• Journal of the Korean Society of Radiology
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• v.17 no.5
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• pp.679-684
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• 2023

Venous puncture is widely used to obtain blood samples for pathological examination. Because the invasive venipuncture method using a needle is repeatedly performed, the pain suffered by the patient increases, so our research team pre-developed a miniaturized near-infrared (NIR) imaging system in advance. To improve the image quality of the acquired NIR images, this study aims to model the non-local means (NLM) algorithm, which is well known to be efficient in noise reduction, and analyze its applicability in the system. The developed NIR imaging system is based on the principle that infrared rays pass through dichroic and long-pass filters and are detected by a CMOS sensor module. The proposed NLM algorithm is modeled based on the principle of replacing the pixel from which noise is to be removed with a value that reflects the distances between surrounding pixels. After acquiring an NIR image with a central wavelength of 850 nm, the NLM algorithm was applied to segment the final vein area through histogram equalization. As a result, the coefficient of variation of the NIR image of the vein using the NLM algorithm was 0.247 on average, which was an excellent result compared to conventional filtering methods. In addition, the dice similarity coefficient value of the NLM algorithm was improved by 62.91 and 9.40%, respectively, compared to the median filter and total variation methods. In conclusion, we demonstrated that the NLM algorithm can acquire accurate segmentation of veins acquired with a NIR imaging system.

• Journal of radiological science and technology
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• v.44 no.1
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• pp.9-14
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• 2021

With the recent advances in radiological science, there was radiographic techniques development and several researches to diagnosing dysphagia. We proposed the new Imaging technology based on Near Infrared radiation (NIR) for video fluoroscopic swallowing study (VFSS). To reduce the risk of the VFSS examination for swallowing rehabilitation, multi-NIR camera system comprised. Based on the multi-NIR camera imaging system, Computational simulation was conducted to identify the potential of the multi-NIR camera imaging system as a clinical tool (screening system). As a result of the simulation applied in this study, the proposed system has a potential to be a clinical solution although there is a few of limitations. we believe that it will be a good tool to support the VFSS as a screening technology in clinical fields.

• Bulletin of the Korean Chemical Society
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• v.34 no.10
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• pp.2937-2941
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• 2013

Fluorescence imaging is considered as one of the most powerful techniques for monitoring biomolecule activities in living systems. Near-infrared (NIR) light is advantageous for minimum photodamage, deep tissue penetration, and minimum background autofluorescence interference. Herein, we have developed a new NIR fluorescent dye, namely, RB-1, based on the Rhodamine B scaffold. RB-1 exhibits excellent photophysical properties including large absorption extinction coefficients, high fluorescence quantum yields, and high photostability. In particular, RB-1 displays both absorption and emission in the NIR region of the "biological window" (650-900 nm) for imaging in biological samples. RB-1 shows absorption maximum at 614 nm (500-725 nm) and emission maximum at 712 nm (650-825 nm) in ethanol, which is superior to those of traditional rhodamine B in the selected spectral region. Furthermore, applications of RB-1 for fluorescence imaging in living cells and small animals were investigated using confocal fluorescence microscopy and in vivo imaging system with a high signal-to-noise ratio (SNR = 10.1).

• KSBB Journal
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• v.27 no.5
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• pp.295-300
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• 2012

Matured dendritic cells (DCs) begin migration with their release from the bone marrow (BM) into the blood and subsequent traffic into peripheral lymphoid and non-lymphoid tissues. Throughout this long movement, migrating DCs must apply specialized skills to reach their target destination. Non-invasive in vivo cell-tracking techniques are necessary to advance immune cell-based therapies. In this study, we used a DiD cell-tracking solution for in vivo dendritic cell tracking in naive mice. We tracked DiD (non-invasive fluorescence dye)-labeled mature dendritic cells using the Near Infrared (NIR) imaging system in normal mice. We examined the immunophenotype of DiD-labeled cells compared with non-labelled mature DCs, and obtained time-serial images of NIR-DC trafficking after mouse footpad injection. In conclusion, we confirmed that DiD-labeled DCs migrated into the popliteal lymph node 24 h after the footpad injection. Here, these data suggested that the cell tracking system with the stable fluorescence dye DiD was useful as a cell tracking tool to advance dendritic cell-based immunotherapy.

• Journal of the Institute of Convergence Signal Processing
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• v.18 no.1
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• pp.25-30
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• 2017

Currently, most of the grain sorter uses CCD optic camera to find defective products. The aim of this paper is to use the CCD camera, and aim for improving the sorting power of the grain separator by using NIR(Near Infrared Radiation) sensor based on moisture content measurement algorithm. We intend to develop a system to develop an NFC imaging system in real time by developing an NIR imaging system and developing the grain sorter system that is considered to be defective in real time by checking the internal moisture content of the raw material in the real time.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.61.1-61.1
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• 2012

We examine both optical and optical/near-infrared (NIR) color distributions of the globular cluster (GC) system in the core of the Coma cluster of galaxies (Abell 1656), centered on the giant elliptical galaxy NGC 4874, to study how non-linearities in the color-metallicity relations of GC systems in large elliptical galaxies are linked to bimodal optical color distributions. Since optical-NIR color distributions of extragalactic GC systems reflect the underlying features of the metallicity distributions, we also present the color-color relation for this GC system. In order to do this, we combine F160W ($H_{160}$) NIR imaging data acquired with the Wide Field Camera 3 IR Channel (WFC3/IR), newly installed on Hubble Space Telescope (HST), with F475W ($g_{475}$) and FF814W ($I_{814}$) optical imaging data from the HST Advanced Camera for Surveys (ACS). To quantitatively explain the feature of color distributions, we use the Gaussian Mixture Modeling (GMM) code. Finally, we show the radial distribution of the GCs in the field of NGC 4874.

• Korean Journal of Optics and Photonics
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• v.28 no.1
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• pp.22-27
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• 2017

Time-encoded near-infrared spectroscopy (NIRS) system is proposed, based on a near-infrared (NIR) swept laser source, for comparison to the conventional NIRS method using a detector-type spectrometer. The cavity of the NIR swept laser source consists of a semiconductor optical amplifier (SOA) with a gain region around 800 nm, and several fiber-optic components. To change the output wavelength in time using an applied electric radio-frequency signal, an acousto-optic tunable filter (AOTF) is introduced in the fiber ring cavity configuration. To demonstrate the feasibility of an NIR swept laser source for NIRS imaging, the spectroscopic comparison of two kinds of absorbance-measuring systems a detector-type spectrometer using a white light source, and a source-type spectrometer using an NIR swept laser is successfully performed with an NIR-absorbing dye.

• Korean Journal of Optics and Photonics
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• v.22 no.3
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• pp.134-140
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• 2011

In this paper, we developed a frequency-domain diffuse optical tomography(DOT) system for non-invasively imaging in vivo. The system uses near-infrared(NIR) light sources and detectors for which the photon propagation in human tissue is dominated by scattering rather than by absorption. We present the experimental reconstruction images of absorption and scattering coefficients using a liquid tissue phantom, and we obtain the location and shape of an anomaly which has different optical properties than the phantom.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.1354-1363
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• 1993

Optical methods were developed to examine their feasibility for quality evaluation of peanut with pod. Surface color and internal quality of peanut were measured without contact. The surface color of peanut was measured by light reflectance at a region of visible wavelengths. Its characteristic was high correlated with a visual grading of peanut. A trial machine for the color grading of peanut was developed using an optical sensor and it was considered to compare with the visual grading. The spectral reflectance at a region of near infrared wavelengths from 1,200 to 2,500nm was measured , and the chemical components of peanut were related to spectral reflectance at special wavelengths. The protein, fat and moisture contents of peanut were estimated by the near infrared methods. An infrared imaging method was developed to evaluate the internal quality of peanut with pod. As thermal characteristic of peanut with pod was deeply related to internal quality , the quality of peanut can be evaluated by temperature changes on the surface of peanut. Measurement of surface color, near infrared reflectance and thermal imaging were shown to be very effective in grading of peanut with pod.

• Publications of The Korean Astronomical Society
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• v.21 no.2
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• pp.43-49
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• 2006

The KASINICS (KASI Near Infrared Camera System) is a ground-based Near-Infrared (NIR) imaging instrument developed by the Korea Astronomy and Space Science Institute (KASI). In this paper, we report the test results of the KASINICS camera optics system which is comprised of a 1-1 Offner relay. We measure that the surface RMS fluctuations of the Offner mirrors are at the level of $10^{-1}-10^{-2}$ of the target wavelengths, showing that the mirrors are sufficiently smooth for NIR observations. The alignment of the Offner optics system has been checked too. Our ray-tracing simulations find that the image quality should not degrade more than the pixel size of the KASINICS ($40{\mu}m$), if a de-centering or a tilt of the Offner mirrors are within 5mm, or $2.5^{\circ}$. Our measurement shows that the de-centering or the tilt of the Offner mirrors are less than 1 mm or $0.5^{\circ}$, assuring that the KASINICS image quality are not affected by the alignment errors. We have also measured that the optics resolution is $20{\mu}m$ and it does not degrade more than 10% over the detector surface area of 14.3 mm ${/times}$ 14.3mm. Overall, we conclude that the KASINICS optics system satisfies the design requirements for NIR imaging observations.