• Journal of Korean Neurosurgical Society
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• 제30권1호
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• pp.78-80
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• 2001

The bone formation accompanied with other diseases in brain has been rarely reported. Furthermore, it has not been reported without any specific disease. We report a case of a 27 year old female who was referred to our hospital because of the incidentally found calcified lesion in plain X-ray of the skull. The CT and MRI of the brain showed a calcification with minimal enhancement at left parietal area. The calcified lesion was removed and biopsy was performed with stereotactic guided craniotomy. Pathologically, the lesion was confirmed as the membranous bone which was composed of bony trabeculations with osteocytes and the biopsy from adjacent area to the bone revealed a gliosis without any other disease.

• The Journal of Korean Physical Therapy
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• 제22권6호
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• pp.91-98
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• 2010

Neurostimulation approaches have been developed and explored to modulate neuroplastic changes of cortical function in human brain. As one of the most primary noninvasive tools, transcranial direct current stimulation (tDCS) was extensively studied in the field of neuroscience. The alternation of cortical neurons depending on the polarity of the tDCS has been used for improving cognitive processing including working memory, learning, and language in normal individuals, as well as in patients with neurological or psychiatric diseases. In addition, tDCS has great advantages: it is a non-invasive, painless, safe, and cost-effective approach to enhance brain function in normal subjects and patients with neurological disorders. Numerous previous studies have confirmed the efficacy of tDCS. However, tDCS has not been considered for clinical applications and research in the field of physical therapy. Therefore, this review will focus on the general principles of tDCS and its related application parameters, and provide consideration of motor behavioral research and clinical applications in physical therapy.

• Molecules and Cells
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• 제42권12호
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• pp.828-835
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• 2019

PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. This review also discusses the consequences of dysregulation of neuronal PIWI-piRNA pathways in certain neurological disorders, including neurodevelopmental and neurodegenerative diseases. A full understanding of neuronal PIWI-piRNA pathways will ultimately provide novel insights into small RNA biology and could potentially provide precise targets for therapeutic applications.

• Annals of Clinical Neurophysiology
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• 제21권2호
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• pp.108-112
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• 2019

Non-Hodgkin's lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.

• 대한신경과학회지
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• 제36권4호
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• pp.329-332
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• 2018

Immune checkpoint inhibitor is associated with variety of immune-related adverse events. We present a case of polyneuropathy induced by immune checkpoint inhibitor, which was refractory to steroid and immunoglobulin. While high-dose steroid and immunoglobulin were not effective, we tried rituximab which is effective in other immune-mediated polyneuropathy. After rituximab treatment, patient's clinical symptom and nerve conduction study finding was markedly improved. We suggest rituximab might be effective in polyneuropathy induced by immune checkpoint inhibitor.

• International Journal of Computer Science & Network Security
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• 제24권6호
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• pp.59-66
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• 2024

Measurable electrophysiological changes in the scalp are frequently linked to brain activities. These progressions are called related evoked potentials (ERP), which are transient electrical responses recorded by electroencephalography (EEG) in light of tactile, mental, or motor enhancements. This painless strategy is gradually being used as a conclusion and clinical help. In this article, we will talk about the main ways to monitor brain activities in people with neurological diseases like Alzheimer's disease by analyzing EEG signals using ERP. We will also talk about how this method helps to detect the disease at an early stage.

• Journal of the Korean Data and Information Science Society
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• 제18권2호
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• pp.429-438
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• 2007

Headache is one of the most common reasons for neurological consultation. Headache as many causes and symptoms. Therefore, screening method using questionaire is helpful in diagnosis of headache. This paper is to propose a medical diagnostic method to grasp patient's diseases using the relations between symptoms and diseases. For this purpose, we develop an interview chart assigned IF(intuitionistic fuzzy) grade with the relation among symptoms and three labels of headache. The method can be used to classify patient's tone of diseases with certain degrees of belief and its concerned symptoms.

• Journal of Ginseng Research
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• 제36권4호
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• pp.342-353
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• 2012

Ginseng, the root of the Panax ginseng, has been a popular and widely-used traditional herbal medicine in Korea, China, and Japan for thousands of years. Now it has become popular as a functional health food and is used globally as a natural medicine. Evidence is accumulating in the literature on the physiological and pharmacological effects of P. ginseng on neurodegenerative diseases. Possible ginseng- or ginsenosides-mediated neuroprotective mechanisms mainly involve maintaining homeostasis, and anti-inflammatory, anti-oxidant, anti-apoptotic, and immune-stimulatory activities. This review considers publications dealing with the various actions of P. ginseng that are indicative of possible neurotherapeutic efficacies in neurodegenerative diseases and neurological disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis and multiple sclerosis.

• 보건행정학회지
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• 제23권4호
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• pp.376-386
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• 2013

Purpose: The purpose of study is to estimate the number of chronic disease patients and medical care expenditure at the time baby-boomers belong to 65 years old aging population, and compare with current 65 year-old aging population. Methods: Analysis method used an estimating formula devised by the researcher and estimated the number of chronic disease patients and medical care expenditure of each generation. Results: When comparing the estimated number of chronic diseases patients of each generation, 40.6% of the first generation, 76.4% of the second generation, 95.2% of third generation are expected to get chronic disease. When comparing each generation's total medical care expenditure, based on the estimated number of chronic diseases patients of each generation, the second generation( 1,206,251,224 thousand won) showed higher than other generation. This study compared the number of chronic disease patients and medical care expenditure between the second generation of the elderly and current elder generation. As a result, the second generation patients was higher than the fourth generation in high blood pressure, diabetes, psychological and behavioral disorder, and neurological diseases whereas the fourth generation is only high the number of patients in heart disease. As for total medical care expenditure, the second generation paid more in high blood pressure, psychological and behavioral disorder while the fourth generation in neurological disease and heart disease. Conclusion: It is desired that considering the number of chronic disease patients and medical care expenditure of baby boomers accounting for 14.6% of total population, in-depth follow-up study is carried out that inquires into what are issues with a current chronic disease management project, what business is needed in order to manage these issues, and how to fund to cover increasing medical care expenditure.

• 한국임상수의학회지
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• 제37권6호
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• pp.297-300
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• 2020

Lameness is a variation of normal gait in an animal, and it means that one or more limbs cannot be used correctly to allow the animal to walk. In the usual context, the incidence of hindlimb lameness in dogs is most likely the result of trauma, joint diseases, and/or congenital diseases. Generally speaking, the factors influencing hindlimb lameness include the animal's specific breed, size, weight, and whether it engages in frequent or strenuous activities. Many studies have investigated the incidence of lameness of large breed dogs, as compared to small breed dogs. Considering that many domestic dogs are small breeds, the lameness of small breed dogs with a high population in Korea was evaluated. The major causes of hindlimb lameness were found to be joint, musculoskeletal, and neurological abnormalities and the most were identified as joint diseases. Among the joint diseases, it was noted that a patellar luxation was the most common, of which the grade 3 medial patellar luxation was the highest rated type of joint disease noted.