• 대한기계학회논문집A
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• 제36권1호
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• pp.97-102
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• 2012

원자력발전소의 대체교류발전기는 소내정전에 대처하기 위하여 설치되고 있다. 국내 원자력발전소에서 사용되고 있는 대체교류발전기의 구동형식은 대부분 디젤발전기이다. 가스터빈은 디젤발전기보다 구조가 간단하고 유지정비주기가 길다는 장점이 있지만 국내 원자력발전소에 적용사례가 없다는 단점이 있다. 본 논문의 목적은 APR+ 대체교류발전기의 구동형식을 선정하기 위하여 디젤발전기와 가스터빈의 민감도 분석을 하는 데 있다. 이를 위하여 디젤발전기와 가스터빈의 물리적 특성과 국내의 대체교류발전기 적용현황, 그리고 US-APWR의 비상발전기 및 대체교류발전기의 가스터빈 적용사례를 조사하였다. 마지막으로 신뢰도 데이터에 대한 민감도 분석과 신형 노형인 APR+에 가스터빈 대체교류발전기를 적용하여 노심손상빈도의 민감도를 분석하였다.

• 대한기계학회논문집A
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• 제36권9호
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• pp.1095-1101
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• 2012

수소를 대량으로 생산하기 위한 원자력수소생산시스템에서 공정열교환기(PHE)는 초고온가스로로 부터 생성된 초고온 열을 화학반응공정으로 전달하는 핵심기기이다. 한국원자력연구원에 구축되어 있는 소형 질소가스루프에서 Hastelloy-X로 제작된 소형 및 중형 PHE 시제품들에 대한 성능시험이 수행되고 있다. 그동안 PHE 시제품에 대한 거시적 고온구조해석은 용접 물성치의 부재로 인해 모재의 물성치만을 사용한 해석이 주로 수행되었으나 본 연구에서는 계장형 압입시험법으로부터 얻은 용접부 기계적 물성치를 이용하여 거시적 고온구조해석을 수행하고 그 결과를 비교, 분석하였다.

• Toxicological Research
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• 제33권4호
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• pp.325-332
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• 2017

3-Bromo-4,5-dihydroxybenzaldehyde (BDB) is a natural bromophenol compound that is most commonly isolated from red algae. The present study was designed to investigate the anti-inflammatory properties of BDB on atopic dermatitis (AD) in mice induced by 2,4-dinitrochlorobenzene (DNCB) and on lipopolysaccharide (LPS)-stimulated murine macrophages. BDB treatment (100 mg/kg) resulted in suppression of the development of AD symptoms compared with the control treatment (induction-only), as demonstrated by reduced immunoglobulin E levels in serum, smaller lymph nodes with reduced thickness and length, a decrease in ear edema, and reduced levels of inflammatory cell infiltration in the ears. In RAW 264.7 murine macrophages, BDB (12.5, 25, 50, and $100{\mu}M$) suppressed the production of interleukin-6, a proinflammatory cytokine, in a dose-dependent manner. BDB also had an inhibitory effect on the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$) and signal transducer and activator of transcription 1 (STAT1; Tyr 701), two major signaling molecules involved in cellular inflammation. Taken together, the results show that BDB treatment alleviates inflammatory responses in an atopic dermatitis mouse model and RAW 264.7 macrophages. These results suggest that BDB may be a useful therapeutic strategy for treating conditions involving allergic inflammation such as atopic dermatitis.

• Food Science and Biotechnology
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• 제17권4호
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• pp.745-750
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• 2008

Anti-inflammatory potential of the enzymatic extract prepared by Kojizyme (ECK), a component of brown seaweeds Ecklonia cava (Alariaceae, Phaeophyta) in vivo was investigated. For the application of mouse ear edema model, 12-O-tetradecanoylphorbol acetate (TPA) was used, a topical inducer of a long-lasting inflammatory response. Our results demonstrated that ECK inhibited ear edema when topically applied to mouse ear skin. In histological evaluation, the inhibition activity of ECK on TPA-induced inflammation is similar to that of dexamethasone, although less strong. In addition, the mRNA expression levels of IL-$1{\beta}$, IFN-$\gamma$, TNF-$\alpha$, and cyclooxygenase-2 (COX2) and the immunoreactivity to inducible nitric oxide synthase (iNOS) and COX2 expressed mainly in inflammatory cells were down-regulated by ECK. These results indicate that ECK has anti-inflammatory effects through the inhibition of Th1 cytokines and 2 inducers of inflammation in TPA-induced ear skin edema.

• Bulletin of the Korean Chemical Society
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• 제19권9호
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• pp.934-942
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• 1998

$^13CO$ chemisorbed on platinum particles in L-zeolite has been investigated by static and magic angle spinning NMR spectroscopy. The representative spectra are composed of a broad asymmetric peak with a center of gravity at 230±30 ppm and a sharp symmetric peak at 124±2 ppm which is tentatively assigned to physisorbed $CO_2$, on inner walls of L-zeolite. Overall, the broad resonance component is similar to our previous results of highly dispersed (80-96%) CO/Pt/silica or CO/Pt/alumina samples, still showing metallic characters. The principal difference is in the first moment value. The broad peak in the spectra is assigned to CO linearly bound to Pt particles in the L-zeolites, and indicates a distribution of isotropic shifts from bonding site to bonding site. The NMR results reported here manifest that the Pt particles inside of the L-zeolites channels are not collectively the same with the ones supported on silica or alumina with similar dispersion in terms of Pt particle shape and/or ordering of Pt atoms in a particle. As a result, Pt particles of CO/Pt/L-zeolite were agglomerated accompanying CO desorption upon annealing. There were no definite changes in the NMR spectra due to differences of exchanged cations. Comparison of our observation on CO/Pt/L-zeolite with Sharma et al.'s reveals that even when the first moment, the linewidtb, and the relaxation times of the static spectra and the dispersion measured by chemisorption are similar, the properties of Pt particles can be dramatically different. Therefore, it is essential to take advantage of the strengths of several techniques together in order to interpret data reliably, especially for the highly dispersed samples.

• 한국항행학회논문지
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• 제22권2호
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• pp.154-162
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• 2018

원전 주요계통의 전자카드에는 열화상태를 평가하기 위한 곱셈기가 필요하며, 이것은 두 개의 입력신호를 곱하는 기능을 가진 것으로서 실제 신호처리를 할 때 곱셈의 정확성을 기하기가 어렵다. 곱셈기 회로에서 중요한 것은 곱셈값이 정확해야 된다는 것과 곱셈의 선형성이 완벽해야 한다는 것이다. 본 논문에서는 연산증폭기와 트랜지스터의 특성을 이용하여 선형성이 우수한 곱셈기를 개발하여 본 논문에서 제시하여 정당성을 입증하려 하였다. 이와 같은 개발회로로서 정확한 곱셈과 곱셈의 우수한 선형성을 확보하기 위해 반도체의 비선형적인 요인을 제거하도록 노력하였다. 개발된 회로의 우수성을 입증하기 위해 개발된 회로에 적합한 각종 부품값을 부여하여 시뮬레이션으로서 곱셈연산을 수행하였다. 시뮬레이션 결과로서 단계별로 출력파형을 보였으며, 논리적인 분석치와 측정치를 비교분석하였다. 이 방법은 기존의 방법들에 비하여 곱셈결과와 선형성이 우수하다는 것을 확인하였다.

• 한국정보통신학회논문지
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• 제23권10호
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• pp.1298-1304
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• 2019

9.11 테러 이후 미국을 비롯한 선진국들의 해운물류 안전 보안체계가 크게 강화되었다. 해운물류의 검색에는 강력한 방사선을 투과하여 컨테이너의 내부를 확인하는 컨테이너 검색기 시스템을 주로 사용하는데, 국내에서는 전량 도입품을 적용하여 운용 중이며 국산화 개발에 대한 요구가 증가하고 있다. 이에 본 논문에서는 컨테이너 검색기 시스템의 핵심 구성요소인 X-Ray 어레이 검출 모듈 신호처리 시스템을 개발하여 제안한다. 아날로그 및 디지털 신호처리부를 통합형 하드웨어로 제작하였으며, X-선 데이터의 실시간 수집과 분석을 위해 FPGA 로직과 소프트웨어를 구현하여 시험하였다. 구현된 시스템은 기존 항만에서 사용되는 도입품 대비 해상도와 소비전력 면에서 우세하다.

• Wind and Structures
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• 제34권5호
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• pp.395-405
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• 2022

Tornado-induced damages to high-rise buildings and low-rise buildings are quite different in nature. Tornado losses to high-rise buildings are generally associated with building envelope failures while tornado-induced damages to low-rise buildings are usually associated with structural or large component failures such as complete collapses, or roofs being torn off. While studies of tornado-induced structural damages tend to focus mainly on low-rise residential buildings, transmission towers, or nuclear power plants, the current rapid expansion of city centers and development of large-scale building complexes increases the risk of tornadoes impacting tall buildings. It is, therefore, important to determine how tornado-induced load affects tall buildings compared with those based on synoptic boundary layer winds. The present study applies an experimentally simulated tornado wind field to the Commonwealth Advisory Aeronautical Research Council (CAARC) building and estimates and compares its pressure coefficient effects against the Atmospheric Boundary Layer (ABL) flow field. Simulations are performed at the Wind Engineering, Energy and Environment (WindEEE) Dome which is capable of generating both ABL and tornadic winds. A model of the CAARC building at a scale of 1:200 for both ABL and tornado flows was built and equipped with pressure taps. Mean and peak surface pressures for TLV flow are reported and compared with the ABL induced wind for different time-averaging. By following a compatible definition of the pressure coefficients for TLV and ABL fields, the resulting TLV pressure field presents a similar trend to the ABL case. Also, the results show that, for the high-rise building model, the mean and 3-sec peak pressures are larger for the ABL case compared to the TLV case. These results provide a way forward for the code implementation of tornado-induced pressures on high-rise buildings.

• Clinical and Experimental Reproductive Medicine
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• 제50권3호
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• pp.200-205
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• 2023

Objective: Polycystic ovary (PCO), a diagnostic component of polycystic ovary syndrome (PCOS), requires either an ovarian volume (OV) criterion or a follicle number per ovary (FNPO) criterion. This study investigated the association of OV and FNPO criteria with various manifestations of PCOS. Methods: This cross-sectional study was conducted at a university hospital among 100 patients newly diagnosed with PCOS (according to the revised Rotterdam criteria). Fasting blood samples were collected to measure glucose, total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), lipid, insulin, and hemoglobin A1c levels. An oral glucose tolerance test was performed. Transabdominal or transvaginal ultrasound of the ovaries was done, depending on patients' marital status. All investigations were conducted in the follicular phase of the menstrual cycle. OV >10 mL and/or FNPO ≥12 indicated PCO. A homeostasis model assessment of insulin resistance (IR) value ≥2.6 indicated IR, and metabolic syndrome (MS) was defined according to the international harmonization criteria. Results: Seventy-six participants fulfilled the OV criterion, 70 fulfilled the FNPO criterion, and 89 overall had PCO. Both maximum OV and mean OV had a significant correlation with TT levels (r=0.239, p=0.017 and r=0.280, p=0.005, respectively) and the LH/FSH ratio (r=0.212, p=0.034 and r=0.200, p=0.047, respectively). Mean OV also had a significant correlation with fasting insulin levels (r=0.210, p=0.036). Multivariate binary logistic regression analysis showed that IR (odds ratio [OR], 9.429; 95% confidence interval [CI], 1.701 to 52.271; p=0.010) and MS (OR, 7.952; 95% CI, 1.821 to 34.731; p=0.006) had significant predictive associations with OV alone, even after adjustment for age and body mass index. Conclusion: OV may be more closely related to the androgenic and metabolic characteristics of PCOS than FNPO.

• Nutrition Research and Practice
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• 제16권3호
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• pp.298-313
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• 2022

BACKGROUND/OBJECTIVES: The effectiveness of natural compounds in improving athletic ability has attracted attention in both sports and research. Gynostemma pentaphyllum (Thunb.) leaves are used to make traditional herbal medicines in Asia. The active components of G. pentaphyllum, dammarane saponins, or gypenosides, possess a range of biological activities. On the other hand, the anti-fatigue effects from G. pentaphyllum extract (GPE) and its effective compound, gypenoside L (GL), remain to be determined. MATERIALS/METHODS: This study examined the effects of GPE on fatigue and exercise performance in ICR mice. GPE was administered orally to mice for 6 weeks, with or without treadmill training. The biochemical analysis in serum, glycogen content, mRNA, and protein expressions of the liver and muscle were analyzed. RESULTS: The ExGPE (exercise with 300 mg/kg body weight/day of GPE) mice decreased the fat mass percentage significantly compared to the ExC mice, while the ExGPE showed the greatest lean mass percentage compared to the ExC group. The administration of GPE improved the exercise endurance and capacity in treadmill-trained mice, increased glucose and triglycerides, and decreased the serum creatine kinase and lactate levels after intensive exercise. The muscle glycogen levels were higher in the ExGPE group than the ExC group. GPE increased the level of mitochondrial biogenesis by enhancing the phosphorylation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein and the mRNA expression of nuclear respiratory factor 1, mitochondrial DNA, peroxisome proliferator-activated receptor-δ, superoxide dismutase 2, and by decreasing the lactate dehydrogenase B level in the soleus muscle (SOL). GPE also improved PGC-1α activation in the SOL significantly through AMPK/p38 phosphorylation. CONCLUSIONS: These results showed that GPE supplementation enhances exercise performance and has anti-fatigue activity. In addition, the underlying molecular mechanism was elucidated. Therefore, GPE is a promising candidate for developing functional foods and enhancing the exercise capacity and anti-fatigue activity.