• BMB Reports
• /
• v.50 no.4
• /
• pp.226-231
• /
• 2017

At the post-transcriptional and translational levels, microRNA (miRNA) represses protein-coding genes via seed pairing to the 3' untranslated regions (UTRs) of mRNA. Although working models of miRNA-mediated gene silencing are successfully established using miRNA transfections and knockouts, the regulatory interaction between miRNA and long non-coding RNA (lncRNA) remain unknown. In particular, how the mRNA-resembling lncRNAs with 5' cap, 3' poly(A)-tail, or coding features, are regulated by miRNA is yet to be examined. We therefore investigated the functional interaction between miRNAs and lncRNAs with/without those features, in miRNA-transfected early zebrafish embryos. We observed that the greatest determinants of the miRNA-mediated silencing of lncRNAs were the 5' cap and 3' poly(A)-tails in lncRNAs, at both the post-transcriptional and translational levels. The lncRNAs confirmed to contain 5' cap, 3' poly(A)-tail, and the canonical miRNA target sites, were observed to be repressed in the level of both RNA and ribosome-protected fragment, while those with the miRNA target sites and without 5' cap and 3' poly(A)-tail, were not robustly repressed by miRNA introduction, thus suggesting a role as a miRNA-decoy.

• Journal of Astronomy and Space Sciences
• /
• v.29 no.4
• /
• pp.363-374
• /
• 2012

This paper studies the problem of tracking a re-entry vehicle (RV) in order to predict its impact point on the ground. Re-entry target dynamics combined with super-high speed has a complex non-linearity due to ballistic coefficient variations. However, it is difficult to construct a database for the ballistic coefficient of a unknown vehicle for a wide range of variations, thus the reliability of target tracking performance cannot be guaranteed if accurate ballistic coefficient estimation is not achieved. Various techniques for ballistic coefficient estimation have been previously proposed, but limitations exist for the estimation of non-linear parts accurately without obtaining prior information. In this paper we propose the ballistic coefficient ${\beta}$ model-based interacting multiple model-extended Kalman filter (${\beta}$-IMM-EKF) for precise tracking of an RV. To evaluate the performance, other ballistic coefficient model based filters, which are gamma augmented filter, gamma bootstrapped filter were compared and assessed with the proposed ${\beta}$-IMM-EKF for precise tracking of an RV.

• Journal of Korean Society on Water Environment
• /
• v.29 no.1
• /
• pp.36-44
• /
• 2013

HSPF model based on BASINS was applied to analyze effects of watershed management measures for water quality conservation in the Hwaseong Reservoir watershed. The model was calibrated against the field measurements of meteorological data, streamflow and water qualities ($BOD_5$, T-N, T-P) at each observatory for 4 years (2007-2010). The water quality characteristics of inflow streams were evaluated. The 4 scenarios for the water quality improvement were applied to inflow streams and critical area from water pollution based on previous researches. The reduction efficiency of point and non-point sources in inflow streams was evaluated with each scenario. The results demonstrate that the expansion of advanced treatment system within wastewater treatment plants (WWTPs) and construction of pond-wetlands would be great effective management measures. In order to satisfactory the target water quality of reservoir, the measures which can control both point source and non-point source pollutants should be implemented in the watershed.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.41 no.1
• /
• pp.110-117
• /
• 2018

Machines and facilities are physically or chemically degenerated by continuous usage. One of the results of this degeneration is the process mean shift. By the result of degeneration, non-conforming products and malfunction of machine occur. Therefore a periodic preventive resetting the process is necessary. This type of preventive action is called 'preventive maintenance policy.' Preventive maintenance presupposes that the preventive (resetting the process) cost is smaller than the cost of failure caused by the malfunction of machine. The process mean shift problem is a field of preventive maintenance. This field deals the interrelationship between the quality cost and the process resetting cost before machine breaks down. Quality cost is the sum of the non-conforming item cost and quality loss cost. Quality loss cost is due to the deviation between the quality characteristics from the target value. Under the process mean shift, the quality cost is increasing continuously whereas the process resetting cost is constant value. The objective function is total costs per unit wear, the decision variables are the wear limit (resetting period) and the initial process mean. Comparing the previous studies, we set the process variance as an increasing concave function and set the quality loss function as Cpm+ simultaneously. In the Cpm+, loss function has different cost coefficients according to the direction of the quality characteristics from target value. A numerical example is presented.

• Transactions on Electrical and Electronic Materials
• /
• v.2 no.3
• /
• pp.24-27
• /
• 2001

The end point of oxide chemical mechanical polishing (CMP) have determined by polishing time calculated from removal rate and target thickness of oxide. This study is about control of oxide removal amounts on the shallow trench isolation (STI) patterned wafers using removal rate and thickness of blanket (non-patterned) wafers. At first, it was investigated the removal properties of PETEOS blanket wafers, and then it was compared with the removal properties and the planarization (step height) as a function of polishing time of the specific STI patterned wafers. We found that there is a relationship between the oxide removal amounts of blanket and patterned wafers. We analyzed this relationship, and the post CMP thickness of patterned wafers could be controlled by removal rate and removal target thickness of blanket wafers. As the result of correlation analysis, we confirmed that there was the strong correlation between patterned and blanket wafer (correlation factor: 0.7109). So, we could confirm the repeatability as applying for STI CMP process from the obtained linear formula. As the result of repeatability test, the differences of calculated polishing time and actual polishing time was about 3.48 seconds. If this time is converted into the thickness, then it is from 104 $\AA$ to 167 $\AA$. It is possible to be ignored because process margin is about 1800 $\AA$.

• Phonetics and Speech Sciences
• /
• v.7 no.3
• /
• pp.165-173
• /
• 2015

This study was aim to compare the phonological error patterns and PCC(Percentage of Correct Consonants) derived from the single word and spontaneous speech contexts of the speech sound disorders with unknown origin(SSD). The present study suggest that the development phonological error patterns and non-developmental error patterns of the target children, in according to speech context. The subjects were 15 children with SSD up to the age of 5 from 3 years of age. This research use 37 words of APAC(Assessment of Phonology & Articulation for Children) in the single word context and 100 eojeol in the spontaneous speech context. There was no difference of PCC between the single word and the spontaneous speech contexts. Significantly different developmental phonological error patterns between the single word and the spontaneous speech contexts were syllable deletion, word-medial onset deletion, liquid deletion, gliding, affrication, fricative other error, tensing, regressive assimilation. Significantly different non-developmental phonological error patterns were backing, addtion of phoneme, aspirating. The study showed that there was no difference of PCC between elicited single word and spontaneous conversational context. And there were some different phonological error patterns derived from the two contexts of the speech sound disorders. The more important interventions target is the error patterns of the spontaneous speech contexts for the immediate generalization and rising overall intelligibility.

• Journal of Information Processing Systems
• /
• v.17 no.2
• /
• pp.306-317
• /
• 2021

The unbalance between system ergodic sum rate and high fairness is one of the key issues affecting the performance of non-orthogonal multiple access (NOMA) system. To solve the problem, this paper proposes a power allocation algorithm to realize the ergodic sum rate maximization of NOMA system. The scheme is mainly achieved by the construction algorithm of fair model based on α fair utility function and the optimal solution algorithm based on the interior point method of penalty function. Aiming at the construction of fair model, the fair target is added to the traditional power allocation model to set the reasonable target function. Simultaneously, the problem of ergodic sum rate and fairness in power allocation is weighed by adjusting the value of α. Aiming at the optimal solution algorithm, the interior point method of penalty function is used to transform the fair objective function with unequal constraints into the unconstrained problem in the feasible domain. Then the optimal solution of the original constrained optimization problem is gradually approximated within the feasible domain. The simulation results show that, compared with NOMA and time division multiple address (TDMA) schemes, the proposed method has larger ergodic sum rate and lower Fairness Index (FI) values.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.17 no.3
• /
• pp.840-860
• /
• 2023

Aiming at the serious occlusion and slow tracking speed in pedestrian target tracking and recognition in complex scenes, a target tracking method based on improved YOLO v5 combined with Deep SORT is proposed. By merging the attention mechanism ECA-Net with the Neck part of the YOLO v5 network, using the CIoU loss function and the method of CIoU non-maximum value suppression, connecting the Deep SORT model using Shuffle Net V2 as the appearance feature extraction network to achieve lightweight and fast speed tracking and the purpose of improving tracking under occlusion. A large number of experiments show that the improved YOLO v5 increases the average precision by 1.3% compared with other algorithms. The improved tracking model, MOTA reaches 54.3% on the MOT17 pedestrian tracking data, and the tracking accuracy is 3.7% higher than the related algorithms and The model presented in this paper improves the FPS by nearly 5 on the fps indicator.

• Nuclear Engineering and Technology
• /
• v.56 no.3
• /
• pp.819-823
• /
• 2024

The main criteria used in NEI 18-04 to define SSCs as risk-significant include (1) the SSC is required to keep all LBEs within the F-C target, and (2) the total frequency with the SSC failed exceeds 1% of the limit for at least one of the three cumulative risk metrics used for evaluating the integrated plant risk. The first one is a reasonable criterion in determining the risk significant SSCs. However, the second criterion may not be adequate to serve the purpose of determining the risk significance of SSCs. In the second criterion, the cumulative risk metric values representing the integrated plant risk (less the preventive and mitigative effects of the SSC being evaluated) are compared to a risk limit that represents a very small contribution to the overall integrated plant risk, which corresponds appropriately to the contributions from individual SSCs. The easiest approach to redefine the NEI 18-04 definition of risk-significant SSCs in relation to the integrated plant risk metrics is to compare the difference, between the risk metric value calculated with the SSC failed and the risk metric value calculated with the SSC credited, with 1% of the risk limit established for the integrated plant risk metrics.

• Korea Journal of Hospital Management
• /
• v.28 no.4
• /
• pp.1-22
• /
• 2023

Purposes: The purpose of this study is to identify and analyze the factors that affect patients reusing non-face-to-face treatments at tertiary general hospitals. Methodology: We retrospectively analyzed a patient's reuse of non-face-to-face treatment from February 1, 2020, to December 31, 2021, at a tertiary general hospital in Seoul within one year of the first non-face-to-face treatment. A frequency analysis was conducted to identify the study subjects' demographic characteristics, treatment type characteristics, disease characteristics, and hospital use type characteristics. Also, across-analysis was conducted to verify the difference in non-face-to-face treatment reuse according to the characteristics a multiple logistic regression analysis was conducted to identify the factors affecting the reuse of non-face-to-face treatment by non-face-to-face treatment patients. Findings: The results of this study can be interpreted as indicating that the following groups are more likely tore use the non-face-to-face treatment: women, children, the elderly, Patients living far from the hospital, psychiatric patients, pediatric patients, medical benefits recipients, chronic patients, patients with mobility difficulties, and patients with high loyalty to hospitals. Practical Implications: When developing a non-face-to-face treatment system in the future, based on the results of this study, it is possible to target patients who prefer non-face-to-face treatment. And this study will be research material for vitalizing non-face-to-face treatment. In addition, the activation of the non-face-to-face treatment system will be an effective means for improving the quality of medical services and generating profits in hospitals in the future.