• 한국방사선학회논문지
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• 제17권5호
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• pp.679-684
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• 2023

정맥의 천자는 병리학적 검사를 위한 혈액 샘플을 획득하기 위해 널리 사용되고 있다. 바늘을 사용한 침습적인 정맥 천자 방법이 반복되서 시행되면 환자가 받는 고통이 증가되는 문제가 있어 본 연구팀은 사전에 소형 근적외선 (near-infrared, NIR) 영상 시스템을 개발하였다. 획득된 NIR 영상의 화질 개선을 위하여 본 연구에서는 노이즈 제거에 효율적으로 잘 알려진 비지역적 평균 (non-local means, NLM) 알고리즘을 모델링하여 시스템에서의 적용 가능성을 분석하고자 한다. 개발된 NIR 영상 시스템은 dichroic 및 long-pass filter를 적외선 (infrared, IR)이 통과하여 최종적으로 CMOS 센서 모듈로 검출되는 원리를 기반으로 구성하였다. 제안하는 NLM 알고리즘은 노이즈를 제거시키고자 하는 픽셀을 주변 픽셀들간의 거리들을 고려한 값으로 대체하는 원리를 기반으로 모델링하였다. 850 nm의 중심 파장을 가진 NIR 영상을 획득 후 NLM 알고리즘을 적용하여 히스토그램 평활화를 통해 최종 정맥 영역을 분할하였다. 결과적으로 NLM 알고리즘을 적용한 정맥의 NIR 영상의 coefficient of variation은 평균 0.247로 기존의 filtering 방법들과 비교하여 우수한 결과값으로 도출되었다. 또한 NLM 알고리즘의 dice similarity coefficient 값은 기존의 median filter와 total variation 방법에 비하여 각각 62.91 및 9.40% 향상된 값이 획득되었다. 결론적으로 NLM 알고리즘은 NIR 영상 시스템으로 획득한 정맥의 정확한 분할이 가능하게 할 수 있음을 증명하였다.

• 대한방사선기술학회지:방사선기술과학
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• 제44권1호
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• pp.9-14
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• 2021

With the recent advances in radiological science, there was radiographic techniques development and several researches to diagnosing dysphagia. We proposed the new Imaging technology based on Near Infrared radiation (NIR) for video fluoroscopic swallowing study (VFSS). To reduce the risk of the VFSS examination for swallowing rehabilitation, multi-NIR camera system comprised. Based on the multi-NIR camera imaging system, Computational simulation was conducted to identify the potential of the multi-NIR camera imaging system as a clinical tool (screening system). As a result of the simulation applied in this study, the proposed system has a potential to be a clinical solution although there is a few of limitations. we believe that it will be a good tool to support the VFSS as a screening technology in clinical fields.

• Bulletin of the Korean Chemical Society
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• 제34권10호
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• pp.2937-2941
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• 2013

Fluorescence imaging is considered as one of the most powerful techniques for monitoring biomolecule activities in living systems. Near-infrared (NIR) light is advantageous for minimum photodamage, deep tissue penetration, and minimum background autofluorescence interference. Herein, we have developed a new NIR fluorescent dye, namely, RB-1, based on the Rhodamine B scaffold. RB-1 exhibits excellent photophysical properties including large absorption extinction coefficients, high fluorescence quantum yields, and high photostability. In particular, RB-1 displays both absorption and emission in the NIR region of the "biological window" (650-900 nm) for imaging in biological samples. RB-1 shows absorption maximum at 614 nm (500-725 nm) and emission maximum at 712 nm (650-825 nm) in ethanol, which is superior to those of traditional rhodamine B in the selected spectral region. Furthermore, applications of RB-1 for fluorescence imaging in living cells and small animals were investigated using confocal fluorescence microscopy and in vivo imaging system with a high signal-to-noise ratio (SNR = 10.1).

• KSBB Journal
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• 제27권5호
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• pp.295-300
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• 2012

Matured dendritic cells (DCs) begin migration with their release from the bone marrow (BM) into the blood and subsequent traffic into peripheral lymphoid and non-lymphoid tissues. Throughout this long movement, migrating DCs must apply specialized skills to reach their target destination. Non-invasive in vivo cell-tracking techniques are necessary to advance immune cell-based therapies. In this study, we used a DiD cell-tracking solution for in vivo dendritic cell tracking in naive mice. We tracked DiD (non-invasive fluorescence dye)-labeled mature dendritic cells using the Near Infrared (NIR) imaging system in normal mice. We examined the immunophenotype of DiD-labeled cells compared with non-labelled mature DCs, and obtained time-serial images of NIR-DC trafficking after mouse footpad injection. In conclusion, we confirmed that DiD-labeled DCs migrated into the popliteal lymph node 24 h after the footpad injection. Here, these data suggested that the cell tracking system with the stable fluorescence dye DiD was useful as a cell tracking tool to advance dendritic cell-based immunotherapy.

• 융합신호처리학회논문지
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• 제18권1호
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• pp.25-30
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• 2017

현재 곡물선별기는 대부분 CCD 광학카메라를 이용하여 불량품을 찾아내고 있다. 본 논문에서는 CCD 카메라를 이용함과 동시에 근거리적외선 센서의 수분측정 방법을 추가하여 곡물선별기의 선별력향상을 목표로 한다. 그리고 구현한 알고리즘을 곡물선별기에 실제로 적용할 수 있도록 근거리적외선 영상보드 시스템을 개발하여, 원료의 내부 수분 함량을 고속으로 체크하여 일정함량 미달인 경우 불량으로 간주하여, 불량품을 실시간으로 제거하는 곡물선별기 시스템을 개발하고자 한다.

• 천문학회보
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• 제37권1호
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• pp.61.1-61.1
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• 2012

We examine both optical and optical/near-infrared (NIR) color distributions of the globular cluster (GC) system in the core of the Coma cluster of galaxies (Abell 1656), centered on the giant elliptical galaxy NGC 4874, to study how non-linearities in the color-metallicity relations of GC systems in large elliptical galaxies are linked to bimodal optical color distributions. Since optical-NIR color distributions of extragalactic GC systems reflect the underlying features of the metallicity distributions, we also present the color-color relation for this GC system. In order to do this, we combine F160W ($H_{160}$) NIR imaging data acquired with the Wide Field Camera 3 IR Channel (WFC3/IR), newly installed on Hubble Space Telescope (HST), with F475W ($g_{475}$) and FF814W ($I_{814}$) optical imaging data from the HST Advanced Camera for Surveys (ACS). To quantitatively explain the feature of color distributions, we use the Gaussian Mixture Modeling (GMM) code. Finally, we show the radial distribution of the GCs in the field of NGC 4874.

• 한국광학회지
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• 제28권1호
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• pp.22-27
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• 2017

본 논문에서는 음향광학 파장선택 필터(acousto-optic tunable filter) 기반의 파장훑음 레이저(wavelength swept laser)를 이용한 시간-인코딩 근적외선 분광 기술(time-encoded near-infrared spectroscopy)을 제안하였다. 파장훑음 레이저는 800 nm 근처 영역에서 이득 스펙트럼을 가지는 반도체 광 증폭기(semiconductor optical amplifier)를 기반으로 제작되었으며, 음향광학 파장선택 필터를 공진기 내부에 삽입함으로써 음향광학 파장선택 필터에 인가되는 전기적 라디오주파수에 따라 출력 파장을 선택할 수 있도록 하였다. 본 연구에서는 종래의 기술인 백색광 분광기 기반의 검출부 분광 근적외선 분광 기술과 제안된 파장훑음 레이저 기반의 광원부 분광 근적외선 분광 기술을 각각 이용하여 근적외선 흡수 염료 샘플의 흡광도를 각기 측정하여 실험적으로 비교함으로써 본 연구에서 제안하는 음향광학 파장선택 필터 기반 파장훑음 레이저를 이용한 근적외선 분광 기술의 특성을 증명하였다.

• 한국광학회지
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• 제22권3호
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• pp.134-140
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• 2011

본 논문에서는 생체 내부를 비침습적으로 영상화하기 위한 방법으로 생체내에서의 빛의 전파가 흡수보다는 산란이 지배적으로 작용하는 근적외선(NIR, near-infrared) 영역의 레이저 광원 및 광 검출기를 이용하여 주파수영역(frequency-domain) 확산 광 단층촬영(DOT, diffuse optical tomography) 시스템을 구현하였으며, 생체조직을 모사한 액체 팬텀에 광학적 특성이 다른 이형성분(anomaly)을 삽입하여 실험적으로 흡수 및 산란 분포에 대한 영상을 복원함으로써 이형성분의 위치와 형태에 대한 정보를 획득하였다.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 1993년도 Proceedings of International Conference for Agricultural Machinery and Process Engineering
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• pp.1354-1363
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• 1993

Optical methods were developed to examine their feasibility for quality evaluation of peanut with pod. Surface color and internal quality of peanut were measured without contact. The surface color of peanut was measured by light reflectance at a region of visible wavelengths. Its characteristic was high correlated with a visual grading of peanut. A trial machine for the color grading of peanut was developed using an optical sensor and it was considered to compare with the visual grading. The spectral reflectance at a region of near infrared wavelengths from 1,200 to 2,500nm was measured , and the chemical components of peanut were related to spectral reflectance at special wavelengths. The protein, fat and moisture contents of peanut were estimated by the near infrared methods. An infrared imaging method was developed to evaluate the internal quality of peanut with pod. As thermal characteristic of peanut with pod was deeply related to internal quality , the quality of peanut can be evaluated by temperature changes on the surface of peanut. Measurement of surface color, near infrared reflectance and thermal imaging were shown to be very effective in grading of peanut with pod.

• 천문학논총
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• 제21권2호
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• pp.43-49
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• 2006

The KASINICS (KASI Near Infrared Camera System) is a ground-based Near-Infrared (NIR) imaging instrument developed by the Korea Astronomy and Space Science Institute (KASI). In this paper, we report the test results of the KASINICS camera optics system which is comprised of a 1-1 Offner relay. We measure that the surface RMS fluctuations of the Offner mirrors are at the level of $10^{-1}-10^{-2}$ of the target wavelengths, showing that the mirrors are sufficiently smooth for NIR observations. The alignment of the Offner optics system has been checked too. Our ray-tracing simulations find that the image quality should not degrade more than the pixel size of the KASINICS ($40{\mu}m$), if a de-centering or a tilt of the Offner mirrors are within 5mm, or $2.5^{\circ}$. Our measurement shows that the de-centering or the tilt of the Offner mirrors are less than 1 mm or $0.5^{\circ}$, assuring that the KASINICS image quality are not affected by the alignment errors. We have also measured that the optics resolution is $20{\mu}m$ and it does not degrade more than 10% over the detector surface area of 14.3 mm ${/times}$ 14.3mm. Overall, we conclude that the KASINICS optics system satisfies the design requirements for NIR imaging observations.