CDV allocation method based On Chernoff accumulation method is proposed and applied to the nodes of national portion. From the result of numerical analysis, the proposed method is more accurate than the equal allocation method for peak -to-peak CDV in case that the CDVs at each node and the number of ATM nodes on the path increase.

• Proceedings of the Korean Society of Rural Planning Conference
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• 1998.10a
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• pp.25-27
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• 1998

The objective of this study is by analyzing villages("Ri" units) to specify the proper unit of the area that the rural development policy is suitable for, and to examine whether the current rural development policy considers the characteristics of community and region. The study included twelve districts(in Korean "Eup" or "Myun") and one hundred one villages(in Korean ri) in Poryong-si, Chungchungnam-do. Twelve and fifteen variables are respectively employe for the analysis of Myun`s and Ri`s. Using Factor Analysis, Cluster Analysis, and Z-Score Analysis, the study examines the degree of disadvantage and the process of growth pattern of each Myun or Ri. The Ri`s are also classified according to their functional characteristics. The results of this study could be summarized as follows; 1) There exist some problems in the current rural development policy because it does not take into consideration the characteristics community and region. 2) Except a few distinct of areas, the proper unit of the area for the rural development policy should be set being based on regional characteristics rather than the administrative units. 3) The spatial boundary of rural development policy should be sets from villages(ri) to beyond the unit of administrative units("Si" or "Gun"), according to the village unit analysis. 4) It is needed that community and region data should be consistently accumulated after specifying Standard Statistical Districts. 5) The application of indicators should be in accordance with the characteristics of the policy.

• Reproductive and Developmental Biology
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• v.41 no.3
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• pp.51-55
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• 2017

The production of therapeutic protein from transgenic domestic animal is the major technology of biotechnology. Insulin-like growth factor-1 (IGF-1) is known to play an important role in the growth of the animal. The objective of this study is construction of knock-in vector that bovine IGF-1 gene is inserted into the exon 7 locus of ${\beta}$-casein gene and expressed using the gene regulatory DNA sequence of bovine ${\beta}$-casein gene. The knock-in vector consists of 5' arm region (1.02 kb), bIGF-1 cDNA, CMV-EGFP, and 3' arm region (1.81 kb). To express bIGF-1 gene as transgene, the F2A sequence was fused to the 5' terminal of bIGF-1 gene and inserted into exon 7 of the ${\beta}$-casein gene. As a result, the knock-in vector is confirmed that the amino acids are synthesized without termination from the ${\beta}$-casein exon 7 region to the bIGF-1 gene by DNA sequence. These knock-in vectors may help to create transgenic dairy cattle expressing bovine bIGF-1 protein in the mammary gland via the expression system of the bovine ${\beta}$-casein gene.

• Journal of Intelligence and Information Systems
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• v.11 no.1
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• pp.17-33
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• 2005

This paper presents the proposed a classifier of liver cirrhotic step using MR(magnetic resonance) imaging and hierarchical neural network. The data sets for classification of each stage, which were normal, 1type, 2type and 3type, were analysis in the number of data was 231. We extracted liver region and nodule region from T1-weight MR liver image. Then objective interpretation classifier of liver cirrhotic steps. Liver cirrhosis classifier implemented using hierarchical neural network which gray-level analysis and texture feature descriptors to distinguish normal liver and 3 types of liver cirrhosis. Then proposed Neural network classifier learned through error back-propagation algorithm. A classifying result shows that recognition rate of normal is $100\%$, 1type is $82.8\%$, 2type is $87.1\%$, 3type is $84.2\%$. The recognition ratio very high, when compared between the result of obtained quantified data to that of doctors decision data and neural network classifier value. If enough data is offered and other parameter is considered this paper according to we expected that neural network as well as human experts and could be useful as clinical decision support tool for liver cirrhosis patients.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.28-33
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• 2002

Backgrounds and objective : EEG reflect dynamic changes of continuous neuronal activities by internal and external stimuli. The aim of this study is to quantify nonlinearly the local dynamic differences among EEG data corresponding to different states of brain. Methods : EEG was recorded from twelve healthy normal subjects(mean age, 29.7 years; 8 men and 4 women) using digital EEG machine. 18-channel EEG data were selected during eyes closed(EC), eyes open(EO), and mental arithmetic(MA) in each subject. Correlation dimension(D2) and largest Lyapunov exponent(LLE) were calculated from three states and average value was mapped 2 dimensionally and compared with each other. Results : The distribution of D2 was relatively symmetric and its value was higher in frontal than in parieto-occipital region during EC. These findings were reversed during EO. Bilateral centro-temporo-parietal region showed high D2 value in MA compared with those in EC, which was more prominent in left side. LLE was larger than zero in all state and showed significant differences among EC, EO and MA(p=0.000). Conclusion : These results suggest that nonlinear analysis of EEG can quantify dynamic state of brain.

• Journal of Auto-vehicle Safety Association
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• v.6 no.1
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• pp.41-47
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• 2014

A new dummy has improved biofidelity from Fair to Good compare with EuroSID2re which is currently used for regulation tests and NCAP tests. Some instrumentation of each body region has been changed to measure the assessment of injury risk. The objective of this study is to find out the injury characteristic of each dummy and to calculate the relation between external force and injury for each dummy with pendulum tests. Finally, this study suggests the optimized external force to meet consumer tests. A new dummy named WorldSID for side impact will be introduced into EuroNCAP tests after 2015. Korea government is also planning to adopt WorldSID at KNCAP tests from 2017 and Global Technical Regulation (GTR) will also adopt WorldSID to oblique side pole crash.