• Journal of Korean Society of Rural Planning
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• v.24 no.2
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• pp.69-78
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• 2018

The purpose of this study is on identifying vegetation change through monitoring representative complementary village forests according to different management. For this, two of complementary village forests around Mai mountain which many ones remain were selected. Those are complementary village forests of Seochon and Wonyeonjang. Seochon forest is a representative one which is managed naturally and Wonyeonjang one is a representative one which is managed artificially. The field survey for monitoring was preformed in 2002 and 2007, 2016. D(Dominant degree) and S(Sociability degree) were measured by Brown-Blanquet's method in field survey. Through the analysis and review of survey data, the change of species richness, appearing species characteristics, species composition and layer structure etc. according to different management was monitored. As a result, it can be seen that natural succession has increased species diversity, improved vegetation structure and circulation of complementary village forest. On the other hand, excessive anthropomorphic management was found to be detrimental to the health of the forests and to the vegetation structure and species composition. And it was found that excessive management threaten sustainability and periodical proper management is necessary. Through this review, the useful management direction of complementary village forests was suggested.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.2
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• pp.63-72
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• 2011

The aim of this study, a traditional residential area in the environmentally friendly design techniques to identify the techniques and principles that have been carried out to reestablish the principles. To do this, through literature review environmental performance is reflected in the traditional residential area side of resources conservation, locational aspects, spatial configuration, and how cases were selected looking for ways to apply modern. Are examples of upper class housing in the Chosen Dynasty Period period construction relatively well-preserved round and a good building with a clear housing Dokrakdang year were selected. Locational aspects of the terrain with minimal changes to the building and construction techniques were entirely in terms of environmental conservation and environmental temperature was adjusted to regulate the room temperature technique could be seen. In terms of cycling in natural materials were recycled. and water make used of positive through water cycling technique & water control. In addition, the importance of landscape views overlooking the landscape from inside to outside through the regulation of the various internal and external space technique was used to attract and expand. Traditionality in the pursuit of modern space, simply cut off because of tradition rather than to restore or recover the organizing principle inherent in the traditional space, and extraction of the contemporary social, cultural and environmental understanding of space is acceptable in basis. Environmentally-friendly design techniques in a traditional residential area for a long time to be developed by the experience of its application of modern environmental and energy problems and pleasant environment to the creation of human life and are subject to significant swings in that.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.370-387
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• 2023

The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems.

• Journal of Environmental Science International
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• v.13 no.6
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• pp.505-512
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• 2004

This study was attempted to review the information data for minimizing the destruction of environmental naturalness and the visual damage of landscape from road construction by establishing a model of environmental naturalness for national roads in the suburb areas to suggest an answer to a research question, ' hat does decide the environmental naturalness of roadscape?'. We found that 1) The road-side slope showed no statistical significance in the description of environmental naturalness of roadscape, but the fact that the road-side slope from road construction is the destruction of natural topography cannot be overlooked. 2) In terms of the direction of value variations for independent variables, signboard and telegraph post, soundproofing and protection wall, structure, and building acted toward negative (-) direction, while mountains, sky, road trees, fields, and surrounding green including the road-side slope acted toward positive(+) direction. 3) The variable with highest relative contribution to dependent variables among independent variables is building, which has importance as many as 148 times of road-side slope, while the variable road-side slope has the least importance. Building has the importance of 7.22 times, mountains 5.51 times, road trees 2.59 times, surrounding green 2.54 times, structure 2.41 times, signboard and telegraph post 2.37 times, soundproofing and protection wall 2.20 times, and sky 1.32 times of the fields as a standard criterion values 1.

• The Journal of Natural Sciences
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• v.19 no.1
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• pp.95-111
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• 2008

This paper aims to discussion the characteristics of location and spatial organization on the Donam SeoWon(confucian academy). To do this, we studied in analysis of the present conditions and photographing, research materials about the from of physical structure and review of historical documents. The result of analysis in the sight of the location and spatial organization was good matched. The spatial organization of the Donam SeoWon(confucian academy) was divided into entry space, lecturing space, management space and sacrificial space. Jonhakhumyo constructs axis of “Sanangru - Ipdeokmun - Yangseongdang - Naesammun - Sungryesa” and Eungdodang that not removed hall with 1880 shows characteristics a right angle in the left side of axis remove to location of present 1971. The result of this study, analysis of axis and Spatial structure shows backgrounds of these locations shows that the political and social, economical phenomena were influenced to the locations and spatial organization of the Donam SeoWon(confucian academy).

• IMMUNE NETWORK
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• v.23 no.1
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• pp.8.1-8.13
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• 2023

CD8⁺ T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8⁺ T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8⁺ T cells have been found to express activating or inhibitory NK receptors. CD8⁺ T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8⁺ T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8⁺ T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations.

• Journal of the Korean Institute of Educational Facilities
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• v.26 no.3
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• pp.15-23
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• 2019

This study aims to suggest a Biophilic classroom design of high school to obtain attention restoration for students. The learning space for youth in the modern society is composed of dry artificial structures. This space is considered to be a space that can not relieve stress caused by learning. "The Attention Restoration Theory" is divided into "Directed Attention" of humans, which is the cause of fatigue and stress, and "Involuntary Attention" as a solution to it. "Involuntary Attention" takes place in a rest state and helps the brain recover when exposed to nature. And the core of "Biophilic-Design Theory" is that humans can recover physical and mental conditions when exposed to nature. The purpose of this study is to apply "The Biophilic-Design Theory" that emphasizes the importance of exposure to nature to the educational space and plan the space where the 'Attention Restoration' can be achieved. The research method is as follows. First, we review previous studies related to "The Biophilic-Design Theory" and "The Attention Restoration Theory". Second, we analyze the application examples of "The Biophilic-Design Theory" and "The Attention Restoration Theory" in domestic and foreign educational spaces. Third, the concept of educational space is set up based on the elements derived from previous studies. Finally, we propose the planning direction of classroom design based on Biophilic-Design. The following conclusions were drawn. First, The creation of the education space to restore the learner's attention requires a visual space plan that utilizes natural elements such as natural light, artificial light, plants, and natural materials that can directly experience nature. Second, the direction in which students in the classroom can be "The Attention Restoration Theory" should consider the use of indirect natural elements that bring the surrounding natural landscape into the interior. This study will be used as the baseline data for the spatial design and planning of education facilities based on Biophilic-Design.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.11
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• pp.61-68
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• 2019

The analysis of outdoor and indoor spatial composition with natural elements is required for the creation of healing environment in healthcare facility to provide basic data for the planning of hospital architecture. Literature review of healing environment and investigation on characteristics of spatial composition in architectural works and healthcare facilities have been conducted. The spatial composition of outdoor space for refuge and prospect from indoor space of Seoul National University Hospital have been analyzed. The result of this research can be summarized as followed. First of all, the main natural elements for healing environment are consisted with refuge in outdoor space and prospect from indoor space. The second one is that natural elements in Seoul National University Hospital are located in central, posterior, and lateral area of main hospital and connectivity, integration, and ERAM(3) which the characteristics of outdoor spatial composition with space syntax are focused on the museum of medicine and landscape area in the center of hospital. The third one is that the outdoor refuge and prospect from indoor space in Seoul National University Hospital can be replaced with cultural heritage like the site of Kyungmogungji and Changgyeonggung palace in and next to the hospital. In addition to the outdoor and indoor spatial composition, it is necessary to analyze the relationship between elements to develop the healing environment of hospital architecture.

• Journal of the Korean Institute of Landscape Architecture
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• v.36 no.6
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• pp.91-101
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• 2009

In this study, the landscape of Insa-dong was interpreted from the viewpoint of a social construction of landscape, which regards the dynamic process of landscape change as more important than landscape visibility. This viewpoint also regards landscape as the result of its interaction with certain actors. From a review of previous studies on the same subject, it was found that the physical environment, institutions, and images are essential factors influencing landscape change. Insa-dong, which was Kwanindaing and Daesadong during the Joseon Dynasty, acquired symbolic meaning as a traditional area during the Japanese colonial period because of its many antique shops and Korean-style buildings. In 1970, the establishment of modern galleries in the district added to its image as a haven of the traditional Korean culture. Insa-dong thus eventually came to be referred to as "the street of traditional culture" by the people of Korea. Thanks to global festivals like the Asian Games, the Olympics, and the World Cup, Insa-dong's reputation as a cultural tourist destination has become stronger as these festivals created a need for a place in Korea where the country's traditional culture can be showcased to foreign tourists. After the mid-1990s, the merchants of Insa-dong began to cash in on the district's image as a showcase of traditional Korean culture due to the economic depression that emerged then. The people of Insa-dong and those outside it, however, came to feel that this trend damaged the district's image. Therefore, the people of Insa-dong and the district's local government started a movement to restore the aesthetic value and symbolic meaning of the district's landscape. This effort induced institutional change. Insa-dong used to be a natural haven of traditional Korean culture. Its landscape has recently been reconstructed so that this image could be restored. This process was made possible by the active interaction of diverse people: merchants, users, administrators, and NGOs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8041-8046
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• 2014

In-depth analysis of how TRAIL signals through death receptors to induce apoptosis in cancer cells using high throughput technologies has added new layers of knowledge. However, the wealth of information has also highlighted the fact that TRAIL induced apoptosis may be impaired as evidenced by experimental findings obtained from TRAIL resistant cancer cell lines. Overwhelmingly, increasing understanding of TRAIL mediated apoptosis has helped in identifying synthetic and natural compounds which can restore TRAIL induced apoptosis via functionalization of either extrinsic or intrinsic pathways. Increasingly it is being realized that biologically active phytochemicals modulate TRAIL induced apoptosis, as evidenced by cell-based studies. In this review we have attempted to provide an overview of how different phytonutrients have shown efficacy in restoring apoptosis in TRAIL resistant cancer cells. We partition this review into how the TRAIL mediated signaling landscape has broadened over the years and how TRAIL induced signaling machinery crosstalks with autophagic protein networks. Subsequently, we provide a generalized view of considerable biological activity of coumarins against a wide range of cancer cell lines and how coumarins (psoralidin and esculetin) isolated from natural sources have improved TRAIL induced apoptosis in resistant cancer cells. We summarize recent updates on piperlongumine, phenethyl isothiocyanate and luteolin induced activation of TRAIL mediated apoptosis. The data obtained from pre-clinical studies will be helpful in translation of information from benchtop to the bedside.