• The Korean Journal of Nuclear Medicine
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• v.29 no.4
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• pp.473-477
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• 1995

Information about regional wall motion obtained with gated $^{99m}Tc-MIBI$ SPECT was compared in 23 subjects(4 normals) to echocardiography or contrast left ventriculography. Gated SPECT study using 20-30 mCi $^{99m}Tc-MIBI$ were aquired lot 8 frames/RR interval (aqusition time=40min.) and processed with Cine Mode computer protocol. Regional wall motion was assessed by visual analysis. The concordance with echocardiography was 88% and with contrast ventriculography was 78%. We conclude that gated $^{99m}Tc-MIBI$ SPECT was effective in assessing the regional wall motion with the information of regional perfusion in one study.

• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.1
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• pp.63-73
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• 2010

A comprehensive mapping project for agroclimatic zoning in South Korea will end by April 2010, which has required 4 years, a billion won (ca. 0.9 million US dollars) and 22 experts from 7 institutions to complete it. The map database from this project may be categorized into primary, secondary and analytical products. The primary products are called "high definition" digital climate maps (HD-DCMs) and available through the state of the art techniques in geospatial climatology. For example, daily minimum temperature surfaces were prepared by combining the climatic normals (1971-2000 and 1981-2008) of synoptic observations with the simulated thermodynamic nature of cold air by using the raster GIS and microwave temperature profiling which can quantify effects of cold air drainage on local temperature. The spatial resolution of the gridded climate data is 30m for temperature and solar irradiance, and 270m for precipitation. The secondary products are climatic indices produced by statistical analysis of the primary products and includes extremes, sums, and probabilities of climatic events relevant to farming activities at a given grid cell. The analytical products were prepared by driving agronomic models with the HD-DCMs and dates of full bloom, the risk of freezing damage, and the fruit quality are among the examples. Because the spatial resolution of local climate information for agronomic practices exceeds the current weather service scale, HD-DCMs and the value-added products are expected to supplement the insufficient spatial resolution of official climatology. In this lecture, state of the art techniques embedded in the products, how to combine the techniques with the existing geospatial information, and agroclimatic zoning for major crops and fruits in South Korea will be provided.

• Annual Conference on Human and Language Technology
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• 1999.10e
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• pp.462-469
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• 1999

본 연구에서는 시각적으로 제시되는 단어 자극의 의미 관련성의 차이에 따라 좌우반구의 처리가 어떻게 이루어지는지 알아보고자 하였다. 이를 위해서 명칭성 실어증 환자와 정상인 대학생 피험자를 대상으로 점화 어휘판단 과제를 수행하였다. 이 연구의 기본 논리는 명칭성 실어증 환자의 왼쪽 뇌가 손상되어 있기 때문에 어떤 정보처리가 왼쪽 뇌에서 일어나는 것이라면 정상인과 명칭성 실어증환자간의 수행에서 어떤 차이가 나타날 것을 기대되는 반면, 만일에 우뇌에서 처리되는 것이라면 정상인의 과제 수행 형태와 명칭성 실어증 환자의 것이 일치하는 형태를 보일 것이라는 것이다. 실험 1에서는 수직적 범주관련성이 어느 반구에서 정보처리 되는지를 조사하였다. 그 결과 정상인은 좌반구에서 유의미한 점화효과가 있고 우반구에서는 점화효과가 없었던 반면에, 명칭성 실어증 환자는 정상인과 정반대의 점화 효과를 보이고 있다. 이러한 결과는 좌반구가 일차적으로 수직적 범주 관련성 정보처리와 관련이 있음을 시사해 준다. 또한 수평적 범주 관련성에 따른 실험 은 정상인과 환자 두 집단 모두 수평적 범주관련성이 우반구에서 처리되는 유사한 패턴을 보여주었다. 실험2에서는 연합적 범주관련성에 따른 두 집단간의 점화 효과를 비교하였다. 정상인 집단과 환자 모두 좌우반구에 점화효과를 보여주고 있지만, 정상인 집단의 경우에는 우반구에서, 환자는 좌반구에서 점화량이 더 컸다. 연합관련 정보처리는 좌우반구 모두에서 일어난다고 하는 기존의 견해와 관련하여 볼 때 연합관련 정보처리는 좌우반구에서 일어난다고 해석할 수 있을 것이다. 명칭 실어증 환자의 정보처리는 정상인과 다르게 이루어지므로 이러한 좌우반구에서의 차이가 난 것으로 볼 수 있다. 이상의 실험1과 2의 결과를 종합해 보면, 시각적으로 제시되는 단어의 범주적 관련성이 주는 어휘정보 처리는 반구에 따라 처리하는 기능이 다르다고 결론 내릴 수 있다. 즉, 좌반구는 수직적 범주 관련성을 담당하고 우반구는 수평적 관련성을 담당하며, 연합적 관련성은 좌우반구 모두에서 정보처리 된다는 것이다.

• Journal of the Korea Computer Graphics Society
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• v.22 no.5
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• pp.1-16
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• 2016

In this paper, we propose and efficient curve reconstruction method based on the classical least-square fitting scheme. Specifically, given planar sample points equipped with normals, we reconstruct the objective curve as the zero set of a hierarchical implicit ZP(Zwart-Powell)-spline that can recover large holes of dataset without loosing the fine details. As regularizers, we adopted two: a Tikhonov regularizer to reduce the singularity of the linear system and a discrete Laplacian operator to smooth out the isocurves. Benchmark tests with quantitative measurements are done and our method shows much better quality than polynomial methods. Compared with the hierarchical bi-quadratic spline for datasets with holes, our method results in compatible quality but with less than 90% computational overhead.

• The Korean Journal of Zoology
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• v.32 no.1
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• pp.48-54
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• 1989

Several proteolytic activities and the level of and-trypsin in neoplastic tissues of human cervix and liver were compared to those in normal tissues to examine if any correlation exists between malignant behavior of the tumors and the changes in overall proteolytic capacity. Proteolysis against casein and insulin in cervix tumor was increased to 2-to 3-fold while that in liver tumor was reduced to one-tenth to one-half. By contrast, the level of anti-trypsin in cervix tumor was lowered to nearly one-tenth of that in normal tissues while the level rose to about 2-fold in malignant tissues of liver. On the other hand, the activities of plasmin-like protease and plasminogen activator were enhanced 10-20% over the activities in normals. These results suggest that the changes in proteolytic capacity are at least in part due to outbalance in either of proteolytic or its inhibitory activity over the other and occur distinctively to each tumor systems for their malignant behavior.

• Journal of the Korean Chemical Society
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• v.50 no.2
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• pp.116-122
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• 2006

In this study we extracted DNA from 100 tissues of breast cancer patients and 103 normals. Then we confirmed single-nucleotide polymorphism(SNP) using PCR-DHPLC(polymerase chain reaction-denaturing high performance liquid chromatogrphy).Also, we studied SNP of samples using several columns to identify relation between packing materials of column and resolution.As a result, we identified 4 C/A, C/G genotypes(4%) in exon 5 and 37 T del genotypes(37%) in exon 8 among 100 breast cancer tissues and 2 in exon 5, 9 in exon 8 among 103 normal samples.In resolution test, we confirmed that PS-DVB(poly styrene-divinylbenzen) column is more efficient than C18 column.

• Journal of the Korean Geographical Society
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• v.52 no.1
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• pp.1-13
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• 2017

This study aims to identify the warm and cold periods(WP, CP) of November appeared in the daily normals of daily minimum temperature of Seoul for 1941~1970 and 1971~2000 and to investigate synoptic characteristics of the temperature changes of WP and CP. The WP temperatures are increased clearly(p value 0.000), the CP temperatures are also warming but not significant statistically. In WP, there are not apparent trends corresponding the warming of WP temperature, in the Siberian High, Sea Level Pressure(SLP), 925hPa surface wind(U925, V925) around the Korean peninsula. In high period(1972~1979) of WP temperature, there are positive SLP anomaly and anomalous anticyclonic circulation pattern of 925hPa wind field over the Korean peninsula then the winter monsoon is weakened and the WP temperature is ascending. In CP, the Siberian high are weakening, the Hokkaido eastern low are strengthening and the westerlies(U925) over the Korean Peninsula are enlarging. So CP temperature are suppressed in rising trend or shows weak descent.

• Korean Journal of Remote Sensing
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• v.17 no.2
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• pp.183-188
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• 2001

The NOAA AVHRR remotely sensed SST data, collected by the National Fisheries Research and Development Institute (NFRDI), are analyzed in order to understand the spatial and temporal distributions of SST in the sea near korea. Our study is based on 10-day SST images during last 7 years (1991-1997). For a time series analysis of multiple SST images, all of images must be consistent exactly at the same position by adjusting the scales and positions of each SST image. We devised an algorithm which automatically detects cloud pixels from multiple SST images. The cloud detection algorithm is based on a physical constraint that SST anomalies in the ocean do not exceed certain limits (we used $\pm$3$^{\circ}C$ as a criterion of SST anomalies). The remotely sensed SST data are tuned by comparing remotely sensed data with observed SST at coastal stations. Seasonal variations of SST are studied by harmonic fit of SST normals at each pixel and the SST anomalies are studied by statistical method. It was found that the SST anomalies are rather persistent for one or two months. Utilizing the persistency of SST anomalies, we devised an algorithm for a prediction of future SST. In the Markov lprocess model of SST anomalies, autoregression coefficients of SST anomalies during a time elapse of 10 days are between 0.5 and 0.7. The developed algorithm with automatic cloud pixel detection and rediction of future SST is expected to be incorporated to the operational real time service of SST around Korea.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.275-283
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• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• International journal of advanced smart convergence
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• v.12 no.4
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• pp.361-369
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• 2023

Achieving realistic visual quality while maintaining optimal real-time rendering performance is a major challenge in evolving computer graphics and interactive 3D applications. Normal mapping, as a core technology in 3D, has matured through continuous optimization and iteration. Hybrid normal mapping as a new mapping model has also made significant progress and has been applied in the 3D asset production pipeline. This study comprehensively explores the hybrid normal techniques, analyzing Linear Blending, Overlay Blending, Whiteout Blending, UDN Blending, and Reoriented Normal Mapping, and focuses on how the various hybrid normal techniques can be used to achieve rendering performance and visual fidelity. performance and visual fidelity. Under the consideration of computational efficiency, visual coherence, and adaptability in different 3D production scenes, we design comparative experiments to explore the optimal solutions of the hybrid normal techniques by analyzing and researching the code, the performance of different hybrid normal mapping in the engine, and analyzing and comparing the data. The purpose of the research and summary of the hybrid normal technology is to find out the most suitable choice for the mainstream workflow based on the objective reality. Provide an understanding of the hybrid normal mapping technique, so that practitioners can choose how to apply different hybrid normal techniques to the corresponding projects. The purpose of our research and summary of mixed normal technology is to find the most suitable choice for mainstream workflows based on objective reality. We summarized the hybrid normal mapping technology and experimentally obtained the advantages and disadvantages of different technologies, so that practitioners can choose to apply different hybrid normal mapping technologies to corresponding projects in a reasonable manner.