BMB Reports
- Volume 51 Issue 5
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- Pages.207-208
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- 2018
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- 1976-670X(eISSN)
DOI QR Code
Chitinase 3-like-1, a novel regulator of Th1/CTL responses, as a therapeutic target for increasing anti-tumor immunity
- Kim, Do-Hyun (Department of Life Science, College of Natural Sciences, Hanyang University) ;
- Choi, Je-Min (Department of Life Science, College of Natural Sciences, Hanyang University)
- Received : 2018.04.10
- Published : 2018.05.31
Abstract
Chitinase-Like Proteins (CLPs) are an evolutionarily conserved protein which lose their enzymatic activity for degrading chitin macromolecules. Chitinase-3-like-1 (Chi3l1) is a type of CLP that is highly expressed in epithelial cells, macrophages, etc., and is known to have correlations with type 2 inflammation and cancer. Although the increased level of Chi3l1 in the blood was reported in various disease patients, the function of Chi3l1 in adaptive immunity has been totally unknown. Recently, we found that Chi3l1 is expressed in T cells and has a negative regulatory role in T-cell activation and proliferation. A genetic ablation study of Chi3l1 in T cells showed hyperresponsiveness to TcR stimulation, which increased proliferation and Th1 differentiation. A significant increase of