• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6227-6231
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• 2013

In the past, hepatitis B virus (HBV) infection was endemic in the general Korean population. The association of HBV infection with the occurrence of liver cancer has been well demonstrated in several epidemiologic studies. While the mortality rates of liver cancer in Korea have decreased steadily over the last decade, the presence of hepatitis B surface antigen (HBsAg) in mothers remains high at 3-4%, and 25.5% of these HBsAg positive mothers are positive for hepatitis B e antigen (HBeAg). HBV infection caused almost a quarter of hepatocellular carcinoma (HCC) cases and one-third of deaths from HCC. These aspects of HBV infection prompted the Korean government to create a vaccination program against HBV in the early 1980s. In 1995, the Communicable Disease Prevention Act (CDPA) was reformed, and the government increased the number of HBV vaccines in the National Immunization Program (NIP), driving the vaccination rate up to 95%. In 2000, the National Health Insurance Act (NHIA) was enacted, which provided increased resources for the prevention of perinatal HBV infection. Then in 2002, the Korean government, in conjunction with the Korean Medical Association (KMA), launched an HBV perinatal transmission prevention program. The prevalence of HBsAg in children had been high (4-5%) in the early 1980s, but had dropped to below 1% in 1995, and finally reached 0.2% in 2006 after the NIP had been implemented. After the success of the NIP, Korea finally obtained its first certification of achievement from the Western Pacific Regional Office of the World Health Organization (WPRO-WHO) for reaching its goal for HBV control. An age-period-cohort analysis showed a significant reduction in the liver cancer mortality rate in children and adolescents after the NIP had been implemented. In addition to its vaccination efforts, Korea launched the National Cancer Screening Program (NCSP) for 5 leading sites of cancer, including the liver, in 1999. As a consequence of this program, the 5-year liver cancer survival rate increased from 13.2% (1996-2000) to 23.3% (2003-2008). The development of both the primary and secondary prevention for liver cancer including HBV immunization and cancer screening has been of critical importance.

• 문화기술의 융합
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• 제6권3호
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• pp.185-191
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• 2020

본 연구는 상대적으로 인식은 부족하나 점차 교역이 확대되는 동유럽 국가인 루마니아를 대상으로 공공보건시설 색채이미지에 대한 국가 간 문화적, 감성적 인식 차이를 파악하고자 하는 목적을 가진다. 이를 위하여 선행연구 고찰을 통해 색채이미지를 선정하였으며, 공공보건시설인 의료시설 8개소, 사회체육시설 4개소, 요양시설 8개소를 직접 방문하여 환경색채를 측색데이터를 기반으로 설문지를 구성하였다. 한국인 89명, 루마니아인 86명을 대상으로 공공시설 색채이미지에 대한 온라인 설문조사를 실시하였고, SPSS 통계분석 프로그램을 활용하여 빈도 및 교차분석을 실시하여 한국인과 루마니아인의 공공보건시설 색채이미지에 대한 인식차이를 파악하였다. 그 결과, 국가 간 공공보건시설에 대한 색채이미지 인식이 어휘평가와 이미지평가에서 통계적으로 유의한 차이가 있음을 파악하였고, 이는 공공보건시설의 색채이미지가 다른 문화권에 거주하는 집단에게 다른 의미로 해석될 수 있으므로 향후, 이와 관련된 환경 구축 시 문화적 인식차이를 고려해야함을 시사한다.

• 동의신경정신과학회지
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• 제26권2호
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• pp.103-116
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• 2015

Objectives: Medical students suffer from mental health and academic problems due to academic stress. We investigated academic stress and exhaustion along with psychological issues caused by medical education during the years in the School of Korean Medicine. Methods: Two hundred fifty-one university students from the School of Korean Medicine, Pusan National University, were asked to complete the Medical Stress Scale (MSS), Maslach Burnout Inventory-Student Survey (MBI-SS), Positive Affect and Negative Affect Schedule (PANAS), and State-Trait Anxiety Inventory (STAI) three times during each semester for two years from 2013 onwards. We analyzed the influence of school term and vacation on educational stress and negative affect with the T-test. The Pearson's correlation analysis and regression analysis were used to predict changes during the first semester or first years of study in the School of Korean Medicine. Results: Academic stress and burnout increased steadily until the first semester of third grade, which was measured with MSS and MBI-SS. The anxiety level was highest when the students started the first grade and it decreased significantly after the first semester. Negative affect repeatedly increased significantly after each school term; however, it reduced after each vacation. In the first grade, 19.5% of the last measure of MSS can be explained with the first measure of MSS. Discussion: This study extensively reviewed the trends and characteristics of four years of academic stress and its related psychological influence, and discussed its importance for developing a more efficient academic curriculum for traditional Korean Medicine.

• 한국방사선학회논문지
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• 제12권1호
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• pp.53-64
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• 2018

AUDIT-K(한국형 알코올 중독 간이선별 검사법)을 이용하여 일상적으로 생활하고 있는 상당수의 잠재적인 위험 음주자들을 선별 할 수 있었으며 연령, 종교, 결혼여부, 직업, 소득음주사망 가족력, 음주시작 연령, 흡연, BMI(체질량지수)는 통계적으로 유의한 차이가 없었으며, 학력, 음주기간만 통계적으로 유의하였다. 이러한 결과는 교육을 더 받은 사람의 남성이 알코올 소비가 더 높다고 한 선행연구와 부합하는 결과를 나타내었으며 교육수준 또한 무엇을 어떻게 배웠는가에 따른 차이를 살펴 볼 필요가 있음을 시사하며, 교육에 따른 알코올 소비도 각각 다른 결과를 나타냄을 알 수 있다. 또한 나이가 적을수록 술을 많이 마시면 음주기간이 길어질 것이고 기존의 음주시작 연령에 대한 연구와 일치하는 결과가 나타났다. 본 연구에서는 음주 기간이 알코올 사용 장애의 가장 큰 요인이었으며 음주 기간을 단축하기 위한 방법으로는 음주 시작 연령을 최대한 늦출 수 있는 국가 정부 제도의 대책 및 교육이 필요하다고 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3129-3132
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• 2014

Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.131-134
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• 2016

Breast cancer is the most common malignancy and also the second leading cause of cancer death among women and also in women that have a high mortality. Previous studies showed that magnesium (Mg) has cytotoxic effects on malignant cell lines. However, the anti-cancer effects of Mg on MCF-7 breast cancer cells are uncertain. This study was aimed at the comparison of the cytotoxic effect of Mg salt (MgCl2) and cisplatin on MCF-7 cells and fibroblasts (as normal cells). After treatment with various concentrations of MgCl2, and cisplatin as a positive control for 24 and 48 hours (h), cytotoxicity activity was measured by MTT assay. In addition, apoptosis was determined by annexin V/propidium iide assay. Both cisplatin and the MgCl2 exhibited dose-dependent cytotoxic effects in the MCF-7 cell line, although the LD50 of the Mg was significantly higher when compared to cispaltin ($40{\mu}g/ml$ vs. $20{\mu}g/ml$). Regarding annexin V/propidium results, treatment of MCF-7 cells with LD50 concentrations of cisplatin and Mg showed 59% and 44% apoptosis at 24h, respectively. Finally, the results indicated that Mg has cytotoxic effects on MCF-7 cells, but less than cisplatin as a conventional chemotherapeutic agent. However, regarding the side effects of chemotherapy drugs, it seems that Mg can be considered as a supplement for the treatment of breast cancer.

• 한방재활의학과학회지
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• 제28권1호
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• pp.73-84
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• 2018

Objectives While Temporomandibular disorders (TMD) is highly prevalent in Korea, studies examining its Korean medical treatment are currently lacking. The aim of this study was to assess current Korean medical treatment practice patterns for TMD. Methods A preliminary questionnaire was developed to investigate current practice patterns of TMD treatment and underwent further revision through external review. The final questionnaire was distributed as a web-based survey to 18,289 potential respondents by email. Results The response rate was 2.23%. Most participants replied that they received multiple Korean medicine interventions for TMD treatment consisting of such methods as acupuncture, chuna manipulation, electroacupuncture. The percentage of treatment services among uncovered services, which need to be covered by national health insurance was high in the order of pharmacopuncture, chuna manipulation, and herbal medicine. The most commonly used diagnostic examination tools for TMD was Physical examination and next was Imaging diagnosis. The frequency of TMD treatment was the highest at 2~3 times per week (76%) and the period was from 4 to 12 weeks (63%). Conclusions This survey study helps determine current practice patterns of TMD, and recognizes the need for use of diagnostic devices in TMD treatment. These results are further anticipated to provide basic data for clinical practice guide lines (CPGs).

• 한국산학기술학회논문지
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• 제21권9호
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• pp.358-372
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• 2020

본 연구는 성인의 인지예비능, 주관적 기억감퇴, 우울 및 삶의 질 등과 같은 요인들이 인지기능에 미치는 직·간접 효과를 규명하고자 하였다. 연구 대상자는 만 40세 이상 80세 미만의 성인 남녀 253명을 대상으로 설문 조사하였고, 본 연구에 사용된 도구는 인지기능 척도, 우울 척도, 삶의 질, 주관적 기억감퇴, 인지예비능 척도를 사용하였다. 데이터 결과는 SPSS 25.0를 이용하여 분석하였고, PROCESS macro for SPSS Version 3.3과 부트스트래핑 방법을 활용하였다. 연구결과, 성인의 인지예비능은 우울과 삶의 질에 영향을 미치는 것으로 나타났으며, 인지예비능과 인지기능의 다중 매개 결과는 우울 및 주관적 기억감퇴에서 매개효과가 나타나지 않았다. 그러나 삶의 질은 성인의 인지예비능과 주관적 인지기능 간의 관계에서 완전매개효과를 나타냈다. 본 연구결과를 토대로 성인들은 다양한 활동과 지속적인 훈련을 통해 인지예비능을 꾸준히 축적하여 인지기능이 긍정적인 방향으로 이어지도록 하는 것이 필요하다. 또한 건강한 성인들을 대상으로 한 인지예비능과 인지기능을 위한 많은 연구들이 실행되기를 제언한다.

• Journal of Preventive Medicine and Public Health
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• 제35권1호
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• pp.1-12
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• 2002

Objective : To estimate the socioeconomic costs of obesity in Korea,1998. Methods : The 1998 National Health and Nutrition Examination Survey(1998 NHNES) data was used and 10,880 persons who had taken health examinations were selected for study. Essential hypertension, NIDDM(non insulin-dependent diabetes mellitus), dyslipidemia, osteoarthritis, coronary heart disease, stroke were included as obesity related disease. The data of direct costs of obesity was obtained from the National Federation of Medical Insurance. The category of indirect costs was the loss of productivity caused by premature death and admission, time costs, traffic costs, nursing fees due to obesity. Multiple logistic regression model was developed to estimate prevalence odds ratio by obesity class adjusted demographic and socio-ecnomic factors and calculate PAF(Population Attributable Fraction) of obesity on obesity related disease. And we finally calculated the socioeconomic costs of obesity in relation to BMI with PAF. Results : The direct costs of obesity were 2,126 billion${\sim}965$ billion Won in considering out of pocket payment to uninsured services, and the indirect costs of obesity were 2,099 billion${\sim}1,086$ billion Won. Consequently, in considering out of pocket payment to uninsured services, the socioeconomic costs of obesity were 4.225 billion${\sim}2,050$ billion Won, which corresponded to about $0.094%{\sim}0.046%$ of GDP and $1.88%{\sim}0.91$ of total health care costs in Korea. Conclusions : Obesity represents a major health problem with significant economic implications for the society. This results are conservative estimates as far as all obesity related disease and all health care and indirect costs were not included due to missing information. further studies are needed to caculate socioeconomic costs of obesity more exactly.

• 대한수의사회지
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• 제20권4호
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• pp.233-238
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• 1984

본 시험은 천연기념물 제265호인 182일령 한국재래종 오골계 20수(남 ; 10, 여 ; 10수)를 대상으로 정상혈액상을 구명하고 성별로 비교하여 유의성을 검정했던 바 다음과 같은 성적을 얻었기에 보고하는 바이다. 1. 적혈구치, 혈색소치 및 적혈구용적은 각각평균 $3.23\pm0.29\times10^6/{\mu}{\iota}$, 11.75$\pm$2.27g/100m1 및 33.41$\pm$4.85ml/100m1를 나타냈으며 이들은 공히 수컷이 암컷에 비해 그 수치가 다소 높았으나 성별 간에 유의성은 없었다. 2. 평균적혈구용적, 평균적혈구혈색소양 및 평균적혈구혈색소농도의 평균치는 각각 102.65$\pm$17.45f1, 36.36$\pm$6.20pg, 및 34.44$\pm$0.63g/100m1을 나타냈으며 성별간에 비슷한 경향이었다. 3. 백혈구수는 평균 $16.33\pm4.75\times10^3/{\mu}{\iota}$ 이고 성별간의 유의성은 없었으며 동요범위는 매우 넓었다. 4. 혈소판수의 평균치는 $2.85\pm0.43\times10^5/{\mu}{\iota}$ 이고 남; 2.79$\pm$0.55, 여 $2.95\pm0.37\times10^5/{\mu}{\iota}$ 으로서 남이 여에 비하여 다소 높았으나 성별간에 유의차는 인정되지 않았다. 5. 백혈구감별계수의 평균치는 Neutrophile $25.8\pm5.32\%$, Lymphocyte $59.1\pm6.48\%$, Eosinophile $3.0\pm1.50\%$, Basophile $2.6\pm1.14\%$ 및 Monocyte $9.5\pm2.95\%$로 성별간에 비슷한 수치를 보였다. 6. 적혈구의 크기는 장경$\times$단경$\times$두께가 남 $13.06\pm0.53{\mu}{\times}8.66\pm0.22{\mu}{\times}3.49\pm0.07{\mu}$, 여 $12.71\pm0.51{\mu}{\times}8.55\pm0.24{\mu}{\times}3.44\pm0.06{\mu}$을 나타내었다. 7. 각 측정치에 있어서 성별간에 대체적으로 차이를 보였으나 유의차는 인정되지 않았다.