• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.12
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• pp.1802-1812
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• 2001

The purpose of this study is to analyze numerically the movement of particles included in turbulent fluid flow characteristics of metallic surfaces. To describe fluid flew, the incompressible Navier-Stokes equation discretized by the finite volume method were solved on the non-orthogonal coordinates with non-staggered variable arrangement, and the k-$\xi$ turbulence model was adapted. After fluid flow was calculated, particle movement was predicted from the Lagrangian approaches. Non-essential complexities were avoided by assuming that the particles had spherical shapes and the Stoke's drag formula only consisted of external farces acting upon them. In order to validate the numerical calculations, the results were compared with the experimental data reported in literature and agreed well with them. The drag force coefficient equation showed better agreement with the experimental data in the prediction of particle movement than the correction factor equation. Impact velocity and impact angle increased as inlet turbulence intensity decreased, relative jet height was lower. or the Reynolds number was larger.

• Korean journal of food and cookery science
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• v.23 no.5
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• pp.749-760
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• 2007

The purpose of this study was to evaluate the microbiological quality of non-heat-processed foods and the effects of HACCP implementation. Here, cabbage salad and cucumber&onion salad were selected and we investigated HA(Hazard Analysis) by checking microbiological quality, time and temperature, pH, and water activity at each processing stage. Thus, the receiving of spices and dressings, washing and sterilizing, cutting, cooking, and serving stages were all considered CCPs. Before implementing HACCP, microbial analysis showed that standard plate counts and coliform counts were higher than standard levels in most of the raw ingredients of each menu, as well as during the production process. The microbiological quality of the utensils and employee's hands used during cooking indicated levels requiring direct management. Evaluations of falling bacteria-in the foodservice establishment work areas ranged from $2{\sim}12CFU/plate$. However, after HACCP implementation, microbiological levels improved to standard levels fly sanitation education. Also, the number of falling bacteria were lower than before implementing HACCP. Therefore, it is essential the foodservice operations make efforts to implement HACCP, so that microbiological hazard levels are lowered and hygienic status improved.

• Smart Structures and Systems
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• v.6 no.3
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• pp.239-262
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• 2010

Tube Lines has carried out a "knowledge and investigation programme" on the deep tube tunnels comprising the Jubilee, Northern and Piccadilly lines, as required by the PPP contract with London Underground. Many of the tunnels have been in use for over 100 years, so this assessment was considered essential to the future safe functioning of the system. This programme has involved a number of generic investigations which guide the assessment methodology and the analysis of some 5,000 individual structures. A significant amount of investigation has been carried out, including ultrasonic thickness measurement, detection of brickwork laminations using radar, stress measurement using magnetic techniques, determination of soil parameters using CPT, pressuremeter and laboratory testing, installation of piezometers, material and tunnel segment testing, and trialling of remote photographic techniques for inspection of large tunnels and shafts. Vibrating wire, potentiometer, electro level, optical and fibre-optic monitoring has been used, and laser measurement and laser scanning has been employed to measure tunnel circularity. It is considered that there is scope for considerable improvements in non-destructive testing technology for structural assessment in particular, and some ideas are offered as a "wish-list". Assessment reports have now been produced for all assets forming Tube Lines' deep tube tunnel network. For assets which are non-compliant with London Underground standards, the risk to the operating railway has to be maintained as low as reasonably practicable (ALARP) using enhanced inspection and monitoring, or repair where required. Monitoring techniques have developed greatly during recent years and further advances will continue to support the economic whole life asset management of infrastructure networks.

• Journal of the Korea Safety Management & Science
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• v.14 no.2
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• pp.193-204
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• 2012

This paper deals with an empirical analysis of the structural relationship among the factors such as quality management activities, organizational learning and firm performance of manufacturing corporations. The findings of the analysis are expected to make lots of contribution to manufacturing corporations establishing strategies for quality management activities and organizational learning. From the analysis, following conclusions and suggestions could be drawn: First, an analysis of the relationship between quality management activities and organizational learning showed that most activities of quality management turned out to exercise great influence upon the factors of organizational learning. This means that the activities of quality management will prompt the members of an organization to actively engage in learning activities individually, by team and organizationally, motivating them to spread such activities across the whole organization, leading ultimately to fundamental renovation of the very organization. Second, from an analysis of the relationship between organizational learning and firm performance, that is, financial and non-financial performances of a company, it was found that most factors of organizational learning have tremendous impact upon financial and non-financial performances of the company. Such result implies that decision and management of the things to be performed in the process of organizational performances are essential to determining firm performance because firm performance depend largely on the outcomes of organizational learning.

• IMMUNE NETWORK
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• v.13 no.6
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• pp.249-256
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• 2013

How Th2 immunity develops in vivo remains obscure. Basophils have been considered key innate cells producing IL-4, a cytokine essential for Th2 immunity. Increasing evidence suggests that basophils are dispensable for the initiation of Th2 immunity. In this study, we revisited the role of basophils in Th2 immune responses induced by various types of adjuvants. Mice deficient in IL-3 or IL-3 receptor, in which basophil lymph node recruitment is completely abolished, fully developed wild type level Th2 CD4 T cell responses in response to parasite antigen or papain immunization. Similar finding was also observed in mice where basophils are inducibly ablated. Interestingly, IL-4-derived from non-T cells appeared to be critical for the generation of IL-4-producing CD4 T cells. Other Th2 promoting factors including IL-25 and thymic stromal lymphopoietin (TSLP) were dispensable. Therefore, our results suggest that IL-3- and basophil-independent in vivo Th2 immunity develops with the help of non-T cell-derived IL-4, offering an additional mechanism by which Th2 type immune responses arise in vivo.

• Journal of Electrical Engineering and Technology
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• v.9 no.5
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• pp.1753-1761
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• 2014

Due to the inherent inhomogeneous and anisotropy nature of the composite materials, the detection of internal defects in these materials with non-destructive techniques is an important requirement both for quality checks during the production phase and in service inspection during maintenance operations. The estimation of the time-of-arrival (TOA) and/or time-of-flight (TOF) of the ultrasonic echoes is essential in ultrasonic non-destructive testing (NDT). In this paper, we used split-spectrum processing (SSP) combined with matching pursuit signal decomposition (MPSD) to develop a dedicated ultrasonic detection system. SSP algorithm is used for Signal-to-Noise Ratio (SNR) enhancement, and the MPSD algorithm is used to decompose backscattered signals into a linear expansion of chirplet echoes and estimate the chirplet parameters. Therefore, the combination of SSP and MPSD (SSP-MPSD) presents a powerful technique for ultrasonic NDT. The SSP algorithm is achieved by using Gaussian band pass filters. Then, MPSD algorithm uses the Maximum Likelihood Estimation. The good performance of the proposed method is experimentally verified using ultrasonic traces acquired from three specimens of carbon fibre reinforced polymer multi-layered composite materials (CFRP).

• Toxicological Research
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• v.25 no.1
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• pp.1-8
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• 2009

Validation specifies and coordinates all relevant activities to ensure compliance with good laboratory practices (GLP) according to suitable international standards. This includes validation activities of past, present and future for the best possible actions to ensure the integrity of non-clinical laboratory data. Recently, validation has become increasingly important, not only in good manufacturing practice (GMP) institutions but also in GLP facilities. In accordance with the guideline for GLP regulations, all equipments used to generate, measure, or assess data should undergo validation to ensure that this equipment is of appropriate design and capacity and that it will consistently function as intended. Therefore, the implantation of validation processes is considered to be an essential step in a global institution. This review describes the procedures and documentations required for validation of GLP. It introduces basic elements such as the validation master plan, risk assessment, gap analysis, design qualification, installation qualification, operational qualification, performance qualification, calibration, traceability, and revalidation.

• BMB Reports
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• v.52 no.10
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• pp.607-612
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• 2019

During meiosis, programmed double-strand breaks (DSBs) are repaired via recombination pathways that are required for faithful chromosomal segregation and genetic diversity. In meiotic progression, the non-homologous end joining (NHEJ) pathway is suppressed and instead meiotic recombination initiated by nucleolytic resection of DSB ends is the major pathway employed. This requires diverse recombinase proteins and regulatory factors involved in the formation of crossovers (COs) and non-crossovers (NCOs). In mitosis, spontaneous DSBs occurring at the G1 phase are predominantly repaired via NHEJ, mediating the joining of DNA ends. The Ku complex binds to these DSB ends, inhibiting additional DSB resection and mediating end joining with Dnl4, Lif1, and Nej1, which join the Ku complex and DSB ends. Here, we report the role of the Ku complex in DSB repair using a physical analysis of recombination in Saccharomyces cerevisiae during meiosis. We found that the Ku complex is not essential for meiotic progression, DSB formation, joint molecule formation, or CO/NCO formation during normal meiosis. Surprisingly, in the absence of the Ku complex and functional Mre11-Rad50-Xrs2 (MRX) complex, a large portion of meiotic DSBs was repaired via the recombination pathway to form COs and NCOs. Our data suggested that Ku complex prevents meiotic recombination in the elimination of MRX activity.

• Structural Engineering and Mechanics
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• v.68 no.5
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• pp.591-601
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• 2018

Non-moment beam-to-column connections, which are usually referred to as simple or shear connections, are typically designed to carry only gravity loads in the form of vertical shears. Although in the analysis of structures these connections are usually assumed to be pinned, they may provide a small amount of rotational stiffness due to the typical connection details. This paper investigates the effects of this small rotational restraint of simple beam-to-column connections on the behavior and seismic response of steel braced non-moment resisting frames. Two types of commonly used simple connections with bolted angles, i.e., the Double Web angle Connection (DWC) and Unstiffened Seat angle Connection (USC) are considered for this purpose. In addition to the pinned condition - as a simplified representation of these connections - more accurate semi-rigid models are established and then applied to some frame models subjected to nonlinear pushover and nonlinear time history analyses. Although the use of bracing elements generally reduces the sensitivity of the global structural response to the behavior of connections, the obtained results indicate considerable effects on the local responses. Namely, our results show that consideration of the real behavior of connections is essential in designing the column elements where the pin-connection assumption significantly underestimates design of outer columns of upper stories.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.2
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• pp.68-75
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• 2019

Chronic recurrent multifocal osteomyelitis (CRMO) is one of the most severe form of chronic non-bacterial osteomyelitis (CNO), which could result in bone and related tissue damage. This autoinflammatory bone disorder (ABD) is very difficult for its clinical diagnosis because of no diagnostic criteria or biomarkers. CRMO in the jaw must be suspected in the differential diagnosis of chronic and recurrent bone pain in the jaw, and a bone biopsy should be considered in chronic and relapsing bone pain with swelling that is unresponsive to treatment. The early diagnosis of CRMO in the jaw will prevent unnecessary and prolonged antibiotic usage or unnecessary surgical intervention. The updated researches for the identification of genetic and molecular alterations in CNO/CRMO should be studied more for its correct pathophysiological causes and proper treatment guidelines. Although our trial consisted of reporting items from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), there are very few articles of randomized controlled trials. This article was summarized based on the author's diverse clinical experiences. This paper reviews the clinical presentation of CNO/CRMO with its own pathogenesis, epidemiology, recent research studies, and general medications. Treatment and monitoring of the jaw are essential for the clear diagnosis and management of CNO/CRMO patients in the field of dentistry and maxillofacial surgery.