• Asian Pacific Journal of Cancer Prevention
• /
• 제16권11호
• /
• pp.4691-4698
• /
• 2015

Background: The tumor suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. However, available results for the prognostic value of PTEN expression in patients with cancer remain controversial. Therefore, a meta-analysis of published studies investigating this issue was performed. Materials and Methods: A literature search via PubMed and EMBASE databases was conducted. Statistical analysis was performed by using the STATA 12.0 (STATA Corp., College, TX). Data from eligible studies were extracted and included into the meta-analysis using a random effects model. Results: A total of 3,810 patients from 27 studies were included in the meta-analysis, 22 investigating the relationship between PTEN expression and overall survival (OS) using univariate analysis, and nine with multivariate analysis. The pooled hazard ratio (HR) for OS was 1.64 (95% confidence interval (CI): 1.32-2.05) by univariate analysis and 1.56 (95% CI: 1.20-2.03) by multivariate analysis. In addition, eight papers including two disease-free-survival analyses (DFSs), four relapse-free-survival analyses (RFSs), three progression-free-survival analyses (PFSs) and one metastasis-free-survival analysis (MFS) reported the effect of PTEN on survival. The results showed that loss of PTEN expression was significant correlated with poor prognosis, with a combined HR of 1.74 (95% CI: 1.24-2.44). Furthermore, in the stratified analysis by the year of publication, ethnicity, cancer type, method, cut-off value, median follow-up time and neoadjuvant therapy in which the study was conducted, we found that the ethnicity, cancer type, method, median follow-up time and neoadjuvant therapy are associated with prognosis. Conclusions: Our study shows that negative or loss of expression of PTEN is associated with worse prognosis in patients with cancer. However, adequately designed prospective studies need to be performed for confirmation.

• 한국패류학회지
• /
• 제29권2호
• /
• pp.97-103
• /
• 2013

In the present study, we monitored the early development of Saccostrea kegakia subtropical oyster species distributing on rocky intertidal off the northern Jeju Island using scanning electron microscope (SEM). The female oyster collected in early August, 2012 were fully mature exhibiting relatively small eggs ($46.5{\pm}1.4{\mu}m$ in diameter) in the gonad, while testis of the mature male oysters were filled with fully developed sperms of 36.9 ${\mu}m$ in length. The fertilized eggs developed into 2-cell stage with polar body after 1 hr 20 min of fertilization, then followed by Morula stage (3 hr 20 min), Blastula stage (4 hr 50 min), Gastrula stage (7 hr), and trochophore larvae stage (9 hr 30 min). The observed early development of S. kegaki in this study was similar the early development of other oysters, although size of the fertilized eggs were somewhat smaller.

• 전기전자학회논문지
• /
• 제11권1호통권20호
• /
• pp.69-76
• /
• 2007

본 논문에서는 CMOS 공정기반의 BiCMOS LVDS 구동기를 설계하여 고속 I/O 인터페이스에 적용하고자 한다. 칩 면적을 줄이고 LVDS 구동기의 감내성을 향상시키기 위해 lateral 바이폴라 트랜지스터를 설계하여 LVDS 구동기의 바이폴라 스위칭으로 대체하였다. 설계된 바이폴라 트랜지스터는 20가량의 전류이득을 지니며, 설계된 LVDS 드라이버 셀 면적은 $0.01mm^2$로 설계되었다. 설계된 LVDS 드라이버는 1.8V의 전원 전압에서 최대 2.8Gb/s의 데이터 전송속도를 가진다. 추가적으로 ESD 현상을 보호하기 위해 새로운 구조의 ESD 보호 소자를 설계하였다. 이는 SCR구조에서 PMOS, NMOS의 턴-온 특성을 이용 낮은 트리거링 전압과 래치 업 현상을 최소화 시킬 수 있다. 시뮬레이션 결과 2.2V의 트리거링 전압과 1.1V의 홀딩 전압을 확인할 수 있었다.

• 한국의학물리학회지:의학물리
• /
• 제18권1호
• /
• pp.20-26
• /
• 2007

망막질환에 의해 변성된 망막에서는 시냅스 조직의 구성이나 전기적 특성이 정상망막과는 크게 다를 것으로 예상된다. 그러므로 본 논문에서는 다채널기록법을 이용하여 정상 망막과 변성 망막에서 망막파형을 기록한 후 그 파형을 주성분 분석법과 독립성분분석법을 이용하여 비교 분석하였다. 주성분분석법은 망막파형 분석법으로 확립된 방법인 반면 독립성분분석법은 EEG 신호의 분석법으로는 확립된 방법이나 아직 망막파형 분석법으로 사용된 적이 없으므로 본 연구진이 최초로 적용하여 보았다. 본 연구진에 의해 프로그램된 독립성분분석법을 위한 toolbox를 사용하여 시공간적 분석을 실시한 결과 정상 마우스에서는 독립성분분석법 또한 주성분분석법과 같이 망막신경절세포 파형의 분석 방법으로서의 사용가능성을 발견하였다 그러나 rd/rd 마우스에서는 독립성분분석법으로 그린 공간지도상에서 다수의 강한 활성과 약한 활성이 혼재되어 나오는 복잡한 양상을 띄었다. 추후 어떠한 기전에 의해 변성망막의 공간지도가 이렇게 복잡한 양상을 띄는지에 관한 연구가 진행되어야 할 것으로 사료된다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제11권4호
• /
• pp.2058-2074
• /
• 2017

Dense Heterogeneous Cellular Networks(HCNs) offer a promising approach to meet the target of 1000x increase in aggregate data rates in 5G wireless communication systems. However how to best utilize the available radio resources at densely deployed small cells remains an open problem as those small cells are typically unplanned. In this paper we focus on balancing loads across macro cells and small cells by offloading users to small cells, as well as dynamically switching off underutilized small cells. We propose a joint user association and base station(BS) sleep mangement(UA-BSM) scheme that proactively offloads users to a fraction of the densely deployed small cells. We propose a heuristic algorithm that iteratively solves the user association problem and puts BSs with low loads into sleep. An interference relation matrix(IRM) is constructed to help us identify the candidate BSs that can be put into sleep. User associations are then aggregated to selected small cells that remain active. Simulation results show that our proposed approach achieves load balancing across macro and small cells and reduces the number of active BSs. Numerical results show user signal to interference ratio(SINR) can be improved by small cell sleep control.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제14권3호
• /
• pp.263-267
• /
• 2014

Super junction trench gate power MOSFETs have been receiving attention in terms of the trade-off between breakdown voltage and on-resistance. The vertical structure of super junction trench gate power MOSFETs allows the on-resistance to be reduced compared with conventional Trench Gate Power MOSFETs. The heat release of devices is also decreased with the reduction of on-resistance. In this paper, Lattice Temperature of two devices, Trench Gate Power MOSFET and Super junction trench gate power MOSFET, are compared in several temperature circumstance with the same Breakdown Voltage and Cell-pitch. The devices were designed by 100V Breakdown voltage and measured from 250K Lattice Temperature. We have tried to investigate how much temperature rise in the same condition. According as temperature gap between top of devices and bottom of devices, Super junction trench gate power MOSFET has a tendency to generate lower heat release than Trench Gate Power MOSFET. This means that Super junction trench gate power MOSFET is superior for wide-temperature range operation. When trench etching process is applied for making P-pillar region, trench angle factor is also important component. Depending on trench angle, characteristics of Super junction device are changed. In this paper, we focus temperature characteristic as changing trench angle factor. Consequently, Trench angle factor don't have a great effect on temperature change.

• 대한기계학회논문집B
• /
• 제35권6호
• /
• pp.641-648
• /
• 2011

고온 발전용 연료전지인 MCFC의 연료극에서 방출되는 미반응 가스를 촉매연소의 열원으로 사용하고, 촉매연소 반응에 의해 발생한 열을 개질 반응에 필요한 공급열로 이용하는 통합형 촉매연소-개질 반응기에 있어서 MCFC의 운전 조건 변경에 따른 반응기의 열적 거동과 반응 특성을 실험적으로 연구하였다. 특히, 연료극에서 연료 이용률을 변동될 때 슬립가스의 조성이 바뀌는 것을 고려하여 촉매연소측에 공급해줄 혼합가스의 조성을 실험조건으로 설정하였다. 또한 개질측에서는 S/C(수증기/탄소)의 비를 운전조건의 변동 조건으로 설정하였다. 실험적으로 얻어진 데이터는 보다 현실적인 통합형 촉매연소-개질반응기를 설계하고 제작하는데 필요한 기본 자료로 활용될 수 있을 것이다.

• 한국식품조리과학회지
• /
• 제16권6호
• /
• pp.557-567
• /
• 2000

An optional ingredient, jasoja(Perillae semen), was adopted to improve the quality of Dongchimi. The final weight percentage of jasoja in Dongchimi was adjusted to 0, 0.25, 0.5, 0.75, or 1.0%, per radish, and sensory and microbiological characteristics were determined during fermentation at 10 for 45 days. The effect was varied depending on the amounts of jasoja, but Dongchimi fermented with 0.5% jasoja was most favored for color, flavor, taste, texture, and overall acceptability in sensory evaluation. According to a quantitative descriptive analysis for the product, the liquid portion of Dongchimi steadily became clearer and less sour in proportion to the amount of added jasoja. However, a strong off-taste was detected from 1.0% treatment. The viable cell numbers of total and lactic acid bacteria drastically increased during the first 2 days, and then gradually increased to their maximum values during fermentation and slowly decreased at the later stage. Dongchimi with 0.5% treatment showed a distinctive high number of microorganisms at the 15th-day of fermentation and this trend was maintained until the completion of fermentation. The lactic acid bacteria isolated and identified from Dongchimi were; Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, Lactococcus faecalis, and Lactococcus lactis. The combined number of Lactobacillus brevis and Lactobacillus plantarum began to increase right after preparation to as much as 10$\^$7/CFU/㎖, then decreased to 10-10$^3$CFU/㎖ afterward. This study showed that the addition of jasoja retarded the initial fermentation of Dongchimi; however, too much jasoja at above 1% weight level per Chinese radish might accelerate fermentation at the later fermentation stage and shoud be avoided. A comparable fermentation pattern was observed among the samples; however, more acceptable Dongchimi could be prepared by fermenting for 11 to 30 days at 0.5% jasoja concentration per radish.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권18호
• /
• pp.7737-7740
• /
• 2014

Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values in locally advanced breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Materials and Methods: Datawere collected retrospectively from the Akdeniz University School of Medicine Database for locally advanced BC patients treated with NACT between January 2000-December 2013. Results: A total of 78 patients were analyzed. Sixteen (20%) patients achieved pCR. Estrogen receptor (ER) positivity was lower in pCR+ than pCR-cases (p=0.011). The median NLR values were similar in both arms. The optimum NLR cut-off point for BC patients with PCR+ was 2.33 (AUC:0.544, 95%CI [0.401-0.688], p=0.586) with sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 50%, 51,6%, 21,1%, and 80%, respectively. Conclusions: This study showed no relationship between the pCR and pretreatment NLR values. Because of a considerable high NPV, in the patients with higher NLR who had luminal type BC in which pCR is lower after NACT, such treatment may not be recommended.

• 대한전자공학회논문지SD
• /
• 제48권7호
• /
• pp.1-9
• /
• 2011

멤리스터(Memristor)는 메모리 레지스터의 합성어로 흐른 전하량에 따라 저항이 스스로 변하고 전원이 끊긴 상태에서도 저항 상태가 기억되는 특수한 메모리 소자이다. 본 논문에서는 차세대 메모리소자로 주목받고 있는 멤리스터를 모델링하고 SPICE 시뮬레이션을 위한 behavior모델을 제시한다. 그리고 제안된 모델을 바탕으로 멤리스터 기반의 M_CAM(Memristor MOS content addressable memory)을 설계하였다. 제안된 M_CAM은 기존의 CAM에 비해서 단위 셀 면적과 평균 전력소모가 각각 40%, 96% 감소하였다. 칩은 0.13${\mu}m$ CMOS 공정에서 공급전압이 1.2V를 갖도록 설계되었다.