• International Journal of Aeronautical and Space Sciences
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• 제15권3호
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• pp.281-292
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• 2014

We propose a novel cooperative guidance law design method based on the finite time disturbance observer (FTDO) for multiple near space interceptors (NSIs) with impact time control. Initially, we construct a cooperative guidance model with head pursuit, and employ the FTDO to estimate the system disturbance caused by target maneuvering. We subsequently separate the cooperative guidance process into two stages, and develop the normal acceleration command based on the super-twisting algorithm (STA) and disturbance estimated value, to ensure the convergence of the relative distance. Then, we also design the acceleration command along the line-of-sight (LOS), based on the nonsingular fast terminal sliding mode (NFTSM) control, to ensure that all the NSIs simultaneously hit the target. Furthermore, we prove the stability of the closed-loop guidance system, based on the Lyapunov theory. Finally, our simulation results of a three-to-one interception scenario show that the proposed cooperative guidance scheme makes all the NSIs hit the target at the same time.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.939-940
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• 2008

In this paper, we propose a novel image clustering method based on weighted sub-sampling to reduce clustering time and the number of clusters for target detection and tracking. Our proposed method first obtain sub-sampling image with specific weights which is the number of target pixels in sampling region. After performing clustering procedure, the cluster center position is properly obtained using weights of target pixels in the cluster. Therefore, our proposed method can not only reduce clustering time, but also obtain proper cluster center.

• 대한음성학회지:말소리
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• 제67호
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• pp.167-180
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• 2008

This paper describes a novel spectral envelope conversion method based on Gaussian mixture model (GMM). The core of this paper is rearranging source feature vectors in input space to the transformed feature vectors in feature space for the better modeling of GMM of source and target features. The quality of statistical modeling is dependent on the distribution and the dimension of data. The proposed method transforms both of the distribution and dimension of data and gives us the chance to model the same data with different configuration. Because the converted feature vectors should be on the input space, only source feature vectors are rearranged in the feature space and target feature vectors remain unchanged for the joint pdf of source and target features using KPCA. The experimental result shows that the proposed method outperforms the conventional GMM-based conversion method in various training environment.

• Molecules and Cells
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• 제43권11호
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• pp.935-944
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• 2020

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with hypoxia-inducible transcription factors (HIF1α and HIF2α) or aryl hydrocarbon receptor (AhR). Here, we have shown that ARNT interacts with DDB1 and CUL4-associated factor 15 (DCAF15), and the aryl sulfonamides, indisulam and E7820, induce its proteasomal degradation through Cullin-RING finger ligase 4 containing DCAF15 (CRL4^DCAF15) E3 ligase. Moreover, the two known neo-substrates of aryl sulfonamide, RNA-binding motif protein 39 (RBM39) and RNA-binding motif protein 23 (RBM23), are not required for ARNT degradation. In line with this finding, aryl sulfonamides inhibited the transcriptional activities of HIFs and AhR associated with ARNT. Our results collectively support novel regulatory roles of aryl sulfonamides in both hypoxic and xenobiotic responses.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권6호
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• pp.2658-2679
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• 2018

This paper proposes a novel Random Scheduling Algorithm based on Subregion Coverage (RSASC), to solve the SET K-cover problem (an NP-complete problem). SET K-cover problem distributes the set of sensors into the maximum number of mutually exclusive subsets (MESSs) in such a way that each of them can be scheduled for lifetime extension of WSN. Sensor coverage divides the target region into different subregions. RSASC first sorts the subregions in the ascending order concerning their sensor coverage. Then, it forms the subregion groups according to their similar sensor coverage. Lastly, RSASC ensures the K-coverage of each subregion from every group by randomly scheduling the sensors. We consider the target-coverage and area-coverage applications of WSN to analyze the usefulness of our proposed RSASC algorithm. The distinct quality of RSASC is that it utilizes less number of deployed sensors (33% less) to form the optimum number of MESSs with the higher computational speed (saves more than 93% of the time) as compared to the existing three algorithms.

• BMB Reports
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• 제36권1호
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• pp.35-42
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• 2003

Heterocyclic amines (HCAs) are potent mutagens generated during the cooking of meat and fish, and several of these compounds produce tumors in conventional experimental animals. During the past 5 years or so, HCAs have been tested in a number of novel in vivo murine models, including the following: lacZ, lacI, cII, c-myc/lacZ, rpsL, and $gpt{\Delta}$ transgenics, $XPA^{-/-}$, $XPC^{-/-}$, $Msh2^{+/-}$, $Msh2^{-/-}$ and $p53^{+/-}$ knock-outs, Apc mutant mice ($Apc^{{\Delta}716}$, $Apc^{1638N}$, $Apc^{min}$), and $A33^{{\Delta}N{\beta}-cat}$ knock-in mice. Several of these models have provided insights into the mutation spectra induced in vivo by HCAs in target and non-target organs for tumorigenesis, as well as demonstrating enhanced susceptibility to HCA-induced tumors and preneoplastic lesions. This review describes several of the more recent reports in which novel animal models were used to examine HCA-induced mutagenesis and carcinogenesis in vivo, including a number of studies which assessed the inhibitory activities of chemopreventive agents such as 1,2-dithiole-3-thione, conjugated linoleic acids, tea, curcumin, chlorophyllin-chitosan, and sulindac.

• Journal of Advanced Marine Engineering and Technology
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• 제39권2호
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• pp.187-194
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• 2015

Accurate relative location estimation is a key requirement in indoor localization systems based on wireless sensor networks (WSNs). However, although these systems have applied not only various optimization algorithms but also fusion with sensors to achieve high accuracy in position determination, they are difficult to provide accurate relative azimuth and locations to users because of cumulative errors in inertial sensors with time and the influence of external magnetic fields. This paper based on ultra-wideband positioning system, which is relatively suitable for indoor localization compared to other wireless communications, presents an indoor localization system for estimating relative azimuth and location of location-unaware nodes, referred to as target nodes without applying any algorithms with complex variable and constraints to achieve high accuracy. In the proposed method, the target nodes comprising three mobile nodes estimate the relative distance and azimuth from two reference nodes that can be installed by users. In addition, in the process of estimating the relative localization information acquired from the reference nodes, positioning errors are minimized through a novel modified rounding estimation technique in which Kalman filter is applied without any time consumption algorithms. Experimental results show the feasibility and validity of the proposed system.

• The Plant Pathology Journal
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• 제24권2호
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• pp.202-206
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• 2008

Antifungal activity of Korean and Chinese lichen-forming fungi (LFF) was evaluated against plant pathogenic fungus of Colletotrichum acutatum, causal agent of anthracnose on hot pepper. This is the first attempt to evaluate antifungal activity of LFF, instead of lichen thalli, against C. acutatum. Total 100 LFF were isolated from the lichens with discharged spore method or tissue culture method. Among the 100 isolates, 8 LFF showed more than 50% of inhibition rates of mycelial growth of the target pathogen. Especially, Lecanora argentata was highly effective in inhibition of mycelial growth of C. accutatum at the rate of 68%. Antifungal activity of other LFF was in the order of Cetrelia japonica (61.4%), Ramalina conduplicans (59.5%), Umbilicaria esculenta (59.5%), Ramalina litoralis (56.7%), Cetrelia braunsiana (56.5%), Nephromopsis pallescensn (56.1%), and Parmelia simplicior (53.8%). Among the tested LFF, 61 isolates of LFF exhibited moderate antifungal activity against the target pathogen at the inhibition rates from 30 to 50%. Antifungal activity of the LFF against C. acutatum was variable at the species level rather than genus level of LFF. This study suggests that LFF can be served as a promising bioresource to develop novel biofungicides.

• BMB Reports
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• 제51권5호
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• pp.207-208
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• 2018

Chitinase-Like Proteins (CLPs) are an evolutionarily conserved protein which lose their enzymatic activity for degrading chitin macromolecules. Chitinase-3-like-1 (Chi3l1) is a type of CLP that is highly expressed in epithelial cells, macrophages, etc., and is known to have correlations with type 2 inflammation and cancer. Although the increased level of Chi3l1 in the blood was reported in various disease patients, the function of Chi3l1 in adaptive immunity has been totally unknown. Recently, we found that Chi3l1 is expressed in T cells and has a negative regulatory role in T-cell activation and proliferation. A genetic ablation study of Chi3l1 in T cells showed hyperresponsiveness to TcR stimulation, which increased proliferation and Th1 differentiation. A significant increase of $IFN{\gamma}$ signaling in Chi3l1-deficient T cells synergistically increased Th1 and CTL functions against melanoma cells in vitro and in vivo. In addition, targeted knockdown by Chi3l1 siRNA complexed with the cell-penetrating peptide dNP2, which showed decreased pulmonary melanoma metastasis with increased infiltration of Th1 and CTL in the lung. This study first suggests that Chi3l1 is a novel regulator of Th1/CTL responses and could be a target for treating cancer to increase tumor immunity.

• 식물병연구
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• 제16권1호
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• pp.10-20
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• 2010

Root-knot nematodes cause billions of dollars in crop losses annually have a broad range of host over 2,000 species of plants. These nematodes are known as obligate, sedentary endo-parasites in a plant host to feed upon to complete their life cycle. To prevent the plant parasitic nematode, methyl bromide was widely applied as a soil fumigant. Other strategies to prevent or control nematodes involve RNAi-mediated suppression, R gene transformation, natural products or chemical treatments, the expression of peptide or proteins in susceptible plants, and others. Over the last decade, the entry in GenBank for Meloidogyne reveals 73,340 ESTs and recently two complete Meloidogyne spp. genomes sequences have simultaneously been presented by two groups. Recent works have demonstrated the effect of RNAi suppression to nematode target genes. These results will provide novel members of genes as a foundation for studies focused on understanding the function of M. incognita nematode genes as well as for the development of novel target genes for parasite control. Thus the successful development of biotechnology-derived plants with nematode resistance will result in large yield benefits for producers as well as environmental benefits and will accelerate the research related to pathogensresistant crops.