• Communications for Statistical Applications and Methods
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• 제23권3호
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• pp.189-201
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• 2016

In survival analysis, the Nelson-Aalen estimator and Peterson estimator are often used to estimate a cumulative hazard function in randomly right censored data. In this paper, we suggested the smoothing version of the cumulative hazard function estimators using a Bezier curve. We compare them with the existing estimators including a kernel smooth version of the Nelson-Aalen estimator and the Peterson estimator in the sense of mean integrated square error to show through numerical studies that the proposed estimators are better than existing ones. Further, we applied our method to the Cox regression where covariates are used as predictors and suggested a survival function estimation at a given covariate.

• Communications for Statistical Applications and Methods
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• 제28권5호
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• pp.411-424
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• 2021

Inference following two-stage adaptive designs (also known as two-stage randomization designs) with survival endpoints usually focuses on estimating and comparing survival distributions for the different treatment strategies. The aim is to identify the treatment strategy(ies) that leads to better survival of the patients. The objectives of this study were to assess the performance three commonly cited methods for estimating survival distributions in two-stage randomization designs. We review three non-parametric methods for estimating survival distributions in two-stage adaptive designs and compare their performance using simulation studies. The simulation studies show that the method based on the marginal mean model is badly affected by high censoring rates and response rate. The other two methods which are natural extensions of the Nelson-Aalen estimator and the Kaplan-Meier estimator have similar performance. These two methods yield survival estimates which have less bias and more precise than the marginal mean model even in cases of small sample sizes. The weighted versions of the Nelson-Aalen and the Kaplan-Meier estimators are less affected by high censoring rates and low response rates. The bias of the method based on the marginal mean model increases rapidly with increase in censoring rate compared to the other two methods. We apply the three methods to a leukemia clinical trial dataset and also compare the results.

• Communications for Statistical Applications and Methods
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• 제9권3호
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• pp.753-763
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• 2002

When there is one change-point in the hazard rate model, a change-point estimator with the partial score process is suggested and compared with the previously developed estimators. The limiting distribution of the partial score process we used is a function of the Brownian bridge. Simulation study gives the comparison of change-point estimators.

• Journal of the Korean Data and Information Science Society
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• 제27권5호
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• pp.1253-1262
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• 2016

위험률에 변화점이 존재할 경우 위험률 변화점에 대한 추정 정확한 모수 추정을 위해 매우 필요하다. 본 연구에서는 한 개 위험률 변화점이 존재하는 경우 위험률의 변화점 추정량에 대한 비교 연구를 수행하였다. 우도함수에 기반한 모수적 방법인 Matthews와 Farewell (1982) 위험률 변화점 추정량과 Nelson-Aalen 누적 위험률에 기반한 비모수적 방법의 Zhang 등 (2014) 위험률 변화점 통계량을 고찰하여 특성을 파악하였다. 모의실험에서 지수분포를 따르는 생존데이터에 대해 위험률 변화점이 한 개 있는 경우 중도절단이 없는 경우와 중도절단이 있는 경위험률 추정량의 능력을 평균제곱오차를 계산하여 비교하였다. 실제 데이터에 대한 적용으로 백혈병 생존데이터와 원발성 담백증 경화 생존데이터에 대해 위험률 변화점을 추정하고 비교해 보았다.

• 한국디지털정책학회:학술대회논문집
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• 한국디지털정책학회 2006년도 추계학술대회
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• pp.327-336
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• 2006

The odds ratio is used for assessing the disease-exposure association, because epidemiological data for case-control of cohort studies are often summarized into 2 ${\times}$ 2 tables. In this paper we define the odds ratio function(ORF) that extends odds ratio used on discrete survival event data to continuous survival time data and propose estimation procedures with censored data. The first one is a nonparametric estimator based on the Nelson-Aalen estimator of comulative hazard function, and the others are obtained using the concept of empirical odds ratio. Asymptotic properties such as consistency and weak convergence results are also provided. The ORF provides a simple interpretation and is comparable to survival function or comulative hazard function in comparing two groups. The mean square errors are investigated via Monte Carlo simulation. The result are finally illustrated using the Melanoma data.

• Communications for Statistical Applications and Methods
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• 제26권6호
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• pp.623-633
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• 2019

This paper proposes two distance measures between two cumulative hazard functions that can be obtained by comparing their difference and ratio, respectively. Then we estimate the measures and present goodness of t test statistics. Since the proposed test statistics are expressed in terms of the cumulative hazard functions, we can easily give more weights on earlier (or later) departures in cumulative hazards if we like to place an emphasis on earlier (or later) departures. We also show that these test statistics present comparable performances with other well-known test statistics based on the empirical distribution function for an exponential null distribution. The proposed test statistic is an omnibus test which is applicable to other lots of distributions than an exponential distribution.