• Herbal Formula Science
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• v.21 no.1
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• pp.51-70
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• 2013

Objectives : The object of this study was to observe anticancer and related immunomodulatory effects of Insamyangyoung-tang extracts (ISYYTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of ISYYTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, which are intact control, tumor bearing control, 5-fluorouracil (FU) 30 mg/kg, ISYYTe 50 mg/kg, ISYYTe 100 mg/kg, ISYYTe 200 mg/kg, each of 8 mice per group were used in the present study. Changes on the body weight, tumor volume and weight, lymphatic organ (spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. Results : As results of ISYYTe 50, 100 and 200 mg/kg treatment, decreases in the tumor volumes and weights were detected. At histopathological observations, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of all three different dosages of ISYYTe. As results of tumor cell inoculation, marked decreases of spleen and popliteal lymph node weights, serum IFN-${\gamma}$, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents and splenocytes were observed with histopathological atrophic changes of spleen and popliteal lymph nodes. Conclusions : Over 50 mg/kg of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in ISYYTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, there are no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1168-1177
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• 2008

Atopic dermatitis(AD) is a chronic inflammatory skin disease. AD has increased gradually, many people are tortured with AD. Chunggi-san(CG) and Samhwangseze-gamibang(SG) has been used for many kinds of skin disease in the Oriental medicine. But reports about the effect of CG and SG are insufficient. So, author investigated the effect of CG and SG on NC/Nga atopic mice. Major findings are summarized as follows: The clinical skin severity scores of experimental group in 13 and 16 week were decreased by 42% and 50% compared to the control group. Serum IgE, IL-4, IL-5, IL-6, IgM, IgGI levels of experimental group were significantly decreased compared to the control group. Serum $IFN-\nu$ was significantly increased in the experimental group compared to the control group. mRNA expression levels of IL-4, IL-5, and CCR3 in the skin tissues of experimental group were significantly decreased, and expression level of IL-6 in the skin tissues of experimental group was significantly decreased compared to the control group. $IFN-\nu$ mRNA expression levels was increased compared to the control group. According to biopsy reports of the ear and skin tissues showed that the tissue damage, experimental group were highly reduced compared to the control group. Judging from that $IL-1{\beta}$, $TNF-{\alpha}$, IL-6 express of gene, the effects of inflammatory cytokines revelation were significantly decreased compared to the control group. Depending on the density of CG, inflammatory RAW 264.7 in the serum of CG were significantly inhibited compared to the control serum that leaded a COX-2 activity model.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.6
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• pp.394-404
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• 2013

In the present study, the characteristics of spectral peakedness parameter $Q_p$, bandwidth parameter ${\varepsilon}$, and spectral width parameter ${\nu}$ were analyzed as a first step to define the swell waves quantitatively. For the analysis, the joint probability density function of significant wave heights and peak periods were newly developed. The MCMC(Markov Chain Monte Carlo) simulations have been performed to generate the significant wave heights and peak periods from the developed probability density functions. Applying the simulated significant wave heights and peak periods to the theoretical wave spectrum models, the spectral shapes parameters were obtained and analyzed. Among the spectral shape parameters, only the spectral peakedness parameter $Q_p$, is shown to be independent with the significant wave height and peak wave period. It also best represents the peakedness of the spectral shape, and henceforth $Q_p$ should be used to define the swell waves with a wave period. For the field verification of the results, wave data obtained from Hupo port and Ulleungdo were analyzed and results showed the same trend with the MCMC simulation results.

• Journal of Energy Engineering
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• v.9 no.3
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• pp.261-268
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• 2000

A heat transfer correlation to predict the vaporization of a water droplet in highly superheated steam during a loss-of-coolant accident(LOCA) of a nuclear power plant is provided. Vaporization of liquid fuel or water droplets in superheated air or steam and subsequent interface heat transfer between a liquid droplet and superheated gas is typically correlated by way of a Nusselt number as a function of Reynolds number, Prantl number, and in some cases including mass transfer number. Presently available correlations and experimental data of the evaporation of liquid droplets in air or steam are analyzed and a new Nusselt number correlation is proposed taking Schmidt number into consideration in order to account for binary diffusion of the vapor as well, Nu$\_$f/(1+B)$\^$0.7/=2+0.53Sc$\_$f/$\^$-1/5/Re$\_$M/$\^$$\sfrac{1}{2}$/Pr$\_$f/$\^$$\sfrac{1}{3}$/ for which properties are evaluated at film condition except the density of Reynolds number evaluated at ambient condition. Diverse correlations for various combinations of liquid and gas species are put into single equation. The blowing correction factor of (1+B)$\^$0.7/ is confirmed appropriate, and a criterion to distinguish so-called high- and low-temperature condition of ambient gas is set forth.

• Journal of Theoretical and Applied Mechanics
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• v.3 no.1
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• pp.16-33
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• 2002

A concept of hierarchical modeling, the newest modeling technology. has been introduced early In 1990. This nu technology has a goat potential to advance the capabilities of current computational mechanics. A first step to Implement this concept is to construct hierarchical models, a family of mathematical models which are sequentially connected by a key parameter of the problem under consideration and have different levels in modeling accuracy, and to investigate characteristics In their numerical simulation aspects. Among representative model problems to explore this concept are elastic structures such as beam-, arch-. plate- and shell-like structures because the mechanical behavior through the thickness can be approximated with sequential accuracy by varying the order of thickness polynomials in the displacement or stress fields. But, in the numerical analysis of hierarchical models, two kinds of errors prevail: the modeling error and the numerical approximation errors. To ensure numerical simulation quality, an accurate estimation of these two errors Is definitely essential. Here, a local a posteriori error estimator for elastic structures with thin domain such as plate- and shell-like structures Is derived using element residuals and flux balancing technique. This method guarantees upper bounds for the global error, and also provides accurate local error Indicators for two types of errors, in the energy norm. Comparing to the classical error estimators using flux averaging technique, this shows considerably reliable and accurate effectivity indices. To illustrate the theoretical results and to verify the validity of the proposed error estimator, representative numerical examples are provided.

• Bulletin of the Korean Mathematical Society
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• v.49 no.4
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• pp.799-813
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• 2012

In this paper, we first show that the iteration {$x_n$} defined by $x_{n+1}=P((1-{\alpha}_n)x_n +{\alpha}_nTP[{\beta}_nTx_n+(1-{\beta}_n)x_n])$ converges strongly to some fixed point of T when E is a real uniformly convex Banach space and T is a quasi-nonexpansive non-self mapping satisfying Condition A, which generalizes the result due to Shahzad [11]. Next, we show the strong convergence of the Mann iteration process with errors when E is a real uniformly convex Banach space and T is a quasi-nonexpansive self-mapping satisfying Condition A, which generalizes the result due to Senter-Dotson [10]. Finally, we show that the iteration {$x_n$} defined by $x_{n+1}={\alpha}_nSx_n+{\beta}_nT[{\alpha}^{\prime}_nSx_n+{\beta}^{\prime}_nTx_n+{\gamma}^{\prime}_n{\upsilon}_n]+{\gamma}_nu_n$ converges strongly to a common fixed point of T and S when E is a real uniformly convex Banach space and T, S are two quasi-nonexpansive self-mappings satisfying Condition D, which generalizes the result due to Ghosh-Debnath [3].

• Journal of Korea Technology Innovation Society
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• v.5 no.1
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• pp.90-109
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• 2002

The national nuclear R&D projects have been implemented for the purpose of supply of nuclear power which was proved to be safety and stability. Evaluating the national nuclear R&D projects has critical importance in nu-clear energy management aspect. This paper employs multi-attribute utility analysis as a basis for obtaining an evaluation index to assess the national nuclear R&D projects using a specific case study of Korea. To structure and quantify basic values for the evaluation, we elicited important attributes, then refined and structured them into a hierarchy. A multi-attribute index is constructed as a multi-attribute utility function, based on value judgments provided by a group of technical experts, policy makers, and faculties. As a result, the objective of attainment of a proposed object is given the highest priority, followed by appropriateness of project and research strategy, utilization of research output, within attribute ranges defined for the attributes. We found that the work and results of this study can provide valuable insights and decision opportunities for virtually all major decision making in evaluation of the national nuclear R&D projects in Korea.

• Journal of the Chungcheong Mathematical Society
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• v.24 no.2
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• pp.287-301
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• 2011

Let X and Y be vector spaces. It is shown that a mapping $f\;:\;X{\rightarrow}Y$ satisfies the functional equation $$(\ddag)\hspace{50}dk\;f\left(\frac{\sum_{j=1}^{dk}x_j}{dk}\right)=\displaystyle\sum_{j=1}^{dk}f(x_j)$$ if and only if the mapping $f$ : X ${\rightarrow}$ Y is Cauchy additive, and prove the Cauchy-Rassias stability of the functional equation ($\ddag$) in Banach modules over a unital $C^{\ast}$-algebra. Let $\mathcal{A}$ and $\mathcal{B}$ be unital $C^{\ast}$-algebras. As an application, we show that every almost homomorphism $h\;:\;\mathcal{A}{\rightarrow}\mathcal{B}$ of $\mathcal{A}$ into $\mathcal{B}$ is a homomorphism when $h((k-1)^nuy)=h((k-1)^nu)h(y)$ for all unitaries $u{\in}\mathcal{A}$, all $y{\in}\mathcal{A}$, and $n$ = 0,1,2,$\cdots$. Moreover, we prove the Cauchy-Rassias stability of homomorphisms in $C^{\ast}$-algebras.

• Journal of the Chungcheong Mathematical Society
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• v.24 no.4
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• pp.617-630
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• 2011

Let X, Y be vector spaces, and let r be 2 or 4. It is shown that if an odd mapping $f:X{\rightarrow}Y$ satisfies the functional equation $${\hspace{50}}rf(\frac{\sum_{j=1}^{d}\;x_j} {r})+\;{\sum\limits_{\iota(j)=0,1 \atop {\sum_{j=1}^{d}}\;{\iota}(j)=l}}\;rf(\frac{\sum_{j=1}^{d}{(-1)^{\iota(j)}x_j}}{r}) \\({\ddag}){\hspace{160}}=(_{d-1}C_l-_{d-1}C_{l-1}+1)\;{\sum\limits_{j=1}^{d}\;f(x_j)}$$ then the odd mapping $f:X{\rightarrow}Y$ is additive, and we prove the Cauchy-Rassias stability of the functional equation in Banach modules over a unital $C^*$-algebra. As an application, we show that every almost linear bijection $h:{\mathcal{A}}{\rightarrow}{\mathcal{B}}$ of a unital $C^*$-algebra ${\mathcal{A}}$ onto a unital $C^*$-algebra ${\mathcal{B}}$ is a $C^*$-algebra isomorphism when $h(2^nuy)=h(2^nu)h(y)$ for all unitaries $u{\in}{\mathcal{A}}$, all $y{\in}{\mathcal{A}}$, and $n=0,1,2,{\cdots}$.

• Journal of the Korean Physical Society
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• v.73 no.10
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• pp.1535-1540
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• 2018

In this study, we prepared and characterized Nb-doped $Li_7La_3Zr_{2-x}O_{12}$ (LLZNO) powder and pellets with a cubic garnet structure by using a modified sol-gel synthesis and hot pressing. LLZNO powder with a very small grain size and cubic structure without secondary phases could be obtained by using a synthesis method in which Li and La sources in a propanol solvent were mixed together with Zr and Nb sources in 2-methoxy ethanol. A pure cubic phase LLZNO pellet could be fabricated from the prepared LLZNO and an additional 6-wt% of $Li_2CO_3$ powder by hot pressing at $1050^{\circ}C$ and 15.8 MPa. The hot-pressed LLZNO pellet with a relative density of 99% exhibited a very dense surface morphology. The total Li ionic conductivity of the hot-pressed LLZNO was $7.4{\times}10^{-4}S/cm$ at room temperature, which is very high level compared to other reported values. The activation energy for ionic conduction was estimated to be 0.40 eV.