• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.3
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• pp.60-67
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• 2016

In cumulative transfer functions, as number of transfer increase, the impact of individual transfer to transfer cost increase linearly or non linearly. This function can effectively explain various passengers's travel behavior who choose their travel routes in integrated transit line networks including bus and railway modes. Using the function, it is possible to simulate general situations such that even though more travel times are expected, less number of transfer routes are preferred. However, because travel cost with cumulative transfer function is known as non additive cost function types in route search algorithms, finding an optimal route in integrated transit networks is confronted by the insolvable enumeration of all routes in many cases. This research proposes a methodology for finding an optimal path considering cumulative transfer function. For this purpose, the reversal phenomenon of optimal path generated in route search process is explained. Also a heuristic methodology for selecting an optimal route among multiple routes predefined by the K path algorithm. The incoming link based entire path deletion method is adopted for finding K ranking path thanks to the merit of security of route optimality condition. Through case studies the proposed methodology is discussed in terms of the applicability of real situations.

• Journal of the Korean association of regional geographers
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• v.9 no.4
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• pp.519-533
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• 2003

The U.S. Conservation Reserve Program (CRP) resulted in the conversion of approximately 14.8 million ha(36.5 million acres) of cropland to grassland, woodland, and other conservation uses throughout the U.S. between 1986 and 1992. One of the major results of CRP has been the addition of millions of hectares of potential wildlife habitat. primarily as grassland. In this study, we examined regional changes in landscape structure caused by the introduction of CRP. Utilizing multi-seasonal Landsat Thematic Mapper imagery, we produced maps of cropland and grassland for the pre- and post- CRP enrollment periods for a six-county region in southwest Kansas. We then applied post-classification differencing to identify regions of cropland that had been converted to CRP. Using the FRAGSTATS spatial pattern analysis program, we calculated a variety of spatial statistics to analyze changes in landscape structure due to CRP. The major impact of CRP in the six-county study area has been the reversal of an overall trend of grassland habitat fragmentation. From the standpoint of potential wildlife habitat, the introduction of CRP has greatly increased the number of patches, mean patch size, and the interior or core area of grassland patches. In addition, CRP has increased connectivity and aggregation between grassland patches, potentially important factors for species of conservation interest, particularly those that require larger expanses of unbroken habitat. Finally, the distance between neighboring patches of grassland has decreased, reducing travel distance between patches. Clearly, the introduction of CRP has substantially modified the spatial structure of the southwest Kansas landscape, with important implications for wildlife habitat.

• Steel and Composite Structures
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• v.13 no.3
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• pp.239-258
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• 2012

In this paper, experimental investigations on high strength steel (HSS) stud connected steel-concrete composite (SCC) girders to understand the effect of shear connector density on their flexural behaviour is presented. SCC girder specimens were designed for three different shear capacities (100%, 85%, and 70%), by varying the number of stud connectors in the shear span. Three SCC girder specimens were tested under monotonic/quasi-static loading, while three similar girder specimens were subjected to non-reversal cyclic loading under simply supported end conditions. Details of casting the specimens, experimental set-up, and method of testing, instrumentation for the measurement of deflection, interface-slip and strain are discussed. It is found that SCC girder specimen designed for full shear capacity exhibits interface slip for loads beyond 25% of the ultimate load capacity. Specimens with lesser degree of shear connection show lower values of load at initiation of slip. Very good ductility is exhibited by all the HSS stud connected SCC girder specimens. It is observed that the ultimate moment of resistance as well as ductility gets reduced for HSS stud connected SCC girder with reduction in stud shear connector density. Efficiency factor indicating the effectiveness of high strength stud connectors in resisting interface forces is estimated to be 0.8 from the analysis. Failure mode is primarily flexure with fracturing of stud connectors and characterised by flexural cracking and crushing of concrete at top in the pure bending region. Local buckling in the top flange of steel beam was also observed at the loads near to failure, which is influenced by spacing of studs and top flange thickness of rolled steel section. One of the recommendations is that the ultimate load capacity can be limited to 1.5 times the plastic moment capacity of the section such that the post peak load reduction is kept within limits. Load-deflection behaviour for monotonic tests compared well with the envelope of load-deflection curves for cyclic tests. It is concluded from the experimental investigations that use of HSS studs will reduce their numbers for given loading, which is advantageous in case of long spans. Buckling of top flange of rolled section is observed at failure stage. Provision of lips in the top flange is suggested to avoid this buckling. This is possible in case of longer spans, where normally built-up sections are used.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.3
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• pp.1-12
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• 2004

Due to the 1989 Loma Prieta, 1995 Hyogoken Nambu earthquakes, etc, a number of bridge columns  were collapsed in flexure-shear failures as a consequence of the premature termination of the column longitudinal reinforcement. Nevertheless, previous researches for the performance of bridge columns were concentrated on the flexural failure mode. It is well understood that the seismic behaviour of RC bridge piers was dependent on the performance of the plastic hinge of RC bridge piers, the ductility of which was desirable to be computed on the basis of the curvature. Experimental investigation was made to evaluate the variation of the curvature of the plastic hinge  region for the seismic performance of earthquake-damaged RC columns in flexure-shear failure mode. Seven test specimens in the aspect ratio of 2.5 were made with test parameters: confinement ratios, lap splices, and retrofitting FRP materials. They were damaged under series of artificial earthquakes that could be compatible in Korean peninsula. Directly after the pseudo-dynamic test, damaged columns were retested under inelastic reversal cyclic loading under a constant axial load, $P=0.1f_{ck}A_g$. Residual seismic capacity of damaged specimens was evaluated by analzying the moment-curvature hysteresis and the curvature ductility. Test results show that the biggest curvature was developed around 15cm above the footing, which induced the column failure. It was observed that RC bridge specimens with lap-spliced longitudinal steels appeared to fail at low curvature ductility but significant improvement was made in the curvature ductility of RC specimens with FRP straps wrapped around the plastic hinge region. Based on the experimental variation of the curvature of RC specimens, new equivalent length of the plastic hinge region was proposed by considering the lateral confinement in this study. The analytical and experimental relationship between the displacement and the curvature ductility were compared based on this proposal, which gave excellent result.

• Journal of Nutrition and Health
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• v.48 no.1
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• pp.1-8
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• 2015

Purpose: Anthocyanins from purple sweet potato (PSP) have been investigated in vitro and in animals and found to have a protective effect against oxidative hepatic damage. In this study, we investigated that aqueous extract of PSP can ameliorate the dysfunction of lipid metabolism in mice fed a high fat/cholesterol diet. Methods: Forty C57BL/6J mice were randomly divided into 5 groups (n = 8) and fed one of the following diets for 8 weeks; normal fat (NF) diet; high fat/cholesterol (HFC) diet; HFC with 1.25% PSP (HFPL) diet; HFC with 2.5% PSP (HFPM) diet; HFC with 5% PSP (HFPH) diet. Results: Non-alcoholic fatty liver was manifested in the HFC group by showing increased levels in plasma alanine aminotransferase (ALT) activity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increased level of TC and presence of many large lipid droplets in the liver, and increased fat cell size in the HFC group compared with the NF group. However, administration of HFC induced a significant decrease in food intake, resulting in decrease in fat mass. Co-administration of PSP did not lead to reversal of body weight changes, ALT activity, and lipid levels in plasma and the liver, but suppressed excess enlargement of the fat cell size through increasing carnitine palmitoyltransferase-1 (CPT-1) gene expression in the liver. Accordingly, the number of fat droplets in the liver was reduced in PSP administered groups. Conclusion: Taken together, these results suggest that PSP may have a protective effect on the dysfunction of lipid metabolism. Conduct of further studies on the coordinated regulation of PSP for lipid metabolic homeostasis at the liver-adipose tissue axis is needed.

• Allergy, Asthma & Immunology Research
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• v.10 no.6
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• pp.614-627
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• 2018

Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Methods: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year. First, a hierarchical cluster analysis was performed using Ward's method to generate a dendrogram for the optimum number of clusters using the complete post-FEV1 sets from 448 subjects. Then, a trajectory cluster analysis of serial post-FEV1 sets was performed using the k-means clustering for the longitudinal data trajectory method. Next, trajectory clustering for the serial post-FEV1 sets of a total of 1,679 asthmatics was performed after imputation of missing post-FEV1 values using regression methods. Results: Trajectories 1 and 2 were associated with normal lung function during the study period, and trajectory 3 was associated with a reversal to normal of the moderately decreased baseline FEV1 within 3 months. Trajectories 4 and 5 were associated with severe asthma with a marked reduction in baseline FEV1. However, the FEV1 associated with trajectory 4 was increased at 3 months, whereas the FEV1 associated with trajectory 5 was persistently disturbed over 1 year. Compared with trajectory 4, trajectory 5 was associated with older asthmatics with less atopy, a lower immunoglobulin E (IgE) level, sputum neutrophilia and higher dosages of oral steroids. In contrast, trajectory 4 was associated with higher sputum and blood eosinophil counts and more frequent exacerbations. Conclusions: Trajectory clustering analysis of FEV1 identified 5 distinct types, representing well-preserved to severely decreased FEV1. Persistent airflow obstruction may be related to non-atopy, a low IgE level, and older age accompanied by neutrophilic inflammation and low baseline FEV1 levels.

• The Korean Society of Law and Medicine
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• v.19 no.1
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• pp.207-254
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• 2018

The major court rulings delivered in 2017 include the ruling that separated the legal character of denture production agreement signed together with medical care agreement and found a subcontracting dimension in the former, and the ruling that overcame the limitations of the theory of entire appearance of a fetus as discussed in civil law by using the legal principle of insurance which suggests that unborn child insurance takes effect after the contract is signed and the first installment of the premium is paid in. As more court rulings find the medical specialists responsible for accidents and injuries from drugs, some argue that medication counseling by the druggist who makes and dispenses drugs should be upgraded. And with respect to a court ruling that denied the hospital's responsibility for an infection-involving accident even if there were no records on specific measures taken in infection management, some criticized the court for being too conservative in recognizing responsibilities. And with respect to infectious disease management, some criticized the court for its interpretation and application of the facts in the direction of denying the negligence. In addition, some claimed that it is necessary to establish institutional system for hospital infection control and its aid for victims, and to improve the system including the reversal of the burden of proof given the special nature of hospital infections. A number of rulings on the duty to disclose included the one which stated that the specific matter did not require a doctor's explanation as it was explained or the specific medical service would have been performed even if no explanation had been given. There was a greatly controversial ruling over the scope of indemnification, which accepted the occurrence of multiple scars and deformation as disorders while regarding breast as a thoracic organ. And a Supreme Court ruling over interpreting Medical Service Act was criticized as overstepping the boundary allowed in the law.

• The Journal of the Acoustical Society of Korea
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• v.42 no.6
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• pp.559-564
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• 2023

It is known that change in the bone strength of cortical bone constituting the outer shell of long bones such as the tibia or radius due to aging and osteoporosis is a risk factor for fracture. In this study, the group velocity of time-reversed Lamb waves generated in tibial cortical bone in vivo was measured using a time reversal method, and the correlations of the group velocity with the cortical bone thickness (cTh) and cortical bone mineral density (cBMD) closely related to the bone strength were investigated. It was found that the group velocity of time-reversed Lamb waves measured in the right tibia of 7 subjects showed a very high correlation, r = 0.90 (p < 0.0001), with the cTh and a relatively low correlation, r = 0.69 (p < 0.0001), with the cBMD. A limitation of this in vivo study is that the group velocity of time-reversed Lamb waves was measured for a normal group consisting of only 7 healthy adults. In the future, if the clinical usefulness of the time-reversed Lamb wave is demonstrated by follow-up studies on normal and osteoporotic groups consisting of a large number of healthy adults and osteoporotic patients, respectively, it is expected to improve the reliability of quantitative ultrasound technology for osteoporosis diagnosis. In addition, it is necessary to expand the skeletal site for measuring the group velocity of time-reversed Lamb waves not only to the tibia but also to the femur or radius.

• The Korean Journal of Financial Management
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• v.26 no.1
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• pp.65-94
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• 2009

The event of change in KOSPI 200 Index composition is one of the main subjects for the test of EMH. According to EMH, when a certain event is not related with firm's fundamental value, stock price should not change after the announcement of news. This hypothesis leads us to the conclusion of horizontal demand curve of stock. This logic was questioned by Shleifer(1986) and argued that downward sloping demand curve hypothesis was supported. But Harris and Gruel(1986) found a different empirical evidence that price reversal occurs in the long run, which is called price pressure hypothesis. They argued that short term price effect by large block trading (price pressure) is offset in the long run because these event is unrelated to fundamental value. Therefor, they argued that EMH can not be rejected in the long run. Until now, there are two empirical studies with Korean market data in this area. Using a data with same time period of $1996{\sim}1999$, Kweon and Park(2000) and Ahn and Park(2005) showed that stock price or beta is not significantly affected by change in index composition. This study retested this event expanding sample period from 1996 to 2006, and analyzed why this event was considered an uninformative events in the preceding studies. We analyzed a market impact by separating samples according to firm size and market condition. In case of newly enlisted firm, we found the evidence supporting price pressure hypothesis on average. However, we found the long run price effect in the sample of large firms under bearish markets. At the same time, we know that the number of samples under the category of large firms under bearish markets is relatively small, which drives the same result of supporting the hypothesis that change in index composition is a non-informative event on average. Also, the long run price effect of large size firms under bearish markets was supported by the analyses using trading volumes. On the other hand, in case of delisting from the index, we found the long run price effect but that was not supported by trading volume analyses.

• Journal of Chest Surgery
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• v.23 no.2
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• pp.222-230
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• 1990

Protamine, a polycationic peptide extracted from fish, has been widely used for the reversal of anticoagulant action of heparin. However it may cause untoward circulatory side effects including hypotension and bradyarrhythmia. Nowadays, histamine and prostacyclin are regarded as one of the causative agents in the underlying mechanism of hemodynamic changes. To certify the possible role of histamine and prostacyclin, we observed simultaneous changes of the hemodynamic status, plasma concentration of thromboxane B, and circulating platelet count before and after intravenous injection of protamine. Experimental dogs, weighing 12-14kg, were divided into 2 groups; group A animals [n=10], were pretreated with indomethacin[2.5mg/kg] and group B animals[n=10] were pretreated with chlorpheniramine[0.5mg/kg] Heparin[3mg/kg] and protamine [3mg/kg] were administered sequentially in both groups. The results were as follows ; 1. The mean systemic arterial pressure was maintained well in groups A, whereas in group B it decreased from 165\ulcorner18mmHg to 138\ulcorner30mmHg[p<0.01] and 151\ulcorner21 mmHg[p<0.05] at 1 minute and 2 minutes after protamine injection. The mean pulmonary arterial pressure was not changed significantly in group A, whereas in group B it increased from 852 mmHg to 11\ulcorner3 mmHg[p<0.05], 11\ulcorner3 mmHg[p<0.05] and 10\ulcorner3 mmHg[p<0.05] at 1 minute, 3 minutes and 5 minutes after protamine injection. 2 The thromboxane B2 was not changed significantly in group A, whereas in group B it increased from 399\ulcorner401 \ulcornerg/ml to 744\ulcorner615 \ulcornerg/ml[p<0.05] and 814\ulcorner1070 \ulcornerg/ml [p<0.0 5] at 1 minute and 3 minutes after protamine injection without concomitant changes of pulmonary vascular resistance and pulmonary capillary wedge pressure. 3. The number of circulating platelet was not changed in group A, whereas in group B it decreased from 207100\ulcorner103600/\ulcornerl to 159700\ulcorner90900/\ulcornerl [p<0.05] at 1 minute after protamine injection, Although thromboxane B2 and platelet count were changed significantly after protamine injection, they did not cause the remarkable hemodynamic changes. Considering the above results, hemodynamic changes may be caused mainly by prostacyclin rather than thromboxane or platelet. Therefore, the pretreatment with cyclooxygenase inhibitor would be beneficial to prevent circulatory adverse effects of protamine for the patients undergoing cardiac surgery.