• Communications for Statistical Applications and Methods
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• 제29권2호
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• pp.239-250
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• 2022

In many applications, we frequently encounter correlated multiple outcomes measured on the same subject. Joint modeling of such multiple outcomes can improve efficiency of inference compared to independent modeling. For instance, in developmental toxicity studies, fetal weight and number of malformed pups are measured on the pregnant dams exposed to different levels of a toxic substance, in which the association between such outcomes should be taken into account in the model. The number of malformations may possibly have many zeros, which should be analyzed via zero-inflated count models. Motivated by applications in developmental toxicity studies, we propose a Bayesian joint modeling framework for continuous and count outcomes with excess zeros. In our model, zero-inflated Poisson (ZIP) regression model would be used to describe count data, and a subject-specific random effects would account for the correlation across the two outcomes. We implement a Bayesian approach using MCMC procedure with data augmentation method and adaptive rejection sampling. We apply our proposed model to dose-response analysis in a developmental toxicity study to estimate the benchmark dose in a risk assessment.

• 한국운동역학회지
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• 제26권2호
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• pp.221-228
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• 2016

Objective: The purpose of this study was to investigate differences in gait parameters and symmetry between walking speed by using the Froude number and preferred walking speed. Method: Fifty adults (age: $21.0{\pm}1.7years$, body weight: $71.0{\pm}9.2kg$, height: $1.75{\pm}0.07m$, leg length: $0.89{\pm}0.05m$) participated in this study. Leg length-applied walking speed was calculated by using the Froude number, defined as Fr = ${\upsilon}^2$/gL, where v is the velocity, g is the gravitational acceleration, and L is the leg length. Video data were collected by using eight infrared cameras (Oqus 300, Qualysis, Sweden) and the Qualisys Track Manager software (Qualisys, Sweden), with a 200-Hz sampling frequency during two-speed walking (preferred walking speed [PS] and leg length-applied walking speed [LS]) on a treadmill (Instrumented Treadmill, Bertec, USA). The step length, stride length, support percentage, cadence, lower joint angle, range of motion (ROM), and symmetry index were then calculated by using the Matlab R2009a software. Results: Step and stride lengths were greater in LS than in PS (p < 0.05). The right single-support percentage was greater in LS than in PS (p < 0.05). The hip joint angle at heel contact and toe-off were greater in LS than in PS (p < 0.05). The hip and knee joint ROM were greater in LS than in PS (p < 0.05). Conclusion: Based on our findings, we suggest that increased walking speed had a significant effect on step length, stride length, support percentage, and lower joint ROM.

• 산업경영시스템학회지
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• 제20권44호
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• pp.311-321
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• 1997

The development of Joint-Logistics System(JTS) for small/medium sized companies has been proposed for, particularity, Namdong Indusrial Complex located in Incheon. In this paper, JTS methodology is introduced and characterized in terms joint-control transportation, material handling and storage and order receipt. This methodology, which is unprecedented in Korea, has been considerably investigated and developed to implement a feasible model in Japan. A number of successful cases in Japanese companies are also presented to show how it works.

• 대한한방부인과학회지
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• 제22권2호
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• pp.1-25
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• 2009

Purpose: The purpose of this study is to investigate the anti-arthritis effects of Jeonsaenghwalhyeoltanggamibang(JHTG) on collagen-induced arthritis(CIA) in mice. Methods: To assess the effects of JHTG on CIA in mice, we conducted several experiments such as analysis of arthritis index, cell count of draining lymph node(DLN) and paw joint, measurement of serum antibody levels and observation of the histological changes of joint. Results: 1. JHTG extract had a suppressive effect on the arthritis index of paw joints in CIA mice. 2. JHTG extract increased the total cell number of DLN, and decreased the total cell number of paw joints in CIA mice. 3. JHTG extract increased the absolute number of various cell surface receptors in DLN, and decreased the absolute number of B220+/CD23+ cells in DLN in CIA mice. 4. JHTG extract decreased the absolute number of CD3+, CD4+, CD11b+/Gr-1 cells in paw joint in CIA mice. 5. JHTG extract didn't decrease the absolute number of CD4+/CD25+ cells in paw joints in CIA mice. 6. JHTG extract decreased levels of total IgM in the serum of CIA mice, but had no effect on levels of collagen II specific antibody. 7. JHTG extract decreased the destruction of articular cartilages and collagen fibers and the proliferation of synovial cells in paw joints from CIA mice. Conclusion: These results indicate that JHTG has clinical potential for the treatment of rheumatoid arthritis by modulating the immune response.

• 한국공간구조학회논문집
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• 제21권3호
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• pp.35-42
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• 2021

An experimental study was carried out to evaluate the shear performance at the interface composed of structural laminates and concrete. The main variables are the number of CLT layers and the shape of the shear connector. The number of CLT layers consisted of 3 and 5 layers. A total of 6 test specimens for shear performance evaluation were prepared in the form of a shear connector, a direct screw type and a vertically embedded type. As a result of the experiment, similar behavior was shown in all specimens, regardless of the number of layers, including direct screw type (SC series) and vertically embedded type (VE series). The behavior at the joint surface was damaged due to the occurrence of initial shear cracks, expansion of shear groove cracks, and splaying at the interface after the maximum load.After the maximum load, the shear strength decreased gradually due to the effect of the shear connector. It can be seen that the shear strength of all specimens is determined by shear and compression stress failure of concrete at the interface of the notch joint.

• 대한통합의학회지
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• 제11권3호
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• pp.171-183
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• 2023

Purpose : This study sought to investigate research trends regarding joint mobilization type among patients with shoulder joint diseases. Methods : A scoping review was conducted according to the five steps outlined by Arskey and O'Malley and PRISMA-ScR. We searched six domestic databases (ScienceOn, DBpia, Riss, Kmbase, Kiss, KCI) and three international databases (CINAHL, Pubmed, Cochrane central) between 2013 and June 2023. The keyword terms used were 'joint mobilization', 'Kaltenborn', 'Maitland', 'Mulligan', and 'shoulder joint'. Results : There were a total of 44 studies that investigated the topic, and these were divided into quantitative analysis and topic analysis. In terms of publication year, the number of studies within the last five years has increased more than compared to the previous five years, with most of them being randomized clinical trials. In shoulder joint diseases, it was found that the majority of joint movement studies focused on adhesive joint cystitis and shoulder collision syndrome. The Mulligan concept was the most commonly studied type of joint motion. The dependent variables used included pain, joint function (disability), and muscle function. The visual analog scale was the most commonly used for the pain variable, followed by the numeric rating scale. For joint function and disability variables, range of motion was the most commonly used, followed by shoulder pain and disability index, and disabilities of the arm, shoulder, and hand. For muscle function, variables such as muscle tone, strength, and activity were used. Conclusion : We believe that findings of this scoping review can serve as valuable mapping data for joint mobilization research on shoulder joint diseases. Further studies including systematic reviews and meta-analyses based on these results are recommended.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제48권1호
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• pp.33-40
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• 2022

Objectives: Prolotherapy is a method that has gained popularity in recent years and has been reported to have positive short-term and long-term clinical results in maxillofacial surgery, especially temporomandibular joint (TMJ) hypermobility. This study aimed to evaluate the changes in the trabecular structure of mandibular condyles in patients who underwent prolotherapy due to TMJ hypermobility using the fractal analysis method. Materials and Methods: Forty-five patients who received dextrose prolotherapy at a concentration of 20% and fifteen control patients were included in the study. All patients had panoramic radiographs just before (T0) and six months after treatment (T1). The patients who received treatment were divided into three groups according to the number of prolotherapy injections. The regions of interest were selected from bone areas close to the articular surfaces of the condyles. The fractal dimension (FD) values were calculated. Results: The main effect of time on the FD value was significant [F (1, 56)=86.176, P<0.001]. This effect was qualified by a significant time×group interaction effect [F (3, 56)=9.023, P<0.001]. The decreases in FD values in all treatment groups between T0 and T1 times were significant (P=0.004). However, changes in FD values were not significant in the control group (P=0.728). Conclusion: Dextrose prolotherapy without the effect of the number of injections caused a decrease in FD values in the mandibular condyles over time.

• Journal of Korean Neurosurgical Society
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• 제38권5호
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• pp.338-343
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• 2005

Objective : The sacroiliac joint complex is often related with functionally incapacitating pain in old aged people. The purpose of this study is to delineate the investigation strategies and to determine the long-term effect of radiofrequency [RF] neurotomies for pain arising from sacroiliac Joint dysfunction[SIJD]. Methods : Sixteen patients were diagnosed as having chronic pain from SIJD by comparative controlled blocks on L5 dorsal rami, sacroiliac Joints and deep interosseous ligaments. After confirming the positive response [more than 50% of pain relief], sensory stimulation was applied to detect the 'pathological' branches. Subsequently, RF neurotomies were performed on the selected nerve branches. Surgical outcome was graded as successful, moderate improvement, and failure after a 6month follow-up period. Results : Stimulation intensity was 0.45V to elicit pain response in the L5 dorsal rami and lateral sacral branches. The number of RF-lesioned nerve branches was 6per patient. The average number of lesions for each branch was 1.3. Most commonly selected branches were L5 dorsal ramus [88%] and S2-upper division [88%]. Ten patients [63%] reported a successful outcome according to the outcome criteria after 6months of follow-up, and five patients [31%] reported complete relief [100%]. Five patients [31%] showed moderate improvements. One patient reported failure. Conclusion : RF neurotomy of lateral sacral branches is an excellent treatment modality for the pain due to SIJD, provided that comparative controlled block shows a positive response.

• 근관절건강학회지
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• 제5권1호
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• pp.72-82
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• 1998

The purpose of this study was to identify functional impairment and psychological status and to analyze their relationships in patients with chronic arthritis. The sample was consisted of 75 arthritic patients who visited H hospital and S welfare center. Functional impairment was measured by ADL, pain, and the number of painful joint. Psychological status was measured by depression, self-efficacy, and quality of life. Data was analyzed by frequency, mean ${\pm} SD$, Pearson's correlation coefficient, and Stepwise multiple regression. The results of this study were as follows : 1. In functional Impairment, ADL was below average which means somewhat difficult, pain was above average, and the number of painful joint was 9.20. 2. In psychological status, scores of quality of life was 97.89, depression was 41.28, self-efficacy was 895.35. 3. Pain was negatively correlated to self-efficacy, ADL and quality of life, and positively correlated to depression. 4. Self efficacy and depression explained 45% of the variance in quality of life. Therefore, it is suggested that nursing intervention improving psychological status would be useful for patients with chronic arthritis. Especially, it is very important to implement nursing intervention focused on increasing self-efficacy and decreasing depression.

• 대한기계학회논문집A
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• 제29권9호
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• pp.1175-1182
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• 2005

General systems have many substructures assembled at joints. The bolted joint is generally used in assembling the mechanical parts. However, there are no effective modeling methods to analyze the dynamic characteristics of bolt jointed structure using the finite element (FE) analysis, especially in case of large area contact. Moreover, the design methods for the appropriate bolt locations and the number of bolts considering the dynamic characteristics are not guided properly. In this study, a proper modeling method is developed to simulate the dynamic characteristics of a structure with the large interfaced area using the cone frusta method and spring elements. The natural frequencies are also controlled by adjusting the bolt-joint location and the number of bolts considering relative distances in mode shapes at the interface of bolt-jointed plates. The Modeling method and the optimized design method are verified based on the experimental and the FE analysis results.