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Toxicity Assessment and Establishment Acceptable Daily Intake of Lepimectin (레피멕틴(Lepimectin)의 독성평가와 일일섭취허용량 설정)

  • Jeong, Mi-Hye;Hong, Soon-Sung;Park, Kyung-Hun;Park, Jae-Eup;Kwack, Seung-Jun;Kim, Young-Bum;Han, Bum-Seok;Son, Woo-Chen
    • The Korean Journal of Pesticide Science
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    • v.15 no.2
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    • pp.218-229
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    • 2011
  • Lepimectin is a insecticide agent. In order to register this new pesticide, the series of toxicity data on animal testing were reviwed to evaluate its hazards to consumers and to determine its acceptable daily intake. Lepimectin was mostly excreted by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic, chronic toxicity and carcinogenicity showed changes of hematology and clinical biochemistry parameter of serum and blood.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Lepimectin is 0.02 mg/kg/ bw/day, based on the NOAEL of 2.02 mg/kg/ bw/day of two-years carcinogenic toxicity study in rats and applying an uncertainty factor of 100.

Direct Strength Assessment of Pure Car and Truck Carrier under Maximum Cargo Loads (최대 화물 적재하중을 받는 자동차운반선의 직접강도평가)

  • Kim, Tae-Yeob;Yoon, Sung-Won;Cho, Je-Hyoung;Jung, Seung-Ho;Kim, Myung-Hyun
    • Journal of Ocean Engineering and Technology
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    • v.33 no.6
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    • pp.641-647
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    • 2019
  • Yearly world vehicle production has continued to increase, and the global seaborne trade volumes also are recovering. Based on these positive trends, as demand for cargo ships increases in the freight transportation market, Pure car and truck carriers (PCTCs) with large gaps between decks continue to be ordered. The structural analysis of the cargo hold was performed in order to confirm its structural safety in accordance with the guidance for the direct strength assessment of the Korean Register (KR) of Shipping. And, according to the type of cargo, the maximum deflection and structurally weak area that occurred in deck 5 was confirmed. Also, it was found that the weight of the cargo had a significant effect on the deck, the primary members of the deck's structure, and pillars. The results of the structural analysis conducted in this study were added to the existing cargo load planning software. This was done so that the prediction of the maximum stress and the deflection of the deck based on the information about the cargo could be confirmed quickly. In addition, the data will be used as the basic data for rapid information management response to changes in cargo items.

Development of HIL simulator for performance validation of stack inlet gases temperature controller of marine solid oxide fuel cell system (선박용 고체산화물형 연료전지 시스템의 스택 공급 가스 온도 제어기 성능 검증을 위한 HIL 시뮬레이터 개발)

  • Ahn, Jong-Woo;Park, Sang-Kyun
    • Journal of Advanced Marine Engineering and Technology
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    • v.37 no.6
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    • pp.582-588
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    • 2013
  • Solid Oxide Fuel Cell (SOFC) has been focused as a promising power source, which can replace a diesel engine regarding as major source of air pollution by the ship, due to high efficiency and eco-friendly. High operating temperature of SOFC is enable to secure of high efficiency, use various fuels and no need of high priced catalyst, but it may damage to components of SOFC. Therefore temperature control system has to be designed and validated before employing the fuel cell system for securing high efficiency and reliability. In this paper, instead of using typical method to validate performance of the controller, which consumes high cost and time, performance validation system using Hardware-in-the-loop simulation was developed and validated performence of the designed temperature controller for SOFC system.

Consideration of the Early Action in the GHG Emission Reduction (국내 온실가스 감축의 조기행동 인정 방안)

  • Song, Bo-Yun;Park, Su-Mi;Chung, Jin-Do
    • Journal of Korean Society for Atmospheric Environment
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    • v.27 no.2
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    • pp.209-213
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    • 2011
  • Enforcement Decree of the Framework Act on Low Carbon, Green Growth for achieving the country's GHG emission reduction goal of 30% was in effect. The remarkable content of the Act is the managements of targets for GHG reduction. So, the entities that have reduced voluntarily have much interest in the recognition of 'early action'. The recognition of early action is necessary to induce the fair competence of business entities and promote the voluntary GHG reduction. The definite and concrete guidance should be prepared. The important principles for this are the environmental integrity and the additionality. Based on this, the early action activities must be restricted to the voluntary, real, permanent, quantifiable, verifiable reduction. In the early action recognition, its credit should be allocated additionally set aside from the GHG target allocation in the national total allowance. Through this, the reward for the early reduction should be realized on market mechanism. The effective period to award the early action should be addressed. This can be the period after the enactment of framework on GHG reduction in effect and before the beginning year of GHG target control. It should be set with flexibility through the collection and consultation of the sector's opinions. The appropriate allowance reserve of early action was estimated as approximately 1~1.5% by using the data from the 'Pilot GHG Emission Trading Program' operated by Ministry of Environment. Also, the concrete and detail guidance to construct the necessary infra which is used to register the related information of early action activities should be prepared.

Stable Oxygen and Carbon Isotope Profiles of the Bivalve Shells collected from Coastal Regions of Korea: Comparison of the Coastal Water Properties

  • Khim, Boo-Keun
    • Journal of the korean society of oceanography
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    • v.32 no.1
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    • pp.28-37
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    • 1997
  • Two marine bivalve shells were collected from the eastern and western coastal regions of Korea, respectively. Stable oxygen and carbon isotope profiles are constructed using the incremental sampling along the axis of maximum growth to provide the continuous ${\delta}^{18}$O and ${\delta}^{13}$C records, which register the physical, biological and chemical properties of seawater where the organisms live. Cycles in the ${\delta}^{18}$O profiles are interpreted as annual along with the identification of annual growth bands; the maximum ${\delta}^{18}$O values correspond with the coldest temperature of seawater whereas the minimum ${\delta}^{18}$O values with the warmest temperature. The primary control on the amplitude of the ${\delta}^{18}$O profiles is seasonal variation of seawater temperature. The offset of the baseline between ${\delta}^{18}$O values of the two specimens is attributed to differences in both temperature and seawater ${\delta}^{18}$O values between two localities. The ${\delta}^{13}$C profiles show the similar seasonality of carbon cycling associated with phytoplankton productivity. The offset in the ${\delta}^{13}$C profiles between two specimens may be, as in the case of oxygen isotope profile, attributed to the different ${\delta}^{13}$C value of the seawater DIC (dissolved inorganic carbon) between the western coast and the eastern coast. Relationships between the shell isotopic composition and the coastal water properties of shell growth are readily interpreted from the ${\delta}^{18}$O-${\delta}^{13}$C pair diagram of the shell isotope data, similar to the use of salinity-${\delta}^{18}$O diagram for identifying water masses. The preliminary stable isotope results of this study suggest that mollusk shell isotope geochemistry may be useful to monitor the properties of water masses in the coastal and inner shelf setting around Korea and improve the interpretation of paleoceanography, provided the fossil mollusks are well preserved.

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Trends in Article Published in the Journal of Trauma and Injury: Bibliometric and Citation Analysis (대한외상학회지에 게재된 문헌들의 추세: 계량서지학과 인용을 이용한 분석)

  • Hutchison, Yejin L.;Cha, Hyun Min;Oh, Jae Hoon;Kang, Hyung Goo;Lim, Tae Ho;Lee, Yoon Je;Kang, Bo Seung;Kim, Chang Sun;Choi, Hyuk Joong
    • Journal of Trauma and Injury
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    • v.28 no.3
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    • pp.182-189
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    • 2015
  • Purpose: We performed a quantitative and qualitative analysis in the Journal of the Korean Society of Traumatology (JKST) by Bibliometrics to know the trends of articles. Methods: We reviewed articles in the JKST retrospectively through 1988 to 2014. Articles were classified into original articles, case reports, review articles, and also it is further classified as topics and the information related to the Department of Medicine of corresponding author. Original article was classified prospective and retrospective studies. Results: 753 studies and average of 27.9 studies per year were posted on JKST. 576 original articles (76.5%) were posted. Retrospective studies around 449 studies (78%) were posted and there were about 35 descript studies and 541 analytic studies. The most common themes were related to abdominal trauma, 144 pieces, 95 pieces following damage to the chest and the 84 pieces of special order of trauma. Emergency department had the highest case whereas general surgery came to the second place. Conclusion: Recently, there has been reduced proportion of original article in JKST. It was not possible to evaluate the Korea Citation index journals due to the fact that it does not correspond to listed register Journal of National Foundation of Korea. There will be the need for the effort to improve the maintenance of the posted article number, as well as the qualitative development of the posted articles.

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A Study on the Architectural Planning Characteristics of Medical Buildings - Focused on Cheong-ju Area (메디컬빌딩의 건축계획특성 연구 - 청주지역을 중심으로)

  • Baek, Sang Yeol;Kim, Gi Soo
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.21 no.3
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    • pp.69-77
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    • 2015
  • Purpose: Under a trend of hospitals that repeated expansion in line with fast increasing factors of medical demands in the past, medical buildings where clinic businesses have regularly gathered in one building have exponentially increased since separation of prescribing and dispensing in 2000. Thus, this study aims at analyzing characteristics of architectural plan of the current medical buildings, identifying strengths and weaknesses through Post Occupancy Evaluation and suggesting an architectural planning method of medical buildings to be planned in the future. Methods: Scope of study has been limited to 23 medical buildings that are registered in the building register as medical buildings out of the Class 1 neighborhood facilities build as 5 floors or more in Cheongju region since 2000 and being actually used for the usage. Study method is to define concepts of the medical buildings through literature review and advanced researches, analyze characteristics of architectural plan through drawing analysis and site survey. Results: General characteristics of architectural plans for the medical buildings in Cheongju have been analyzed. There are the most frequencies in general commercial area and semi-residential area, most of them are reinforced concrete structure and the Class 1 neighborhood facilities. Average land area is $482.68m^2$, gross floor area $3720.8m^2$, the number of underground floors level 1.16, the number of floors level 7.76, total number of floors 8.92, the building-to-land ratio 67.28%, floor area ratio 452.6%, height 31.44m, and the number of parked vehicles 24.16. Implications: This research will contribute to the establishment of the planning methods which increase the quality of Medical Buildings in Cheongju.

환경 오염물질에 대한 건강 위해성 평가 및 관리

  • Jeong, Yong
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 1997.12a
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    • pp.81-90
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    • 1997
  • 위해성평가 방법론이란 환경오염으로 인해 유발될 수 있는 인체의 위해성을 정성또는 정량적으로 추정하여 구체적이고도 과학적으로 평가하고자 하는 방법론으로서, 단순히 환경중 오염도를 위해도(risk)로써 알기 쉽게 수치적으로 제사하는 과정만이 아니라 오염물질의 발생에서부터 인체로의 영향까지를 통계학적, 동성학적, 수학적, 사회정책 및 경제학적 측면 등을 모두 고려하여, 정책 결정자들과 일반대중이 과학적 기반 위에서 합일점을 찾도록 하는데 과학적 근거로 제시될 수 있는 방법론이다. 과거에는 환경오염에 의한 피해의 유무, 즉 인간관계를 규명하는 것이 일차적 관심의 대상이었으나 구체적이고 정량적인 정보를 요구하는 현대 사회에서는 오염피해의 정도와 심각성을 평가하여 주민들에게 알려주어야 하며 어느 정도의 오염수준을 우리 사회에서 받아들일 수 있는가의 판단이 매우 중요한 문제로 떠오르게 되었다. 또한 복잡 다기화 되어 가고 있는 사회현상 속에서 이해관계와 불확실성으로 얽혀 있는 환경문제를 풀어나가기 위해서는 과학적이고 합리적인 방법론이 요구되고 있으며 이러한 방법론들이 환경관리정책의 기본이 되고 있음을 미국등 선진국의 예를 보아 알 수 있다. 위해성 평가의 필요성은 첫째, 환경오염 심화에 따른 인체건강영향에 대한 관심이 증대되었으며 둘째. 사회적 행정적으로 독성정보의 정량화 필요성이 대두되었고, 셋째, 현실성 있는 오염관리와 넷째. 기준치 제정, 제도시행 전후의 비용효과분석이 가능하다는 점들이다. 위해성 평가를 통하여 환경오염의 인체영향에 대한 종합적이고 계량적인 정보가 제공될 수 있어 국민, 정부, 기업 등 각 주체간의 의사 교환이 수월해지고 국민의 신뢰 회복에 기여할 수 있으며 수질 등 오염에 대한 합리적 기준을 제시할 수 있고 이에 따른 공학적 처리기술 목표 설정을 가능케 한다. 본 원고의 환경오염물질의 위해성 평가에 대한 방법론은 주로 미국 환경보호청의 자료 (US EPA, 1993)와 NAS(National Academy of Sciences, 1983), 미국에서 발행되는 정부 지침서 (Federal Register)에 고시된 내용 등을 토대로 하였다.

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A Study on the Prediction of the Optimal Welding Condition for Automotive Steel Sheets in MAG Welding Process (자동차용 강판의 MAG 용접시 최적용접조건 선정에 관한 연구)

  • Bang, Han-Sur;Bang, Hee-Seon;Joo, Sung-Min;Ro, Chan-Seung;Sung, Bo-Ram;Suk, Han-Gil
    • Journal of Welding and Joining
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    • v.27 no.3
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    • pp.38-43
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    • 2009
  • The optimization of the welding parameters was studied to maximize the weldability and minimize the amount of spatter in the MAG welding of automotive steel sheets under different shielding gas composition ratio. JS-EFSC, JS-SPHC steel plates and Ar mixture gases were used as a substrate and shielding gas for welding respectively. The five welding parameters were selected through preliminary experiments and their effects on the weldability were analyzed. Experiments were performed using the Taguchi experimental method. As results, appropriate range for welding could be achieved. Amount of spatter in 80%Ar+20%$CO_2$ shielding gas was 20% of that of $CO_2$welding. Therefore, in terms of high productivity and welding cost, Ar mixture gas(80%Ar+20%$CO_2$) was recommended as a shielding gas for application of MAG process, indicating the low spatter and good weld quality.

Breast Cancer Survival at a Leading Cancer Centre in Malaysia

  • Abdullah, Matin Mellor;Mohamed, Ahmad Kamal;Foo, Yoke Ching;Lee, Catherine May Ling;Chua, Chin Teong;Wu, Chin Huei;Hoo, LP;Lim, Teck Onn;Yen, Sze Whey
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8513-8517
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    • 2016
  • Background: GLOBOCAN12 recently reported high cancer mortality in Malaysia suggesting its cancer health services are under-performing. Cancer survival is a key index of the overall effectiveness of health services in the management of patients. This report focuses on Subang Jaya Medical Centre (SJMC) care performance as measured by patient survival outcome for up to 5 years. Materials and Methods: All women with breast cancer treated at SJMC between 2008 and 2012 were enrolled for this observational cohort study. Mortality outcome was ascertained through record linkage with national death register, linkage with hospital registration system and finally through direct contact by phone or home visits. Results: A total of 675 patients treated between 2008 and 2012 were included in the present survival analysis, 65% with early breast cancer, 20% with locally advanced breast cancer (LABC) and 4% with metastatic breast cancer (MBC). The overall relative survival (RS) at 5 years was 88%. RS for stage I was 100% and for stage II, III and IV disease was 95%, 69% and 36% respectively. Conclusions: SJMC is among the first hospitals in Malaysia to embark on routine measurement of the performance of its cancer care services and its results are comparable to any leading centers in developed countries.