• Journal of Oriental Medical Thermology
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• v.2 no.1
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• pp.11-16
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• 2003

Purpose D.I.T.I. can be used to diagnose the dysmenorrhea and prove the Oriental Medical Theory and the Sasang Constitutional Medicine concerning Dysmenorrhea. According to the Sasang Constitutional Medicine, we chose 39 dysmenorrhea patients (Soeumin 26 Patients, Taeumin 13 Patients) and expremented D.I.T.I. to find difference of chilliness and fever in the upper part of body and the lower part of body. Methods We expremented 39 dysmenorrhea patients chosena expremental group from Apr 1. 2002 to May 30, 2002. We diagnosed the constitution by Q.S.C.C. and selected six acu-points CV-17, CV-12, CV-4, G-21, B-15 and B-23. To appraise difference of temperature according to constitution we compared skin temperature of front to back. Result Mean Absolute Value of ${\Delta}T$ in body (front and back) shows significant difference. Totally the temperature of front is higher than the temperature of back. the temperature of Soeumin is higher than the temperature of Taeumin in whole. Conciusion Especially the upper abdomen area(CV-17) shows high temperature in 39 dysmenorrhea patients, the lower abdomen area (CV-4) of Soeumin shows lower temperature relatively.

• Journal of Oriental Medical Thermology
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• v.7 no.1
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• pp.1-13
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• 2009

Purpose: To evaluate the hot flush relief efficacy of Yiseontang-gami in climacteric women with hot flushes, a vasomotor symptom. Methods: The 20 subjects who signing on the clinical trial written consent by self-will is registered this clinical trial after decided suitable by selection and exception standard, after take a medical experiment and checkup according to clinical trial plan. Registered subject should valuated by settled schedule after take the testing medicine(Yiseontang-gami)during thirty-day. The evaluating indexes of this trial are hot flush VAS, hot flush frequency, hot flush consistence time, sweating VAS, palpitation VAS, sleep disturbance VAS, MRS, MENQOL, PGA. Results: The results were as follows 1. 4 subjects dropped out of the clinical trial and 16 subjects completed it. 2. After Yiseontang-gami treatment, hot flush VAS, hot flush frequent, sweating VAS, Palpitation VAS, sleep disturbance VAS improved significantly. 3. After Yiseontang-gami treatment, hot flush consistence time was not improved significantly. 4. After Yiseontang-gami treatment, blood test value were not different significantly. Conclusion: In this clinical trial we consider that Yiseontang-gami is suitable treatment for the hot flushes and related symptoms.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.168-178
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• 2008

Purpose: To verify the relationship of SA2000E results and acupuncture treatment efficacy on postmenopausal women. Methods: Longitudinal analyze relationship of the SA2000E results and hot flush VAS score changes of a clinical trial participants in 2006. Results: Someone who has high Vaso-aging degree by SA2000E represented better hot flash VAS decreasing efficacy. And the diminution rate of hot flash VAS, after 1week from the 1st treatment day was 0.311(p=0.0001), and finally 0.672(p = 0.0396). There are no statistical differences between study group and control group. Conclusion: Clinical trial participant who has better Vaso-physiological function present more hot flash reduce efficacy by acupuncture therapy. Vaso-aging degree by SA2000E could be use as a predictor of acupuncture hot flash treatment result.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.3
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• pp.171-189
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• 2011

Objectives: Female Sexual Dysfuction(FSD) is a common gynecologic condition and its prevalence is more higher than men. Despite its high prevalence and clinical importance, research on FSD is not enough in both of oriental and western medicine. The purpose of this study is to review research tendency of recent oriental medicine studies on FSD and to suggest the following research on FSD. Methods: We searched oriental medicine papers related to FSD published in the last 10 years(2001-2011) through Korean Medicine Gynecology Society database, KISS, RISS, NDSL, CNKI(China National Knowledge Infrastructure), and Pubmed. Results: 26 papers were searched, then 18 papers of them were related to Traditional Chinese Medicine(TCM), 8 papers of them were related to Korean Medicine(KM). In classification according to paper type, 16 papers were clinical study, 1 paper was experimental study, 2 papers were bibliographic study, and 7 papers were the other study. Then 5 papers of clinical study was Randomized Controlled Trial(RCT). Conclusion: There was a lack of oriental medicine research on FSD. On the base of this study, so further research is needed. Especially, Clinical trials such as RCT have strong objective evidence power in the viewpoint of Evidence Based Medicine(EBM) are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.3
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• pp.116-126
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• 2011

Objectives: To identify the difference of autonomic nervous system activity in women with overactive bladder between women with pre-menopausal onset and post-menopausal onset. Methods: Total of 46 women with overactive bladder participated in this study. Patients were categorized in two groups, patients with pre-menopausal onset(n=31) and post-menopausal onset(n=15). We measured and compared parameters of Heart Rate Variability of patients. The results were analysed using SPSS for windows 12.0. Results: On frequency domain analysis, the patients with post-menopausal onset had significantly decreased mean value of Total Power, High Frequence, Low Frequence, compared with the patients with post-menopausal onset. Conclusion: Decreased Total Power of patients with post-menopausal onset indicated that they may have had decreased activity of autonomic nervous system. Also, the patients with pre-menopausal onset had relatively increased sympathetic activity than the patients with post-menopausal onset.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.2
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• pp.25-42
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• 2007

Purpose : Uterine leiomyoma (fibroids) are benign smooth muscle tumors originating from the myometrium. These benign neoplasms of monoclonal origin are typically diagnosed during the reproductive years, occurring only after puberty and tending to regress after menopause. In the present study we used Chiljehyangbu-hwan to determine its growth inhibitory effect and apoptosis in human uterine leiomyoma cells. Methods : Primary cultured human uterine leiomyoma cells were treated with Chiljehyangbu-hwan. Cell viability analysis was analyzed by MTS assay and FACS was performed to ascertain the effects Chiljehyangbu-hwan. DNA fragmentation analysis and casapase-3 activity test were done. Expression of apoptosis related proteins were evaluated by Western blot analysis. Results : Cell viability was significantly influenced by Chiljehyangbu-hwan treatment in a dose-dependent manner in leiomyoma cells compare to normal myometrial cells. FACS showed that Chiljehyangbu-hwan induced Sub G1 arrest. DNA fragmentation assay was carried out and apoptosis was detected. Activation of caspase-3, down-regulation of Bcl-2, with concomitant increased expression in Bid and Bax were observed. Chiljehyangbu-hwan treatment of uterine leiomyoma cells resulted in a concentration-dependent cell death induced via the mitochondrial pathway.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.2
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• pp.83-102
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• 2014

Objectives: This study aimed to review Korean medical clinical management of female overactive bladder (OAB). Methods: We reviewed domestic and foreign papers related to Korean Medicine Treatment for OAB and literatures on Korean Medicine added clinical views of authors. Results: OAB is usually diagnosed to Deficiency pattern (Kidney qi deficiency-cold, Spleen-Lung qi deficiency et al.). The primary treatment goals of OAB is improvement of urinary symptom. But a comprehensive treatment approach including improvement of accompanied symptoms such as depression, insomnia, sexual dysfunction and improvement of quality of life is needed. Warming and tonifying herbal medicine, electro-acupuncture and moxibustion using acupoints specially acting bladder function in lower abdomen and lumbar-sacral area and behavioral therapies such as lifestyle modification, bladder training are usually primary treatments. Treatment period is recommended about 3~6 months to recover and stabilize bladder function. Conclusions: OAB is a clinical area that Korean Medicine tend to be more effective. but additional research about Korean Medical Clinical Management of OAB is needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.2
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• pp.108-124
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• 2008

Purpose: This study was examined to verify the anti-oxidative effect of Dioscoreae Rhizoma on HeLa cells by proteomic approach. Methods: Aqueous extract was used to treat HeLa cell with different concentrations treated with water or MeOH extract of Dioscoreae Rhizoma. HeLa cells were co-treated with $H_2O_2$ and Dioscoreae Rhizoma extracts. Proteomics was done to identify, characterize, and quantitate proteins expressed in HeLa cells treated by $H_2O_2$ and Dioscoreae Rhizoma. Results: When HeLa cells were Co-treated with $H_2O_2$ and Dioscoreae batatas extracts, 16 proteins identified by 2-DE and MALDI-TOF mass spectrometry and database search. PRDX, HSP27 was major proteins of antioxidant effect by Dioscoreae batatas. Conclusion: Our results suggest that Dioscoreae Rhizoma extracts induce antioxidant effects by regulating proteins such as PRDX, HSP27.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1513-1519
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• 2005

This study carried out to develop the questionnaires that can measure objectively menstrual pain and determine pain index. First, we made questionnaires to measure menstrual pain by VAS, MVRS, VRS and question about trouble of daily life and so on. Then we investigated 1039 women's questionnaires who has the menses. Results are follow as : The questionnaires that can measure objectively menstrual apin and determine pain index was high a correlation coefficient therefore those were used Method of Menstrual Pain(here after MMP) calculation. Those were added and averaged. We examined correlation of calculated MMP and women's questionnaires who has the menses. MMP confidence was high as 99.42% comparatively so we thought MMP was appropriate as the measured method of menstrual pain.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.4
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• pp.31-45
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• 2015

Objectives : The purpose of this study is to examine the relationship between the symptoms of primary dysmenorrhea and pulse energy of Chon, Gwan and Cheok. Methods The subjects of this study who had certain range of dysmenorrhea symptom. The degree of dysmenorrhea were assessed by Visual Analog Scale (VAS), Multidimensional Verbal Rating Scale (MVRS), Cox Menstrual Symptom Scale (CMSS) and measured by 3D Blood Pressure Pulse Analyzer(3D-MAC) tests at menstruation start date. Data analysis included descriptive statistics and multiple linear regression using the SPSS/WIN 18.0 program. Results : The induced results are as follows;The induced results are as follows 1. There were no significant relationship between the pulse energy and the sum values of VAS, MVRS and checking part of severity of CMSS. 2. The frequency domain of CMSS were significantly associated with pulse energy. 3. In linear regression models, the model of Left Chon had the especially highest value of explanatory power. (R ² = 0.517) Conclusions : The pulse energy changes are related to the symptoms of primary dysmenorrhea.