• CELLMED
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• v.2 no.2
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• International Journal of Industrial Entomology and Biomaterials
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• v.20 no.2
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• pp.79-85
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• 2010

Eight bivoltine inbred lines of silkworm Bombyx mori L. viz., AP8, AP10, AP17 and AP18 with marked female and plain male larvae and AP1, AP54, AP71 and AP72 with all plain larvae synthesized from Chinese commercial hybrids were evaluated for their general combining ability (gca), specific combining ability (sca) and reciprocal effects for eight quantitative traits. The line AP18 was found to be best general combiner by virtue of significant positive and positive gca effects for seven out of eight traits studied followed by the lines AP10, AP8 and AP17. Seven hybrids recorded significant positive and positive sca effects for all the traits under study reflecting the interaction of alleles, additive and non additive gene action and dominant effects expressed by genes. Among the 28 reciprocal hybrids, AP54$\times$AP18 and AP1$\times$AP17 revealed significant reciprocal effects for the six traits followed by AP54$\times$AP8 for five and AP10$\times$AP71 for four traits.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.385-395
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• 2017

Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.

• English Language & Literature Teaching
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• no.6
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• pp.1-24
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• 2000

Listening comprehension is an integrative and creative process of interaction through which listeners receive speakers' production of linguistic or non-linguistic knowledge. Compared with reading comprehension, it may arouse difficulties and thus impose more burdens on foreign learners. The Audio-Lingual Method focused primarily on speaking. Mimicry, repetition, rote memory, and transformation drills actually interfered with listening comprehension. So learners lost interest and were not highly motivated. Improving listening comprehension requires continual attentiveness and interest. Listening skill can be extended systematically only when students are frequently exposed to a wide range of listening materials with an affective, cultural, social, and psycholinguistic approach. Therefore, teachers should help students learn how to comprehend intactly the overall meaning of intended messages. The literature on teaching listening skill suggests various useful activities: TPR, dictation, role playing, singing, picture recognition, completion, prediction, seeking specific information, summarizing, labeling, humor, jokes, cartoons, media, and so on. Practical classroom teaching necessitates a systematic procedure in which students should take part in meaningful tasks/activities. In addition to this, learners must practice listening comprehension trough a self-study process.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.214-216
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• 2006

Expressive face and human body gestures are among the main non-verbal communication channels in human-human interaction. Understanding human emotions through body gesture is one of the necessary skills both for humans and also for the computers to interact with their human counterparts. Gesture analysis is consisted of several processes such as detecting of hand, extracting feature, and recognizing emotions. Skin color information for tracking hand gesture is obtained from face detection region. We have revealed relationships between paricular body movements and specific emotions by using HMM(Hidden Markov Model) classifier. Performance evaluation of emotional human body recognition has experimented.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.13 no.4
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• pp.83-90
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• 2014

The spiral up milling of an aluminum alloy was performed in this study. In accordance with the cutting condition, the surface roughness behavior and significance of the research with regard to specific factors were analyzed. The cutting speed, feed, and depth of the cut were found to be statistically significant. A higher cutting speed improved the surface roughness. On the other hand, as the feed and depth of the cut increase, the surface roughness decreases. An interaction effect between the feed and depth of the cut was detected. According to the surface roughness in relation to the cutting conditions, the model showed non-linear behavior.

• Bulletin of the Korean Chemical Society
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• v.15 no.1
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• pp.45-52
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• 1994

We present a theoretical study of the non-symmetrical A/BC polymeric system. The polymer blends consist of two phases, a pure polymeric phase A on one side and a mixture of polymers B as a compatibilizer and C on the other. The adsorption of homopolymer B to the interface improves the interfacial adhesion between two phases. By employing the functional integral techniques, we derive the mean-field equations and solve them numerically to obtain the interfacial properties including the concentration profiles in the limit of infinite molecular weight for the polymers. Thecalculations of the interfacial properties are performed for typical values of the Flory X parameters and the volume fraction of polymer B in the asymptotic mixture phase. The interfacial adsorption of polymer B and the degrees of the specific interaction between the polymers play an important role in modification of the interfacial properties.

• Nuclear Engineering and Technology
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• v.54 no.9
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• pp.3551-3566
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• 2022

The STELLA program was launched to support the PGSFR development in 2012 and for the 2nd stage, the STELLA-2 facility was designed to investigate the integral effect of safety systems including the comprehensive interaction among PHTS, IHTS and DHRS. In STELLA-2, the long-term transient behavior after accidents can be observed and the overall safety aspect can also be evaluated. In this paper, the basic design concept from engineering basis to specific design is described. The design was aimed to meet similarity criteria and requirements based on various non-dimensional numbers and the result satisfied the key features to explain the reasoning of safety evaluation. The result of this study was used to construct the facility and the experiment is on-going. In general, the final design meets the similarity criteria of the multidimensional physics inside the reactor pool. And also, for the conservation of natural circulation phenomena, the design meets the similarity requirements of geometry and thermo-dynamic behavior.

• Journal of Mechanical Science and Technology
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• v.16 no.9
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• pp.1147-1155
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• 2002

Discharge flows from a centrifugal pump impeller with a specific speed of 150 [rpm, m$^3$/min, m] were experimentally investigated. A large axisymmetric collector instead of a volute casing was installed to obtain circumferentially uniform flow, i.e. without interaction of the impeller and the volute. The unsteady flow was measured at the impeller exit and vaneless diffuser using a hot film probe and a pressure transducer. The flow at impeller exit showed pronounced jet-wake flow patterns. The wake, which was on the suction/hub side at high flow rate, became enlarged pitchwisely on both the hub and the shroud side as the flow rate decreases. The pitchwise non-uniformity of the flow rapidly decreased along the downstream and the non-uniformity almost disappeared at radius ratio of 1.18 for medium flow rate. The mean vaneless diffuser flow was reasonably predicted using a one dimensional analysis when an empirical constant was used to specify the skin friction coefficient. The data can be used for a centrifugal pump impeller design and validation of CFD codes and flow modeling.

• Carbon letters
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• v.20
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• pp.19-25
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• 2016

Activated carbon fiber (ACF) surfaces are modified using an electron beam under different aqueous solutions to improve the NO gas sensitivity of a gas sensor based on ACFs. The oxygen functional group on the ACF surface is changed, resulting in an increase of the number of non-carbonyl (-C-O-C-) groups from 32.5% for pristine ACFs to 39.53% and 41.75% for ACFs treated with hydrogen peroxide and potassium hydroxide solutions, respectively. We discover that the NO gas sensitivity of the gas sensor fabricated using the modified ACFs as an electrode material is increased, although the specific surface area of the ACFs is decreased because of the recovery of their crystal structure. This is attributed to the static electric interaction between NO gas and the non-carbonyl groups introduced onto the ACF surfaces.