Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin's lymphoma

  • Son, Hyoshin (Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Choi, Jongsuk (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Sung Un (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Park, Kyung Seok (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • Received : 2019.03.27
  • Accepted : 2019.07.02
  • Published : 2019.07.31
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Abstract

Non-Hodgkin's lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.

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References

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