• 한방재활의학과학회지
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• 제27권1호
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• pp.53-65
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• 2017

Objectives The purpose of this study is to evaluate the safety of Non-toxic bee venom (BV) and observe VAS change before and after Non-toxic BV treatment in pain patients. Methods We surveyed the clinical practitioners who treated with Non-toxic BV in pain patients who visited the Korean medical clinic. The questionnaire survey was conducted for clinical practitioners who agreed to participate after hearing the explanation for the purpose and characteristics of the questionnaire. Patients in the questionnaires were reviewed based on their medical records from July 1, 2016 to October 28, 2016. Results We received 445 cases and selected 403 cases finally. 2 cases, however, were not able to continue treatment for 3 weeks and were eliminated. Depending on when the pain occurred, we divided the 401 cases into three groups (Acute, Subacute, Chronic group). In all groups, VAS scores were significantly decreased after treatment. Adverse reactions following Non-toxic BV treatment had occurred was 16 cases (3.60%). Except for 3 cases with hives, most of adverse reactions were mild or moderate and were not in need of extra treatment. The total safety of treatment for 3 weeks was mostly safe. The number of cases discontinued treatment was 42 cases (9.44%). Most of these cases, treatment was stopped for personal reason unrelated to the Non-toxic BV treatment. Conclusions These results suggest that the Non-toxic BV treatment has no serious adverse reactions and is a relatively safe treatment. Further studies are needed to prove the efficacy and clinical safety of Non-toxic BV treatment.

• Journal of the korean society of oceanography
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• 제34권3호
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• pp.167-171
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• 1999

Since toxic Alexandrium catenella and non-toxic A. fraterculus are morphologically similar, they are difficult to discriminate under the light microscope. However, a novel technology, such as fluorescein isothiocyanate (FITC)-conjugated lectin probes enables easy and rapid differentiation. Toxic A. catenella bound seven different lectins, whereas the non-toxic A. fratercuzus did not bind Arachis hypogaea (PNA) lectin. In addition, Pseudo-nitrschia species in this study were also difficult to identify to species level with light microscope techniques, but it was possible to classify them using fluorescent lectins. Pseudo-nitzschia multistriata, P. subfraudulenta and P. pungens bound Canavalia ensiformis (ConA), whereas P. subpaclfica did not, and P. pungens also bound Ricinus communis (RCA). These results imply that lectin could be used as a critical tool in the differentiation of P. multistriata, P. subfraudulenta and P. pungens. However, P. subpacifica was not differentiated by the lectins tested. Therefore, it isconcluded that lectin probes are useful for discriminating toxic A. catenella from non-toxic A. fraterculus, and for the identification of some Pseudo-nitzschia species. In addition, this method has a great potential to speed and detection between non-toxic and toxic harmful algal blooms (HABs) in Korean biotoxin monitoring systems.

• Animal cells and systems
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• 제5권2호
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• pp.139-143
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• 2001

Alzheimer's disease is the most common form of dementia and no cure is known so far. Extensive genetic works and in vitro experiments combined with clinical observations link amyloid $\beta$--protein (A$\beta$-) to the pathogenesis of Alzheimer's disease (AD). It was hypothesized that $A\beta$- becomes toxic when it adopts a fibrillar conformation. Recently, non-fibrillar form of $A\beta$- was observed and the potential role in the pathogenesis of AD became an interesting subject. In this study, the cytotoxicity of non-fibrillar $A\beta$- and fibrillar $A\beta$- was compared on oxidative stress, membrane damage, or nucleosome break down. Non-fibrillar $A\beta$- was not toxic in peripheral nervous system-derived cells but significantly toxic in central nervous system-derived cells while fibrillar $A\beta$- was non-selectively toxic in both cell culture. The neurotoxicity of non-fibrillar $A\beta$- was reproduced in semi-in vivo culture of mouse brain slice. In conclusion, non-fibrillar $A\beta$- could be more relevant to the selective neurodegeneration in Alzheimer's brains than fibrillar $A\beta$- and further research needs to be done for identification of the cause of AD.

• 한국응용곤충학회지
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• 제34권4호
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• pp.373-377
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• 1995

전국의 토양시료로부터 3가지의 곤충목인, 나비목, 파리목, 딱정벌레목에 속하는 10종의 곤충에 대하여 독성을 보이지 않는 4종의 Bacillus thunngiensis 균주를 분리하였다. 이들 4종의 균주를 각각 NTB-1, NTB-2, NTB-3, NTB-4로 명명하였다. 취상차 현미경과 주사전자현미경을 통해 관찰된 이들 4종 균주의 내독소 단백질 형태는 모두 원형이었으며, 각 균주의 내독소 단백질과 plasmid DNA 특성을 규명하기 위해 단백질 전기영동과 제한효소 분석을 실시하였다. 그 결과 이들 균주의 내독소 단백질과 plasmid DNA pattern은 이미 알려져 있는 무독성 균주들과는 다른 양상을 보여, 기존의 무독성 균주와 다른 새로운 균주임을 알 수 있었다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.437-441
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• 2008

A non-toxic Post Boost Stage(PBS) with LOX/Ethanol engine was successfully demonstrated at the Tomioka Facility of IHI Aerospace. IHI Aerospace has researched and developed the nontoxic propulsion systems and the LOX/Ethanol is one of the most attractive non-toxic bipropellant candidates. ${\rho}ISP$ of LOX/Ethanol is higher than ${\rho}ISP$ of the other non-toxic bipropellants as LOX/HC or $LOX/LH_2$. The authors studied the combustion characteristics of LOX/Ethanol propellant with the engine designed for LOX/LNG propellant. Also the injector with a built-in igniter was designed and examined its feasibility, ignition and combustion characteristics. We have demonstrated Post Boost Stage with future LOX/Ethanol engines. This propulsion system is targeted for expandable vehicle upper stage to accelerate delta-V to reach the required orbit. PBS Demonstration Model is designed as a test stand to evaluate feed system for integrated propulsion system and also to demonstrate Integrated Vehicle Health Management(IVHM) technique using local valve control and also valve behavior-monitoring capability.

• Corrosion Science and Technology
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• 제8권5호
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• pp.197-202
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• 2009

The high toxicity of wax, oil, varnish and volatile corrosion inhibitor(VCI) corrosion inhibitors lead to an increasing interest in using non-toxic alternatives such as anti-corrosive film. This study aims to investigate the possibility to use acryl based anti-corrosive film as a substitution of toxic corrosion inhibitors. Acryl emulsions were polymerized by several acryl monomers(acrylonitrile(AN), n-butyl acrylate(nBA), methylmethacrylate(MMA) and glycycyl methacrylate(GMA)), non-toxic corrosion inhibitor, crosslinking agents(diethylene glycol dimethacrylate(DEGDA)) and various additives in order to apply substrate of anti-corrosive film. Acryl emulsion for anti-corrosive film(AeACF) as a substrate of corrosion inhibitor film has excellent removal characteristic at above $25^{\circ}C$. The crosslinked by DEGDA in a range of above 4 wt% content anti-corrosive film can easily remove from the metal surface by using hands because it kept a balance of cohesion and adhesion strength. Anti - corrosive performance of AeACF is better than anti-corrosive oil by corrosion rate test, which was measured $54.3mg/dm^2$ day(MDD) and $142.9mg/dm^2$ day, respectively. Anti-corrosive film consisting of acryl monomers and inorganic anti-corrosive ingredients did not emit any toxic pollutants by gas chromatography. Thus it is estimated that acryl based anti-corrosion film can substitute toxic corrosion inhibitors.

• Ecology and Resilient Infrastructure
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• 제2권2호
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• pp.161-166
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• 2015

최근 생태하천 복원 사업용으로 개발된 호안 공법에 대한 수리학적 설계기준이 부적절하여 이 공법이 적용된 하천에서 홍수기에 큰 경제적 손실을 유발하고 있다. 본 연구에서는 생태복원용으로 개발된 무독성 호안 블록을 실규모 수로에 설치하여 최고 유량 $3.0m^3/s$, 최고 유속 3.0 m/s에서 수리적 안정성을 평가하였다. 설치된 무독성 호안 블록은 실험 조건에서 상하 ${\pm}3mm$ 정도로 미미하게 이동하였다. 그러므로 실험에 적용한 무독성 호안 블록은 고유속에서 대규모 이동, 블록 파괴, 침상 침하 등이 나타나지 않는 것으로 보아 충분한 안정성을 확보한 것으로 판단되었다.

• 한국전기전자재료학회논문지
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• 제36권1호
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• pp.93-97
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• 2023

A triboelectric nanogenerator (TENG) is a device that converts mechanical energy into electrical energy, and has been considered as a substitute for continuous power supply due to its high performance, simple structure and eco-friendliness. Recently, it is important to develop a TENG using a non-toxic material in order to use it as a power source for wearable, attachable, and body-embeddable electronics. Here, we developed a human friendly TENG using polyvinyl chloride (PVC) gel containing acetyl tributyl citrate (ATBC), a non-toxic plasticizer. PVC gels were fabricated using various ratios of PVC and ATBC, and optimized by investigating dielectric properties, surface potential, output performance, and durability. The PVC gel based TENG generates output signals of 73 V and 4.3 μA, i.e., a 5-fold enhancement in the output power compared to pristine PVC-based TENG. In addition, the PVC gel can be stretched over 500% of strain. This study is expected to be helpful in the future development of non-toxic wearable TENG.

• Journal of Yeungnam Medical Science
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• 제37권1호
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• pp.22-31
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• 2020

There has been a growing concern and subsequent interest surrounding numerous reproductive toxic agents found in various working and non-working environments. Meanwhile, there have been many efforts in medical fields such as toxicology and epidemiology applying experimental studies to elucidate reproductive toxic agents' characterization and health effects. However, there remains insufficient research data and inadequate evidence in humans. Adverse reproductive outcomes vary from transient, moderate health effects to severely detrimental consequences, such as permanent infertility or childhood cancer of one's offspring. Furthermore, upon exposure to toxic agents, the latent period before reproductive health effects are observed is relatively short compared to other occupational diseases (e.g., occupational cancer); instant action is required once exposure to reproductive toxic agents is detected. Therefore, it is very important for workers and healthcare professionals to know about the reproductive toxic agents they are likely to be exposed to. In this review, we discuss the general epidemiology of reproductive health in Korea, and the information regarding these reproductive toxic agents.

• 한국주조공학회지
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• 제32권4호
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• pp.177-180
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• 2012

Ti-based bulk metallic glasses with high glass forming ability were developed through a systematic alloy design technique. The main alloy design strategy was the selection of alloying elements that may not be toxic in the human body. The $Ti_{45.0}Cu_{40.1}Zr_{12.7}Si_{2.2}$ alloy could be cast into an amorphous rod with the diameter of 3 mm by a suction casting technique using Cu mold. The compressive strength of the amorphous rod was measured as 1826 MPa. Since the Ti-based amorphous alloys consist of non-toxic elements, they can be widely used as bio-materials and eco-materials with unique and beneficial properties.