• Korean Journal of Agricultural Science
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• v.43 no.2
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• pp.205-214
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• 2016

A drought-tolerant transgenic rice (Agb0103) was developed using a pepper methionine sulfoxide reductase (CaMsrB2) under the control of rice Rab21 promoter with a selection marker, the phosphinothricin acetyltransferase (PAT) gene. Commercialization of genetically modified (GM) crops will require the evaluation of risks associated with the release of GM crops. With the potential problems associated to GM crops safety testing, the investigation of their effects on non-target organisms is necessary for environmental risk research. This study was carried out to assess acute toxicity of a GM crop using the water flea (Daphnia magna) for non-target organism risk evaluation. The effect of acute toxicity on Daphnia magna of Agb0103 rice and a non-GM rice, Ilmibyeo, were investigated at different concentrations (0, 625, 1,250, 2,500, 5,000, and 10,000 mg/L). The Agb0103 rice used for the test was confirmed to express the CaMsrB2/PAT gene by the PCR and ELISA. Daphnia magna feeding tests showed no significant differences in cumulative immobility or abnormal response with either Agb0103 rice or non-GM rice. The 48hr-EC50 values showed no difference between Agb0103 rice (2243 mg/L) and non-GM rice (2694 mg/L). These results suggest that there is no significant difference in toxicity to Daphnia magna between Agb0103 rice and its non-GM counterpart.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.2
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• pp.193-198
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• 2011

This study aimed to provide basic data for permeable pavement application upon design and installation stages by analyzing the effect of permeable pavement used on the facility area rather than using non-point pollutants treatment facility upon development business in accordance with recent trend. To perform this study, the area of development target was separately applied as impermeable and permeable developments so as to compare and analyze the economics of cut pollution load and installation construction cost. Consequently, the processing amount and cut load of non-point pollutant sources are influenced much by permeable and impermeable developments, and it was turned out to be better to develop target river area as permeable area rather than installing non-point pollutants treatment facility of equipment type or natural type upon development to yield smaller discharge load. If we can prepare a countermeasure regulating impermeable area ratio to certain level to manage non-point pollutants upon development based on this result, we can minimize the source of pollution caused by the development.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.3
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• pp.259-268
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• 2019

Even if only two ships are encountered, a collision may occur due to the mistaken judgment of the positional relationship. In other words, if an officer does not know a target ship's intention, there is always a risk of collision. In this paper, the experiments are conducted to investigate how the intention affects the action of collision avoidance in cooperative and non-cooperative situations. In non-cooperative situation, each ship chooses a course that minimizes costs based on the current situation. That is, it always performs a selfish selection. In a cooperative situation, the information is exchanged with a target ship and a course is selected based on this information. Each ship uses the Distributed Stochastic Search Algorithm so that a next-intended course can be selected by a certain probability and determines the course. In the experimental method, four virtual ships are set up to analyze the action of collision avoidance. Then, using the actual AIS data of eight ships in the strait of Dover, I compared and analyzed the action of collision avoidance in cooperative and non-cooperative situations. As a result of the experiment, the ships showed smooth trajectories in the cooperative situation, but the ship in the non-cooperative situation made frequent big changes to avoid a collision. In the case of the experiment using four ships, there was no collision in the cooperative situation regardless of the size of the safety domain, but a collision occurred between the ships when the size of the safety domain increased in cases of non-cooperation. In the case of experiments using eight ships, it was found that there are optimal parameters for collision avoidance. Also, it was possible to grasp the variation of the sailing distance and the costs according to the combination of the parameters, and it was confirmed that the setting of the parameters can have a great influence on collision avoidance among ships.

• Journal of Korean Neurosurgical Society
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• v.60 no.1
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• pp.21-29
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• 2017

Objective : The purpose of this study was to analyze outcomes and identify prognostic factors in patients with cerebral metastases from non-small cell lung cancer (NSCLC) treated with gamma knife radiosurgery (GKS) particularly, focusing on associations of biomarkers and systemic treatments. Methods : We retrospectively reviewed the medical records of 134 patients who underwent GKS for brain metastases due to NSCLC between January 2002 and December 2012. Representative biomarkers including epidermal growth factor receptor (EGFR) mutation, K-ras mutation, and anaplastic lymphoma kinase (ALK) mutation status were investigated. Results : The median overall survival after GKS was 22.0 months (95% confidence interval [CI], 8.8-35.1 months). During follow-up, 63 patients underwent salvage treatment after GKS. The median salvage treatment-free survival was 7.9 months (95% CI, 5.2-10.6 months). Multivariate analysis revealed that lower recursive partition analysis (RPA) class, small number of brain lesions, EGFR mutation (+), and ALK mutation (+) were independent positive prognostic factors associated with longer overall survival. Patients who received target agents 30 days after GKS experienced significant improvements in overall survival and salvage treatment-free survival than patients who never received target agents and patients who received target agents before GKS or within 30 days (median overall survival: 5.0 months vs. 18.2 months, and 48.0 months with p-value=0.026; median salvage treatment-free survival: 4.3 months vs. 6.1 months and 16.6 months with p-value=0.006, respectively). To assess the influence of target agents on the pattern of progression, cases that showed local recurrence and new lesion formation were analyzed according to target agents, but no significant effects were identified. Conclusion : The prognosis of patients with brain metastases of NSCLC after GKS significantly differed according to specific biomarkers (EGFR and ALK mutations). Our results show that target agents combined with GKS was related to significantly longer overall survival, and salvage treatment-free survival. However, target agents were not specifically associated with improved local control of the lesion treated by GKS either development of new lesions. Therefore, it seems that currently popular target agents do not affect brain lesions themselves, and can prolong survival by controlling systemic disease status.

• Journal of Environmental Impact Assessment
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• v.20 no.6
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• pp.857-866
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• 2011

This research categorized EIA target highways into following three types in order to minimize non-point source pollution from highway runoff. 1. Big drainage basin. 2. Small drainage basin. 3. Bridge section. The Natural, Filter and Swirl-Type devices were evaluated in terms of removal efficiency of TSS, BOD, COD, T-N, T-P, compatibility of site selection, economic feasibility, and maintenance convenience through which the final BMP was selected. According to the removal efficiency result, the area of Big and Small Drainage basin and bridge section had higher removal efficiency with natural facility than that of the Filter or Swirl-Type device. To make appropriate selection of highways'BMP for non-point source pollution, this study will aim to contribute to building more environmentally friendly highways by proposing the selection process that is made of 5 stages. 1. Selecting the target drainage basin. 2. Selecting the land for the mitigation facility. 3. Analysing the ease of maintenance. 4. Technically evaluating each installation. 5. Evaluating the effective implementation methods.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3725-3728
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• 2013

Background: The mammalian target of rapamycin (mTOR) /RPS6KB1 activation has recently been implicated in tumour development, but its role in lung cancer remains unclear. The aim of this study was to explore the role of mTOR/RPS6KB1 signaling pathway in non-small-cell lung cancer (NSCLC). Methods: Immunohistochemistry was performed to assess the expression of phosphorylated mammalian target of rapamycin (p-mTOR) and its downstream ribosomal phosphorylated RPS6KB1 (p-RPS6KB1) in NSCLC patients. We also analyzed p-mTOR/p-RPS6KB1 protein expression in 45 fresh NSCLC tissues using Western blotting. Results: The expression level of p-mTOR and p-RPS6KB1 was significantly higher in NSCLC tumor specimens than that in adjacent noncancerous normal lung tissues (P<0.01). p-mTOR expression correlated with p-RPS6KB1. Furthermore, high expression level of p-mTOR or p-RPS6KB1 in NSCLC was associated with a shorter overall survival (both P<0.01). Multivariate analysis indicated high level of p-mTOR expression was an independent prognostic factor (HR=2.642, 95%CI 1.157-4.904, p=0.002). Conclusions: p-mTOR and p-RPS6KB1 could be useful prognostic markers for NSCLC.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.4
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• pp.657-670
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• 2018

This study investigated the wearing of jackets by down-aging middle-aged women in their 40s to 50s who enjoy wearing attire from ladies' apparel brands that target the 20s to 30s age group. As a method of research, a survey was done on middle-aged women in their 40s and 50s as the target age group. Based on the survey results, comparison and analysis was done on the wearing of jackets as well as preferred extra space and fitness of the clothes, with the distinction between the down-aging group and the non down-aging group. The down-aging middle-aged women purchased jackets mainly at department stores, outlets, discount outlets, and internet shopping malls, and showed the highest frequency of wearing the jackets once or twice a week. For the item "importance in selecting a jacket", both groups chose "the design" as the most important aspect; however, the non down-aging group took "size and fitness" and "activity and comfort" more than the down-aging group. Especially regarding the size of the jackets, size S (55) was the most often worn by the down-aging group, whereas size M (66) was the most often worn by the non down-aging group.

• Journal of Intelligence and Information Systems
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• v.8 no.1
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• pp.1-13
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• 2002

Estimating the Value-at-Risk (VaR) of a non-listed or newly listed company in stock market is impossible due to lack of stock exchange data. This study employes Case-Based Reasoning (CBR) for estimating VaR's of those companies. CBR enables us to identify and select existing companies that have similar financial and non-financial characteristics to the unlisted target company. The VaR's of those selected companies can give estimates of VaR for the target company. We developed a system called VAS-CBR and showed how well the system estimates the VaR's of unlisted companies.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4147-4156
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• 2015

Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality. More than 80% of lung cancers feature a non-small cell histology. Over few decades, systemic chemotherapy and surgery are the only treatment options in this type of tumor but due to their limited efficacy and overall poor survival of patients, there is an urge to develop newer therapeutic strategies which circumvent the problems. Enhanced knowledge of translational science and molecular biology have revealed that lung tumors carry diverse driver gene mutations and adopt different intracellular pathways leading to carcinogenesis. Hence, the development of targeted agents against molecular subgroups harboring critical mutations is an attractive approach for therapeutic treatment. Targeted therapies are clearly more preferred nowadays over systemic therapies because they target tumor specific molecules resulting with enhanced activity and reduced toxicity to normal tissues. Thus, this review encompasses comprehensive updates on targeted therapies for the driver mutations in non-small cell lung cancer (NSCLC) and the potential challenges of acquired drug resistance faced i n the field of targeted therapy along with the imminent newer treatment modalities against lung cancer.

• International Journal of Aerospace System Engineering
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• v.2 no.2
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• pp.29-33
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• 2015

The multidisciplinary design optimization (MDO) of a launch vehicle (LV) with a hybrid rocket engine (HRE) was carried out to investigate the ability of an HRE for a single-stage LV. The non-dominated sorting genetic algorithm-II (NSGA-II) was employed to solve two design problems. The design problems were formulated as two-objective cases involving maximization of the downrange distance over the target flight altitude and minimization of the gross weight, for two target altitudes: 50.0 km and 100.0 km. Each objective function was empirically estimated. Several non-dominated solutions were obtained using the NSGA-II for each design problem, and in each case, a trade-off was observed between the two objective functions. The results for the two design problem indicate that economical performance of the LV is limited with the HRE in terms of the maximum downrange distances achievable. The LV geometries determined from the non-dominated solutions were examined.