• 대한치과의사협회지
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• 제45권8호통권459호
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• pp.491-499
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• 2007

Deproteinized bovine bone mineral has been widely used as graft material in sinus augmentation procedure. The efficacy of OCS-B(r)(Nibec Inc., Seoul, Korea) as a graft material for sinus augmentaion was evaluated in 10 patients. A total of 13 sinus augmentation procedures were performed, and an average of 6.3 months later 27 implants were placed into the augmentation sinuses. The biopsy specimens were examined histologically and hitomorphometrically. Radiographical evaluation was done also. The average distance form grafted sinus to implant apex at the final evaluation period was $5.7\pm3.1$mm. The average percentage of newly formed bone at an average of 6.3 months was $20.0\pm8.4%$. The degree of bone to graft material contact was $18.7\pm6.4%$. It was shown from both radiographic evaluation and histologic results that sinus augmentation can successfully be performed with $\OCS-B^textcircledR$.

• 한국콘텐츠학회논문지
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• 제9권9호
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• pp.90-96
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• 2009

본 연구의 목표는 당뇨 및 심혈관계 질환자의 상태를 주기적 지속적으로 관리하기 위하여 당뇨 심혈관 관련 질병 DB를 구축하고, 기존 OCS, PACS, EMR, ERP등의 환자 DB를 통합 연계하는 지능형 통합 인터페이스 환경을 통해 환자가 원하는 최적의 서비스를 최적의 타이밍에 제공할 수 있는 개인 맞춤형 의료정보 융합시스템을 설계하는 것이다. 이를 위해 당뇨 및 심혈관 질환에 대한 지능형 DB를 구축하고, OCS, EMR, PACS 등 기존의 타 시스템과의 유연한 연계처리를 통한 데이터 통합 환경을 제공한다. 또한, 개인 맞춤형 의료정보 응합 시스템의 QoS와 신뢰성, 확장성 등을 고려하여 H/W설계, S/W설계와 데이터호환 방법을 설계한다.

• BMB Reports
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• 제52권11호
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• pp.659-664
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• 2019

Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs) obtained from Vav1-deficient ($Vav1^{-/-}$) and wild-type (WT) mice to differentiate into mature OCs upon stimulation with macrophage colony stimulating factor and receptor activator of nuclear kappa B ligand in vitro. Our results suggested that Vav1 deficiency promoted the differentiation of BMMCs into OCs, as indicated by the increased expression of tartrate-resistant acid phosphatase, cathepsin K, and calcitonin receptor. Therefore, Vav1 may play a negative role in OC differentiation. This hypothesis was supported by the observation of more OCs in the femurs of $Vav1^{-/-}$ mice than in WT mice. Furthermore, the bone status of $Vav1^{-/-}$ mice was analyzed in situ and the femurs of $Vav1^{-/-}$ mice appeared abnormal, with poor bone density and fewer number of trabeculae. In addition, Vav1-deficient OCs showed stronger adhesion to vitronectin, an ${\alpha}_v{\beta}_3$ integrin ligand important in bone resorption. Thus, Vav1 may inhibit OC differentiation and protect against bone resorption.

• 한국의료질향상학회지
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• 제13권1호
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• pp.81-85
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• 2007

문제: 방사선 처방전달시스템(OCS) 프로그램에 대한 내부고객의 불만사항이 제기되었다. 목적: 방사선부분 OCS에 대한 내부고객의 만족도를 평가하고 문제점을 개선하여 만족도를 향상시킨다. 의료기관: 경기도에 소재한 의과대학 소속 병원의 영상의학과 질 향상 활동: 방사선 부분의 내부고객 만족도 조사를 통한 개선 방안 도출 및 평가 개선효과: 전체 만족도 영역에서는 개선 전 불량률 7.49%에서 개선 후 1.41%로 감소하였으며 촬영 및 재료 소모 관리 부문에서 불량률은 개선 전 14.28%에서 개선 후 3.84%로 감소하였다. 교훈: 프로그램 매일 사용하는 내부고객의 평가를 통해 업무효율을 높일 수 있었으며, 개선 효과를 최대화하기 위해서는 각 관련부서간의 협력이 필수적이다.

• Journal of Preventive Medicine and Public Health
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• 제24권4호
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• pp.473-484
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• 1991

Hospitals have been very susceptable to changes in external environment. Accordingly, they have been experiencing great financial difficulty due to low insurance rates and increasing competition. As a remedy, hospitals have attempted to use computer in a strategic manner. Such system is called strategic information system(SIS), and order communication system(OCS ) is an example of SIS in hospital setting. While OCS has known to be effective in reducing waiting time for outpatients, many hospitals are reluctant to introduce this system mainly because there are no real data or methods for justifying the cost of the system. Cost-benefit analysis has been traditionally used for such purpose, but this method deals with limited portion of benefits and therefore not very useful for analyzing the economic feasibility of SIS. In this paper, information economics tools which expand cost with value was used to analyze the economic feasibility of OCS. To assist the analysis, financial simulation model was developed using simulation package, called IFPS(Interactive Financial Planning System).

• International Journal of Naval Architecture and Ocean Engineering
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• 제6권4호
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• pp.775-787
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• 2014

Availabilities of subsea Blowout Preventers (BOP) in the Gulf of Mexico Outer Continental Shelf (GoM OCS) is investigated using a Markov method. An updated ${\beta}$ factor model by SINTEF is used for common-cause failures in multiple redundant systems. Coefficient values of failure rates for the Markov model are derived using the ${\beta}$ factor model of the PDS (reliability of computer-based safety systems, Norwegian acronym) method. The blind shear ram preventer system of the subsea BOP components considers a demand rate to reflect reality more. Markov models considering the demand rate for one or two components are introduced. Two data sets are compared at the GoM OCS. The results show that three or four pipe ram preventers give similar availabilities, but redundant blind shear ram preventers or annular preventers enhance the availability of the subsea BOP. Also control systems (PODs) and connectors are contributable components to improve the availability of the subsea BOPs based on sensitivity analysis.

• IMMUNE NETWORK
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• 제22권5호
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• pp.43.1-43.12
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• 2022

Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened novel chemical inhibitors targeting OC differentiation to identify drug candidates for metabolic bone diseases. We identified that 1,3-dibenzyl-5-fluorouracil, also named OCI-101, is a novel inhibitor of osteoclastogenesis. The formation of multinucleated OCs is reduced by treatment with OCI-101 in a dose-dependent manner. OCI-101 inhibited the expression of OC markers via downregulation of receptor activator of NF-κB ligand and M-CSF signaling pathways. Finally, we showed that OCI-101 prevents ovariectomy-induced bone loss by suppressing OC differentiation in mice. Hence, these results demonstrated that OCI-101 is a good drug candidate for treating metabolic bone diseases.

• 한국의료질향상학회지
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• 제12권1호
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• pp.104-112
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• 2006

Background : The necessity of unify and standardize codes used at hospital has been emphasized since OCS (Order Communicating System) was adopted. Therefore, the purpose of this study were to standardize operation code by continuous training of the ICD-9-CM code that is used as standard code in OCS program at operating room. Method : In 400 operation data, operation code entered in OCS program at operating room was compared to operation name recorded in medical record. In addition, a matching rate between input data of operation code by medical record department and computing input data of operation code in 3,710 cases was compared for each department. User operation name and operation code were matched and major diagnosis by operation department and operation name were also matched. Results : User operation name was reflected in operation classification code in detail, and operation code entered on user was registered. Input rate and matching rate of operation code were gradually improved after improvement activity. In particular, a matching rate was high at ophthalmology where operation name is segmented. Plastic surgery and orthopedics with a lot of emergency operation and comprehensive operation name show low input rates. Conclusions : As the medical field makes progress in computerlization, awareness of information exchange and sharing becomes higher. Among codes to classified medical institution, codes related to surgical operation are all different by user of hospital and department. Computerlization and standardization is essential. And when efforts of standardization continue in alliance with individual hospital and institution, initiative of preparing medical policy data at a national level will be accelerated.

• 한국환경농학회지
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• 제28권2호
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• pp.209-220
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• 2009

옥타클로르스티렌은 환경중에서 잔류성이 높아 쉽게 분해되지 않으며 먹이연쇄상의 생물상에 고농도로 축적될 뿐만 아니라 환경 및 인간에 대한 독성이 매우 높은 물질군으로 알려져있다. 따라서 본 연구에서는 옥타클로르스티렌에 대한 노출위험 가능성이 있는 오염 우려지역을 설정하여 그 지역의 수질, 토양 및 어류에 대한 옥타클로르스티렌의 잔류량을 조사하기 위해서 잔류분석법을 확립하고 잔류실태를 조사하였다. 그 결과 옥타클로르스티렌의 물에 대한 회수율은 93.1${\sim}$토양에 대한 회수율은 90.4${\sim}$94.8%, 어체에 대한 회수율은 81.5${\sim}$90.2% 이었고 분석법의 검출한계는 물 0.0004 mg $L^{-1}$이었고, 토양 및 어체는 각각 0.002 mg $L^{-1}$이었다. 오염 우려지역으로 선정된 울산, 여수, 대전 및 시화공단에서 옥타클로르스티렌의 잔류량은 물, 토양 및 어체의 모든 시료에서 검출한계 미만이었고, 전국 각지의 소각장을 대상으로 실시한 토양시료에서도 옥타클로르스티렌은 검출되지 않았다. 따라서 우리나라는 아직 옥타클로르스티렌이 노출로부터 위험성이 없는 것으로 판단된다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권1호
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• pp.9-17
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• 2018

Background: The structure and function of bone tissue is maintained through a constant remodeling process, which is maintained by the balance between osteoblasts and osteoclasts. The failure of bone remodeling can lead to pathological conditions of bone structure and function. Remifentanil is currently used as a narcotic analgesic agent in general anesthesia and sedation. However, the effect of remifentanil on osteoclasts has not been studied. Therefore, we investigated the effect of remifentanil on pre-osteoclast (pre-OCs) differentiation and the mechanism of osteoclast differentiation in the absence of specific stimulus. Methods: Pre-OCs were obtained by culturing bone marrow-derived macrophages (BMMs) in osteoclastogenic medium for 2 days and then treated with various concentration of remifentanil. The mRNA expression of NFATc1 and c-fos was examined by using real-time PCR. We also examined the effect of remifentanil on the osteoclast-specific genes TRAP, cathepsin K, calcitonin receptor, and DC-STAMP. Finally, we examined the influence of remifentanil on the migration of pre-OCs by using the Boyden chamber assay. Results: Remifentanil increased pre-OC differentiation and osteoclast size, but did not affect the mRNA expression of NFATc1 and c-fos or significantly affect the expression of TRAP, cathepsin K, calcitonin receptor, and DC-STAMP. However, remifentanil increased the migration of pre-OCs. Conclusions: This study suggested that remifentanil promotes the differentiation of pre-OCs and induces maturation, such as increasing osteoclast size. In addition, the increase in osteoclast size was mediated by the enhancement of pre-OC migration and cell fusion.