• Toxicological Research
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• 제23권2호
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• pp.179-187
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• 2007

An International Nonproprietary Name (INN) identifies a pharmaceutical substance or active pharmaceutical ingredient by a unique name that is globally recognized and is of public property. Also known as the generic or common names, the official INNs are provided by national and international nomenclature bodies such as United States Adopted Names (USAN), British Approved Names (BAN), Japanese Accepted Names (JAN) and World Health Organization (WHO). Due to the increasing interest on the development of biotechnological products in Korea, needs for the formulated nomenclature body in Korea are arising for systemic management of newly developed biotechnological products. This study investigated and analyzed nomenclature systems and procedures for the selection of recommended INN for biotechnological products in WHO, USAN and JAN. Based on these documents from advanced countries, we suggested a Korean INN nomenclature organization named KAN (Korean Adopted Names or Korean Agreed Names). Composition and roles of KAN and KAN expert committee and a working process for INN selection/approval were also proposed. Taken together, this study provides a detailed information on INN system recognized worldwide and suggests guidelines for establishment of INN nomenclature system for biotechnological products in Korea.

• 대한한의학회지
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• 제24권1호
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• pp.92-99
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• 2003

Postpartum physiological, psychosocial, and economic changes bring with them some disorders of maternal mind and body, so postpartum management has been emphasized to date. After labor, some problems may appear like uterine bleeding, infection, depression and ache in or around joints. Some reports from traditional medical practitioners remark that over 50% of postpartum women have complaints within or around joints. For this study, arrangement of nomenclature, criteria and historical summarization are needed.

• 혜화의학회지
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• 제5권2호
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• pp.449-461
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• 1997

Anatomical terms is very important for the whole medical area. In the past, medical student have confused with the anatomical terms which were base on Japanish-Chinese. So they have to be made easily for reading and learning. Fortunately the anatomical terms in Korean had completely made through the fourth edition. According to the oriental law and customs human dissection was prohibited, therefore human anatomy naturally undeveloped. In this study, on the view of the Korean terms carried out the comparison between oriental and western anatomical terms in osteology and splanchnology. The oriental anatomical terms expressed with only looking at and touching the part of the human body. The gross structure of the osteology, is similar to oriental and western medicine but there's no detailed nomenclature of the bone. Instead of it, they expressed connection to acupuncture point or disease in the human body. So it's difficult to find out the anatomical terms of the splanchnology like recent ones.

• 한국세라믹학회지
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• 제24권2호
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• pp.155-160
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• 1987

본 연구는 제2보에서 합성한 $ZrSiO_4-Cd(SxSe_{1-x})$ 채료의 실용성을 조사하기 위하여 행하였다. 기존의 유명회사 제품의 채료와 본 합성채료를 비교 검사하였다. 우선 각각의 채료에 Frit를 적당한 비로 혼합하고 일정조성의 Tile에 시유하여 각각다른 온도(850-120$0^{\circ}C$)에서 소성한 다음 colorimeter를 사용하여 XYZ 주파장에 따른 색도도를 측정하였다. 또한 Munsell 계의 ISCC-NBS 색명법을 적용하여 색을 정량화 시킴으로서 채료의 적응성을 연구하였다. 그 결과 $ZrSiO_4-Cd(SxSe_{1-x})$ 채료는 V나 P 계통의 여타 채료와 같이 Frit 대 Stain의 비가 9:1의 최소비로 사용이 가능하며 100$0^{\circ}C$의 높은 온도에서도 밝은 적색으로 재현 될 뿐만 아니라 내산성이 강하고 고온에서 적응성이 있음을 확인하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권3호
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• pp.200-209
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• 2013

Over the past few years, a large number of perforator flaps have been revised by several microsurgeons in the USA, France, Canada and Japan. A perforator flap is a flap of skin or subcutaneous tissue that is based on the dissection of a perforating vessel, which is a perforator. In short, a perforator is a vessel that has its origin in one of the axial vessels of the human body. By reducing any muscle harvesting and trauma to a minimum, perforator flaps aim to minimize donor site morbidity, and by avoiding the transfer of dennervated muscle, the long-term bulk of the free tissue transfer becomes more predictable. There are a finite number of potential perforator flaps in the body, which are based on the named source arteries. The most commonly used perforator flaps are deep inferior epigastric perforator, superior gluteal artery perforator, thoraco dorsal artery perforator, medial sural artery perforator, and anterolateral thigh perforator flap. For a better understanding of perforators as a routine reconstructive procedure in oral and maxillofacial surgery, the definition with nomenclature, classifications with special characteristics, and review points for their individual applications must be learned and memorized by the young doctors in the course regarding the special curriculum periods for the Korean national board of oral and maxillofacial surgery. Perforator flaps have been known to have many advantages, so this review article summarized their applications to the maxillofacial reconstruction in the Korean language.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.253-263
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• 2023

The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluids and contain various bioactive materials, including proteins, lipids, nucleic acids, and mitochondrial DNA. Based on their origin and biogenesis, EVs can be classified as apoptotic bodies, microvesicles, and exosomes. Among these, exosomes are the smallest EVs (30-150 nm in diameter), which play a significant role in cell-to-cell communication and epigenetic regulation. Moreover, exosomal content analysis can reveal the functional state of the parental cell. Therefore, exosomes can be applied to various purposes, including disease diagnosis and treatment, drug delivery, cell-free vaccines, and regenerative medicine. However, exosome-related research faces two major limitations: isolation of exosomes with high yield and purity and distinction of exosomes from other EVs (especially microvesicles). No standardized exosome isolation method has been established to date; however, various exosome isolation strategies have been proposed to investigate their biological roles. Exosome-mediated intercellular communications are known to be involved in alcoholic liver disease and nonalcoholic fatty liver disease development. Damaged hepatocytes or nonparenchymal cells release large numbers of exosomes that promote the progression of inflammation and fibrogenesis through interactions with neighboring cells. Exosomes are expected to provide insight on the progression of liver disease. Here, we review the biogenesis of exosomes, exosome isolation techniques, and biological roles of exosomes in alcoholic liver disease and nonalcoholic fatty liver disease.