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The Assessment of Risk of Bias on Randomised Controlled Trials of Oriental Medicine in Korea (한의학 관련 무작위배정비교임상연구의 비뚤림 위험 평가)

  • Lee, Yoon-Jae;Jang, Bo-Hyoung;Go, Ho-Yeon;Hyun, Min-Kyung;Park, Sun-Young;Lee, Chang-Hoon;Kim, Jin-Sung;Cho, Ki-Ho
    • The Journal of Korean Obstetrics and Gynecology
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    • v.24 no.4
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    • pp.105-113
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    • 2011
  • Objectives: To examine the current status of clinical research in oriental medicine, and to assess 'risk of bias'(ROB) of randomized clinical trials(RCTs) in oriental medicine in Korea. Methods: Special committee for EBM, KOMS(Korean Oriental Medicine Society) reviewed 17 journals related to oriental medicine in Korea (from the first issue to May 2010), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 2, 2010), and PubMed (1966 to May 2010). Then we selected eligible RCTs in terms of oriental medicine, and assessed 'risk of bias'. Results: We reviewed 12,653 articles from the 17 journals, and 41 articles from CENTRAL and PubMed. After non-clinical articles were excluded, 1,004 articles were left. Among them, the number of eligible studies in terms of oriental medicine was 306. In these eligible studies, 130 were RCTs. Of RCTs, 69 were on acupuncture, 25 on herbal medicine. The proportion of 'unclear' is high in the criteria of 'Allocation concealment', 'Blinding of participants and personnel', 'Blinding of outcome assessment' and 'Other bias'. On the other hand, 'low' has high in the criteria of 'Incomplete outcome data' and 'Selective reporting'. Conclusions: Risk of bias on oriental medicine is unclear in terms of 'allocation concealment' and 'blinding'. For high-quality research in oriental medicine, further research should be needed on randomization and blinding in the RCTs.

Development of Environmental Safety Real-Time Monitoring System by Living Area (생활권역별 환경안전 실시간 모니터링 시스템의 개발)

  • Lee, Joo-Hyun;Kim, Joo-Ho;Lee, Seung-Ho
    • Journal of IKEEE
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    • v.23 no.3
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    • pp.1088-1091
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    • 2019
  • In this paper, a real-time monitoring system for environmental safety by living area is proposed. The proposed system is designed to measure radiation, fine dust and basic living information (temperature) using fixed and mobile measuring equipment, and constitutes a web database that stores data received from the equipment. It also develops web programs for displaying received data on PCs and mobile phones. The results of testing the performance of the system by an authorized testing agency showed that the radiation measurement range was measured in the range of $10{\mu}Sv/h$ to 10mSv/h, which is comparable to the world's highest level, and that the accuracy was measured between ${\pm}6.7$ and ${\pm}8.7$ percent of the measurement uncertainty was measured and normal operation at or below the international standard of ${\pm}15$ percent. In addition, the temperature test was conducted on a section of $-20^{\circ}C$ to $50^{\circ}C$ and normal operation was confirmed in response to the temperature change. Stability of radiated electromagnetic waves was ensured by a suitable judgment. The product's testing in general and high and low temperature environments for about four months after the prototype was made confirmed to be more than five years of durability. The measurement range and accuracy of fine dust sensors are compared with those of companies that measure the air environment, and the performance level is similar through the air quality measurement register.

A 10-bit 20-MS/s Asynchronous SAR ADC using Self-calibrating CDAC (자체 보정 CDAC를 이용한 10비트 20MS/s 비동기 축차근사형 ADC)

  • Youn, Eun-ji;Jang, Young-Chan
    • Journal of IKEEE
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    • v.23 no.1
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    • pp.35-43
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    • 2019
  • A capacitor self-calibration is proposed to improve the linearity of the capacitor digital-to-analog converter (CDAC) for an asynchronous successive approximation register (SAR) analog-to-digital converter (ADC) with 10-bit resolution. The proposed capacitor self-calibration is performed so that the value of each capacitor of the upper 5 bits of the 10-bit CDAC is equal to the sum of the values of the lower capacitors. According to the behavioral simulation results, the proposed capacitor self-calibration improves the performances of differential nonlinearity (DNL) and integral nonlinearity (INL) from -0.810/+0.194 LSBs and -0.832/+0.832 LSBs to -0.235/+0.178 LSBs and -0.227/+0.227 LSBs, respectively, when the maximum capacitor mismatch of the CDAC is 4%. The proposed 10-bit 20-MS/s asynchronous SAR ADC is implemented using a 110-nm CMOS process with supply of 1.2 V. The area and power consumption of the proposed asynchronous SAR ADC are $0.205mm^2$ and 1.25 mW, respectively. The proposed asynchronous SAR ADC with the capacitor calibration has a effective number of bits (ENOBs) of 9.194 bits at a sampling rate of 20 MS/s about a $2.4-V_{PP}$ differential analog input with a frequency of 96.13 kHz.

Analysis of Spatial Characteristics of Old Building Districts to Evaluate Fire Risk Factors (화재 위험요소의 도출을 위한 노후건축지구의 공간구성 특성분석)

  • Son, Byeung-Hun;Kang, Kyung-Ha;Ryu, Jung-Rim;Roh, Seung-Jun
    • Journal of the Korea Institute of Building Construction
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    • v.22 no.1
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    • pp.69-80
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    • 2022
  • The proportion of buildings over 30 years old in Korea has increased, from 29.0% in 2005 to 37.8% in 2019. These old buildings were built during a time in which there was a lack of building-related safety standards in areas such as fire safety performance. Worse, during their years of use, many such old buildings have had illegal changes and extensions made, making them more vulnerable in terms of safety. Fire safety investigations are being conducted to prevent large-scale disasters in multi-use buildings, but no investigation has been conducted at the regional district level, where small-scale old buildings are concentrated. Therefore, to identify fire risk factors in the old building district where old buildings are concentrated, the composition characteristics of the buildings were first analyzed. To examine the spatial characteristics of old building districts in order to derive fire risk factors, the results of this analysis based on the structure, use, roof type, and year of approval for use are as follows. It was found through our analysis that as of the date of approval for the use of the building, the main structure of the building has the greatest impact.

Designing a Blockchain-based Smart Contract for Seafarer Wage Payment (블록체인 기반 선원 임금지불을 위한 스마트 컨트랙트 설계)

  • Yoo, Sang-Lok;Kim, Kwang-Il;Ahn, Jang-Young
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.7
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    • pp.1038-1043
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    • 2021
  • Guaranteed seafarer wage payment is essential to ensure a stable supply of seafarers. However, disputes over non-payment of wages to seafarers often occur. In this study, an automatic wage payment system was designed using a blockchain-based smart contract to resolve the problem of seafarers' wage arrears. The designed system consists of an information register, a matching processing unit, a review rating management unit, and wage remittance before deploying smart contracts. The matching process was designed to send an automatic notification to seafarers and shipowners if the sum of the weight of the four variables, namely wages, ship type/fishery, position, and license, exceeded a pre-defined threshold. In addition, a review rating management system, based on a combination of mean and median, was presented to serve as a medium to mutually fulfill the normal working conditions. The smart contract automatically fulfills the labor contract between the parties without an intermediary. This system will naturally resolve problems such as fraudulent advance payment to seafarers, embezzlement by unregistered employment agencies, overdue wages, and forgery of seafarers' books. If this system design is commercialized and institutionally activated, it is expected that stable wages will be guaranteed to seafarers, and in turn, the difficulties in human resources supply will be solved. We plan to test it in a local environment for further developing this system.

Analysis of Keywords in national river occupancy permits by region using text mining and network theory (텍스트 마이닝과 네트워크 이론을 활용한 권역별 국가하천 점용허가 키워드 분석)

  • Seong Yun Jeong
    • Smart Media Journal
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    • v.12 no.11
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    • pp.185-197
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    • 2023
  • This study was conducted using text mining and network theory to extract useful information for application for occupancy and performance of permit tasks contained in the permit contents from the permit register, which is used only for the simple purpose of recording occupancy permit information. Based on text mining, we analyzed and compared the frequency of vocabulary occurrence and topic modeling in five regions, including Seoul, Gyeonggi, Gyeongsang, Jeolla, Chungcheong, and Gangwon, as well as normalization processes such as stopword removal and morpheme analysis. By applying four types of centrality algorithms, including stage, proximity, mediation, and eigenvector, which are widely used in network theory, we looked at keywords that are in a central position or act as an intermediary in the network. Through a comprehensive analysis of vocabulary appearance frequency, topic modeling, and network centrality, it was found that the 'installation' keyword was the most influential in all regions. This is believed to be the result of the Ministry of Environment's permit management office issuing many permits for constructing facilities or installing structures. In addition, it was found that keywords related to road facilities, flood control facilities, underground facilities, power/communication facilities, sports/park facilities, etc. were at a central position or played a role as an intermediary in topic modeling and networks. Most of the keywords appeared to have a Zipf's law statistical distribution with low frequency of occurrence and low distribution ratio.

Development of 'Soomany' for New Cultivar of Gomchwi with Disease Resistant and High Yield (내병 다수성 곰취 신품종 '수마니' 육성)

  • Suh, Jong Taek;Yoo, Dong Lim;Kim, Ki Deog;Lee, Jong Nam;Sohn, Hwang Bae;Nam, Jeong Hwoan;Kim, Su Jeong;Hong, Su Young;Kim, Yul Ho
    • Korean Journal of Plant Resources
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    • v.33 no.2
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    • pp.80-85
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    • 2020
  • A new Gomchwi cultivar 'Soomany' was derived from a cross between Gomchwi (Ligularia fischeri (Ledeb.) Turcz.) and Handaeri-gomchwi (Ligularia fischeri var. spiciformis Nakai). The investigation and selection of growth and yield characteristics were conducted from 2007 to 2015 in field and greenhouse of Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration, in Korea. On a newly developed cultivar 'Soomany', color of petiole ear is light green, petiole trichome is existent, trichome and light on the back of the leaves don't exist, and density of leaf vein is degree 4. Plant height, leaf length, leaf width and petiole length are 77.1, 22.3, 21.5 and 57.2 cm, respectively in the growth characteristics of the 2nd year. Plant size was also higher than that of 'Sammany' generally. Bolting date was on August 15. Flowering date was on September 19, about 9 days later than 'Sammany'. 'Soomany' and 'Sammany' had 149 and 133 leaves per plant, respectively. Total yield of 'Soomany' (1,623 g/plant) made a very good comparison with that of 'Sammany' (1,385 g/plant). 'Soomany' showed harder leaves (25.8 ㎏/㎠) than 'Sammany' (20.8 ㎏/㎠), whereas 'Soomany' had thinner leaves (0.53 mm) than 'Sammany' (0.62 mm). 'Soomany' variety has shown strong resistance to powdery mildew disease compared to 'Sammany'. In May 2019, the right of variety protection of 'Soomany' was registered as a new Gomchwi variety (Register No. 192).

Preparation and Measures for Elderly with Dementia in Korea : Focus on National Strategies and Action Plan against Dementia (한국의 치매에 대한 대응과 대책 : 국가 전략과 활동계획)

  • Lee, Moo-Sik
    • Journal of agricultural medicine and community health
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    • v.44 no.1
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    • pp.11-27
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    • 2019
  • Dementia is major epidemic disease of the 21st century in the world. Dementia is one of the major issues in public health globally. Also in Korea, the estimated prevalence of dementia was 8.7%(0.47 million) in 2010, the number will reach the 1 million mark in 2024, it will become a 15.1%(2.71 million) by 2050. Among Koreans aged 65 or older, 725,000 are estimated to be suffering from dementia in 2017. Against dementia, Korea developed three National Dementia Plans in 2008, 2012, and 2016. The 1st plan was came into effect in 2008 and focused on prevention, early diagnostic, development and coordination of infrastructures and management, and improving awareness. The 2nd plan was launched in 2012, addressed the same priorities but had a stronger focus on supporting family members. In 2012 the Dementia Management Act established a statutory basis for organization of the National Dementia Plans. Under the Dementia Management Act, the government is required to produce a comprehensive plan for dementia every 5 years. The Act also orders that the government should register the dementia patients and collect statistics on epidemiology and the management of the dementia conditions. The Dementia Management Act of Korea required the operation of the National Institute of Dementia and Metropolitan/Provincial Dementia Centers to make and carry out dementia management plans throughout the nation. The Act also mandate to establish Dementia Counselling Centers in every public health center and the National Dementia Helpline. The 3rd National Dementia Plan of 2016 aims to build a dementia friendly community to ensure people with dementia and their carer live well. This plan focus on community-based prevention and management of dementia, convenient and safe diagnosis, treatment, and care for people with dementia, the reduction of the care burden for family care-givers of people with dementia, and support for dementia research through research, statistics and technology. In 2017, Moon's government will introduce the "National Dementia Responsibility System," which guarantees most of the burden caused by dementia. This plan include that the introduction of a ceiling on self-pay for dementia diseases, expansion of the application of dementia care standards through alleviating the support criteria for long-term care insurance for mild dementia, expansion of dementia support centers, expansion of national and public dementia care facilities. In the meantime, Korea has accomplished many accomplishments by establishing many measures related to dementia and promoting related projects in a short time, but there are still many challenges.

Toxicity Assessment and Establishment Acceptable Daily Intake of Penthiopyrad (펜티오피라드(Penthiopyrad)의 독성평가와 일일섭취허용량 설정)

  • Jeong, Mi-Hye;Hong, Soon-Sung;Park, Kyung-Hun;Kim, Chan-Sub;Park, Jae-Eup;Hong, Moo-Ki;Im, Moo-Hyeog;Kim, Young-Bum;Han, Bum-Seok;Han, Jeung-Sul
    • The Korean Journal of Pesticide Science
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    • v.14 no.4
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    • pp.478-489
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    • 2010
  • Penthiopyrad is a fungicide agent in types of pyrazole which is showing the effect of prevention in fungal disease and powdery mildew. In order to register this new pesticide, reports of acute toxicity and chronic toxicity by animal study were examined to set acceptable daily intake to evaluate hazards of consumers. Acute toxicity was low in toxic, and it did not have the effect of acute dermal toxicity, acute eye irritation, or skin sensitization. As the result of the study in chronic toxicity, the common effect of chemical appeared in the liver and thyroid which was proven as a toxic effect. Two-generation reproduction toxicity, genotoxicity, and prenatal development toxicity were not proven. As the result of carcinogenic study, increase of thyiroid follicular adenoma in the rat and the frequency of liver hepatocellar adenoma in mice were also increased. However, it was decided that the threshold value on the effect in chemicals could be controlled through study liver enzyme induction. Therefore, the ADI for penthiopyrad is 0.081 mg/kg/ bw/day, based on the NOAEL of 8.10 mg/kg bw/day of twelve-months dogs study and applying an uncertainty factor of 100.

Current Status and Management of Alien Turtles in Korea (외래거북의 국내 현황 및 관리방안)

  • Lee, Do-Hun;Kim, Young-Chae;Chang, Min-Ho;Kim, Suhwan;Kim, Dongeon;Kil, Jihyon
    • Journal of Environmental Impact Assessment
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    • v.25 no.5
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    • pp.319-332
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    • 2016
  • Alien turtles belonging to Genus Trachemys have been designated as Invasive Alien Species since 2001 and their import has been banned in Korea. However, current status of import and distribution of the other alien turtles have not been reported. In this study, we aimed to investigate the taxa of alien turtles introduced into Korea, to assess their potential risks to the natural ecosystems and to suggest the future management directions of them in Korea. We identified 73 species of alien turtles belonging to 9 families. Since 2008, more than 6,000 kg of turtles have been imported annually and widely distributed through the pet shops, traditional markets and individual transactions. From the survey of natural habitats, we found that 8 species belonging to 3 families including Chrysemys picta, Pseudemys concinna, P. nelsoni, P. peninsularis, P. rubriventris, Mauremys sinensis, Macrochelys temminckii and Trachemys scripta have inhabited in 12 study sites. Out of 73 alien turtles, the potential adverse impacts of 13 species to ecosystems are serious when we considered status of designation of invasive alien species in other countries. For the management of alien turtles, it is required to register alien turtles in the import list and share general information such as import purpose, distribution and management condition among relevant authorities. The breeders and distributors must be obliged to identify turtles and to record management. The government must check transfer and migration of turtles periodically to prevent their introduction and spread into natural environments. The change of alien turtle populations in natural habitats should be monitored and their management plan should be developed to control the alien turtles in areas where the impacts are significant.