• BMB Reports
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• v.57 no.9
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• pp.381-387
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• 2024

The nucleus, a highly organized and dynamic organelle, plays a crucial role in regulating cellular processes. During cell differentiation, profound changes occur in gene expression, chromatin organization, and nuclear morphology. This review explores the intricate relationship between nuclear architecture and cellular function, focusing on the roles of the nuclear lamina, nuclear pore complexes (NPCs), sub-nuclear bodies, and the nuclear scaffold. These components collectively maintain nuclear integrity, organize chromatin, and interact with key regulatory factors. The dynamic remodeling of chromatin, its interactions with nuclear structures, and epigenetic modifications work in concert to modulate gene accessibility and ensure precise spatiotemporal control of gene expression. The nuclear lamina stabilizes nuclear shape and is associated with inactive chromatin regions, while NPCs facilitate selective transport. Sub-nuclear bodies contribute to genome organization and gene regulation, often by influencing RNA processing. The nuclear scaffold provides structural support, impacting 3D genome organization, which is crucial for proper gene expression during differentiation. This review underscores the significance of nuclear architecture in regulating gene expression and guiding cell differentiation. Further investigation into nuclear structure and 3D genome organization will deepen our understanding of the mechanisms governing cell fate determination.

• Nuclear Engineering and Technology
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• v.56 no.8
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• pp.3286-3297
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• 2024

Traditional text-based system engineering, which has been used in the design and application of passive residual heat removal system (PRHRS) for lead-cooled fast reactors, is prone to several problems such as low development efficiency, long iteration cycles, and model ambiguity. This study aims to effectively address the abovementioned problems by adopting a model-based system engineering (MBSE) method, which has been preliminarily applied to meet the design requirements of a PRHRS. The design process has been implemented based on the preliminary design of the system architecture and consists of three stages: top-level requirement analysis, functional requirements analysis, and design requirements synthesis. The results of the top-level requirements analysis and the corresponding use case diagram can determine the requirements, top-level use cases, and scenario flow of the system. During the functional requirements analysis, the sequence, activity, and state machine diagrams are used to develop the system function model and provide early confirmation. By comparing these sequence diagrams, the requirements for omissions and inconsistencies can be effectively checked. In the design requirements synthesis stage, the Analytic Hierarchy Process is used to conduct preliminary trade-off calculations on the system architecture, after which a white box model is established during the system architecture design. Through these two steps, the analysis and design of the system architecture are ultimately achieved. The resulting system architecture ensures the consistency of the design requirements. Ultimately, a functional hazard analysis was conducted for a specific incident to validate case requirements and further refine the system architecture. Future research can further reduce the design risk, improve the design efficiency, and provide a practical reference for the design and optimization of PRHRS in digital lead-cooled fast reactors.

• Nuclear Engineering and Technology
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• v.54 no.6
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• pp.2321-2328
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• 2022

The passive safety system is adopted in an AP1000 nuclear power unit to improve the operation safety of the whole unit. However, due to boron diffusion and periodic sampling, boron dilution occurs in the core makeup tank. The boron replenishment process in the core makeup tank is essential and becomes particularly important. Based on the validated models, this article numerically investigates the influence of the replenishment flow rate and the position on the boron distribution in the core makeup tank. The thermal fatigue phenomenon of the "T" connection caused by replenishment is analyzed. Finally, the replenishment strategy is proposed to benefit both boron mixing in the core makeup tank and eliminating the thermal fatigue of the "T" connection.

• Journal of Korean Association for Spatial Structures
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• v.24 no.3
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• pp.43-51
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• 2024

Dynamic responses of nuclear power plant structure subjected to earthquake loads should be carefully investigated for safety. Because nuclear power plant structure are usually constructed by material of reinforced concrete, the aging deterioration of R.C. have no small effect on structural behavior of nuclear power plant structure. Therefore, aging deterioration of R.C. nuclear power plant structure should be considered for exact prediction of seismic responses of the structure. In this study, a machine learning model for seismic response prediction of nuclear power plant structure was developed by considering aging deterioration. The OPR-1000 was selected as an example structure for numerical simulation. The OPR-1000 was originally designated as the Korean Standard Nuclear Power Plant (KSNP), and was re-designated as the OPR-1000 in 2005 for foreign sales. 500 artificial ground motions were generated based on site characteristics of Korea. Elastic modulus, damping ratio, poisson's ratio and density were selected to consider material property variation due to aging deterioration. Six machine learning algorithms such as, Decision Tree (DT), Random Forest (RF), Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Artificial Neural Networks (ANN), eXtreme Gradient Boosting (XGBoost), were used t o construct seispic response prediction model. 13 intensity measures and 4 material properties were used input parameters of the training database. Performance evaluation was performed using metrics like root mean square error, mean square error, mean absolute error, and coefficient of determination. The optimization of hyperparameters was achieved through k-fold cross-validation and grid search techniques. The analysis results show that neural networks present good prediction performance considering aging deterioration.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2669-2681
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• 2021

Valve is widely used in the various industry areas to adjust and control the flow. Cavitation frequently takes place and sometimes is inevitable in various types of valve to cause the erosion damage. Therefore, how to control and minimize the effect of cavitation is still an important topic. This study numerically investigates the cavitating flow in a control valve with a perforated cage. The effects of some parameters on the cavitation are discussed. It also discusses to use the throttling steps to govern the cavitating flow. The results show that the opening degree of valve and the length of downstream divergent connection both influence the cavitation. The increase of the divergent length reinforces the cavitation. And the larger the opening of valve is, the intenser the cavitation is and the more vapor is present. The more throttling steps are helpful to decrease the cavitation.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.1047-1048
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• 2005

• Journal of the Korea Institute of Military Science and Technology
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• v.8 no.4 s.23
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• pp.41-49
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• 2005

This work describes the ventilative NBC CPS(Nuclear Biological and Chemical Collective Protection Systems). The operational requirements of NBC CPS is derived using systems engineering approach. The NBC CPS system operational architecture which describes the operational concept of NBC CPS is proposed using a computer aided systems engineering tool.

• Nuclear Engineering and Technology
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• v.53 no.1
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• pp.69-78
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• 2021

Venturi meter is frequently used in feed water flow control system in a nuclear power plant. Its accurate measurement plays a vital role in the safe operation of the plant. This paper firstly investigates the influence of the length of each section of pipeline, the throat inner diameter of Venturi and the flow characteristics in a single-phase flow on the accuracy of Venturi measurement by numerical calculation. Then the flow and the accuracy are discussed in a multi-phase flow. Numerical results show that the geometrical parameters and the characteristics of complex turbulent flow in the single-phase flow have little impact on the accuracy of Venturi flow rate measurement. In the multi-phase flow, the calculated flow rate of Venturi deviated from the actual flow rate and this deviation value is closely related to the amount of steam in the pipeline and increases sharply with the increase of the amount of steam. The over-reading of Venturi flow rate is present.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.353-358
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• 2020

Recent efforts to develop a common standard for nuclear power plants (NPPs) with the aim of creating (1) a digital environment for a better understanding of NPPs life-cycle management aspect and (2) engineering data interoperability by using existing standards among different unspecified project participants (e.g., owners/operators, engineers, contractors, equipment suppliers) during plants' life cycle process (EPC, O&M, and decommissioning). In order to meet this goal, there is a need for formulating a standardized high-level physical breakdown structure (PBS) for NPPs project management office (PMO). However, high-level PBS must be comprehensive enough and able to represent the different types of plants and the new trends of technologies in the industry. This has triggered the need for addressing the issues of the recent operational NPPs and future technologies' ramification for evaluating the changes in the NPPs physical components in terms of structure, system, and component (SSC) configuration. In this context, this ongoing study examines the recent conventional NPPs and technological trends in the development of future NPPs facilities. New reactor models regarding the overlap of variant issues of nuclear technology were explored. Finally, issues on PBS for project management are explored by the examination of the configuration of NPPs primary system. The primary systems' configuration of different reactor models is assessed in order to clarify the need for analyzing the new trends in nuclear technology and to formulate a common high-level PBS. Findings and implications are discussed for further studies.

• Proceedings of the Korean Nuclear Society Conference
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• 2001.10a
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• pp.86.1-86
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• 2001