• Title/Summary/Keyword: Negative Side-Effects

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Beliefs about Physical Activity in Sedentary Cancer Patients: an In-depth Interview Study in France

  • Falzon, Charlene;Chalabaev, Aina;Schuft, Laura;Brizzi, Christophe;Ganga, Marion;d'Arripe-Longueville, Fabienne
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.6033-6038
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    • 2012
  • This study was designed to identify beliefs about physical activity in cancer patients. Semi- structured interviews were conducted with 20 patients under treatment, who were invited to identify perceived barriers for not adopting a physically active lifestyle and to express their beliefs about physical activity. Content analyses revealed five main categories of beliefs including four types of barriers: (a) barriers related to the side effects of treatment; (b) barriers related to a lack of perceived physical abilities; (c) barriers related to a lack of interest for physical activity; (d) beliefs about the negative effects of physical activity, and (e) beliefs about the positive effects of physical activity. These findings extend the existing literature by indicating how stereotypes may play a role in explaining sedentary lifestyles in cancer patients.

Augmentation Strategies for the Treatment of Schizophrenia (정신분열증 치료의 Augmentation Strategies)

  • Chung, Young Ki
    • Korean Journal of Biological Psychiatry
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    • v.5 no.2
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    • pp.149-154
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    • 1998
  • Antipsychotic drugs(APDs) have been effective to alleviate psychotic symptoms of schizophrenia. However, some schizophrenic patients do not respond to APDs. In addition to psychotic symptoms of schizophrenia, negative symptoms, excitement, violence, agitation, depression, and disorganization are frequently noted in patients with schizophrenia. Though APDs are the first line drugs for these symptoms, other drugs than APDs to augment the effects of APDs are efficacious for the treatment of these symptoms. Such augmenting drugs include benzodiazepines, anticonvulsants, antidepressants, lithium, and electroconvulsive therapy. These augmentation strategies can boost the effects of APDs or decrease the requirements of APDs, and consequently decrease the chance of the occurrence of side effects of APDs. Augmenting strategies are revewed for each class of drugs or treatment modality.

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A Numerical Study of a Effect of the Uniform Flow in Horizontal Convection (일반류가 수평대류에 미치는 영향에 관한 수치연구)

  • Lee, Hwa-Woon;Kim, Yoo-Keun;Jung, Woo-Sik
    • Journal of Environmental Science International
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    • v.7 no.3
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    • pp.349-360
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    • 1998
  • Effects of uniform flow on a two-dimensional mesoscale horizontal convection were investigated by using the vorticity and thermodynamic equations. For thins purpose, We simulated properties of a thermal convection m a stably stratified Boussinesq flued caused by partial heating at the center of a lower boundary If we don't consider effects of the uniform flow, the convection takes the form of aidsymmetrlc with respect to the z-alds. But when uniform flow Is strong, velocity field and temperature field consist of a sin91e cell structure which spreads upstream side of the partial heating area. The flow pattern for strong uniform flows takes the form of positive temperatue near the ground and negative temperature perturbation soft over the partial heating area, and downward motion directly over the upwind portion of the partial heating area and upward motion on the downstream side. The downstream edge of the upstream cell Is shifted in the downstream direction with the Increase of uniform flow almost linearly.

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Microstructure and Mechanical Properties of Cu-Ni-Si Alloy Deformed by Differential Speed Rolling (이속압연에 의해 가공된 Cu-Ni-Si 합금의 미세 조직 및 기계적 성질)

  • Lee, Seong-Hee;Han, Seung Zeon
    • Korean Journal of Materials Research
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    • v.26 no.1
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    • pp.8-12
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    • 2016
  • Effects of conventional rolling(CR) and differential speed rolling(DSR) on the microstructure and mechanical properties of Cu-Ni-Si alloy were investigated in detail. The copper alloy with thickness of 3 mm was rolled to 50 % reduction at ambient temperature without lubricant with a differential speed ratio of 2:1. The conventional rolling in which the rolling speed of upper and lower rolls is identical was performed under identical rolling conditions. The shear strain introduced by the CR showed positive values at positions of upper roll side and negative values at positions of lower roll side. However, it showed zero or positive values at all positions for the samples rolled by the DSR. The microstrucure and texture development of the as-rolled copper alloy did not show any significant difference between CR and DSR. The tensile strength of the DSR processed specimen was larger than that of the CR processed specimen. The effects of rolling methods on the microstructure and mechanical properties of the as-rolled copper alloy are discussed in terms of the shear strain.

Colorado Potato Beetle (Leptinotarsa decemlineata Say) Control Potential of Essential Oil Isolated from Iranian Cymbopogon citratus Stapf

  • Ebadollahi, Asgar;Geranmayeh, Jafar;Kamrani, Morteza
    • Natural Product Sciences
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    • v.23 no.4
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    • pp.235-238
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    • 2017
  • Colorado potato beetle is a most destructive insect pest of potato throughout the world. Although utilization of chemical insecticides is a main method for management of this pest, their negative side-effects such as threat to humans and the environmental pollution prompted researchers to search for natural alternatives. Recently plant essential oils with low or without side-effects against noun-targeted organisms and with high availability were considered as safe bio-pesticides. In the present study, toxicity of essential oil of Iranian lemongrass, Cymbopogon citratus Stapf, was evaluated against 3th instar larvae and adults of Colorado potato beetle by a leaf dipping method. Results displayed essential oil had notable toxicity against both larvae and adults after 24 and 48 h exposure times. Probit analysis revealed $LC_{50}$ values (lethal concentration to kill 50% of population) with 95% confidence limits were 10.32 (9.17 - 11.72) and 7.76 (6.80 - 8.74) ${\mu}l/ml$ for larvae and 6.27 (4.82 - 8.15) and 4.35 (3.24 - 5.62) ${\mu}l/ml$ for adults after 24 and 48 h, respectively. Based on regression analysis, a positive correlation between log concentration of essential oil and insect mortality was achieved. Results indicated C. citratus essential oil can be candidate as a natural alternative to the harmful chemical insecticides in the management of Colorado potato beetle.

A Case Report of a Chronic Schizophrenia Treated with Combined Treatment of Korean and Western Medicine

  • Park, Na-Eun;Park, Jun-Hyun;Kim, Dae-Eok;Seo, Young-Min;Kim, Sang-Ho;Chung, Dae-Kyoo
    • Journal of Oriental Neuropsychiatry
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    • v.26 no.4
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    • pp.349-356
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    • 2015
  • Objectives: Schizophrenia is difficult to treat effectively and the antipsychotics used have many side effects. However, few studies have focused on the combined treatment of Korean and Western medicine as an alternative. In this study, we reported an inpatient with chronic schizophrenia who was treated by a combination of Korean and Western medicine. Methods: We experienced a case of a diagnosed schizophrenia patient as whose chief complaint was avolition, diminished emotional expression and hallucination. The patient was treated with Western medicine and Korean traditional treatment including acupuncture, moxa and herbal medicine. The Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS) were used for assessment. Results: After treatment, symptoms involving avolition, diminished emotional expression and hallucination were improved; furthermore, the scores of the BPRS and the PANSS were decreased by approximately 50%, respectively. In addition, there were no notable side effects. Conclusions: The combined treatment of Korean and Western medicine can be an effective and well-tolerated treatment modality for patients with chronic schizophrenia.

Association of COVID-19 vaccine attitudes and cognitions of COVID-19-related stigma with vaccine hesitancy among college students

  • Kim, Ji-Soo
    • The Journal of Korean Academic Society of Nursing Education
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    • v.28 no.3
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    • pp.296-304
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    • 2022
  • Purpose: This study aimed to examine the association of COVID-19 vaccine attitudes and cognitions of COVID-19-related stigma with vaccine hesitancy among college students. Methods: This cross-sectional study using a web-based survey was conducted with 242 college students in April 2021 before Korea's national COVID-19 vaccination program had begun. Data were analyzed using multinominal logistic regression analyses. Results: Of the participants who were unsure of their intention to receive the COVID-19 vaccine, 66.0% had less experience with flu vaccinations and were 1.43 times more likely to report a mistrust of vaccine benefits (OR=1.43, CI=1.22, 1.68). Those with no intention of receiving the vaccine were 25.0% less likely to be aware of COVID-19 stigma (OR=0.75, CI=0.65, 0.86), 2.08 times more likely to mistrust vaccine benefits (OR=2.08, CI=1.62, 2.68), and 1.53 times more likely to worry about an unforeseen future negative side effects from vaccination (OR=1.53. CI=1.16, 2.00). Conclusion: Nurses could play an important role in educating college students about vaccination benefits, including reviewing vaccines' side effects with evidence, to reduce vaccine hesitancy. College students who have less empathy for others regarding COVID-19 infection might have higher COVID-19 vaccine hesitancy. Accordingly, explaining to students the necessity of their vaccination in preventing transmission to the surrounding community and vulnerable populations is critical.

A Study for Dose-Reduction of Antipsychotics in Chronic Schizophrenics (만성 정신분열병 환자에서 항정신병약물 감량에 관한 연구)

  • Hwang, Tae-Yeon;Lee, Min Soo;Kim, Hyeong-Seob
    • Korean Journal of Biological Psychiatry
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    • v.5 no.2
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    • pp.263-277
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    • 1998
  • Conventional high-dose antipsychotics tend to result in more side effects, negative symptoms and dysphoria, and at the same time lower the cognitive function which is already impaired in most schizophrenics. Florid psychotic symptoms, negative symptoms and cognitive impairment greatly impede psychosocial performance and eventual reintegration into society. The reduction of symptom and the improvement of cognitive funtions and social skills are therefore central to the psychiatric rehabilitation process. The purpose of this study was to evaluate the dose-reduction effects of antipsychotics on chronic schizophrenics prescribed conventional high-dose antipsychotics more than 1,500mg equivalent of chlorpromazine. Fifty-one chronic schizophrenics who maintained high-dose antipsychotics for more than three months were randomly assigned to two groups : 20 patients comprised the dose-maintaining group and 31 patients made the dose-reduction group. Over a sixteen weekperiod Positive and Negative Syndrome Scale(PANSS), Extrapyramidal Symptom(EPS), Nurses' Observation Scale for Inpatient Evaluation(NOSIE-30), Continuous Performance Test(CPT), Quality of Life(QOL), and haloperidol/reduced haloperidol blood levels were determined at the base line and after 2, 4, 6, 8, 12, 16 weeks to evaluate the dose reduction effects of high-dose antipsychotics. The results were as follows : 1) Dose-reduction is highly effective in reducing positive and negative symptoms, and general psychopathology. Effects were most prominent at 8, 12, 16 weeks. Among the dose reduction group, positive symptoms in positive symptom group and negative symptoms in negative symptom group were more reduced. 2 Extrapyramidal symptoms showed no significant difference between two groups. But the EPS was reduced time after time within two groups. 3) Hit rates of Continuous Performance Test, which indicate attentional capacity, increased significantly after dose reduction. 4) Haloperidol and reduced haloperidol blood levels decreased until the 4th week, after which they were constant. 5) Total scores of Nurses' Observation Scale for Inpatient Evaluation were unchanged between the two groups. But among the indices, social interest and personal neatness were improved in the dose-reduction group and retardation was aggrevated in the dose-maintaining group. 6) Total quality of life scores were unchanged between two groups. But in the dose maintaining group, satisfaction scores of attention, autonomy, and interpersonal relationship decreased progressively. These findings suggest that the dose reduction of antipsychotics for chronic schizophrenics on programs of high-dose antipsychotics were effective. Dose reduction should therefore be implemanted to spread the rehabilitation and improve quality of life for chronic schizophrenics.

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Structural Relationship of School Risk Factors and Suicide Ideation in Adolescence, Based on 'Escape Theory' Model ('도피이론(Escape Theory)' 모형에 기반한 학교위험요인과 청소년 자살생각의 구조적 관계)

  • Park, Jae-Sook
    • Korean Journal of Social Welfare
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    • v.63 no.3
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    • pp.5-27
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    • 2011
  • This study was based on the 'Escape Theory' model suggested by Baumeister(1990). Based on this analysis framework, this study attempted to examine that complicated direct and indirect effect of school risk factors(risk of academic scores, risk of relation with teacher and risk of peer relation) on suicide ideation in adolescence, through negative self-esteem, depression and withdrawal coping. To this end, this study used the data from the '2008 Gyeongsangbuk-Do youth crisis survey' conducted by the Youth service center in province of Gyeongsangbuk-Do. The target number of this study was 2,335 students in the age group of middle school and high school. The result of the Analysis indicate that risk of relation with teacher among school risk factors was only one which affected directly and indirectly on suicide ideation. The other side, risk of academic scores and risk of peer relation had indirect effects, via negative self-esteem, depression and withdrawal coping. In conclusion, this study confirmed that school risk factors had effects on suicide ideation directly or indirectly, they were complicatedly connected, through negative self-esteem, depression and withdrawal coping. Therefore, Prevention program for adolescence' suicide ideation or suicide risk require integrated strategies and tactics.

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A Study on the Stress of Social Network Service and Using Reluctant Intention (SNS 스트레스와 이용의도저하에 관한 연구)

  • Park, Hyun-Sun;Kim, Sang-Hyun
    • The Journal of Information Systems
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    • v.24 no.2
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    • pp.53-72
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    • 2015
  • Purpose The purpose of this study was to investigate the factors affecting the users' stress and using reluctant intention to use social network service(SNS). This study especially focused on stress of SNSs' user. Because SNS has led to negative effects such as invasion of privacy, addiction and social overload recently. In addition, adverse effects of SNS had caused SNSs' user to feel stress and fatigue. Design/methodology/approach This study developed hypotheses to empirically examine the factors that affect SNS users' stress and using reluctant intention. In order to verify research hypotheses, this study collected data from 362 users who currently use the SNS in Korea. Further, we used the smartPLS analysis. Findings The results of this study are as follows; First, reputation perception, unwanted relation burden, privacy concern, information overload and interaction overload had a significant positive effect on SNS users' stress. But international influence had no significant positive effect on SNS users' stress. Second, SNS users' stress had a significant positive effect on using reluctant intention. The results of this study provides theoretical foundations on the research for dark side of SNS and implies that SNS providers are in need of exerting an effort to minimize the negative aspects.