• 한국산업보건학회지
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• 제21권2호
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• pp.82-89
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• 2011

Methylcyclohexane is frequently used in industrial sites (2,592tons/year) as rubber adhesives, ink, paint thinners, organic solvents, and so on. However, there are limited data on the toxic evaluation of methylcyclohexane. This study aims to predict the hazards and neurological effects of methylcyclohexane using SD rats in order to prevent health disorders of workers. The OECD Guideline for Testing of Chemicals (OECD, 2001) was used as a reference during the tests. For 13 weeks (once a day, five days per week) 0, 10, 100 and 1,000mg/kg/day of methylcyclohexane was injected to SD rats to observe any changes in the body or organ weight, hematology, histopathology, mobility, blood pressure, and neurotransmitter. As a result, some male and female SD rats injected with 1,000mg/kg/day of methylcyclohexane died. On the other hand, surviving rats showed significant changes such as hematological changes involving the decrease in the number of red blood corpuscles, and the decrease or increase in the weight of the lungs, kidneys, spleens, and livers (p< 0.05, p<0.01). Also histopathological lesions were observed in the hearts and kidneys. In the test for the effect on the nervous system, SD rats injected with 100mg/kg/day of methylcyclohexane had higher blood pressure levels compared to the control group. However, no abnormal effects was observed in the mobility, serotonin, neurotransmitter, and the biopsy of the brain and coronary arteries. The study results revealed that the livers, hearts, and kidneys were affected by methylcyclohexane. The absolute toxic dose of methylcyclohexane is 1,000mg/kg/day, NOAEL is 100 mg/kg/day, and it is not a toxic substance to the nervous system.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제6권11호
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• pp.37-45
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• 2000

The purpose of this study was to analyze the ambulatory care facilities according to the change of medical circumstance and to find the proper ones in Korea. A logical model was used with the data which were obtained from the National Statistical Office, the Ministry of Health and Welfare in Korea and OECD Health Data. A proper ambulatory care facility in Korea is suggested as like as MOB (Medical Office Building). It should be considered for outpatient in distance within 1km long. It's proper size may be designed for 10,000persons to 50,000persons by regions.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2293-2303
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• 2013

목적: 본 연구의 목적은 국내 환자안전지표 산출 가능성을 확인하는 것이다. 조사방법: 환자안전지표의 정의는 OECD에서 AHRQ에 근거하여 작성한 보건기술문서 19의 기준을 이용하였고, 이에 따라 2004-2008년 퇴원손상심층조사 875,622건에서 환자안전지표(PSIs)를 산출하였다. 로지스틱 회귀분석을 이용하여 환자안전지표별 비율의 변이요인을 확인하였다. 분석결과: 2004-2008년간 약 80만 건의 퇴원 중에서 8개의 환자안전지표에 해당하는 위해사건은 3,084건이었다. 욕창(PSI3, 4.88), 시술 중 이물질 체내 잔류(PSI5, 0.05), 수술 후 패혈증(PSI13, 1.32), 출생손상-신생아(PSI17, 7.92), 산과적 외상-도구를 이용한 질식 분만(PSI18, 32.81)의 퇴원 1,000건당 비율은 모두 OECD 환자안전지표 비율의 최소-최대 범위 내에 포함되었다. 그러나 내과적 치료에 의한 감염(PSI7, 0.22), 수술 후 폐색전증 또는 심부정맥혈전증(PSI12, 0.90), 우발적 천공 또는 열상(PSI15, 0.71)의 퇴원 1,000건당 비율은 OECD 환자안전지표 최소값에 못 미쳤다. PSI 18을 제외한 7개의 지표값 모두 부진단명의 개수와 유의한 상관관계가 있는 것으로 나타났다. 또한 환자안전지표 비율은 환자특성을 보정했을 때, 병상규모 및 병원소재지 등 병원특성에 따른 유의한 차이를 보였다. 결론: 본 연구는 국가적인 행정자료를 이용하여 위해사고를 스크리닝 하는 환자안전지표를 산출한 최초의 실증적 연구이다. 본 연구의 결과는 자료의 질, 임상 관련 변수 등의 결과에 영향을 미치는 요소가 여전히 있지만, 환자안전에 대한 국가적인 통계를 추계하는 기초자료를 제공하였다는데 의의가 있다. 향후 본 연구결과를 바탕으로 위해사건으로 인한 사망 규모 산출 등의 결과연구가 필요하다.

• Environmental Engineering Research
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• 제22권2호
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• pp.224-229
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• 2017

Zinc oxide nanoparticles (ZnO NPs) have been used as additives in a variety of consumer products. While these particles may enter the environment, only a limited number of studies have investigated the effects of ZnO NPs on soil exoenzymes. Here, we investigate the long-term effects of ZnO NPs at concentrations of 50 and 500 mg/kg on the activities of six soil exoenzymes in planted soils: Dehydrogenase, fluorescein diacetate (FDA) hydrolase, urease, acid phosphatase, arylsulfatase, and ${\beta}-glucosidase$. Significant effects were observed at one or more time points for all enzymes except for FDA hydrolase. These effects included both decreases and increases in enzyme activity. Our results suggest that ZnO NP treatments of 50 and 500 mg/kg can adversely affect soil enzymes, particularly acid phosphatase and urease, and thus, these data may have implications for phosphorous and nitrogen cycles in the soil.

• Environmental Analysis Health and Toxicology
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• 제19권1호
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• pp.65-72
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• 2004

Environmental risk assessment of cadmium compounds was conducted using national monitoring data of aquatic and terrestrial compartments of local area. Aquatic and terrestrial toxicities of cadmium compounds on algae, daphnid, fish, earthworm, springtails and other species were evaluated. The toxicity data evaluated in this study were mainly from ECOTOX database provided by US EPA. Assessment factors were determined according to the EU technical guidance document and/or OECD proposal. Predicted no effect concentration (PNEC) values of aquatic and terrestrial toxicity were 25$\mu\textrm{g}$/L and 0.2 mg/kg, respectively and they were compared with cadmium exposure data of several local areas, which were used as Predicted exposure concentration(PEC) values. Most of the local area were found to be not risky. However, the risk values (PEC/NEC) of some metropolitan areas were greater than 1 when the most conservative PNEC value was applied.

• 보건행정학회지
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• 제32권3호
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• pp.293-303
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• 2022

Background: Coronavirus disease 2019 (COVID-19), which has occurred since the end of 2019, has caused tremendous damage not only in terms of disease and death but also in terms of economy. Accordingly, governments implemented health and quarantine policies to prevent the transmission and spread of COVID-19 and minimize economic effects, and implemented various countermeasures to reduce social and economic damage. However, the damage varies from country to country, and there are differences in the response of each government. Methods: Using 2020 data from the Organization for Economic Cooperation and Development countries, the effectiveness of governments' quarantine and economic policies in response to COVID-19 was calculated, and what factors determine the effectiveness were analyzed. While most of the previous studies analyzed the relationship between the government's quarantine policy and corona transmission and death, this study is characterized by considering the economic aspect in addition. Results: As a result of the analysis, the following results were obtained. First, when economic aspects are not considered, Asian and European countries have similar levels of efficiency, but when economic aspects are taken into account, Asian countries have higher efficiency. Second, population density had a negative effect on the efficiency of each country's policy, and long-term orientation was found to have an important impact when considering the economic aspect. Conclusion: We found that the governance index is an important variable influencing the efficiency, which shows that the effectiveness of government policies in response to the coronavirus depends heavily on the trust relationship between the government and the people.

• 한국가스학회지
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• 제21권1호
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• pp.6-17
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• 2017

본 연구는 3-methylpentane에 대한 흡입유해성을 평가하여 국제연합에서 정하는 화학물질의 분류 및 표지에 관한 세계조화시스템(Globally harmonized system, GHS)지침 및 고용노동부고시 제2013-37호에 따른 3-methylpentane의 화학물질 분류 표시 자료를 생산하기 위하여 OECD 화학물질 시험가이드라인 아급성흡입독성시험 TG 412(Subacute inhalation toxicity) 시험법에 따라 수행하였다. 본 연구를 위하여 6주령의 랫드(Rat)를 도입하여 1주간 순화시킨 후 암수 각각 대조군 5마리, 저농도군(284 ppm) 5마리, 중농도군(1,135 ppm) 5마리, 고농도군(4,540 ppm) 5마리 등으로 군을 구성하여 일일 6시간, 주 5일, 4주 동안 시험물질을 랫드에 전신으로 노출시켰다. 시험물질 노출을 종료하고 2주 후 시험동물을 희생하여 시험물질에 의한 시험동물의 영향을 평가하였다. 사료섭취량 변화, 체중 변화, 임상관찰, 혈액검사, 부검 소견, 장기무게 측정, 조직병리검사 등 모든 시험결과에서 시험물질에 의한 영향은 나타나지 않아 3-methylpentane의 무유해영향농도는 암수 모두 4,540 ppm이상으로 판단되어 세계조화시스템(GHS) 지침 및 고용노동부고시 제2013-37호(화학물질의 분류 표시 및 물질안전보건에 관한 기준)의 특정표적장기독성(반복노출) 구분 표시 물질에 해당하지 않은 물질로 판단되었다.

• 아동학회지
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• 제33권1호
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• pp.183-203
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• 2012

While efforts to measure and monitor children's well-being have gained increasing recognition across the OECD, there has been relatively little research on the subject of indicators of children's well-being in Korea. This study was undertaken in order to develop the domains and indicators which can be used to measure the quality of life of Korean children from birth to age 17 and to put forward a possible well-being index for Korean children. The 35 indicators of well-being were grouped into eight domains and were designed for this study, using previous research on key child indicators for Korea and the child well-being index in foreign countries, such as the FCD-Land Index, Kids Count, the index of child well-bing in the European Union and OECD area. These domains are composed of the following : economic well-being, health, education, spiritual/emotional well-being, children's relationships, civic participation, safety/risk behavior, and housing and environment. The establishment of a Korean children's well-being index requires access to and use of national statistical data analyzed annually by the government as well as a general consensus regarding such issues as scope and its indicators.

• 대한예방한의학회지
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• 제21권2호
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• pp.79-94
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• 2017

Objectives : The elderly in South Korea are the poorest among OECD countries in 2015. The aim of this study was to explore the health and life of the low-income elderly living in vulnerable areas in a metropolitan city. Methods : Data were collected through in-depth individual interviews with 7 participants from October to November 2015 and analyzed through Colaizzi's phenomenological methodology. The participants were interviewed for over 60 minutes in each person. Results : 7 categories were identified from 17 subcategories: "My life history: sick body," "Living with a sick body," "My poor but precious life," "A sense of distance from the hospital," "Narrowed area of my life," "Thankful for help," and "The village where I have lived my destiny." There is a lack of medical accessibility, mobility, and economic independence for low-income seniors. In addition, full-fledged redevelopment comes to them as violence. Conclusions : The health and life of the low-income elderly in vulnerable areas are products of many social factors, reaffirming the importance of social health.

• 보건교육건강증진학회지
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• 제21권4호
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• pp.1-13
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• 2004

This study conducted descriptive literature review on adolescent smoking and the related factors to realize significance of adolescent smoking onset in Korea and to identify risk factors of smoking incidence. Korean adolescent smoking status was generated based on the cumulated data of the Korean Association of Smoking and Health. Risk factors of adolescent smoking were identified based on 18 studies written in English, with cross-sectional research design and published as a peer-reviewed journal article between 1994 and 2003. The results were as follows. 1. Korean adolescent smoking rate was the highest among OECD affiliated countries; in particular, male adolescent smoking incidence was very serious. 2. Risk factors related to smoking of adolescent population were personal factor, friend factor, family factor, and mass-media factor. Demographic characteristics, attitudes on smoking, and willingness of smoking, and health behaviors were selected as personal factor of smoking. 3. Best friends smoking was a strong factor of students' smoking set. Prevalent popularity of smoking in peer-group allowed students to feel free to smoking. 4. Concerning family factor related to smoking status, parents' smoking and sibling's smoking were significant indicators of adolescent smoking status. 5. Seeing smoking behaviors and scenes through films, TV shows, drama, and advertisement was a significant risk factor of adolescent smoking status.