• Biomedical Science Letters
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• v.12 no.4
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• pp.311-318
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• 2006

The GJB2 mutation is mostly recessive in non-syndromic hearing loss, but specific mutations display a dominant type and syndromic hearing impairment. Both U54K and R75Q mutations present a dominant type in pedigrees with associated skin disorders. The purpose of this study was to investigate whether two GJB2 mutations can exhibit a dominant-negative effect on the growth abrogation and the gap junctional intercellular communication capacity exerted by wild-type connexin 26. A specific mutant region of GJB2 showed a loss of gap junction activity and a dominant negative effect on wild-type GJB2. The two mutants exerted a dominant-negative effect on the GJIC capacity and have independently effected GJB2 regulated growth of Hela cells; however, they have no dominant-negative growth effect on wild-type GJB2. It is proposed that the different mechanisms of the dominant-negative effect on wild-type GJB2 involve cell growth and GJIC function. This study describes mutations found in Korean deaf patients and that are typical of other east Asian regions.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.5
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• pp.333-343
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• 2010

In Mokpo coastal zone, the characteristics showing ebb-dominant tidal flow was confirmed by analysis of observed tide and tidal currents, Physical factors occurring ebb-dominant flow were reviewed. Influence of critical depth for drying, bottom shear stress, coastal reclamation, tidal amplitude, nonlinear tide, and eddy viscosity on the change of ebb-dominant flow was investigated by applying a two-dimensional circulation model. The simulation results for a variety of conditions showed that eddy viscosity and critical depth for drying does little or no impact on the generation of asymmetric flow. Strong bottom friction stress makes ebb-dominant flow clearly. Change of tidal flat into land swells ebb- dominant flow, and change of tidal flat into sea disappears ebb-dominant flow. Nonlinear tides play a decisive role in the generation of asymmetrical tidal flow. Non-linear tides should be included in the open boundary conditions of hydrodynamic modeling in the Mokpo coastal zone.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.5
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• pp.502-510
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• 2000

Evaporation heat transfer characteristics were studied in a horizontal tube using R22/R114 non-azotropic refrigerant mixture. the heat transfer coefficient was high in the upper part for pure refrigerants, and heat transfer coefficient was low in the lower part for refrigerant mixtures. In the low quality region where nucleate boiling was dominant, the average heat transfer coefficient was low. In the region where forced convection was dominant, heat transfer coefficient was high. Results show that the heat transfer coefficient for pure refrigerants obtained by experiments were lower than those of Yoshida et al. but agreed well with Jung et al., and Chen et al. data. But the heat transfer coefficients for refrigerant mixtures were lower about 20% than those predicted by the equation for pure refrigerant.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.2
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• pp.211-216
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• 2015

Recently, because of the growth in the leisure industry and interest in health, the demand for bicycles has increased. In this research, considering the vertical load on a bike frame under static state conditions, the deflection and mass of the bike frame were minimized by satisfying the service condition and performing optimization. The thickness of the bicycle-frame tube was set to a design variable, and its sensitivity was confirmed by an analysis of means (ANOM). To optimize the solution, a response-surface-method (RSM) model was constructed using D-Optimal and central composite design(CCD). The optimization was performed using a non-dominant sorting genetic algorithm (NSGA-II), and the optimal solution was verified by finite-element analysis.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.2
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• pp.192-197
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• 2015

In many fields, the importance of reducing weight is increasing. A product should be designed such that it is profitable, by lowering costs and exhibiting better performance than other similar products. In this study, the mass and deflection of steel structures have to be reduced as objective functions under constraint conditions. To reduce computational analysis time, central composite design(CCD) and D-Optimal are used in design of experiments(DOE). The accuracy of approximate models is evaluated using the $R^2$ value. In this study, the objective functions are multiple, so the non-dominant sorting genetic algorithm(NSGA-II), which is highly efficient, is used for such a problem. In order to verify the validity of Pareto solutions, CAE results and Pareto solutions are compared.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.485-489
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• 2015

Purpose: The kappa angles of human eye were measured by photographs. The relationship between the dominant eye and far refractivity is studied. Methods: 112 adults participated in this study. The mean age was $22.54{\pm}5.90$ years. The kappa angles were measured by the deviation of the flash image in the photographs of eye. the dominant eye and the far refractivity were analyzed. Results: The distributions of kappa angles were 78.6% (176 eyes) in the positive angle, 15.2% (34 eyes) in the negative angle, and 6.2% (14 eyes) in the $0^{\circ}$. The kappa angles were $4.50{\pm}4.70^{\circ}$ for the dominant eye, $4.93{\pm}4.34^{\circ}$ for the non-dominant eye, $+6.00{\pm}2.22^{\circ}$ for the hypermetropia, $4.91{\pm}4.97^{\circ}$ for the emmetropia, and $+4.61{\pm}4.49^{\circ}$ for the myopia. The biggest kappa angles was odserved in the hypermetropia and the angles was getting smaller in the emmetropia, and the myopia. Conclusions: The kappa angle of the dominant eye was smaller than non-dominant eye. The kappa angle was smaller as the far refractivity is lower. The kappa angle can be directly measured by the photographic method.

• Therapeutic Science for Rehabilitation
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• v.2 no.2
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• pp.61-66
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• 2013

Objective : The purpose of this study was to analysis of disparity between bilateral hand movement when performing activity of daily living using accelerometer. Methods : The subjects of this study included 6 healthy adults. The assessment tool used Jebsen Hand Function Test and accelerometer. The subjects performed 7 sub-tests after wearing accelerometer around wrist. Results : Among sub-tests, writing was the only significantly correlated with difference between dominant and non-dominant hand(t=-2.394, p<.05). Further, non-dominant hand (M=2476.2, SD=802.2) showed more movement than dominant hand(M=1456.2, SD=667.6). Conclusion : This results indicated that accelerometer is useful tool for assessment of bilateral hand movement. Considering demographic characteristics, various subject group, further study is needed.

• Physical Therapy Korea
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• v.25 no.1
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• pp.47-52
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• 2018

Background: A limited hip rotational range of motion (ROM) has been considered to be one of characteristics of low back pain (LBP) in athletes. Although LBP frequently occurs in jiu-jitsu athletes, no previous has compared hip rotational ROM between jiu-jitsu athletes with and without LBP. Objects: The aim of the study was to compare ROM for hip internal rotation (IR) and external rotation (ER), and total hip rotation between jiu-jitsu athletes with and without LBP. Methods: Jiu-jitsu athletes were recruited for the LBP group ($n_1=15$) and control group without LBP ($n_2=15$). IR, ER, and total rotational range of hip joint were measured using a goniometer. Analysis of variance was used to compare the ROM between groups and sides. Results: The LBP group showed a significantly lower range of passive hip IR, passive total rotation, active IR, active ER, and active total rotation than the control group (p<.05). Dominant side of passive hip IR and active IR had a significantly lower ROM than non-dominant side (p<.05). In passive ER ROM, non-dominant side was significantly greater than dominant side (p<.05). Conclusion: Compared to jiu-jitsu athletes without LBP, athletes with LBP exhibit a loss of hip rotational ROM. Based on these results, clinicians and athletic trainers should measure hip rotational ROM when designing the management plan for jiu-jitsu athletes with LBP.

• Korean Journal of Applied Biomechanics
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• v.27 no.1
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• pp.19-23
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• 2017

Objective: The aim of this study was to investigate the relationship between the ball velocity and the upper extremity kinematics for both dominant and non-dominant side in inexperienced participants about an overarm throwing task. Method: Seven women who are inexperienced in overarm throwing participated in this study (Age: $25.1{\pm}2.4years$, Height: $160.8{\pm}3.5$; Weight $56.5{\pm}7.8$). Participants visit the laboratory for three days with one day rest between test sessions. Whole body 3-dimensional (3D) motion capture was recorded during the overarm throwing trials with ten cameras Vicon motion analysis system (T-10, T40, Oxford Metrics Ltd, UK). Total 45 overarm throwing were recorded for each side for each test session. Ball speed also was measured 3 meters away behind the subjects and recorded for every trial. Results: Mean ball velocity was higher for dominant hand compared to non-dominant hand (p <.05). Trunk segment variables (maximum angles and angular velocities) showed the most consistent relationship with the ball velocity. Conclusion: The importance of the trunk segment during the throwing activities can be seen in some individuals. But inconsistent results between subjects emphasize the importance of the individuals' movement patterns especially for bilateral sports. The future studies should be conduct about the sequence of segments, kinetic variables and effect of training.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.3
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• pp.89-98
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• 2020

PURPOSE: This study investigated the effects of unilateral static stretching on the flexibility and symmetry of the lower leg, and temporal gait variables in gait asymmetry people. METHODS: Twenty gait asymmetry people were divided into a unilateral static stretching group (USG, n = 10) and control group (CON, n = 10). The USG performed unilateral static stretching for 60 minutes, three times a week, and eight weeks. The flexibility of the lower leg (SR), and symmetry (BR), and temporal gait variables (Step length; SL, gait speed; GS) were measured before, after four and eight weeks of unilateral static stretching. Moreover, SI (symmetry index; SI) was calculated from the measured SL value. Statistical analyses were conducted using one-way ANOVA and two-way ANOVA with repeated measures, a paired t-test, and multiple comparisons according to Scheffe. RESULTS: SR and BR in the dominant and non-dominant side, and GS were increased significantly at USG after eight-weeks compared to before unilateral static stretching (p < .05). The difference in BR in the dominant and non-dominant side, and step length (SI) decreased significantly at USG after eight-weeks compared to before unilateral static stretching (p < .05). CONCLUSION: Unilateral static stretching improves the flexibility and symmetry of the lower leg, and temporal gait variables in gait asymmetry people.