• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1732-1741
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• 2006

Obesity is chronic disease which influenced on health severly. The causes of obesity have been known as life change, lack of excercise, genetic factor, mental and social economic factors. Especially the obesity of women increased the risk of the diseases such as DM, osteoarthritis, cardiovascular disease, breast cancer and infertility. The limitations of the widely used negative definition of health as the absence of disease and WHO's 1946 definition of health as total social, psychological and physical well-being have long been recognized (WHO 1958). The Quality of Life (QoL) includes functional ability, the degree and quality of social and community interaction, psychological well-being as somatic sensation and life satisfaction. I investigated to compare the differences between obese women (n=63), non-obese women (n=37) in clinic and general women (n=43, control) on baseline characteristics and WHO QoL-BREF. The purpose of this study is to assist the diagnosis and treatment of obesity. WHO QoL-BREF is self administered type which consisted of 26 questions. The prospective question is calculated with 5 scores by Likert's method. The results are as follows : The means of physical, psychological, social, overall and total scores of QoL were significant among BMI group (P<0.05). The score of control group (BMI < 25) was higher than other groups significantly (P<0.05). In multiple regression analysis, the variable of high school/below middle school was significant in environmental and overall domain of QoL scores (P<0.05). The variable of college/below middle school was significant in environmental, overall domain and total score of QoL scores (P<0.05). The variable of above university/below middle school was significant in physical health, environmental, overall domain and total score in QoL scores (P<0.05). The variable of Health perception (moderate/bad) was positively significant in physical health, environmental, overall domain and total score of QoL scores (P<0.05). The variable of Health perception (good/bed) was positively significant in physical health, environmental, social, overall domain and total score of QoL scores (P<0.05). The variable as BMI non-=obese women/control was negatively significant in social domain of QoL scores (P<0.05). Above the results, It suggests that the variable as BMI did't affect on the QoL in patients and control, but the variables as education and health perception affected on the QoL scores. Further study is required to conduct QoL differences between before and after treatment of obese patients.

• The Journal of the Korea Contents Association
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• v.18 no.3
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• pp.196-204
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• 2018

The purpose of this study is to provide basic data for the oral health and obesity management of adults by grasping the relationship between obesity and oral health. Among the patients who visited the dental clinic, 229 patients who agreed to fill out questionnaires were analyzed by self - filling questionnaire. Body mass index and waist circumference were used for the study of obesity. Body mass index and poor periodontal health status were significantly higher(33.3%) and abdominal obesity and poor periodontal health status were 10.9%.Abdominal obesity was significantly higher(28.6%) in the group with less than 20 teeth. Body mass index and abdominal obesity were higher in body pain, psychological discomfort, physical abilities, psychological abilities, social disadvantage, and oral health than in normal subjects. As a result of correlation analysis with obesity index, it was found that the more period of obesity, the more periodontal disease and mucosal state related symptoms appeared(p<0.05). Therefore, in order to solve health problems such as obesity, it is necessary to recognize the importance of oral health and to make efforts to induce positive oral health behavior.

• The Journal of Korean Medicine
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• v.45 no.1
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• pp.65-79
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• 2024

Objectives: The purpose of this study is to evaluate weight change and analyze adverse events in post-menopausal obese women with Gamitaeeumjowee-tang for weight loss. Methods: A retrospective chart review was conducted for medical records of 115 post-menopausal obese women (body mass index, BMI≥25 kg/m²) who were administered with Gamitaeeumjowee-tang for 12 weeks for the purpose of weight loss. Weight, skeletal muscle ratio and BMI changes were compared before and after the program. Adverse events were evaluated by causality, severity and system-organ classes. Results: A total of 115 patients were included in this study. The average total weight loss in post-menopausal women was 5.72±2.04kg(p<0.001) and the average weight loss rate was 8.06±2.70%(p<0.001). After the 12-week program, the body fat rate was significantly decreased(3.76±2.20%)(p<0.001) and the skeletal muscle ratio was significantly increased(2.07±1.24%)(p<0.001). There were no significant differences in weight loss, skeletal muscle ratio change and body fat rate change depending on the number of hospital visits. Insomnia was frequently reported throughout the period, and no serious adverse events were reported. Conclusions: This study showed the potential that weight management treatment with Gamitaeeumjowee-tang could be a good way to lose weight of post-menopausal obese women without serious adverse events. Continuous well designed clinical studies are needed.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.1
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• pp.107-115
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• 2007

This report is to introduce a specific acupuncture methods as a cosmetic treatment. I applied wu-xing(五行) acupuncture technique to 11 patients for smooth out skin wrinkles. There were visual improvement of patients' facial skin. This methods cuts SMAS, stimulates dermis, and helps to recover skin volume and generate new dermal tissue by wound-healing mechanism.

• Sleep Medicine and Psychophysiology
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• v.12 no.1
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• pp.17-22
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• 2005

Sleep-disordered breathing (SDB) is associated with increased cardiovascular and cerebrovascular morbidity. Epidemiological and clinic-based studies have shown that SDB is related to impaired glucose tolerance and increased insulin resistance, independent of obesity. Despite of a consistent association between SDB and impaired glucose-insulin metabolism, the mechanism underlying this relationship has not been fully elucidated. It is recognized that hypoxemia and hypercapnia that occur in SDB provoke sympathetic nervous activity and catecholamine, epinephrine and norepinephrine, and cortisol are released. Sympathetic hyperactivity and increased catecholamines can impair glucose homeostasis by increasing glycogenolysis and gluconeogenesis, which can result in increased circulating insulin levels and increased risk of insulin resistance. A prospective study is needed to investigate the causal relationship between SDB and impaired glucose-insulin metabolism in a healthy population without diabetes, hypertension and obesity as etiologic risk factors.

• Journal of Korean Medicine for Obesity Research
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• v.16 no.1
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• pp.1-10
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• 2016

Objectives: The purpose of this study was to develop Russian version of Korean obese pattern identification questionnaire (KOPIQ) and classify the pattern of Uzbekistan obese patients. Methods: This study was conducted from 10 September 2014 to 10 December 2014 in Korea-Uzbekistan Oriental Hospital. The KOPIQ was translated to Russian language with the help of local expert in Russia and Korean Medicine. The patients who visited obese clinic in hospital were guided to join this study and informed consent was obtained. The inclusion criteria was >$23kg/m^2$ in body mass index. The Cronbach's alpha was used for it's inter consistency reliability and the KOPIQ result was compared with the experts one. Results: The Russian version of KOPIQ was developed. The 103 patient (25 males, 78 females; average age 57.2 years) joined in this study. The Cronbach's alpha of questionnaire was 0.787~0.883 according to individual pattern. The agreement rate of pattern Identification between local expert and KOPIQ was 13%. This developed questionnaire was realized as web version, which could be easily used in Uzbekistan. Conclusions: The Russian version of KOPIQ is developed in this study with suitable reliability. Further study is needed for KOPIQ to be applied in Uzbekistan with high validity.

• Nutritional Sciences
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• v.5 no.4
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• pp.221-227
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• 2002

The objective of this study was to examine the effects of a weight loss program on the degree of obesity and levels of resting energy expenditure (REE) in overweight subjects according to their mitochondrial uncoupling protein 2 (UCP 2) genotype. Twenty-three subjects with a body mass index (BMI) greater than 27 were recruited from the Obesity Clinic of the Kyung-Hee University Hospital during the period of December 2000 - August 2001. The subjects were genotyped for the exon 8 allele; 15 subjects were found to be of del/del genotype, 8 were del/ins, and none were of ins/ins genotype. No significant association was found between the different UCP 2 genotypes and the initial levels of weight, fat mass (FM), lean body mess (LBM), BMI, REE, and REE/LBM ratio. After 12 weeks of a weight loss program, body weight and FM were significantly decreased, while LBM, total body water (TBW), and REE were not changed, irrespective of UCP 2 genotype. Initial fasting plasma levels of albumin, glucose, triglyceride, lipoprotein cholesterol, insulin, free triiodo-thyronine (T3), free fatty acid (FFA), and leptin were not different according to the UCP 2 genotype; furthermore, these blood parameters were not changed after the 12-week weight loss program. However, plasma levels of leptin decreased in both the del/del and ins/del genotypes, from 18.7 ng/ml to 13.4 ng/ml (p<.05), and from 18.1 ng/ml to 13.9 ng/ml (p＜.05), respectively, after the weight loss program. In conclusion, this study found no significant association between the del/del or del/ins UCP 2 genotypes and differing levels of REE or differing degrees of obesity, either before or after a weight loss program. This study provided evidence that a well- managed weight loss program could maintain levels of REE, which plays an important role in the maintenance of energy balance.

• The Korea Journal of Herbology
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• v.31 no.4
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• pp.11-18
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• 2016

Objectives : The objective of this study was to investigate the effect of Myrrh 80% ethanol extract on adipocyte differentiation and adipogenesis in 3T3-L1 cell.Methods : Myrrh was prepared by extracting with 80% ethanol. Cell viability was assessed by MTT assay using 3T3-L1 cells. Anti-obesity activity was measured in lipid droplets and triglyceride (TG) accumulation in 3T3-L1 cells. We also analyzed the expression of C/EBPβ, C/EBPα, PPARγ, SREBP1c, and aP2 by reverse transcriptase polymerase chain reaction (RT-PCR). In addition, we observed the production of fatty acid, acetyl-CoA carboxylase and Oil-red O stainingResults : No cytotoxicity from Myrrh 80% ethanol extracts was observed at the concentration of 1, 10, 100 (㎍/㎖) in 3T3-L1 cells. Treatment with Myrrh significantly suppressed the terminal differentiation of 3T3-L1 in a dose-dependent manner, as confirmed by a decrease in triglyceride and Fatty acid and Acetyl-CoA carboxylase. Also, Myrrh exhibited potential adipogenesis inhibition and downregulated the expression of pro-adipogenic transcription factors, such as sterol regulatory element binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer binding proteins α (C/EBPα) and C/EBPβ, and adipocyte expressed genes, such as adipocyte fatty acid binding protein (aP2) and Fas. In addition, lipid accumulation determined by Oil-red O staining showed that Myrrh extract had inhibitory effects on lipid accumulation in 3T3-L1 cells.Conclusions : These results suggest that Myrrh suppresses obesity factors in 3T3-L1 cells. Myrrh may be a useful medical herbs for attenuating metabolic diseases such as obesity.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.4
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• pp.89-103
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• 2020

Objectives This study has been conducted to verify frequently used herbs and herbal formulas to treat obesity in Korea during 2015 to 2019. Methods Publications related to treatment of obesity using herbal medicines from 2015 to 2019 were retrieved from 12 databases (PubMed, EMBASE, Scopus, China National Knowledge Infrastructure [CNKI], Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], Research Information Sharing Service [RISS], DBPIA, KMBASE, KoreaMed, KoreanTK, Oriental Medicine Advanced Searching Integrated System [OASIS]). Extracted articles were analyzed in terms of publication year, journal, and type of herbs. Results A total of 136 studies have been included in this study. 33 herbal formulaes and 129 herbs have been analyzed. Taeyeumjowui-tang was the most frequently studied herbal formulae and Ephedrae Herba was the most frequently studied herb. Ginseng Radix was the most frequently studied single herb in isolation from herbal formulae. Conclusions These results suggest that various herbs and herbal formulae can be used to treat obesity. Since this study includes every type of study, additional studies based on clinic are thought to be necessary.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.77-83
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• 2001

We wanted to study the effect of Taeyeumjowee-tang and electroacupunctre combined-therapy on obese patients. From 1 March, 2000 to 30, September, 2000 we studied 33 out-ward patients who clinically diagnosed obesity and classified Tae-Em-In by QSCC(Questionnaire of Sasang Constitution Classification). We treated the patients by electroacupuncture therapy and taeyeumjowee-tang for 6 weeks, We investigated the change of mean body weight, mean body mass index, mean obesity degree, percent body fat and waist-hip circumference ratio. To analyze the results we used repeat measure method by SPSS ver 7.5. The results were as follows: 1. From $70.4{\pm}11.4\;to\;64.9{\pm}8.7$, mean body weight was significantly decreased according to combined-therapy. 2. From $27.2{\pm}3.2\;to\;24.6{\pm}2.7$, mean BMI was significantly decreased according to combined-therapy. 3. From $116.7{\pm}13.9\;to\;104.4{\pm}12.1$, mean obesity degree was significantly decreased according to combined-therapy. 4. From $32.1{\pm}6.8\;to\;27.4{\pm}7.5$, percent body fat was significantly decreased according to combined-therapy. 5. From $0.90{\pm}0.06\;to\;$0.86{\pm}0.06$, waist-hip circumference ratio was significantly decreased according to combined-therapy. In this study we knew the combined-therapy of electroacupuncture and taeyeumjowee-tang is very efficient in obese patient.